Leda Dimou

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Nogo-A-deficient mice reveal strain-dependent differences in axonal regeneration
    Leda Dimou
    Brain Research Institute, University of Zurich, Department Biology, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 26:5591-603. 2006
  2. doi request reprint Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex
    Leda Dimou
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, 80336 Munich, Germany
    J Neurosci 28:10434-42. 2008
  3. doi request reprint Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]
    Swetlana Sirko
    Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, D 80336, Germany
    Cell Stem Cell 12:426-39. 2013
  4. doi request reprint Nogo-A and myelin-associated glycoprotein differently regulate oligodendrocyte maturation and myelin formation
    Vincent Pernet
    Department of Biology, Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 28:7435-44. 2008
  5. doi request reprint Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men
    Gwendolyn Behrendt
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University, Munich, Germany
    Glia 61:273-86. 2013
  6. doi request reprint Progenitors in the adult cerebral cortex: cell cycle properties and regulation by physiological stimuli and injury
    Christiane Simon
    Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Germany
    Glia 59:869-81. 2011
  7. pmc Neuronal Nogo-A modulates growth cone motility via Rho-GTP/LIMK1/cofilin in the unlesioned adult nervous system
    Laura Montani
    Brain Research Institute and Functional Genomics Center, University of Zurich, Switzerland
    J Biol Chem 284:10793-807. 2009
  8. doi request reprint Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling
    Felipe Ortega
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Nat Cell Biol 15:602-13. 2013
  9. doi request reprint Sox10-iCreERT2 : a mouse line to inducibly trace the neural crest and oligodendrocyte lineage
    Christiane Simon
    Physiological Genomics, Institute of Physiology, Ludwig Maximilians University, Munich, Germany
    Genesis 50:506-15. 2012
  10. ncbi request reprint Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis
    Stefanie Robel
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Glia 57:1630-47. 2009

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Nogo-A-deficient mice reveal strain-dependent differences in axonal regeneration
    Leda Dimou
    Brain Research Institute, University of Zurich, Department Biology, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 26:5591-603. 2006
    ....
  2. doi request reprint Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex
    Leda Dimou
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, 80336 Munich, Germany
    J Neurosci 28:10434-42. 2008
    ..Thus, our results demonstrate the continuous generation of mature, myelinating oligodendrocytes in the WM, whereas cells in the GM generated mostly postmitotic NG2(+) glia...
  3. doi request reprint Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]
    Swetlana Sirko
    Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, D 80336, Germany
    Cell Stem Cell 12:426-39. 2013
    ....
  4. doi request reprint Nogo-A and myelin-associated glycoprotein differently regulate oligodendrocyte maturation and myelin formation
    Vincent Pernet
    Department of Biology, Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 28:7435-44. 2008
    ..Together, our results demonstrate that Nogo-A and MAG are differently involved in oligodendrocyte maturation in vivo, and suggest that Nogo-A may influence also remyelination in pathological conditions such as multiple sclerosis...
  5. doi request reprint Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men
    Gwendolyn Behrendt
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University, Munich, Germany
    Glia 61:273-86. 2013
    ..Strikingly, possible repair mechanisms from newly generated oligodendrocytes are evident in APPPS1 mice, whereas a similar reaction of oligodendrocyte progenitors seems to be strongly limited in final stages of human AD pathology...
  6. doi request reprint Progenitors in the adult cerebral cortex: cell cycle properties and regulation by physiological stimuli and injury
    Christiane Simon
    Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Germany
    Glia 59:869-81. 2011
    ....
  7. pmc Neuronal Nogo-A modulates growth cone motility via Rho-GTP/LIMK1/cofilin in the unlesioned adult nervous system
    Laura Montani
    Brain Research Institute and Functional Genomics Center, University of Zurich, Switzerland
    J Biol Chem 284:10793-807. 2009
    ..Our study suggests that in the unlesioned adult nervous system, neuronal Nogo-A can restrict neuronal growth through negative modulation of growth cone motility...
  8. doi request reprint Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling
    Felipe Ortega
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Nat Cell Biol 15:602-13. 2013
    ....
  9. doi request reprint Sox10-iCreERT2 : a mouse line to inducibly trace the neural crest and oligodendrocyte lineage
    Christiane Simon
    Physiological Genomics, Institute of Physiology, Ludwig Maximilians University, Munich, Germany
    Genesis 50:506-15. 2012
    ....
  10. ncbi request reprint Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis
    Stefanie Robel
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Glia 57:1630-47. 2009
    ..Alterations in beta1-integrin-mediated signaling may hence be implicated in eliciting specific aspects of reactive gliosis after injury...
  11. doi request reprint Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation
    Sophia Bardehle
    Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Nat Neurosci 16:580-6. 2013
    ..Thus, astrocyte recruitment after injury relies solely on proliferation in a specific niche...
  12. doi request reprint Long-term genetic fate mapping of adult generated neurons in a mouse temporal lobe epilepsy model
    Mehrnoosh Jafari
    Institute of Pharmacology, Toxicology, and Pharmacy, Graduate School of Systemic Neurosciences, Ludwig Maximilians University, Munich, Germany
    Neurobiol Dis 48:454-63. 2012
    ..However, seizure density also seems to play a critical role with more frequent seizures resulting in increased fractions of new neurons...
  13. pmc The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model
    Natasa Jokic
    INSERM, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, 11 rue Humann, F 67085 Strasbourg, France
    EMBO Rep 7:1162-7. 2006
    ..This suggests that the expression of Nogo-A occurring early in ALS skeletal muscle could cause repulsion and destabilization of the motor nerve terminals, and subsequent dying back of the axons and motor neurons...
  14. pmc Nogo receptor antagonizes p75NTR-dependent motor neuron death
    Luc Dupuis
    Institut National de la Sante et de la Recherche Medicale, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, F 67085 France
    Proc Natl Acad Sci U S A 105:740-5. 2008
    ..These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration...