Affiliation: University of Hamburg
- Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in the Na,K-ATPaseSusanne Dobler
Department of Biology, Hamburg University, 20146 Hamburg, Germany
Proc Natl Acad Sci U S A 109:13040-5. 2012..Thus, even across deep phylogenetic branches, evolutionary degrees of freedom seem to be limited by physiological constraints, such that the same molecular substitutions confer adaptation...
- Coping with toxic plant compounds--the insect's perspective on iridoid glycosides and cardenolidesSusanne Dobler
Biocenter Grindel, Hamburg University, Martin Luther King Platz 3, 20146 Hamburg, Germany
Phytochemistry 72:1593-604. 2011..Cardenolides, on the other hand, may lose their toxicity if their target site is modified and this strategy has evolved multiple times independently in cardenolide-adapted insects...
- Stepwise evolution of resistance to toxic cardenolides via genetic substitutions in the Na+/K+ -ATPase of milkweed butterflies (lepidoptera: Danaini)Georg Petschenka
Biozentrum Grindel, Martin Luther King Platz 3, 20146, Hamburg, Germany
Evolution 67:2753-61. 2013..Thus, the interplay between bottom-up selection by plant compounds and top-down selection by natural enemies can explain the evolutionary sequence of adaptations to these toxins...
- Functional evidence for physiological mechanisms to circumvent neurotoxicity of cardenolides in an adapted and a non-adapted hawk-moth speciesGeorg Petschenka
Molekulare Evolutionsbiologie, Biozentrum Grindel, Martin Luther King Platz 3, 20146 Hamburg, Germany
Proc Biol Sci 280:20123089. 2013..This may explain the high in vivo resistance to cardenolides observed in some lepidopteran larvae, despite their highly sensitive Na(+)K(+)-ATPases...
- Direct evidence for membrane transport of host-plant-derived pyrrolizidine alkaloid N-oxides in two leaf beetle generaIngo Narberhaus
Biozentrum Grindel und Zoologisches Museum, Universitat Hamburg, Martin Luther King Platz 3, 20146 Hamburg, Germany
J Chem Ecol 30:2003-22. 2004..Accumulation of detrimental free base PA is prevented by glucosylation (Oreina) or N-oxidation (Longitarsus)...
- Host dependent iridoid glycoside sequestration patterns in Cionus hortulanusChristian Ulrich Baden
Molecular Evolutionary Biology, Department of Biology, Hamburg University, Hamburg, Germany
J Chem Ecol 39:1112-4. 2013..Our data thus contradict genetically fixed differences between populations living on either plant but rather document the host plants' influence on the beetles' metabolism. ..
- The interplay between toxin-releasing β-glucosidase and plant iridoid glycosides impairs larval development in a generalist caterpillar, Grammia incorrupta (Arctiidae)Helga Pankoke
Biozentrum Grindel, Martin Luther King Platz 3, 20146 Hamburg, Germany
Insect Biochem Mol Biol 42:426-34. 2012....
- Evidence for selective sweeps by Wolbachia infections: phylogeny of Altica leaf beetles and their reproductive parasitesRegina Jäckel
Zoological Institute, University of Hamburg, Martin Luther King Platz 3, 20146, Hamburg, Germany
Mol Ecol 22:4241-55. 2013..As for effects of Wolbachia on reproduction, infection with wLytA1 appears to be correlated with a substantial sex ratio distortion, which was most prominent in A. lythri. ..
- Amino acid substitutions of Na,K-ATPase conferring decreased sensitivity to cardenolides in insects compared to mammalsSafaa Dalla
Molecular Evolutionary Biology, Biocenter Grindel, Universitat Hamburg, Martin Luther King Pl 3, 20146 Hamburg, Germany
Insect Biochem Mol Biol 43:1109-15. 2013..Obviously, the intense selection pressure on cardenolide exposed insects has resulted in very efficient substitutions that decrease cardenolide sensitivity extremely...
- Physiological screening for target site insensitivity and localization of Na(+)/K(+)-ATPase in cardenolide-adapted LepidopteraGeorg Petschenka
Biozentrum Grindel Molekulare Evolutionsbiologie, Martin Luther King Platz 3, 20146 Hamburg, Germany
J Insect Physiol 58:607-12. 2012..Most plausibly, the perineurium surrounding the nervous tissue functions as a barrier which prevents cardenolides from reaching Na(+)/K(+)-ATPase in the ventral nerve cord...