Susanne Dobler

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. pmc Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in the Na,K-ATPase
    Susanne Dobler
    Department of Biology, Hamburg University, 20146 Hamburg, Germany
    Proc Natl Acad Sci U S A 109:13040-5. 2012
  2. doi request reprint Coping with toxic plant compounds--the insect's perspective on iridoid glycosides and cardenolides
    Susanne Dobler
    Biocenter Grindel, Hamburg University, Martin Luther King Platz 3, 20146 Hamburg, Germany
    Phytochemistry 72:1593-604. 2011
  3. doi request reprint Stepwise evolution of resistance to toxic cardenolides via genetic substitutions in the Na+/K+ -ATPase of milkweed butterflies (lepidoptera: Danaini)
    Georg Petschenka
    Biozentrum Grindel, Martin Luther King Platz 3, 20146, Hamburg, Germany
    Evolution 67:2753-61. 2013
  4. pmc Functional evidence for physiological mechanisms to circumvent neurotoxicity of cardenolides in an adapted and a non-adapted hawk-moth species
    Georg Petschenka
    Molekulare Evolutionsbiologie, Biozentrum Grindel, Martin Luther King Platz 3, 20146 Hamburg, Germany
    Proc Biol Sci 280:20123089. 2013
  5. ncbi request reprint Direct evidence for membrane transport of host-plant-derived pyrrolizidine alkaloid N-oxides in two leaf beetle genera
    Ingo Narberhaus
    Biozentrum Grindel und Zoologisches Museum, Universitat Hamburg, Martin Luther King Platz 3, 20146 Hamburg, Germany
    J Chem Ecol 30:2003-22. 2004
  6. doi request reprint Host dependent iridoid glycoside sequestration patterns in Cionus hortulanus
    Christian Ulrich Baden
    Molecular Evolutionary Biology, Department of Biology, Hamburg University, Hamburg, Germany
    J Chem Ecol 39:1112-4. 2013
  7. doi request reprint The interplay between toxin-releasing β-glucosidase and plant iridoid glycosides impairs larval development in a generalist caterpillar, Grammia incorrupta (Arctiidae)
    Helga Pankoke
    Biozentrum Grindel, Martin Luther King Platz 3, 20146 Hamburg, Germany
    Insect Biochem Mol Biol 42:426-34. 2012
  8. doi request reprint Evidence for selective sweeps by Wolbachia infections: phylogeny of Altica leaf beetles and their reproductive parasites
    Regina Jäckel
    Zoological Institute, University of Hamburg, Martin Luther King Platz 3, 20146, Hamburg, Germany
    Mol Ecol 22:4241-55. 2013
  9. doi request reprint Amino acid substitutions of Na,K-ATPase conferring decreased sensitivity to cardenolides in insects compared to mammals
    Safaa Dalla
    Molecular Evolutionary Biology, Biocenter Grindel, Universitat Hamburg, Martin Luther King Pl 3, 20146 Hamburg, Germany
    Insect Biochem Mol Biol 43:1109-15. 2013
  10. doi request reprint Physiological screening for target site insensitivity and localization of Na(+)/K(+)-ATPase in cardenolide-adapted Lepidoptera
    Georg Petschenka
    Biozentrum Grindel Molekulare Evolutionsbiologie, Martin Luther King Platz 3, 20146 Hamburg, Germany
    J Insect Physiol 58:607-12. 2012

Detail Information

Publications10

  1. pmc Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in the Na,K-ATPase
    Susanne Dobler
    Department of Biology, Hamburg University, 20146 Hamburg, Germany
    Proc Natl Acad Sci U S A 109:13040-5. 2012
    ..Thus, even across deep phylogenetic branches, evolutionary degrees of freedom seem to be limited by physiological constraints, such that the same molecular substitutions confer adaptation...
  2. doi request reprint Coping with toxic plant compounds--the insect's perspective on iridoid glycosides and cardenolides
    Susanne Dobler
    Biocenter Grindel, Hamburg University, Martin Luther King Platz 3, 20146 Hamburg, Germany
    Phytochemistry 72:1593-604. 2011
    ..Cardenolides, on the other hand, may lose their toxicity if their target site is modified and this strategy has evolved multiple times independently in cardenolide-adapted insects...
  3. doi request reprint Stepwise evolution of resistance to toxic cardenolides via genetic substitutions in the Na+/K+ -ATPase of milkweed butterflies (lepidoptera: Danaini)
    Georg Petschenka
    Biozentrum Grindel, Martin Luther King Platz 3, 20146, Hamburg, Germany
    Evolution 67:2753-61. 2013
    ..Thus, the interplay between bottom-up selection by plant compounds and top-down selection by natural enemies can explain the evolutionary sequence of adaptations to these toxins...
  4. pmc Functional evidence for physiological mechanisms to circumvent neurotoxicity of cardenolides in an adapted and a non-adapted hawk-moth species
    Georg Petschenka
    Molekulare Evolutionsbiologie, Biozentrum Grindel, Martin Luther King Platz 3, 20146 Hamburg, Germany
    Proc Biol Sci 280:20123089. 2013
    ..This may explain the high in vivo resistance to cardenolides observed in some lepidopteran larvae, despite their highly sensitive Na(+)K(+)-ATPases...
  5. ncbi request reprint Direct evidence for membrane transport of host-plant-derived pyrrolizidine alkaloid N-oxides in two leaf beetle genera
    Ingo Narberhaus
    Biozentrum Grindel und Zoologisches Museum, Universitat Hamburg, Martin Luther King Platz 3, 20146 Hamburg, Germany
    J Chem Ecol 30:2003-22. 2004
    ..Accumulation of detrimental free base PA is prevented by glucosylation (Oreina) or N-oxidation (Longitarsus)...
  6. doi request reprint Host dependent iridoid glycoside sequestration patterns in Cionus hortulanus
    Christian Ulrich Baden
    Molecular Evolutionary Biology, Department of Biology, Hamburg University, Hamburg, Germany
    J Chem Ecol 39:1112-4. 2013
    ..Our data thus contradict genetically fixed differences between populations living on either plant but rather document the host plants' influence on the beetles' metabolism. ..
  7. doi request reprint The interplay between toxin-releasing β-glucosidase and plant iridoid glycosides impairs larval development in a generalist caterpillar, Grammia incorrupta (Arctiidae)
    Helga Pankoke
    Biozentrum Grindel, Martin Luther King Platz 3, 20146 Hamburg, Germany
    Insect Biochem Mol Biol 42:426-34. 2012
    ....
  8. doi request reprint Evidence for selective sweeps by Wolbachia infections: phylogeny of Altica leaf beetles and their reproductive parasites
    Regina Jäckel
    Zoological Institute, University of Hamburg, Martin Luther King Platz 3, 20146, Hamburg, Germany
    Mol Ecol 22:4241-55. 2013
    ..As for effects of Wolbachia on reproduction, infection with wLytA1 appears to be correlated with a substantial sex ratio distortion, which was most prominent in A. lythri. ..
  9. doi request reprint Amino acid substitutions of Na,K-ATPase conferring decreased sensitivity to cardenolides in insects compared to mammals
    Safaa Dalla
    Molecular Evolutionary Biology, Biocenter Grindel, Universitat Hamburg, Martin Luther King Pl 3, 20146 Hamburg, Germany
    Insect Biochem Mol Biol 43:1109-15. 2013
    ..Obviously, the intense selection pressure on cardenolide exposed insects has resulted in very efficient substitutions that decrease cardenolide sensitivity extremely...
  10. doi request reprint Physiological screening for target site insensitivity and localization of Na(+)/K(+)-ATPase in cardenolide-adapted Lepidoptera
    Georg Petschenka
    Biozentrum Grindel Molekulare Evolutionsbiologie, Martin Luther King Platz 3, 20146 Hamburg, Germany
    J Insect Physiol 58:607-12. 2012
    ..Most plausibly, the perineurium surrounding the nervous tissue functions as a barrier which prevents cardenolides from reaching Na(+)/K(+)-ATPase in the ventral nerve cord...