V M Dirsch

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Apoptosis signaling triggered by the marine alkaloid ascididemin is routed via caspase-2 and JNK to mitochondria
    Verena M Dirsch
    Department of Pharmacy, Center of Drug Research, University of Munich, Butenandtstrasse 5 13, D 81377 Munich, Germany
    Oncogene 23:1586-93. 2004
  2. ncbi request reprint Garlic metabolites fail to inhibit the activation of the transcription factor NF-kappaB and subsequent expression of the adhesion molecule E-selectin in human endothelial cells
    Verena M Dirsch
    Dept of Pharmacy, Center of Drug Research, Butenandtstr 5 13, 81377, Munich, Germany
    Eur J Nutr 43:55-9. 2004
  3. ncbi request reprint Structural requirements of sesquiterpene lactones to inhibit LPS-induced nitric oxide synthesis in RAW 264.7 macrophages
    V M Dirsch
    Institute of Pharmacy, Center of Drug Research, University of Munich, Germany
    Bioorg Med Chem 8:2747-53. 2000
  4. ncbi request reprint Ajoene, a natural product with non-steroidal anti-inflammatory drug (NSAID)-like properties?
    V M Dirsch
    Institute of Pharmacy, Center of Drug Research, Butenandtstrasse 5 13 B, University of Munich, 81377, Munich, Germany
    Biochem Pharmacol 61:587-93. 2001
  5. ncbi request reprint Helenalin triggers a CD95 death receptor-independent apoptosis that is not affected by overexpression of Bcl-x(L) or Bcl-2
    V M Dirsch
    Department of Pharmacy, Center of Drug Research, University of Munich, Butenandtstrasse 5 13, D 81377 Munich, Germany
    Cancer Res 61:5817-23. 2001
  6. ncbi request reprint Cephalostatin 1 selectively triggers the release of Smac/DIABLO and subsequent apoptosis that is characterized by an increased density of the mitochondrial matrix
    Verena M Dirsch
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany
    Cancer Res 63:8869-76. 2003
  7. ncbi request reprint Ajoene, an experimental anti-leukemic drug: mechanism of cell death
    V M Dirsch
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany
    Leukemia 16:74-83. 2002
  8. ncbi request reprint The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages
    V M Dirsch
    Institute of Pharmacology, Toxicology and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Eur J Pharmacol 336:211-7. 1997
  9. doi request reprint Role of Smac in cephalostatin-induced cell death
    A Rudy
    Department of Pharmacy, Center for Drug Research, University of Munich, Munich, Germany
    Cell Death Differ 15:1930-40. 2008
  10. ncbi request reprint Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase
    V M Dirsch
    Institute of Pharmacology, Toxicology and Pharmacy, Munich, Germany
    Atherosclerosis 139:333-9. 1998

Collaborators

  • H Wagner
  • Angelika M Vollmar
  • S Fulda
  • Markus Rehm
  • Anita Rudy
  • GEORGE PETTIT
  • Elke H Heiss
  • Jean Luc Cracowski
  • Kathy Griendling
  • Hitoshi Hori
  • A K Kiemer
  • Nancy López-Antón
  • Niraldo Paulino
  • Kathrin Karg
  • Olumayokun A Olajide
  • Irina M Müller
  • Ursula G B Haider
  • Hans Peter Keiss
  • Jürgen F Leikert
  • J F Leikert
  • Sheila Rago Lemos Abreu
  • Amarilis Scremin
  • Yoshihiro Uto
  • Daisuke Koyama
  • Walter A Bretz
  • Hideko Nagasawa
  • Gerhard Wanner
  • Irmgard Merfort
  • Daniel Schachner
  • Francois Laporte
  • Colin W Wright
  • Corinna Hermann
  • Martin J Mueller
  • Renato Murillo
  • Lienhard M Schmitz
  • Klaus Schulze-Osthoff
  • M Lienhard Schmitz
  • Nicole Barth
  • Thomas U Roos
  • Dan Sorescu
  • Maria I Kontaridis
  • Benjamin G Neel
  • Thomas Hartung
  • Laurence Trueman
  • Thomas Haffner
  • Jacques Auger
  • Remi Kahane
  • Thomas R Räthel
  • Veronique Cheynier
  • Paulus Wohlfart

Detail Information

Publications22

  1. ncbi request reprint Apoptosis signaling triggered by the marine alkaloid ascididemin is routed via caspase-2 and JNK to mitochondria
    Verena M Dirsch
    Department of Pharmacy, Center of Drug Research, University of Munich, Butenandtstrasse 5 13, D 81377 Munich, Germany
    Oncogene 23:1586-93. 2004
    ..The activation of JNK contributes to this signaling upstream of mitochondria...
  2. ncbi request reprint Garlic metabolites fail to inhibit the activation of the transcription factor NF-kappaB and subsequent expression of the adhesion molecule E-selectin in human endothelial cells
    Verena M Dirsch
    Dept of Pharmacy, Center of Drug Research, Butenandtstr 5 13, 81377, Munich, Germany
    Eur J Nutr 43:55-9. 2004
    ..Garlic is consumed as food or dietary supplement in order to benefit from its antiatherogenic effect...
  3. ncbi request reprint Structural requirements of sesquiterpene lactones to inhibit LPS-induced nitric oxide synthesis in RAW 264.7 macrophages
    V M Dirsch
    Institute of Pharmacy, Center of Drug Research, University of Munich, Germany
    Bioorg Med Chem 8:2747-53. 2000
    ..These results suggest that different biological activities of sesquiterpene lactones have different structural requirements...
  4. ncbi request reprint Ajoene, a natural product with non-steroidal anti-inflammatory drug (NSAID)-like properties?
    V M Dirsch
    Institute of Pharmacy, Center of Drug Research, Butenandtstrasse 5 13 B, University of Munich, 81377, Munich, Germany
    Biochem Pharmacol 61:587-93. 2001
    ..This finding may add a novel aspect to the biological profile of the garlic-derived natural product ajoene which might be important for understanding the usefulness of garlic for chemoprevention of gastrointestinal carcinomas...
  5. ncbi request reprint Helenalin triggers a CD95 death receptor-independent apoptosis that is not affected by overexpression of Bcl-x(L) or Bcl-2
    V M Dirsch
    Department of Pharmacy, Center of Drug Research, University of Munich, Butenandtstrasse 5 13, D 81377 Munich, Germany
    Cancer Res 61:5817-23. 2001
    ..Thus, helenalin is a promising experimental cytotoxic agent that possibly points to new strategies to overcome apoptosis resistance attributable to overexpression of antiapoptotic Bcl-2 proteins...
  6. ncbi request reprint Cephalostatin 1 selectively triggers the release of Smac/DIABLO and subsequent apoptosis that is characterized by an increased density of the mitochondrial matrix
    Verena M Dirsch
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany
    Cancer Res 63:8869-76. 2003
    ..This new mitochondrial pathway is accompanied by marked structural changes of mitochondria as shown by transmission electron microscopy...
  7. ncbi request reprint Ajoene, an experimental anti-leukemic drug: mechanism of cell death
    V M Dirsch
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany
    Leukemia 16:74-83. 2002
    ..These results indicate that apoptosis in leukemia cells triggered by ajoene is based on the activation of a mitochondria-dependent caspase cascade which includes also the activation of the initiator caspase-8...
  8. ncbi request reprint The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages
    V M Dirsch
    Institute of Pharmacology, Toxicology and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Eur J Pharmacol 336:211-7. 1997
    ..This feature of pristimerin is likely to contribute to its anti-inflammatory activity...
  9. doi request reprint Role of Smac in cephalostatin-induced cell death
    A Rudy
    Department of Pharmacy, Center for Drug Research, University of Munich, Munich, Germany
    Cell Death Differ 15:1930-40. 2008
    ..The bis-steroid cephalostatin proves to be both a helpful tool to investigate apoptotic signaling and a promising chemotherapeutic agent...
  10. ncbi request reprint Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase
    V M Dirsch
    Institute of Pharmacology, Toxicology and Pharmacy, Munich, Germany
    Atherosclerosis 139:333-9. 1998
    ..These observations indicate that allicin and ajoene inhibit the expression of iNOS in activated macrophages. The possible link of this effect to the beneficial features attributed to garlic is discussed...
  11. ncbi request reprint Reliable in vitro measurement of nitric oxide released from endothelial cells using low concentrations of the fluorescent probe 4,5-diaminofluorescein
    J F Leikert
    Department of Pharmacy, Center of Drug Research, University of Munich, Butenandtstr. 5-13, D-81377, Munich, Germany
    FEBS Lett 506:131-4. 2001
    ..1 microM) and (b) by subtracting the DAF-2 auto-fluorescence from the measured total fluorescence. The described method allows easy real-time detection of endothelial NO formation...
  12. doi request reprint The cephalostatin way of apoptosis
    Anita Rudy
    Department of Pharmacy, University of Munich, Munich, Germany
    J Nat Prod 71:482-6. 2008
    ..Cephalostatin 1 ( 1), therefore, provides a very good tool to discover novel apoptotic pathways, which might be important in the understanding and treatment of chemo-resistant cancer...
  13. ncbi request reprint The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway
    Nancy López-Antón
    Department of Pharmacy, Center of Drug Research, University of Munich, 81377 Munich, Germany
    J Biol Chem 281:33078-86. 2006
    ..Importantly, the endoplasmic reticulum-associated caspase-4 is required and as shown by biochemical and genetic inhibition experiments, acts upstream of caspase-9 in cephalostatin-induced apoptosis...
  14. ncbi request reprint Cephalostatin 1 inactivates Bcl-2 by hyperphosphorylation independent of M-phase arrest and DNA damage
    Irina M Müller
    Department of Pharmacy, Center of Drug Research, University of Munich, Germany
    Mol Pharmacol 67:1684-9. 2005
    ..Reported triggers, such as the induction of an M-phase arrest or DNA damage are not involved in this process, suggesting a novel mechanism for cephalostatin 1-mediated Bcl-2 hyperphosphorylation...
  15. ncbi request reprint Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2
    Ursula G B Haider
    Department of Pharmacy, Center of Drug Research, Butenandtstrasse 5 13, D 81377 Munich, Germany
    Mol Pharmacol 68:41-8. 2005
    ..We therefore propose that RV blocks Akt activation in Ang II- and EGF-stimulated VSMCs by activating Shp2, thus preventing interaction between Gab1 and PI3K that is necessary for further signal transduction...
  16. ncbi request reprint Synthetic cryptolepine inhibits DNA binding of NF-kappaB
    Olumayokun A Olajide
    Department of Pharmacy, Center of Drug Research, University of Munich, Butenandtstr 5 13, 81377 Munich, Germany
    Bioorg Med Chem 15:43-9. 2007
    ..This indicates that cryptolepine may exhibit its anti-inflammatory action by blocking DNA binding of activated NF-kappaB and thus transcription of NF-kappaB-regulated proinflammatory proteins...
  17. ncbi request reprint Sesquiterpene lactones induce distinct forms of cell death that modulate human monocyte-derived macrophage responses
    Nancy López-Antón
    Department of Pharmacy, Center of Drug Research, University of Munich, Germany
    Apoptosis 12:141-53. 2007
    ..We propose that this type of SQTL may influence local inflammation by transiently activating the immune system and help to clear cells by inducing a form of cell death that promotes phagocytosis...
  18. ncbi request reprint Biologically active oxidized lipids (phytoprostanes) in the plant diet and parenteral lipid nutrition
    Kathrin Karg
    Julius von Sachs Institute for Biosciences, Pharmaceutical Biology, University of Wuerzburg, Julius von Sachs Platz 2, D 97082, Wuerzburg, Germany
    Free Radic Res 41:25-37. 2007
    ..Here, we show that PPA1- and deoxy-PPJ1 display potent anti-inflammatory and apoptosis inducing activities similar to PGA1 and deoxy-PGJ2. Results of this study indicate that PP are novel, biologically active lipids in plant nutrition...
  19. ncbi request reprint Chronic treatment with resveratrol induces redox stress- and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells
    Elke H Heiss
    Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
    J Biol Chem 282:26759-66. 2007
    ..This is the first report linking cell cycle effects with a pro-oxidant and pro-senescent effect of RV in cancer cells...
  20. ncbi request reprint Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-activated human blood thereby inhibiting NF-kappaB activity
    Hans Peter Keiss
    Department of Pharmacy, Center of Drug Research, University of Munich, D 81377 Munich, Germany
    J Nutr 133:2171-5. 2003
    ..In summary, garlic may indeed promote an anti-inflammatory environment by cytokine modulation in human blood that leads to an overall inhibition of NF-kappaB activity in the surrounding tissue...
  21. doi request reprint Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis
    Niraldo Paulino
    Programa de Pós graduação em Farmácia, Universidade Bandeirante de São Paulo, Sao Paulo, Brazil
    Eur J Pharmacol 587:296-301. 2008
    ..Collectively, Artepillin C showed anti-inflammatory effects mediated, at least in part, by prostaglandin E(2) and nitric oxide inhibition through NF-kappaB modulation, and exhibited bioavailability by oral administration...
  22. ncbi request reprint Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells
    Jürgen F Leikert
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany
    Circulation 106:1614-7. 2002
    ....