Christine Dierks

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi request reprint GDC-0449--targeting the hedgehog signaling pathway
    Christine Dierks
    Department of Hematology and Oncology, Freiburg University Medical Center, Hugstetterstrasse 55, 79106, Freiburg, Germany
    Recent Results Cancer Res 184:235-8. 2010
  2. doi request reprint Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
    Christine Dierks
    Department of Hematology Oncology, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Cancer Cell 14:238-49. 2008
  3. doi request reprint The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease
    Christine Dierks
    Hematology Oncology, University of Freiburg, Freiburg, Germany
    Cancer Res 70:6193-204. 2010
  4. doi request reprint Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia
    Maike Buchner
    Department of Hematology and Oncology, University Medical Center Freiburg, Freiburg, Germany
    Blood 115:4497-506. 2010
  5. doi request reprint Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL
    Sarah Decker
    Department of Hematology Oncology, University Medical Center Freiburg, Hugstetter Strasse 55, Freiburg, Germany
    Blood 119:997-1007. 2012
  6. doi request reprint The microenvironment differentially impairs passive and active immunotherapy in chronic lymphocytic leukaemia - CXCR4 antagonists as potential adjuvants for monoclonal antibodies
    Maike Buchner
    Department of Haematology and Oncology, University Medical Centre Freiburg, Freiburg, Germany
    Br J Haematol 151:167-78. 2010
  7. doi request reprint Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia
    Niuscha Yaktapour
    Department of Hematology Oncology, University Medical Center Freiburg, Freiburg, Germany
    Blood 122:1621-33. 2013
  8. doi request reprint Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia
    Maike Buchner
    University Medical Center Freiburg, Department of Hematology and Oncology, Germany
    Cancer Res 69:5424-32. 2009
  9. pmc MPN patients harbor recurrent truncating mutations in transcription factor NF-E2
    Jonas S Jutzi
    Department of Hematology Oncology, University Hospital Freiburg, 79106 Freiburg, Germany
    J Exp Med 210:1003-19. 2013

Collaborators

  • Stephan Stilgenbauer
  • Hendrik Veelken
  • Markus Warmuth
  • John G Gribben
  • H Jumaa
  • Gorica Nikoloski
  • Thorsten Zenz
  • Hong Ma
  • Maike Buchner
  • Katja Zirlik
  • Meike Burger
  • Dietmar Pfeifer
  • Gabriele Prinz
  • Jonas S Jutzi
  • Konrad Aumann
  • Niuscha Yaktapour
  • Sarah Decker
  • Julia Schuler
  • Heike L Pahl
  • Konstanze Dohner
  • Thalia S Seeger
  • Kamar Hamdi
  • Sven Schwemmers
  • Wei Kamar Wang
  • Albert Gründer
  • Julius Wehrle
  • Joop H Jansen
  • Rudolf Ubelhart
  • Monika Gothwal
  • Jan C Peeken
  • Corina A Schmid
  • Frank Stegelmann
  • Tilman Brummer
  • Ruzhica Bogeska
  • Dieter Herchenbach
  • Lauritte Djebatchie
  • Annette Schmitt-Graeff
  • Gabriele Ihorst
  • David Hartmann
  • Ariane Ott
  • Philipp Brantner
  • Roland Mertelsmann
  • Natalie Stickel
  • Constance Bär
  • Constance Baer
  • Kilian Bartholomé
  • Laurent Vallat
  • Jens Timmer
  • Nina Chevalier
  • Simon Fuchs

Detail Information

Publications9

  1. doi request reprint GDC-0449--targeting the hedgehog signaling pathway
    Christine Dierks
    Department of Hematology and Oncology, Freiburg University Medical Center, Hugstetterstrasse 55, 79106, Freiburg, Germany
    Recent Results Cancer Res 184:235-8. 2010
    ..It was successfully tested in a phase-I clinical trial demonstrating good pharmacodynamic (PD) and pharmacokinetic (PK) properties and showing objective response and clinical benefit in several patients with basal cell carcinoma...
  2. doi request reprint Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
    Christine Dierks
    Department of Hematology Oncology, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Cancer Cell 14:238-49. 2008
    ..Pharmacological Smo inhibition reduced LSCs in vivo and enhanced time to relapse after end of treatment. Our results indicate that Smo inhibition might be an effective treatment strategy to reduce the LSC pool in CML...
  3. doi request reprint The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease
    Christine Dierks
    Hematology Oncology, University of Freiburg, Freiburg, Germany
    Cancer Res 70:6193-204. 2010
    ..Therefore, pharmacologic inhibition of SYK in patients with U-PTCLs carrying the ITK-SYK fusion protein might be an effective treatment strategy...
  4. doi request reprint Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia
    Maike Buchner
    Department of Hematology and Oncology, University Medical Center Freiburg, Freiburg, Germany
    Blood 115:4497-506. 2010
    ..SYK blockade in CLL is a promising therapeutic principle not only for its inhibition of the BCR signaling pathway, but also by inhibiting protective stroma signals in a manner entirely independent of BCR signaling...
  5. doi request reprint Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL
    Sarah Decker
    Department of Hematology Oncology, University Medical Center Freiburg, Hugstetter Strasse 55, Freiburg, Germany
    Blood 119:997-1007. 2012
    ....
  6. doi request reprint The microenvironment differentially impairs passive and active immunotherapy in chronic lymphocytic leukaemia - CXCR4 antagonists as potential adjuvants for monoclonal antibodies
    Maike Buchner
    Department of Haematology and Oncology, University Medical Centre Freiburg, Freiburg, Germany
    Br J Haematol 151:167-78. 2010
    ..Our data identify the combination of CXCR4 antagonists with passive - but not active - immunotherapy as a promising potential treatment concept in CLL...
  7. doi request reprint Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia
    Niuscha Yaktapour
    Department of Hematology Oncology, University Medical Center Freiburg, Freiburg, Germany
    Blood 122:1621-33. 2013
    ..Importantly, IGF1R inhibitors compromise CLL viability in their microenvironment context, implicating this RTK as a promising therapeutic target. ..
  8. doi request reprint Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia
    Maike Buchner
    University Medical Center Freiburg, Department of Hematology and Oncology, Germany
    Cancer Res 69:5424-32. 2009
    ..Combination of SYK inhibitors with fludarabine might be a novel treatment option particularly for CLL patients with poor prognosis and should be further evaluated in clinical trials...
  9. pmc MPN patients harbor recurrent truncating mutations in transcription factor NF-E2
    Jonas S Jutzi
    Department of Hematology Oncology, University Hospital Freiburg, 79106 Freiburg, Germany
    J Exp Med 210:1003-19. 2013
    ..NF-E2 mutant cells acquire a proliferative advantage, witnessed by clonal dominance over WT NF-E2 cells in MPN patients. Our data underscore the role of increased NF-E2 activity in the pathophysiology of MPNs...