V M Dirsch

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages
    V M Dirsch
    Institute of Pharmacology, Toxicology and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Eur J Pharmacol 336:211-7. 1997
  2. ncbi request reprint Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase
    V M Dirsch
    Institute of Pharmacology, Toxicology and Pharmacy, Munich, Germany
    Atherosclerosis 139:333-9. 1998
  3. ncbi request reprint Ajoene, a natural product with non-steroidal anti-inflammatory drug (NSAID)-like properties?
    V M Dirsch
    Institute of Pharmacy, Center of Drug Research, Butenandtstrasse 5 13 B, University of Munich, 81377, Munich, Germany
    Biochem Pharmacol 61:587-93. 2001
  4. ncbi request reprint Reliable in vitro measurement of nitric oxide released from endothelial cells using low concentrations of the fluorescent probe 4,5-diaminofluorescein
    J F Leikert
    Department of Pharmacy, Center of Drug Research, University of Munich, Butenandtstr. 5-13, D-81377, Munich, Germany
    FEBS Lett 506:131-4. 2001
  5. ncbi request reprint Ajoene, an experimental anti-leukemic drug: mechanism of cell death
    V M Dirsch
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany
    Leukemia 16:74-83. 2002
  6. doi request reprint Role of Smac in cephalostatin-induced cell death
    A Rudy
    Department of Pharmacy, Center for Drug Research, University of Munich, Munich, Germany
    Cell Death Differ 15:1930-40. 2008

Collaborators

Detail Information

Publications6

  1. ncbi request reprint The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages
    V M Dirsch
    Institute of Pharmacology, Toxicology and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Eur J Pharmacol 336:211-7. 1997
    ..This feature of pristimerin is likely to contribute to its anti-inflammatory activity...
  2. ncbi request reprint Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase
    V M Dirsch
    Institute of Pharmacology, Toxicology and Pharmacy, Munich, Germany
    Atherosclerosis 139:333-9. 1998
    ..These observations indicate that allicin and ajoene inhibit the expression of iNOS in activated macrophages. The possible link of this effect to the beneficial features attributed to garlic is discussed...
  3. ncbi request reprint Ajoene, a natural product with non-steroidal anti-inflammatory drug (NSAID)-like properties?
    V M Dirsch
    Institute of Pharmacy, Center of Drug Research, Butenandtstrasse 5 13 B, University of Munich, 81377, Munich, Germany
    Biochem Pharmacol 61:587-93. 2001
    ..This finding may add a novel aspect to the biological profile of the garlic-derived natural product ajoene which might be important for understanding the usefulness of garlic for chemoprevention of gastrointestinal carcinomas...
  4. ncbi request reprint Reliable in vitro measurement of nitric oxide released from endothelial cells using low concentrations of the fluorescent probe 4,5-diaminofluorescein
    J F Leikert
    Department of Pharmacy, Center of Drug Research, University of Munich, Butenandtstr. 5-13, D-81377, Munich, Germany
    FEBS Lett 506:131-4. 2001
    ..1 microM) and (b) by subtracting the DAF-2 auto-fluorescence from the measured total fluorescence. The described method allows easy real-time detection of endothelial NO formation...
  5. ncbi request reprint Ajoene, an experimental anti-leukemic drug: mechanism of cell death
    V M Dirsch
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany
    Leukemia 16:74-83. 2002
    ..These results indicate that apoptosis in leukemia cells triggered by ajoene is based on the activation of a mitochondria-dependent caspase cascade which includes also the activation of the initiator caspase-8...
  6. doi request reprint Role of Smac in cephalostatin-induced cell death
    A Rudy
    Department of Pharmacy, Center for Drug Research, University of Munich, Munich, Germany
    Cell Death Differ 15:1930-40. 2008
    ..The bis-steroid cephalostatin proves to be both a helpful tool to investigate apoptotic signaling and a promising chemotherapeutic agent...