Affiliation: University of Hamburg
- Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in the Na,K-ATPaseSusanne Dobler
Department of Biology, Hamburg University, 20146 Hamburg, Germany
Proc Natl Acad Sci U S A 109:13040-5. 2012..Thus, even across deep phylogenetic branches, evolutionary degrees of freedom seem to be limited by physiological constraints, such that the same molecular substitutions confer adaptation...
- Coping with toxic plant compounds--the insect's perspective on iridoid glycosides and cardenolidesSusanne Dobler
Biocenter Grindel, Hamburg University, Martin Luther King Platz 3, 20146 Hamburg, Germany
Phytochemistry 72:1593-604. 2011..Cardenolides, on the other hand, may lose their toxicity if their target site is modified and this strategy has evolved multiple times independently in cardenolide-adapted insects...
- Functional evidence for physiological mechanisms to circumvent neurotoxicity of cardenolides in an adapted and a non-adapted hawk-moth speciesGeorg Petschenka
Molekulare Evolutionsbiologie, Biozentrum Grindel, Martin Luther King Platz 3, 20146 Hamburg, Germany
Proc Biol Sci 280:20123089. 2013..This may explain the high in vivo resistance to cardenolides observed in some lepidopteran larvae, despite their highly sensitive Na(+)K(+)-ATPases...
- Direct evidence for membrane transport of host-plant-derived pyrrolizidine alkaloid N-oxides in two leaf beetle generaIngo Narberhaus
Biozentrum Grindel und Zoologisches Museum, Universitat Hamburg, Martin Luther King Platz 3, 20146 Hamburg, Germany
J Chem Ecol 30:2003-22. 2004..Accumulation of detrimental free base PA is prevented by glucosylation (Oreina) or N-oxidation (Longitarsus)...
- Stepwise evolution of resistance to toxic cardenolides via genetic substitutions in the na(+) /k(+) -ATPase of milkweed butterflies (lepidoptera: danaini)Georg Petschenka
Biozentrum Grindel, Martin Luther King Platz 3, 20146, Hamburg, Germany
Evolution 67:2753-61. 2013..Thus, the interplay between bottom-up selection by plant compounds and top-down selection by natural enemies can explain the evolutionary sequence of adaptations to these toxins. ..
- The interplay between toxin-releasing β-glucosidase and plant iridoid glycosides impairs larval development in a generalist caterpillar, Grammia incorrupta (Arctiidae)Helga Pankoke
Biozentrum Grindel, Martin Luther King Platz 3, 20146 Hamburg, Germany
Insect Biochem Mol Biol 42:426-34. 2012....
- Physiological screening for target site insensitivity and localization of Na(+)/K(+)-ATPase in cardenolide-adapted LepidopteraGeorg Petschenka
Biozentrum Grindel Molekulare Evolutionsbiologie, Martin Luther King Platz 3, 20146 Hamburg, Germany
J Insect Physiol 58:607-12. 2012..Most plausibly, the perineurium surrounding the nervous tissue functions as a barrier which prevents cardenolides from reaching Na(+)/K(+)-ATPase in the ventral nerve cord...