Ralf Dittrich


Affiliation: University of Erlangen-Nuremberg
Country: Germany


  1. Liverani L, Raffel N, Fattahi A, Preis A, Hoffmann I, Boccaccini A, et al. Electrospun patterned porous scaffolds for the support of ovarian follicles growth: a feasibility study. Sci Rep. 2019;9:1150 pubmed publisher
    ..Relevant results showed that more than the scaffold pattern and struts dimension, the selection of proper biomaterials improve the follicles adhesion and development. ..
  2. Dittrich R, Mueller A, Oppelt P, Hoffmann I, Beckmann M, Maltaris T. Differences in muscarinic-receptor agonist-, oxytocin-, and prostaglandin-induced uterine contractions. Fertil Steril. 2009;92:1694-700 pubmed publisher
    ..This study demonstrated that oxytocin, the prostaglandins, and carbachol modulate contractility in nonpregnant swine uteri in a characteristic way, resulting in different contractility patterns. ..
  3. Dittrich R, Hackl J, Lotz L, Hoffmann I, Beckmann M. Pregnancies and live births after 20 transplantations of cryopreserved ovarian tissue in a single center. Fertil Steril. 2015;103:462-8 pubmed publisher
    ..These data clearly demonstrate that preserving fertility by cryopreserving ovarian tissue is a successful and safe clinical option that can be considered for selected cancer patients. ..
  4. Nichols Burns S, Lotz L, Schneider H, Adamek E, Daniel C, Stief A, et al. Preliminary observations on whole-ovary xenotransplantation as an experimental model for fertility preservation. Reprod Biomed Online. 2014;29:621-6 pubmed publisher
    ..Our results demonstrate transplantation of whole-pig ovary into nude rats is possible and support development of this xenograft model system for human studies. ..
  5. Lotz L, Maktabi A, Hoffmann I, Findeklee S, Beckmann M, Dittrich R. Ovarian tissue cryopreservation and retransplantation--what do patients think about it?. Reprod Biomed Online. 2016;32:394-400 pubmed publisher
    ..Analyses of the clinical outcomes in these patients are essential in order to identify those patients capable of benefiting most from the procedure and in order to improve the technique. ..
  6. request reprint
    Dittrich R, Maltaris T, Hoffmann I, Oppelt P, Beckmann M, Mueller A. Fertility preservation in cancer patients. Minerva Ginecol. 2010;62:63-80 pubmed
    ..The various diagnostic methods of assessing the fertility potential at the time of diagnosis and the efficacy of the different fertility preserving methods after cancer treatment are also presented. ..
  7. Dittrich R, Beckmann M, Mueller A, Binder H, Hoffmann I, Maltaris T. Uterus cryopreservation: maintenance of uterine contractility by the use of different cryoprotocols. Reprod Domest Anim. 2010;45:86-91 pubmed publisher
    ..This study demonstrates clearly that the perfusion of the organ with cryoprotectants is the only factor which allows the uterus to contract. ..
  8. Dittrich R, Lotz L, Keck G, Hoffmann I, Mueller A, Beckmann M, et al. Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation. Fertil Steril. 2012;97:387-90 pubmed publisher
    ..However, further investigations are needed before this procedure can be offered as a chance for women to preserve fertility independently of direct access to a tissue-processing bank. ..
  9. request reprint
    Dittrich R, Schibel A, Hoffmann I, Mueller A, Beckmann M, Cupisti S. Influence of maternal smoking during pregnancy on oxidant status in amniotic fluid. In Vivo. 2012;26:813-8 pubmed
    ..The results were confirmed by two assays measuring the total antioxidant capacity (TAC), as well as the malon dialdehyde concentration (MDA) in the amniotic fluid of smoking and non-smoking mothers...

More Information


  1. Oppelt P, Baier F, Fahlbusch C, Heusinger K, Hildebrandt T, Breuel C, et al. What do patients want to know about contraception and which method would they prefer?. Arch Gynecol Obstet. 2017;295:1483-1491 pubmed publisher
    ..The small number of women who use long-term contraception is in clear contrast to the fact that many women want to have a very safe but also behavior-independent method. ..
  2. Ji S, Fattahi A, Raffel N, Hoffmann I, Beckmann M, Dittrich R, et al. Antioxidant effect of aqueous extract of four plants with therapeutic potential on gynecological diseases; Semen persicae, Leonurus cardiaca, Hedyotis diffusa, and Curcuma zedoaria. Eur J Med Res. 2017;22:50 pubmed publisher
    ..05). In conclusion our results showed that both S. persicae and H. diffusa teas and not L. cardiaca and C. zedoaria could have medicinal therapeutic effects partly through direct oxidation prevention. ..
  3. Dittrich R, Henning J, Maltaris T, Hoffmann I, Oppelt P, Cupisti S, et al. Extracorporeal perfusion of the swine uterus: effect of human seminal plasma. Andrologia. 2012;44 Suppl 1:543-9 pubmed publisher
    ..This perfusion model as well as the use of pressure-time integrals is suitable for patho-physiological studies of the uterus...
  4. Lotz L, Schneider H, Hackl J, Wachter D, Hoffmann I, Jurgons R, et al. Does stimulation with human gonadotropins and gonadotropin-releasing hormone agonist enhance and accelerate the developmental capacity of oocytes in human ovarian tissue xenografted into severe combined immunodeficient mice?. Fertil Steril. 2014;101:1477-84 pubmed publisher
    ..Administering human gonadotropin and GnRHa does not enhance the developmental capacity of xenografted oocytes. The optimal stimulation schedule for grafted tissue remains unknown. ..
  5. Dittrich R, Lotz L, Fehm T, Krüssel J, von Wolff M, Toth B, et al. Xenotransplantation of cryopreserved human ovarian tissue--a systematic review of MII oocyte maturation and discussion of it as a realistic option for restoring fertility after cancer treatment. Fertil Steril. 2015;103:1557-65 pubmed publisher
    ..This review furthermore describes the value of xenotransplantation as a tool in reproductive biology and discusses the ethical and potential safety issues regarding ovarian tissue xenotransplantation as a means of recovering fertility. ..
  6. Beckmann M, Dittrich R, Lotz L, Oppelt P, Findeklee S, Hildebrandt T, et al. Operative techniques and complications of extraction and transplantation of ovarian tissue: the Erlangen experience. Arch Gynecol Obstet. 2017;295:1033-1039 pubmed publisher
    ..The pregnancy rate after ovarian tissue transplantation, currently 15-30%, can be expected to rise further in the near future. ..