Han Christoph Diener

Summary

Affiliation: University of Essen
Country: Germany

Publications

  1. doi request reprint Novel oral anticoagulants in secondary prevention of stroke
    H C Diener
    Department of Neurology and Stroke Center, University Hospital Essen, Germany
    Best Pract Res Clin Haematol 26:131-9. 2013
  2. doi request reprint Treatment of acute ischaemic stroke with thrombolysis or thrombectomy in patients receiving anti-thrombotic treatment
    Hans Christoph Diener
    Department of Neurology and Stroke Centre, University Hospital Essen, Essen, Germany
    Lancet Neurol 12:677-88. 2013
  3. doi request reprint Apixaban versus aspirin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a predefined subgroup analysis from AVERROES, a randomised trial
    Hans Christoph Diener
    Department of Neurology, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Lancet Neurol 11:225-31. 2012
  4. doi request reprint [New anticoagulants for stroke prevention in atrial fibrillation]
    H C Diener
    Klinik fur Neurologie, Universitatsklinikum Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Herz 37:370-7. 2012
  5. doi request reprint Detoxification for medication overuse headache is not necessary
    Hans Christoph Diener
    University Hospital Essen, Germany
    Cephalalgia 32:423-7. 2012
  6. doi request reprint Chronic migraine--classification, characteristics and treatment
    Hans Christoph Diener
    Department of Neurology and Headache Center, University Hospital Essen, Hufelandstrasse 55, Essen, Germany
    Nat Rev Neurol 8:162-71. 2011
  7. doi request reprint The king is dead (warfarin): direct thrombin and factor Xa inhibitors: the next Diadochian War?
    Hans Christoph Diener
    Department of Neurology, University Hospital Essen, Germany
    Int J Stroke 7:139-41. 2012
  8. ncbi request reprint Is clopidogrel the antiplatelet drug of choice for high-risk patients with stroke/TIA?: Yes
    H C Diener
    Department of Neurology, University of Essen, Essen, Germany
    J Thromb Haemost 3:1133-6. 2005
  9. ncbi request reprint [Migraine therapy]
    H C Diener
    Universitätsklinik für Neurologie, Essen
    Internist (Berl) 46:1087-95. 2005
  10. ncbi request reprint Part IV: effects of zolmitriptan orally disintegrating tablet on migraine symptoms and ability to perform normal activities: a post-marketing surveillance study in Germany
    Hans Christoph Diener
    Department of Neurology, University Essen, Germany
    Curr Med Res Opin 21:S18-24. 2005

Detail Information

Publications121 found, 100 shown here

  1. doi request reprint Novel oral anticoagulants in secondary prevention of stroke
    H C Diener
    Department of Neurology and Stroke Center, University Hospital Essen, Germany
    Best Pract Res Clin Haematol 26:131-9. 2013
    ..Aspirin is no longer an option in secondary stroke prevention in patients with atrial fibrillation. Consideration of these new anticoagulants will improve clinical decision making. ..
  2. doi request reprint Treatment of acute ischaemic stroke with thrombolysis or thrombectomy in patients receiving anti-thrombotic treatment
    Hans Christoph Diener
    Department of Neurology and Stroke Centre, University Hospital Essen, Essen, Germany
    Lancet Neurol 12:677-88. 2013
    ..Thrombectomy can be done in patients given antiplatelets and probably in those given anticoagulants; however, conclusions about anticoagulants are based on findings from observational studies with small patient numbers...
  3. doi request reprint Apixaban versus aspirin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a predefined subgroup analysis from AVERROES, a randomised trial
    Hans Christoph Diener
    Department of Neurology, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Lancet Neurol 11:225-31. 2012
    ....
  4. doi request reprint [New anticoagulants for stroke prevention in atrial fibrillation]
    H C Diener
    Klinik fur Neurologie, Universitatsklinikum Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Herz 37:370-7. 2012
    ..Consideration of these new anticoagulants will improve clinical decision-making...
  5. doi request reprint Detoxification for medication overuse headache is not necessary
    Hans Christoph Diener
    University Hospital Essen, Germany
    Cephalalgia 32:423-7. 2012
    ..Current textbook knowledge states that patients with chronic migraine and medication overuse should be withdrawn from acute medication before initiating preventive drug therapy...
  6. doi request reprint Chronic migraine--classification, characteristics and treatment
    Hans Christoph Diener
    Department of Neurology and Headache Center, University Hospital Essen, Hufelandstrasse 55, Essen, Germany
    Nat Rev Neurol 8:162-71. 2011
    ..This Review discusses the evolution of our understanding of chronic migraine, including its epidemiology, pathophysiology, clinical characteristics and treatment options...
  7. doi request reprint The king is dead (warfarin): direct thrombin and factor Xa inhibitors: the next Diadochian War?
    Hans Christoph Diener
    Department of Neurology, University Hospital Essen, Germany
    Int J Stroke 7:139-41. 2012
    ..The new oral anticoagulants substances show similar results in secondary as in primary stroke prevention in patients with AF and will on the long run replace warfarin...
  8. ncbi request reprint Is clopidogrel the antiplatelet drug of choice for high-risk patients with stroke/TIA?: Yes
    H C Diener
    Department of Neurology, University of Essen, Essen, Germany
    J Thromb Haemost 3:1133-6. 2005
  9. ncbi request reprint [Migraine therapy]
    H C Diener
    Universitätsklinik für Neurologie, Essen
    Internist (Berl) 46:1087-95. 2005
    ....
  10. ncbi request reprint Part IV: effects of zolmitriptan orally disintegrating tablet on migraine symptoms and ability to perform normal activities: a post-marketing surveillance study in Germany
    Hans Christoph Diener
    Department of Neurology, University Essen, Germany
    Curr Med Res Opin 21:S18-24. 2005
    ....
  11. ncbi request reprint Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention--a randomized, double-blind, multicentre, placebo-controlled study
    H C Diener
    Neurologische Universitatsklinik, Essen, Germany
    Cephalalgia 25:1031-41. 2005
    ..4 in favour of MIG-99 (P = 0.0049). Adverse events possibly related to study medication were 9/107 (8.4%) with MIG-99 and 11/108 (10.2%) with placebo (P = 0.654). MIG-99 is effective and shows a favourable benefit-risk ratio...
  12. ncbi request reprint Prophylaxis of thrombotic and embolic events in acute ischemic stroke with the low-molecular-weight heparin certoparin: results of the PROTECT Trial
    Hans Christoph Diener
    University of Essen, Germany
    Stroke 37:139-44. 2006
    ....
  13. ncbi request reprint Stroke prevention using the oral direct thrombin inhibitor ximelagatran in patients with non-valvular atrial fibrillation. Pooled analysis from the SPORTIF III and V studies
    Hans Christoph Diener
    Department of Neurology, University of Essen, Hufelandstrasse 55, DE 45122 Essen, Germany
    Cerebrovasc Dis 21:279-93. 2006
    ..To show results of a prespecified pooled analysis of the studies SPORTIF III (open-label) and SPORTIF V (double-blind), to assess the homogeneity of the results and to explore subgroup analyses and adverse events...
  14. ncbi request reprint Efficacy of acupuncture for the prophylaxis of migraine: a multicentre randomised controlled clinical trial
    Hans Christoph Diener
    Department of Neurology, University Essen, Essen, Germany
    Lancet Neurol 5:310-6. 2006
    ....
  15. ncbi request reprint Almotriptan in migraine patients who respond poorly to oral sumatriptan: a double-blind, randomized trial
    Hans Christoph Diener
    Department of Neurology, University Essen, Germany
    Eur Neurol 53:41-8. 2005
    ..To investigate the efficacy and tolerability of almotriptan 12.5 mg in migraine patients who respond poorly to sumatriptan 50 mg...
  16. ncbi request reprint Eletriptan in migraine
    Hans Christoph Diener
    Department of Neurology, University of Essen, Hufelandstr 55, D45122 Essen, Germany
    Expert Rev Neurother 5:43-53. 2005
    ..An early treatment study suggests that treatment of mild headache is associated with unusually high sustained pain-free rates and a tolerability profile that is equivalent to placebo...
  17. ncbi request reprint Medication-overuse headache: a worldwide problem
    Hans Christoph Diener
    Department of Neurology, University Hospital Essen, Germany
    Lancet Neurol 3:475-83. 2004
    ..Withdrawal therapy is the only treatment for this disorder and clear restriction of monthly doses is the central requirement for successful prevention...
  18. ncbi request reprint Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial
    Hans Christoph Diener
    Department of Neurology, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Lancet 364:331-7. 2004
    ..We aimed to assess whether addition of aspirin to clopidogrel could have a greater benefit than clopidogrel alone in prevention of vascular events with potentially higher bleeding risk...
  19. ncbi request reprint Predicting the response to sumatriptan: the Sumatriptan Naratriptan Aggregate Patient Database
    Hans Christoph-Diener
    Dept of Neurology, University of Essen, Hufelandstr 55, 45147 Essen, Germany
    Neurology 63:520-4. 2004
    ..The authors analyzed these data to identify factors predicting response (headache relief and pain-free response) to sumatriptan...
  20. ncbi request reprint Topiramate in migraine prophylaxis--results from a placebo-controlled trial with propranolol as an active control
    Hans Christoph Diener
    Department of Neurology, University Essen, Hufelandstr 55, 45122 Essen, Germany
    J Neurol 251:943-50. 2004
    ..No unusual or unexpected safety risks emerged. These findings demonstrate that TPM 100 mg/d is effective in migraine prophylaxis. TPM 100 mg/d and PROP 160 mg/d exhibited similar efficacy profiles...
  21. ncbi request reprint Placebo-controlled comparison of effervescent acetylsalicylic acid, sumatriptan and ibuprofen in the treatment of migraine attacks
    H C Diener
    Department of Neurology, University Essen, Germany
    Cephalalgia 24:947-54. 2004
    ..Regarding pain-free at 2 h sumatriptan was most effective...
  22. ncbi request reprint [Treatment and prophylaxis of an acute migraine attack]
    H C Diener
    Universitätsklinik für Neurologie, Essen
    MMW Fortschr Med 146:41, 43-5. 2004
    ..Through nonmedicinal and medicinal prophylactic measures, the frequency and intensity of the migraine attacks can be reduced. Keeping a headache diary for documentation is essential...
  23. ncbi request reprint [Carotid endarterectomy in patients without neurological symptoms]
    H C Diener
    Universitätsklinik für Neurologie, Essen
    Internist (Berl) 46:83-5. 2005
  24. ncbi request reprint [Migraine]
    H C Diener
    Klinik und Poliklinik fur Neurologie, Universitat Essen
    Fortschr Neurol Psychiatr 73:44-56; quiz 57-9. 2005
  25. ncbi request reprint Patent foramen ovale, migraine and stroke: no reason to intervene
    Hans Christoph Diener
    Department of Neurology, University Duisburg Essen, Germany
    Nat Clin Pract Cardiovasc Med 3:176-7. 2006
  26. ncbi request reprint Primary and secondary stroke prevention with antiplatelet drugs
    Hans Christoph Diener
    Department of Neurology, University of Essen, Hufelandstr 55, D45122 Essen, Germany
    Curr Pharm Des 12:1293-7. 2006
    ..The combination of aspirin plus clopidogrel is not more effective than clopidogrel alone but carries a higher bleeding risk. None of the antiplatelet agents is able to reduce mortality...
  27. doi request reprint Utility of topiramate for the treatment of patients with chronic migraine in the presence or absence of acute medication overuse
    H C Diener
    Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, Essen 45122, Germany
    Cephalalgia 29:1021-7. 2009
    ..These studies may have important implications for the future of chronic migraine management, suggesting that detoxification prior to initiating prophylactic therapy may not be required in all patients if MO is present...
  28. doi request reprint Telmisartan in migraine prophylaxis: a randomized, placebo-controlled trial
    H C Diener
    Department of Neurology and Headache Centre, University Hospital Essen, Essen, Germany
    Cephalalgia 29:921-7. 2009
    ..03), and a borderline significant difference in responders (40% vs. 25%, P = 0.07). The incidence of adverse events was similar between treatments. This study indicates that telmisartan might be effective in migraine prophylaxis...
  29. doi request reprint Headache associated with ischemic cerebrovascular disease
    H C Diener
    Department of Neurology and Headache Center, University Hospital Essen, Hufelendstrass 55, 45112 Essen, Germany
    Rev Neurol (Paris) 164:819-24. 2008
    ..Transient ischemic attacks (TIA) can also lead to headache. The pathophysiology of headache associated with acute ischemic stroke includes edema, hemorrhagic transformation, and changes in the trigeminovascular system...
  30. pmc Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFE
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Lancet Neurol 7:875-84. 2008
    ..The putative neuroprotective effects of antiplatelet compounds and the angiotensin II receptor antagonist telmisartan were investigated in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial...
  31. doi request reprint Secondary stroke prevention with antiplatelet drugs: have we reached the ceiling?
    Hans Christoph Diener
    Department of Neurology, University of Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Int J Stroke 1:4-8. 2006
    ..Therefore, selection of patients who might benefit from antiplatelet therapy other than aspirin is important...
  32. doi request reprint [Current diagnosis and treatment of migraine]
    H C Diener
    Universitätsklinik für Neurologie und Westdeutsches Kopfschmerzzentrum, Universitatsklinikum Essen, Hufelandstrasse 55, 45147 Essen
    Ophthalmologe 105:501-8; quiz 509-10. 2008
    ..Nonpharmacologic treatment also plays an important role in migraine prevention. New medical care structures such as integrated headache care provide better support for patients with migraine, particularly those with chronic migraine...
  33. doi request reprint [Current diagnosis and treatment of migraine]
    H C Diener
    Universitätsklinik für Neurologie und Westdeutsches Kopfschmerzzentrum, Universitatsklinikum Essen, Hufelandstrasse 55, 45147, Essen, Germany
    Schmerz 22:51-8; quiz 59-60. 2008
    ..Nonpharmacologic treatment also plays an important role in migraine prevention. New medical care structures such as integrated headache care provide better support for patients with migraine, particularly those with chronic migraine...
  34. ncbi request reprint Identification of negative predictors of pain-free response to triptans: analysis of the eletriptan database
    H C Diener
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Cephalalgia 28:35-40. 2008
    ..placebo (all P < 0.01). Thus, eletriptan and sumatriptan are efficacious in difficult-to-treat patients at high risk for non-response to triptans...
  35. ncbi request reprint The PRoFESS trial: future impact on secondary stroke prevention
    Hans Christoph Diener
    University Duisburg Essen, Department of Neurology, Hufelandstrasse 55, 45122 Essen, Germany
    Expert Rev Neurother 7:1085-91. 2007
    ..With over 20,000 patients randomized, and utilizing a 2 x 2 factorial design, PRoFESS is the largest stroke trial to investigate the prevention of recurrent stroke...
  36. ncbi request reprint Lower cervical disc prolapse may cause cervicogenic headache: prospective study in patients undergoing surgery
    H C Diener
    Department of Neurology, University Duisberg Essen, Essen, Germany
    Cephalalgia 27:1050-4. 2007
    ..These results indicate that pain afferents from the lower cervical roots can converge on the cervical trigeminal nucleus and the nucleus caudalis...
  37. ncbi request reprint Rationale, design and baseline data of a randomized, double-blind, controlled trial comparing two antithrombotic regimens (a fixed-dose combination of extended-release dipyridamole plus ASA with clopidogrel) and telmisartan versus placebo in patients with
    Hans Christoph Diener
    Department of Neurology, University Duisburg EssenHufelandstrasse 55DE 45122 Essen, Germany
    Cerebrovasc Dis 23:368-80. 2007
    ....
  38. pmc Patent foramen ovale and migraine: no reason to intervene
    Hans Christoph Diener
    Department of Neurology, University Essen, Hufelandstr 55, 45122, Essen, Germany
    J Headache Pain 8:3-6. 2007
  39. ncbi request reprint How much esprit is in ESPRIT?
    Hans Christoph Diener
    Department of Neurology, University Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Stroke 37:2856-7. 2006
  40. ncbi request reprint [Headaches in nonneurologic diseases]
    Hans Christoph Diener
    Universitätsklinik für Neurologie, Universitat Duisburg Essen, Essen
    Med Klin (Munich) 101:167-9. 2006
    ..Ibuprofen, immunoglobulins, and antibiotics might lead to aseptic meningitis. Drug-induced headaches are seen after use of nitroglycerine, calcium channel blockers and immunoglobulins...
  41. ncbi request reprint Efficacy and tolerability of diclofenac potassium sachets in migraine: a randomized, double-blind, cross-over study in comparison with diclofenac potassium tablets and placebo
    H C Diener
    Department of Neurology, University of Essen, Essen, Germany, and Péterfy Sandor Hospital, Budapest, Hungary
    Cephalalgia 26:537-47. 2006
    ..placebo. No safety issues were identified. This study demonstrates that sachets offer patients suffering from migraine pain a more effective treatment with a faster onset of analgesia when compared with tablets...
  42. ncbi request reprint Aspirin in the treatment of acute migraine attacks
    Hans Christoph Diener
    Department of Neurology, University Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Expert Rev Neurother 6:563-73. 2006
    ..This review summarizes and analyzes clinical data of aspirin in the treatment of acute migraine attacks with respect to the different galenic formulations...
  43. doi request reprint Treatment of chronic migraine
    Hans Christoph Diener
    Department of Neurology and Headache Centre, University Duisburg Essen, Essen, Germany
    Curr Pain Headache Rep 15:64-9. 2011
    ..Many other substances have been investigated in chronic daily headache. All trials were underpowered and, therefore, recommendations concerning possible efficacy are not possible...
  44. ncbi request reprint Efficacy of 1,000 mg effervescent acetylsalicylic acid and sumatriptan in treating associated migraine symptoms
    H C Diener
    Department of Neurology, University of Essen, Hufelandstrasse 55, DE 45147 Essen, Germany
    Eur Neurol 52:50-6. 2004
    ..The study showed that administration of effervescent ASA leads to remission of the migraine symptoms nausea, photophobia and phonophobia, reduces migraine headache and is comparable to sumatriptan...
  45. ncbi request reprint Nitrous oxide modulator: lubeluzole
    Hans Christoph Diener
    Department of Neurology, University Essen, Germany
    Curr Med Res Opin 18:s23-6. 2002
    ..Phase II and early phase III trials indicated an improvement in neurological outcome, whereas a final large randomized and placebo controlled trial did not show superiority versus placebo...
  46. ncbi request reprint [Does early high dosage dipyridamole in prevention of secondary stroke induce cardiac events?]
    H C Diener
    Klinik und Poliklinik für Neurologie der Universität Essen Hufelandstr 55 45122 Essen, Germany
    Z Kardiol 90:348-51. 2001
    ..DP did not result in a higher number of cardiac events, e.g., angina pectoris, myocardial infarction or death. The combination of ASA plus DP was superior to either drug alone in the prevention of strokes...
  47. ncbi request reprint The efficacy and safety of sc alniditan vs. sc sumatriptan in the acute treatment of migraine: a randomized, double-blind, placebo-controlled trial
    H C Diener
    Department of Neurology, University Hospital, University of Essen, Essen, Germany
    Cephalalgia 21:672-9. 2001
    ..4 mg for pain free at 2 h. The difference, however, was small and clinically not important. For alniditan, a dose-dependent adverse event relationship was seen. The safety profile of alniditan 1.4 mg was similar to that of sumatriptan...
  48. ncbi request reprint Advances in pharmacological treatment of migraine
    H C Diener
    Department of Neurology, University Essen, Hufelandstr 55, 45122 Essen, Germany
    Expert Opin Investig Drugs 10:1831-45. 2001
    ..Recently anti-epileptic drugs (valproic acid, gabapentin, topiramate) were evaluated for the prophylaxis of migraine. The use of botulinum toxin is under investigation...
  49. ncbi request reprint Efficacy, tolerability and safety of oral eletriptan and ergotamine plus caffeine (Cafergot) in the acute treatment of migraine: a multicentre, randomised, double-blind, placebo-controlled comparison
    Hans Christoph Diener
    Department of Neurology, University of Essen, Essen, Germany
    Eur Neurol 47:99-107. 2002
    ..001) at 2 h. Adverse events were generally mild or moderate and transient. This randomised trial shows that oral eletriptan is more efficacious in the acute treatment of migraine than oral Cafergot and is well tolerated...
  50. ncbi request reprint RPR100893, a substance-P antagonist, is not effective in the treatment of migraine attacks
    H C Diener
    Department of Neurology, University of Essen, Essen, Germany
    Cephalalgia 23:183-5. 2003
    ..Headache intensity and improvement of headache after 2 h were not different in the four treatment groups. Therefore, it is concluded that this oral substance-P antagonist in the doses used here is not effective...
  51. ncbi request reprint Treatment of migraine attacks with intranasal alniditan: an open study
    H C Diener
    Department of Neurology, University of Essen, Hufelandstr 55, 45122 Essen, Germany
    Cephalalgia 21:140-4. 2001
    ..Alniditan 2 mg, administered via the intranasal route, was effective in relieving migraine headaches in over two-thirds of the patients at 1 h...
  52. ncbi request reprint Analgesics
    H C Diener
    Department of Neurology, University of Essen, Germany
    Curr Med Res Opin 17:s13-6. 2001
    ..Few data on the efficacy of opioid drugs in the treatment of migraine are available. They seem to be effective but carry the risk of dependency and may cause drug-induced headache...
  53. ncbi request reprint Efficacy and tolerability in migraine prophylaxis of flunarizine in reduced doses: a comparison with propranolol 160 mg daily
    H C Diener
    Department of Neurology, University Essen, Germany
    Cephalalgia 22:209-21. 2002
    ..In addition, no significant differences between the three treatments were found with regard to safety: all three treatments were generally well-tolerated and safe...
  54. ncbi request reprint [Risk factor, symptom, differential diagnosis. How headache and cerebral infarct are correlated]
    H C Diener
    Universitätsklinik für Neurologie Universität Essen
    MMW Fortschr Med 144:41-2. 2002
  55. ncbi request reprint Aspirin therapy should be first-line treatment in secondary prevention of stroke--against
    Hans Christoph Diener
    Department of Neurology, University Essen, Essen, Germany
    Stroke 33:2138-9. 2002
  56. ncbi request reprint [Which triptan is best? Rating of triptans in migraine treatment]
    Hans Christoph Diener
    Klinik und Poliklinik für Neurologie der Universität Essen Hufelandstr 55 45122 Essen
    Pharm Unserer Zeit 31:462-9. 2002
  57. ncbi request reprint [Primary prevention of stroke. What helps--what does not help? The guidelines of the German Society of Neurology briefly summarized]
    H C Diener
    Abteilung fur Neurologie, Universitatsklinikum Essen, D 45122 Essen
    MMW Fortschr Med 145:9-10. 2003
  58. ncbi request reprint A comparative study of oral acetylsalicyclic acid and metoprolol for the prophylactic treatment of migraine. A randomized, controlled, double-blind, parallel group phase III study
    H C Diener
    Department of Neurology, University of Essen, Hufelandstr 55, 45122 Essen, Germany
    Cephalalgia 21:120-8. 2001
    ..Acetylsalicylic acid is better tolerated than metoprolol. Using a strict responder criterion ASA showed a responder rate comparable with the placebo rate in the literature...
  59. ncbi request reprint Treatment of acute ischemic stroke with the low-molecular-weight heparin certoparin: results of the TOPAS trial. Therapy of Patients With Acute Stroke (TOPAS) Investigators
    H C Diener
    Neurologische Klinik und Poliklinik, Universit tsklinikum Essen, Hufelandstra e 55, 45122 Essen, Germany
    Stroke 32:22-9. 2001
    ..To study the safety and efficacy of the low-molecular-weight heparin certoparin, we performed a randomized, double-blind, dose-finding multicenter trial in patients with acute ischemic stroke (Therapy of Patients With Acute Stroke [TOPAS])...
  60. ncbi request reprint Acute management of migraine: triptans and beyond
    H C Diener
    Department of Neurology, University of Essen, Germany
    Curr Opin Neurol 12:261-7. 1999
    ..New drugs in migraine treatment include substance-P antagonists, nitric oxide synthetase inhibitors and calcitonin gene-related peptide antagonists...
  61. ncbi request reprint The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria
    H C Diener
    Department of Neurology, University of Essen, Hufelandstrasse 55, DE 45122 Essen, Germany
    Eur Neurol 51:89-97. 2004
    ..Butterbur was well tolerated. This small trial indicates that butterbur may be effective in the prophylaxis of migraine...
  62. ncbi request reprint Efficacy and safety of intravenous acetylsalicylic acid lysinate compared to subcutaneous sumatriptan and parenteral placebo in the acute treatment of migraine. A double-blind, double-dummy, randomized, multicenter, parallel group study. The ASASUMAMIG St
    H C Diener
    Department of Neurology, University Essen, Germany
    Cephalalgia 19:581-8; discussion 542. 1999
    ..6%, sumatriptan 37.8%). In conclusion, subcutaneous sumatriptan and lysine acetylsalicylate i.v. are effective treatments for patients suffering from migraine attacks. Sumatriptan is more effective, but resulted in more adverse events...
  63. ncbi request reprint The 40-mg dose of eletriptan: comparative efficacy and tolerability versus sumatriptan 100 mg
    Hans Christoph Diener
    Department of Neurology, University of Essen, Essen, Germany
    Eur J Neurol 11:125-34. 2004
    ..Combined analysis demonstrates that E40 has superior efficacy versus S100 across all clinically relevant outcomes...
  64. ncbi request reprint Management of atherothrombosis with clopidogrel in high-risk patients with recent transient ischaemic attack or ischaemic stroke (MATCH): study design and baseline data
    Hans Christoph Diener
    Department of Neurology, University of Essen, Germany
    Cerebrovasc Dis 17:253-61. 2004
    ..The benefit of clopidogrel over ASA is amplified in high-risk patients. Proof of concept for the benefit of clopidogrel in addition to ASA in patients with coronary manifestations of atherothrombosis was provided by the CURE trial...
  65. ncbi request reprint Stroke prevention: anti-platelet and anti-thrombolytic therapy
    H C Diener
    Professor, Department of Neurology, University of Essen, Germany
    Neurol Clin 18:343-55. 2000
    ..It will be replaced by clopidgrel which has a better safety profile. Anticoagulation with an INR between 3.0 and 4.5 is too dangerous. Whether anticoagulation with lower INR is safe and effective is not yet known...
  66. ncbi request reprint [Secondary prevention of ischemic infarct]
    H C Diener
    Klinik und Poliklinik fur Neurologie, Universitat Essen
    Z Arztl Fortbild Qualitatssich 93:209-12. 1999
    ..Patients with > 70% stenosis of the internal carotid artery and TIA or minor stroke receive carotid endarterectomy in combination with aspirin. Stroke risk is reduced between 20 and 65% by these measures...
  67. ncbi request reprint Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo
    H C Diener
    Department of Neurology, University Essen, Germany
    Stroke 31:2543-51. 2000
    ..5 mg followed by a daily intravenous dose of 10 mg lubeluzole for 5 days in acute ischemic stroke patients...
  68. ncbi request reprint [Therapeutic concepts in the treatment of headache]
    H C Diener
    Universitätsklinik für Neurologie, Essen
    MMW Fortschr Med 146:33-4, 36-7. 2004
    ..The more rare forms of nonsymptomatic headache include paroxysmal hemicrania and trigeminal neuralgia, in the prevention of which carbamazepine, phenytoin or oxcarbazepine have proven of value...
  69. ncbi request reprint A practical guide to the management and prevention of migraine
    H C Diener
    Department of Neurology, University of Essen, Germany
    Drugs 56:811-24. 1998
    ..The efficacy of aspirin or magnesium is still under evaluation...
  70. ncbi request reprint Self-initiated movements in chronic prefrontal traumatic brain injury: an event-related functional MRI study
    Holger Wiese
    Department of Neurology, University of Duisburg Essen, Germany
    Neuroimage 30:1292-301. 2006
    ..Since attentional and working memory functions are supposed to modulate preparatory processes, differences between the patient subgroups are suggested to result from the more pronounced cognitive impairments in the right-lesioned group...
  71. ncbi request reprint Activity of attention related structures in multiple sclerosis patients
    Katharina Nebel
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Brain Res 1151:150-60. 2007
    ....
  72. ncbi request reprint Assessment of functioning and disability after ischemic stroke
    Christian Weimar
    Department of Neurology, University of Essen, Essen, Germany
    Stroke 33:2053-9. 2002
    ..Functioning and disability after ischemic stroke are clinically meaningful and of major relevance to patients. Despite many instruments available to assess these outcomes, little is known about their interrelation and predictive factors...
  73. ncbi request reprint Adherence to secondary stroke prevention strategies--results from the German Stroke Data Bank
    Gerhard F Hamann
    Department of Neurology, Ludwig Maximilian University, Klinikum Grosshadern, Munich, Germany
    Cerebrovasc Dis 15:282-8. 2003
    ..The highest adherence rate is noticed for aspirin and oral anticoagulation. After one year, very few patients stopped taking stroke preventive medication...
  74. doi request reprint NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II Trials
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Stroke 39:1751-8. 2008
    ..SAINT I and II were randomized, placebo-controlled, double-blind trials to investigate the efficacy of NXY-059 in patients with AIS...
  75. ncbi request reprint Antiplatelet agents and randomized trials
    Hans Christoph Diener
    Department of Neurology, University Dusiburg Essen, Essen, Germany
    Rev Neurol Dis 4:177-83. 2007
    ..Another ongoing trial is currently investigating the possible benefit and side effects of aspirin plus ER-DP versus clopidogrel in secondary stroke prevention...
  76. ncbi request reprint Systemic risk score evaluation in ischemic stroke patients (SCALA): a prospective cross sectional study in 85 German stroke units
    Christian Weimar
    Dept of Neurology, University of Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
    J Neurol 254:1562-8. 2007
    ..hospitalized with TIA/IS to stratify the risk of recurrent stroke according to the Essen Stroke Risk Score (ESRS) and of future cardiovascular events according to the ankle brachial index (ABI) as a marker of generalized atherosclerosis..
  77. ncbi request reprint Important advances in headache
    Hans Christoph Diener
    Department of Neurology, University Essen, Germany
    Lancet Neurol 3:12. 2004
  78. ncbi request reprint [Secondary prevention of stroke with antiplatelet drugs]
    Hans Christoph Diener
    Klinik fur Neurologie, Universitatsklinikum Essen
    Med Klin (Munich) 99:21-5. 2004
    ....
  79. ncbi request reprint Treatment of acute ischaemic stroke with the low-affinity, use-dependent NMDA antagonist AR-R15896AR. A safety and tolerability study
    Hans Christoph Diener
    Department of Neurology, University Essen, Hufelandstr 55, 45122 Essen, Germany
    J Neurol 249:561-8. 2002
    ..The aim of the present study was to examine the safety and tolerability of a new and higher dosage regimen that would enable acute stroke patients to achieve and maintain neuroprotective plasma concentrations...
  80. ncbi request reprint Improving patient selection for clinical acute stroke trials
    Christian Weimar
    Department of Neurology, University of Essen, Essen, Germany
    Cerebrovasc Dis 21:386-92. 2006
    ..To optimize patient inclusion criteria for clinical acute stroke trials...
  81. ncbi request reprint Patent foramen ovale: paradoxical connection to migraine and stroke
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Germany
    Curr Opin Neurol 18:299-304. 2005
    ..In this article we aim to elucidate the relationship between patent foramen ovale, cryptogenic stroke and migraine...
  82. ncbi request reprint Efficacy of almotriptan 12.5 mg in achieving migraine-related composite endpoints: a double-blind, randomized, placebo-controlled study in patients controlled study in patients with previous poor response to sumatriptan 50 mg
    Hans Christoph Diener
    Department of Neurology, University of Essen, D 45145 Essen, Germany
    Curr Med Res Opin 21:1603-10. 2005
    ..Triptans are not identical and migraine sufferers respond differently to different triptans. Few studies have evaluated the efficacy of switching triptans in migraine patients who have shown poor response to another agent...
  83. ncbi request reprint CNS manifestations of cytomegalovirus infections: diagnosis and treatment
    Matthias Maschke
    Department of Neurology, University Clinic of Essen, Germany
    CNS Drugs 16:303-15. 2002
    ..Despite therapy, the prognosis for long-term survival is very poor, especially in patients with AIDS...
  84. doi request reprint Habituation of the auditory startle response in cervical dystonia and Parkinson's disease
    Norman Putzki
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Eur Neurol 59:172-8. 2008
    ..Normal latencies and sequence activation indicate intact neural pathways mediating the ASR in FD. Impaired habituation of the ASR points towards a reduced inhibition of acoustic stimuli in FD...
  85. ncbi request reprint Patent foramen ovale, stroke, and cardiovascular disease in migraine
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Curr Opin Neurol 20:310-9. 2007
    ..We will review the literature on the association between migraine with patent foramen ovale, stroke, and coronary heart disease...
  86. ncbi request reprint Predicting functional outcome and survival after acute ischemic stroke
    Christian Weimar
    Department of Neurology, University of Essen, Hufelandstr 55, Germany
    J Neurol 249:888-95. 2002
    ..We therefore developed prognostic models for functional dependence and death after 100 days in a large cohort of stroke patients...
  87. ncbi request reprint Cessation versus continuation of 6-month migraine preventive therapy with topiramate (PROMPT): a randomised, double-blind, placebo-controlled trial
    Hans Christoph Diener
    Department of Neurology, Universitat Duisburg Essen, Germany
    Lancet Neurol 6:1054-62. 2007
    ..We assessed the effects of discontinuation of topiramate after a treatment period of 6 months...
  88. ncbi request reprint Effectiveness and satisfaction with zolmitriptan 5 mg nasal spray for treatment of migraine in real-life practice: results of a postmarketing surveillance study
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Clin Drug Investig 27:59-66. 2007
    ..Patient feedback can be collected in postmarketing surveillance (PMS) studies. The objective of this PMS study was to evaluate the efficacy and tolerability of zolmitriptan 5 mg nasal spray in the acute treatment of migraine attacks...
  89. ncbi request reprint Pain related potentials by electrical stimulation of skin for detection of small-fiber neuropathy in HIV
    Zaza Katsarava
    Department of Neurology, University of Essen, Hufelandstr 55, 45122, Essen, Germany, and Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    J Neurol 253:1581-4. 2006
    ..SNC testing revealed a neuropathy in only 31%, whereas PREP was abnormal in 74% of symptomatic patients. This result hints that PREP is more sensitive in the detection of HIV-associated small fiber neuropathy than standard neurography...
  90. ncbi request reprint Kinesthesia is impaired in focal dystonia
    Norman Putzki
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Mov Disord 21:754-60. 2006
    ..Results of the present study point to impaired kinesthesia in FD. Defective sensory processing could be involved in the pathophysiology of the disease and may influence dystonic contractions...
  91. ncbi request reprint On the neural basis of focused and divided attention
    Katharina Nebel
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Brain Res Cogn Brain Res 25:760-76. 2005
    ..As conditions become more difficult, left-lateralized homologue areas activate...
  92. ncbi request reprint Limb flexion reflex-related areas in human cerebellum
    Matthias Maschke
    Department of Nuclear Medicine, University of Essen, Hufelandstr 55, 45122 Essen, Germany
    Neuroreport 13:2325-30. 2002
    ..Limb flexion reflex areas probably reflect efferent reflex modulation as well as sensory inputs from the stimulus itself and/or the reflex response...
  93. ncbi request reprint Sparse imaging and continuous event-related fMRI in the visual domain: a systematic comparison
    Katharina Nebel
    Department of Neurology, University of Duisburg Essen, 45122 Essen, Germany
    Hum Brain Mapp 24:130-43. 2005
    ..However, only sparse fMRI offers the opportunity to apply stimuli and record further biosignals free of scanner-related artifacts during intervals without image acquisition...
  94. ncbi request reprint Almotriptan in migraine patients who respond poorly to oral sumatriptan: a double-blind, randomized trial
    Hans Christoph Diener
    Department of Neurology, University Essen and Bayer Healthcare, Essen, Germany
    Headache 45:874-82. 2005
    ..To investigate the efficacy and tolerability of almotriptan 12.5 mg in migraine patients who respond poorly to sumatriptan 50 mg...
  95. ncbi request reprint Reorganization of motor execution rather than preparation in poststroke hemiparesis
    Holger Wiese
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Stroke 36:1474-9. 2005
    ..The aim of the present study was to examine movement-related potentials (MRPs) in patients in the "chronic" stage after cortical stroke with recovered hemiparesis compared with healthy control subjects...
  96. ncbi request reprint Cerebellar representation of the eyeblink response as revealed by PET
    Matthias Maschke
    Department of Neurology, University of Essen, Hufelandstr 55, 45122 Essen, Germany
    Neuroreport 14:1371-4. 2003
    ..In conclusion, vermal lobule VI extending to ipsilateral paravermal areas appears to be involved in control of the unconditioned eyeblink response...
  97. ncbi request reprint Medication overuse headaches -- what is new?
    Guenther Fritsche
    Department of Neurology, University Essen, Germany
    Expert Opin Drug Saf 1:331-8. 2002
    ..In view of the high prevalence and relapse rate, it is necessary to establish a structured post-treatment programme for patients after the acute withdrawal phase, which considers the predictors for relapse...
  98. ncbi request reprint Development and validation of a prognostic model to predict recovery following intracerebral hemorrhage
    Christian Weimar
    Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    J Neurol 253:788-93. 2006
    ..While several models have been developed to predict mortality following intracerebral hemorrhage (ICH), the functional outcome and its predictors in surviving patients have been poorly investigated so far...
  99. ncbi request reprint Differences in trace and delay visuomotor associative learning in cerebellar patients
    Matthias Maschke
    Department of Neurology, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Exp Brain Res 147:538-48. 2002
    ..The lack of a better performance in the trace-condition compared to the delay-condition in cerebellar patients suggests deficits in learning the stimulus-response association...
  100. pmc Learning of sensory sequences in cerebellar patients
    Markus Frings
    Department of Neurology, University of Duisburg Essen, 45122 Essen, Germany
    Learn Mem 11:347-55. 2004
    ..No major disturbances in acquisition or discrimination of various sensory sequences were observed in the group of cerebellar patients. Sequence learning may be impaired only in tasks with significant motor demands...
  101. ncbi request reprint Acquisition of simple auditory and visual sequences in cerebellar patients
    Markus Frings
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Cerebellum 5:206-11. 2006
    ..Differences in findings between previous and the present study may be explained by differences in motor demands and the explicit nature of the tasks...