U Drebber

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. doi request reprint Postoperative fulminant varicella zoster virus hepatitis with fatal outcome: a case report
    U Drebber
    Institute of Pathology, University of Cologne, Cologne, Germany
    Z Gastroenterol 46:45-7. 2008
  2. pmc High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF
    Andreas Claudius Hoffmann
    Department of Biochemistry and Molecular Biology and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    Neoplasia 10:674-9. 2008
  3. doi request reprint Extracapsular lymph node spread: a new prognostic factor in gastric cancer
    Hakan Alakus
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    Cancer 116:309-15. 2010
  4. ncbi request reprint [Primary infection with Epstein-Barr virus in a 77-year-old patient with B symptoms and hepatitis -- a case report]
    U Drebber
    Institut für Pathologie der Universität Köln
    Z Gastroenterol 44:387-90. 2006
  5. doi request reprint Liver biopsy in primary biliary cirrhosis: clinicopathological data and stage
    Uta Drebber
    Institute of Pathology, University Hospital, University of Cologne, Kerpener Strasse 62, Cologne, Germany
    Pathol Int 59:546-54. 2009
  6. ncbi request reprint [Histopathology in liver transplantation]
    U Drebber
    Institut für Pathologie der Universität Köln
    Pathologe 29:84-92. 2008
  7. ncbi request reprint The role of Epstein-Barr virus in acute and chronic hepatitis
    Uta Drebber
    Institute of Pathology, University of Cologne, Cologne, Germany
    J Hepatol 44:879-85. 2006
  8. ncbi request reprint [Diagnosis and differential diagnosis of hepatocellular carcinoma]
    U Drebber
    Institut für Pathologie der Universität zu Köln, Joseph Stelzmann Strasse 9, 50931, Koln
    Pathologe 27:294-9. 2006
  9. ncbi request reprint Induction of early murine cytomegalovirus infection by different reporter gene-associated recombinant viruses
    U Drebber
    Institute of Pathology, University of Cologne, Cologne, Germany
    J Viral Hepat 13:363-70. 2006
  10. ncbi request reprint The overexpression of c-met as a prognostic indicator for gastric carcinoma compared to p53 and p21 nuclear accumulation
    Uta Drebber
    Institute of Pathology, University of Cologne, Cologne, Germany
    Oncol Rep 19:1477-83. 2008

Collaborators

Detail Information

Publications77

  1. doi request reprint Postoperative fulminant varicella zoster virus hepatitis with fatal outcome: a case report
    U Drebber
    Institute of Pathology, University of Cologne, Cologne, Germany
    Z Gastroenterol 46:45-7. 2008
    ..Fulminant hepatitis due to varicella zoster virus (VZV) infection has a poor prognosis although an effective treatment is available...
  2. pmc High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF
    Andreas Claudius Hoffmann
    Department of Biochemistry and Molecular Biology and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    Neoplasia 10:674-9. 2008
    ..In this study, we investigated the prognostic values of HIF1a, bFGF, VEGF, and PDGFA gene expressions as well as their interrelationships...
  3. doi request reprint Extracapsular lymph node spread: a new prognostic factor in gastric cancer
    Hakan Alakus
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    Cancer 116:309-15. 2010
    ..The aim of the current study was to examine the prognostic value of extracapsular lymph node involvement in gastric cancer and to find correlations with clinicopathological parameters...
  4. ncbi request reprint [Primary infection with Epstein-Barr virus in a 77-year-old patient with B symptoms and hepatitis -- a case report]
    U Drebber
    Institut für Pathologie der Universität Köln
    Z Gastroenterol 44:387-90. 2006
    ..The relevance of EBV in the differential diagnosis of atypical infectious diseases with hepatitis of unknown aetiology is strengthened on taking data reports from the literature into consideration...
  5. doi request reprint Liver biopsy in primary biliary cirrhosis: clinicopathological data and stage
    Uta Drebber
    Institute of Pathology, University Hospital, University of Cologne, Kerpener Strasse 62, Cologne, Germany
    Pathol Int 59:546-54. 2009
    ..Biochemistry reflects only in part the degree of severity of histopathological lesions in PBC. Histopathology indicates comorbidity in a high percentage of patients...
  6. ncbi request reprint [Histopathology in liver transplantation]
    U Drebber
    Institut für Pathologie der Universität Köln
    Pathologe 29:84-92. 2008
    ..A high percentage of adult patients reveal histological features of idiopathic chronic hepatitis 6 months after LTX. Histopathological differential diagnosis of the combined underlying causes or complications is often difficult...
  7. ncbi request reprint The role of Epstein-Barr virus in acute and chronic hepatitis
    Uta Drebber
    Institute of Pathology, University of Cologne, Cologne, Germany
    J Hepatol 44:879-85. 2006
    ..However, little is known about the underlying pathogenesis and immunmechanisms and no standard diagnostic criteria to diagnose EBV-hepatitis are available...
  8. ncbi request reprint [Diagnosis and differential diagnosis of hepatocellular carcinoma]
    U Drebber
    Institut für Pathologie der Universität zu Köln, Joseph Stelzmann Strasse 9, 50931, Koln
    Pathologe 27:294-9. 2006
    ..The existence of underlying cirrhosis is helpful for the diagnosis and an ample spectrum of antibodies against liver antigens and adenocarcinomas are commercially available to confirm the correct diagnosis...
  9. ncbi request reprint Induction of early murine cytomegalovirus infection by different reporter gene-associated recombinant viruses
    U Drebber
    Institute of Pathology, University of Cologne, Cologne, Germany
    J Viral Hepat 13:363-70. 2006
    ..The morphological changes can be analysed while the respective reporter gene product is expressed by the virus construct...
  10. ncbi request reprint The overexpression of c-met as a prognostic indicator for gastric carcinoma compared to p53 and p21 nuclear accumulation
    Uta Drebber
    Institute of Pathology, University of Cologne, Cologne, Germany
    Oncol Rep 19:1477-83. 2008
    ..P21 proved to be a significant prognostic factor in the multivariate analysis. Our data suggest that the overexpression of c-met and p21 may represent independent prognostic factors in gastric carcinoma...
  11. doi request reprint Hepatic granulomas: histological and molecular pathological approach to differential diagnosis--a study of 442 cases
    Uta Drebber
    Institute of Pathology, University of Cologne, Cologne, Germany
    Liver Int 28:828-34. 2008
    ..The incidence of hepatic granulomas is reported in 2-15% of liver biopsies. This study was carried out to evaluate the incidence and aetiology of hepatic granulomas in a German Institute of Pathology with specialization in liver diseases...
  12. doi request reprint [Current aspects of liver allograft pathology]
    U Drebber
    Institut fur Pathologie, Universitätsklinik Köln, Kerpener Str 62, 50937, Koln, Deutschland
    Pathologe 32:113-23. 2011
    ..Furthermore, disease recurrence plays an important role and combined patterns of disease poses a challenge for the pathologist...
  13. ncbi request reprint Severe chronic diarrhea and weight loss in cholesteryl ester storage disease: a case report
    Uta Drebber
    Institute of Pathology, University of Cologne, Joseph Stelzmann Strasse 9, D 59031 Cologne, Germany
    World J Gastroenterol 11:2364-6. 2005
    ..An inherited deficiency of human lysosomal acid lipase (LAL) results in the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD). We want to present the rare case of CESD in an adult...
  14. doi request reprint [Cytomegalovirus. Pathological-anatomical manifestations and detection methods]
    U Drebber
    Institut fur Pathologie, Universitat Koln, Kerpener Str 62, 50937, Koln, Deutschland
    Pathologe 32:418-27. 2011
    ..The present article discusses the methods of pathological diagnostic approaches and describes organ manifestations of HCMV...
  15. ncbi request reprint [Clear cell tumor of the lung]
    U Drebber
    Institut fur Pathologie, Universitat Koln
    Pathologe 26:378-82. 2005
    ..The difficulty of the correct diagnosis of the clear cell tumor of the lung in frozen sections is discussed as well as the differential diagnosis...
  16. doi request reprint β-catenin and Her2/neu expression in rectal cancer: association with histomorphological response to neoadjuvant therapy and prognosis
    Uta Drebber
    Institute of Pathology, University Hospital Cologne, Kerpener Str 62, 50937, Cologne, Germany
    Int J Colorectal Dis 26:1127-34. 2011
    ..We examined the association of β-catenin and Her2/neu protein expression with histopathologic response to neoadjuvant radiochemotherapy and prognosis in patients with locally advanced rectal cancer...
  17. doi request reprint Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs 143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy
    Uta Drebber
    Institute of Pathology, University Hospital of Cologne, Kerpener Str 62, 50937 Cologne, Germany
    Int J Oncol 39:409-15. 2011
    ..The present results support the hypothesis that chemoradiotherapy can profoundly alter miRNA expression profiles. miRNAs might play important roles as molecular biomarkers in the prediction of response to treatment and prognosis...
  18. ncbi request reprint [The central odontogenic fibroma. A rare tumor]
    U Drebber
    Zentrum für Pathologie der Universität zu Köln, Cologne
    Pathologe 24:136-40. 2003
    ..Obvious problems concerning the differential diagnosis of odontogenic fibromas as well as current concepts regarding their exact designation and classification are discussed...
  19. doi request reprint Survivin expression in gastric cancer: Association with histomorphological response to neoadjuvant therapy and prognosis
    D Vallbohmer
    Department of General, Visceral and Cancer Surgery, Center for Integrated Oncology, University Hospital Cologne, Cologne 50937, Germany
    J Surg Oncol 99:409-13. 2009
    ..We examined the association of survivin protein expression with histopathologic response to neoadjuvant chemotherapy and prognosis in patients with gastric cancer...
  20. doi request reprint MicroRNA profiling in locally advanced esophageal cancer indicates a high potential of miR-192 in prediction of multimodality therapy response
    M Odenthal
    Institute of Pathology, University of Cologne, Cologne, Germany
    Int J Cancer 133:2454-63. 2013
    ....
  21. doi request reprint Prognostic impact of nodal micrometastasis in early esophageal cancer
    K L Prenzel
    Department of General, Visceral and Cancer Surgery, University of Cologne, Germany
    Eur J Surg Oncol 38:314-8. 2012
    ..There is a trend toward endoscopic resection for early cancer of the esophagus without lymphadenectomy. Frequency and prognostic impact of nodal micrometastasis in early cancer of the esophagus have not been investigated so far...
  22. doi request reprint Histological type of esophageal cancer might affect response to neo-adjuvant radiochemotherapy and subsequent prognosis
    E Bollschweiler
    Department of General, Visceral and Cancer Surgery, University of Cologne, Germany
    Ann Oncol 20:231-8. 2009
    ..This study investigates response and prognosis after neo-adjuvant chemoradiation (CTx/RTx) in patients with advanced esophageal carcinoma, according to histological type...
  23. ncbi request reprint Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer
    H Alakus
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Histol Histopathol 23:917-23. 2008
    ....
  24. ncbi request reprint Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors
    D Vallbohmer
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Oncol Rep 20:779-83. 2008
    ..Since our data are merely hypothesis-generating, serosal penetration should be evaluated in large prospective databases...
  25. doi request reprint GNAS1 T393C polymorphism is associated with histopathological response to neoadjuvant radiochemotherapy in esophageal cancer
    H Alakus
    Department of General, Visceral and Cancer Surgery, Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany
    Pharmacogenomics J 9:202-7. 2009
    ..The results support the role of the T393C polymorphism as a predictive molecular marker for tumor response to cisplatin/5-FU-based radiochemotherapy in esophageal cancer...
  26. ncbi request reprint Evaluation of histological regression grading systems in the neoadjuvant therapy of rectal cancer: do they have prognostic impact?
    D Vallbohmer
    Department of General, Visceral and Cancer Surgery, University of Cologne, Kerpenerstrasse 62, Cologne, Germany
    Int J Colorectal Dis 27:1295-301. 2012
    ..However, currently no accepted comprehensive grading system for clinical use is available. Therefore, we studied the impact of four histological regression grading systems in the neoadjuvant therapy of rectal cancer...
  27. doi request reprint Lymph node size and metastatic infiltration in adenocarcinoma of the pancreatic head
    K L Prenzel
    Department of General, Visceral and Cancer Surgery, University of Cologne, Germany
    Eur J Surg Oncol 36:993-6. 2010
    ..In imaging procedures lymph nodes >1 cm in size are regarded as metastatic nodes. The extend of lymphadenectomy and potential application of neoadjuvant therapy regimens could be dependent on this evaluation...
  28. pmc Nuclear survivin expression is associated with HPV-independent carcinogenesis and is an indicator of poor prognosis in oropharyngeal cancer
    S F Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University Hospital of Cologne, Cologne, Germany
    Br J Cancer 98:627-32. 2008
    ..975; 95% CI=2.377-107.360; P=0.004, respectively). Our data show that nuclear accumulation of survivin correlates with HPV-independent carcinogenesis and is an independent predictor of poor survival in patients with OSCC...
  29. doi request reprint HIF-1alpha protein expression is associated with the environmental inflammatory reaction in Barrett's metaplasia
    F C Ling
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Dis Esophagus 22:694-9. 2009
    ..All were significantly increased in metaplasia compared to SE without further change in tumor development. HIF-1alpha protein expression appears to be associated with inflammatory processes in the development of BM...
  30. pmc Tissues from routine pathology archives are suitable for microRNA analyses by quantitative PCR
    U Siebolts
    Institute of Pathology, University Hospital of Cologne, Cologne, Germany
    J Clin Pathol 62:84-8. 2009
    ..MicroRNAs have recently taken centre stage as short non-coding RNAs that regulate mRNA expression...
  31. doi request reprint Histopathological assessment of tumour regression, nodal stage and status of resection margins determines prognosis in patients with oral squamous cell carcinoma treated with neoadjuvant radiochemotherapy
    I Wedemeyer
    Department of Pathology, University of Cologne, Cologne, Germany Center of Integrated Oncology CIO Cologne Bonn, Cologne, Germany
    Oral Dis 20:e81-9. 2014
    ....
  32. pmc Analysis of microsatellite instability in colorectal carcinoma by microfluidic-based chip electrophoresis
    M Odenthal
    Institute of Pathology, University Hospital of Cologne, Germany
    J Clin Pathol 62:850-2. 2009
    ..In conclusion, microfluidic chip technology is a simple and reliable approach for MSI detection that allows label-free and very fast analysis of microsatellite amplicons...
  33. ncbi request reprint [Report of a spindle cell myoepithelialioma of the minor salivary glands with extensive lipomatous component]
    M A Kern
    Zentrum für Pathologie der Universität zu Köln
    Laryngorhinootologie 84:432-5. 2005
    ..We present the case report of a 38-year old man with a myoepithelioma of the minor palatinal salivary glands with extensive lipomatosis as an example of this rare phenomena...
  34. ncbi request reprint [ANCA-negative subglottic laryngeal stenosis in childhood]
    C Wittekindt
    Klinik und Poliklinik Fur Hals, Nasen, Ohren Heilkunde, Kopf und Hals Chirurgie am Klinikum der Universität zu Köln
    HNO 55:807-11. 2007
    ..Surgical interventions within the larynx or trachea might only be considered after ineffective therapy with immunosuppressive drugs...
  35. ncbi request reprint [Multiple primary pleomorphic adenomas of the unilateral parotid gland]
    V Helmstaedter
    Hals Nasen Ohren Klinik der Universität zu Köln
    Laryngorhinootologie 86:448-50. 2007
    ..Extracapsular dissection and subtotal lateral parotidectomy are alternatively discussed in current literature and preferred by many authors...
  36. ncbi request reprint [Liver metastases: incidence and histogenesis]
    H U Kasper
    Institut für Pathologie der Universität zu Köln
    Z Gastroenterol 43:1149-57. 2005
    ..Other entities were rarely found. Metastases in cirrhotic livers are seldom. The gross findings, the histology, the differential diagnosis including immunohistochemistry and the value of the liver biopsy is discussed...
  37. ncbi request reprint [Vascularized tumor of the scalp]
    C Wittekindt
    Klinik und Poliklinik Fur Hals, Nasen und Ohrenkrankenheiten, Universitat, Cologne
    HNO 51:737-8. 2003
  38. ncbi request reprint Expression of MUC1, MUC2 and oligosaccharide epitopes in breast cancer: prognostic significance of a sialylated MUC1 epitope
    Stephan E Baldus
    Institute of Pathology, University of Cologne, D 50931 Cologne, Germany
    Int J Oncol 27:1289-97. 2005
    ..Our data suggest that only the presence of a sialylated short-chain MUC1 glycoform is associated with a better prognosis, whereas the other molecules under study are not correlated with the course of disease and survival probability...
  39. pmc Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases
    Johannes W Rey
    Institute for Pathology, University Hospital Cologne, Kerpener Str 62, 50924 Cologne, Germany
    World J Gastroenterol 16:5830-7. 2010
    ..To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (PPARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD)...
  40. ncbi request reprint Precision cut tissue slices of the liver as morphological tool for investigation of apoptosis
    Hans Udo Kasper
    Institute of Pathology, University of Cologne, Joseph Stelzmann Str 9, D 50931 Koeln, Germany
    In Vivo 19:423-31. 2005
    ..For the study of apoptosis in liver diseases, different in vivo models and different in vitro approaches have been developed. They include cell culture models based on hepatocellular carcinoma cell lines or isolated primary hepatocytes...
  41. doi request reprint Expression of cyclooxygenase-2 (COX-2) in an advanced metastasized hypopharyngeal carcinoma and cultured tumor cells
    Martin Scheer
    Department for Oral and Craniomaxillo and Facial Plastic Surgery, University of Cologne, Kerpener Strasse 62, 50931, Cologne, Germany
    Oral Maxillofac Surg 14:53-7. 2010
    ..However, the role of COX-2 expression in cervical lymph node metastases of head and neck cancer has not been clarified yet...
  42. ncbi request reprint Mixed hepatoblastoma in an adult
    Hans Udo Kasper
    Institute of Pathology, Center for Molecular Medicine, University of Cologne, Cologne, Germany
    Arch Pathol Lab Med 129:234-7. 2005
    ..We believe that this case of a mixed hepatoblastoma in an adult should be added to the growing number of presumed hepatic precursor cell neoplasms in adults...
  43. ncbi request reprint Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: correlation with microvessel density
    Hans U Kasper
    Department of Pathology, University of Cologne, Joseph Stelzmann Strasse 9, D 50931 Koeln, Germany
    World J Gastroenterol 10:1918-22. 2004
    ..The inducible isoforms (iNOS and COX-2) are of great interest as regulators of tumor angiogenesis, tumorigenesis and inflammatory processes. This study was to clarify their role in pancreatic adenocarcinomas...
  44. ncbi request reprint Detection of opportunistic infections by low-density microarrays: a diagnostic approach for granulomatous lymphadenitis
    Margarete Odenthal
    Institute for Pathology, University Clinic of Cologne, Cologne, Germany
    Diagn Mol Pathol 16:18-26. 2007
    ..Our results show that microarray technology combined with multiplex PCR is a promising and time-saving tool in molecular pathology of infectious diseases, allowing sensitive, simultaneous analyses of different pathogens...
  45. ncbi request reprint Primary intraosseous carcinoma of the jaws arising from an odontogenic cyst--a case report
    Martin Scheer
    Department for Cranio Maxillofacial and Facial Plastic Surgery, University of Cologne, Cologne 50931, Germany
    J Craniomaxillofac Surg 32:166-9. 2004
    ..Squamous cell carcinoma of the jaw located purely in the bone is extremely rare. Most of these intraosseous carcinomas, also called odontogenic carcinomas are thought to arise from the epithelial lining of an odontogenic cyst...
  46. ncbi request reprint Dominance of CD4+ alpha/beta T-cells and inferior role of innate immune reaction in liver metastases
    Hans Udo Kasper
    Institute of Pathology, University of Cologne, Joseph Stelzmann Str 9, D 50931 Cologne, Germany
    Anticancer Res 23:3175-81. 2003
    ..Despite the well established knowledge about primary tumors, only little is known about metastatic disease, especially for liver metastases. The role of the innate immune system in the tumor defence is still enigmatic...
  47. ncbi request reprint Submandibular gland excision: 15 years of experience
    Simon Florian Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany
    J Oral Maxillofac Surg 65:953-7. 2007
    ..The aim of this study was to review a single institution's experience of a nonselected case series of submandibular gland excision over 15 years...
  48. doi request reprint Podoplanin expression in oral leukoplakia: prognostic value and clinicopathological implications
    M Kreppel
    Department for Oral and Cranio maxillo and Facial Plastic Surgery, University of Cologne, Cologne, Germany
    Oral Dis 18:692-9. 2012
    ..The aim of our study was to assess whether podoplanin expression in pretreatment biopsies could serve as a biomarker to predict the risk of malignant transformation in patients with oral leukoplakia...
  49. ncbi request reprint Long-term results of the combined modality therapy for advanced cervical metastatic head and neck squamous cell carcinoma
    S F Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, Medical School, University of Cologne, Josef Stelzmann Str 9, 50924 Cologne, Germany
    Eur J Surg Oncol 33:358-63. 2007
    ..The aim of this retrospective study was to investigate the outcome of these patients uniformely using a strategy which consists of surgery for the primary tumor and the neck metastases followed by postoperative radio(chemo)therapy...
  50. doi request reprint Early gastric cancer: lymph node metastasis starts with deep mucosal infiltration
    Arnulf H Holscher
    Department of General, Visceral and Cancer Surgery, University of Cologne, Kerpener St 62, D 50937 Cologne, Germany
    Ann Surg 250:791-7. 2009
    ..The purpose of this study was to evaluate the frequency of lymph node metastasis according to the depth of tumor infiltration of the mucosa and submucosa...
  51. doi request reprint Extracapsular lymph node involvement differs between squamous cell and adenocarcinoma of the esophagus
    Ralf Metzger
    Department of General, Visceral, and Cancer Surgery, University of Cologne, Germany
    Ann Surg Oncol 16:447-53. 2009
    ..005) higher in patients with pN1 AC (median = 5) compared with pN1 SCC (median = 3). We conclude that extracapsular LNI is an independent negative prognostic factor which occurs more frequently in esophageal AC than SCC...
  52. ncbi request reprint Liver biopsy in hepatitis C
    H P Dienes
    Institute of Pathology, University of Cologne, Germany
    J Hepatol 31:43-6. 1999
    ..Histopathology grade and stage of liver damage in chronic hepatitis C is not reflected by serum aminotransaminase level or serological status...
  53. doi request reprint Survivin and epidermal growth factor receptor expression in surgically treated oropharyngeal squamous cell carcinoma
    Simon Florian Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Cologne, Cologne, Germany
    Head Neck 30:1318-24. 2008
    ..Their correlation in oropharyngeal squamous cell carcinoma (OSCC) has not been evaluated yet...
  54. ncbi request reprint Differential c-erbB-1 and c-erbB-2 mRNA expression in cancer of the pancreas compared with cancer of the papilla of Vater
    Klaus L Prenzel
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Str 9, 50931 Cologne, Germany
    World J Gastroenterol 12:437-42. 2006
    ....
  55. doi request reprint Adiponectin inhibits steatotic CD95/Fas up-regulation by hepatocytes: therapeutic implications for hepatitis C
    Inga Wedemeyer
    Institute for Pathology, University Hospital, University of Cologne, Cologne, Germany
    J Hepatol 50:140-9. 2009
    ..We investigated this concept and potential roles of adiponectin and its receptors (AdipoR1; AdipoR2) in chronically HCV-infected patients...
  56. ncbi request reprint Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases
    Ute Warnecke-Eberz
    Department of Visceral and Vascular Surgery, Laboratory for Molecular Oncology, University of Cologne, Kerpener Strasse 62, Cologne, Germany
    Oncol Rep 20:619-24. 2008
    ..8%). Down-regulation occurs already in the early stage of NSCLC and is either directly involved in the lymphatic progression in NSCLC or represents a surrogate marker...
  57. pmc Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer
    Hakan Alakus
    Department of General, Visceral and Cancer Surgery, Center for Integrated Oncology, University Hospital of Cologne, Kerpener Str 62, D 50937 Cologne, Germany
    World J Gastroenterol 15:6061-7. 2009
    ..To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer...
  58. ncbi request reprint Comparative analysis of four histopathological classification systems to discriminate benign and malignant behaviour in gastrointestinal stromal tumors
    D Vallbohmer
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Anticancer Res 28:367-72. 2008
    ..The prognostic value of the four most common histopathological classification systems in gastrointestinal stromal tumors (GISTs) was evaluated retrospectively...
  59. doi request reprint Failure in downregulation of intratumoral survivin expression following neoadjuvant chemoradiation in esophageal cancer
    Daniel Vallbohmer
    Department of Visceral and Vascular Surgery, University of Cologne, Kerpenerstrasse 62, 50937 Cologne, Germany
    Pharmacogenomics 9:681-90. 2008
    ..We aimed to examine the association of survivin protein expression, an inhibitor of apoptosis, with histopathologic response to neoadjuvant chemoradiation and prognosis in patients with esophageal cancer...
  60. doi request reprint XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer
    Peter P Grimminger
    Department of General, Visceral, and Cancer Surgery, University of Cologne, Cologne, Germany
    J Surg Res 164:e61-6. 2010
    ..The gene polymorphism of the X-ray-repair-cross complementing (XRCC1-) gene (rs25487) was analyzed to predict response to neoadjuvant radiochemotherapy and prognosis in patients with locally advanced rectal cancer...
  61. doi request reprint MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma
    Heike Varnholt
    Institute for Pathology, University Hospital Cologne, Cologne, Germany
    Hepatology 47:1223-32. 2008
    ..Conclusion: A subset of microRNAs are aberrantly expressed in primary liver tumors, serving both as putative tumor suppressors and as oncogenic regulators...
  62. ncbi request reprint Florid ischemic cholangitis due to leucocytoclastic vasculitis
    Hans Udo Kasper
    Department of Pathology, University of Cologne, Joseph Stelzmann Str 9, D 50931, Cologne, Germany
    J Gastroenterol 39:188-91. 2004
    ..We conclude that hypersensitivity vasculitis must be included in the differential diagnosis of cholestasis and cholangitis...
  63. ncbi request reprint Ex vivo analysis of antineoplastic agents in precision-cut tissue slices of human origin: effects of cyclooxygenase-2 inhibition in hepatocellular carcinoma
    Michael A Kern
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Liver Int 26:604-12. 2006
    ..The analysis of COX-2 inhibition lends further support to the antineoplastic effects previously demonstrated in vitro and in animal models...
  64. ncbi request reprint Dendritic cells are significantly reduced in non-Hodgkin's lymphoma and express less CCR7 and CD62L
    Francesca Fiore
    Molecular Tumor Biology and Tumor Immunology, Clinic I for Internal Medicine, University of Cologne, Cologne, Germany
    Leuk Lymphoma 47:613-22. 2006
    ..Taken together, dendritic cells are phenotypically altered and reduced in number in NHL, potentially contributing to the loss of tumor control in these patients...
  65. ncbi request reprint Prognostic impact of protein overexpression of the proto-oncogene PIM-1 in gastric cancer
    Ute Warnecke-Eberz
    Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Kerpener Str 62, 50937 Cologne, Germany
    Anticancer Res 29:4451-5. 2009
    ..Here the prognostic impact of proto-oncogene PIM-1 was analyzed in gastric carcinoma...
  66. doi request reprint Prognostic relevance of skip metastases in esophageal cancer
    Klaus L Prenzel
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    Ann Thorac Surg 90:1662-7. 2010
    ..Little is known about this form of lymphatic spread in esophageal cancer. The aim of this study was to assess nodal skip metastasis and its clinical importance for patients with cancer of the esophagus...
  67. doi request reprint CUL2 and STK11 as novel response-predictive genes for neoadjuvant radiochemotherapy in esophageal cancer
    Ralf Metzger
    Department of General, Visceral and Cancer Surgery, Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, Kerpener Strasse 62, Koln, Germany
    Pharmacogenomics 11:1105-13. 2010
    ..Since only patients with major histopathological response benefit from multimodality treatment, we profiled the genome of patients with esophageal cancer for markers indicating response or nonresponse...
  68. doi request reprint Liver distribution of gammadelta-T-cells in patients with chronic hepatitis of different etiology
    Hans Udo Kasper
    Department of Pathology, University of Cologne, Cologne, Germany
    APMIS 117:779-85. 2009
    ..The immune-mediated phenomena in chronic hepatitis are dominated by alphabeta T cells. Thus, the adapted immune system is responsible for the inflammatory processes in chronic hepatitis...
  69. doi request reprint Hepatocyte expression of angiotensin II type 1 receptor is downregulated in advanced human liver fibrosis
    Sigrid Schulte
    Department of Gastroenterology and Hepatology, University of Cologne, Cologne, Germany
    Liver Int 29:384-91. 2009
    ..In bile duct-occluded rats, AT1R expression is significantly decreased in advanced liver fibrosis. Therefore, we studied the AT1R expression in human liver tissue during different stages of fibrosis caused by chronic hepatitis C...
  70. doi request reprint Variable 18F-fluorodeoxyglucose uptake in gastric cancer is associated with different levels of GLUT-1 expression
    Hakan Alakus
    Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Cologne, Germany
    Nucl Med Commun 31:532-8. 2010
    ..To clarify this observation, FDG uptake in gastric carcinoma was analyzed by focusing on histopathology and on the expression of the glucose transporter (GLUT-1) in the primary tumor...
  71. doi request reprint Impact of podoplanin expression in oral squamous cell carcinoma: clinical and histopathologic correlations
    Matthias Kreppel
    Department for Oral and Cranio maxillo and Facial Plastic Surgery, University of Cologne, Kerpener Strasse 62, Cologne, Germany
    Virchows Arch 456:473-82. 2010
    ..We concluded that podoplanin is expressed frequently in OSCC and that podoplanin expression correlates with cervical lymph node metastases and clinical outcome...
  72. doi request reprint Pathology of immune-mediated liver injury
    Hans Peter Dienes
    Institute of Pathology, University of Cologne, Cologne, Germany
    Dig Dis 28:57-62. 2010
    ..The main effector lymphocytes belong to the CD8 population, which are antigen-specific; however, the mechanisms seem to be suppressed by regulatory T cells...
  73. ncbi request reprint Mapping of Ki-67 protein distribution on whole organ serial sections of the larynx
    Claus Wittekindt
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Jena, Jena, Germany
    Acta Otolaryngol 128:207-12. 2008
    ..Immunostaining of whole organ serial sections of the larynx is feasible and will allow analysis of cellular alterations in the undisturbed anatomical context of whole organ serial sections of the larynx...
  74. ncbi request reprint Induction of antibodies to the PreS region of surface antigens of woodchuck hepatitis virus (WHV) in chronic carrier woodchucks by immunizations with WHV surface antigens
    Mengji Lu
    Institut fur Virologie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany
    J Hepatol 39:405-13. 2003
    ..Here we investigated the induction of antibody responses to hepadnaviral surface antigens in the woodchuck model, with emphasis on the vaccination of woodchucks chronically infected with woodchuck hepatitis virus (WHV)...
  75. ncbi request reprint Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses
    Lorraine M Work
    BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Avenue, Glasgow G12 8TA, UK
    Mol Ther 13:683-93. 2006
    ..Our findings significantly impact the design of viral vectors for targeting individual vascular beds in vivo...
  76. doi request reprint A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation
    Maria Quasdorff
    Molecular Infectiology at the Center for Molecular Medicine Cologne, Institute for Medical Microbiology, Goldenfelsstr 19 21, 50935 Cologne, Germany
    Cell Microbiol 10:1478-90. 2008
    ..Thus, a concerted action of HNF4alpha and HNF1alpha, which also determines morphological and functional differentiation of hepatocytes, links HBV replication to hepatocyte differentiation...