H C Diener

Summary

Affiliation: University of Duisburg-Essen
Country: Germany

Publications

  1. doi The importance of placebo in headache research
    H C Diener
    Department of Neurology, University Duisburg Essen, Essen, Germany
    Cephalalgia 28:1003-11. 2008
  2. doi Integrated headache care
    H C Diener
    University Hospital Essen, Germany
    Cephalalgia 31:1039-47. 2011
  3. doi [Chronic migraine]
    H C Diener
    Universitätsklinik für Neurologie, Westdeutsches Kopfschmerzzentrum, Universitatsklinikum Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Nervenarzt 84:1460-6. 2013
  4. pmc Aerobic endurance training versus relaxation training in patients with migraine (ARMIG): study protocol for a randomized controlled trial
    Andreas Totzeck
    Headache Center, Department of Neurology, University Hospital Essen, University Duisburg Essen, Hufelandstrase 55, 45147 Essen, Germany
    Trials 13:46. 2012
  5. ncbi Telmisartan on top of antihypertensive treatment does not prevent progression of cerebral white matter lesions in the prevention regimen for effectively avoiding second strokes (PRoFESS) MRI substudy
    Ralph Weber
    Department of Neurology, University Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Stroke 43:2336-42. 2012
  6. doi [Neurostimulation for treatment of headaches]
    H C Diener
    Universitätsklinik für Neurologie und Westdeutsches Kopfschmerzzentrum, Universitatsklinikum Essen, Hufelandstr 55, 45147 Essen, Deutschland
    Nervenarzt 83:994-1000. 2012
  7. pmc Evaluating integrated headache care: a one-year follow-up observational study in patients treated at the Essen headache centre
    Charly Gaul
    Headache Centre, Department of Neurology, University Duisburg Essen, Essen, Germany
    BMC Neurol 11:124. 2011
  8. doi Headache classification by history has only limited predictive value for headache episodes treated in controlled trials with OTC analgesics
    H C Diener
    Department of Neurology, University Duisburg Essen, Essen, Germany
    Cephalalgia 29:188-93. 2009
  9. ncbi [Diagnosis and treatment of head and facial pain]
    H C Diener
    Klinik für Neurologie und Westdeutsches Kopfschmerzzentrum WKZ, Universitatsklinikum Essen, Hufelandstrasse 55, 45122, Essen, Deutschland
    Internist (Berl) 49:1343-8; quiz 1349-50. 2008
  10. ncbi [Diagnosis and treatment of head and facial pain]
    H C Diener
    Klinik für Neurologie und Westdeutsches Kopfschmerzzentrum, Universitatsklinikum Essen, Essen
    HNO 57:931-6; quiz 937-8. 2009

Collaborators

Detail Information

Publications174 found, 100 shown here

  1. doi The importance of placebo in headache research
    H C Diener
    Department of Neurology, University Duisburg Essen, Essen, Germany
    Cephalalgia 28:1003-11. 2008
    ..Variables known to influence the placebo response have to be taken into consideration to calculate properly the power of planned randomized trials...
  2. doi Integrated headache care
    H C Diener
    University Hospital Essen, Germany
    Cephalalgia 31:1039-47. 2011
    ..This is called integrated headache care. This review summarizes experiences in integrated headache care settings in Europe and the USA, describes these settings, and reports outcome data...
  3. doi [Chronic migraine]
    H C Diener
    Universitätsklinik für Neurologie, Westdeutsches Kopfschmerzzentrum, Universitatsklinikum Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Nervenarzt 84:1460-6. 2013
    ..The efficacy for prophylactic treatment compared with placebo is proven for topiramate and onabotulinum toxin A...
  4. pmc Aerobic endurance training versus relaxation training in patients with migraine (ARMIG): study protocol for a randomized controlled trial
    Andreas Totzeck
    Headache Center, Department of Neurology, University Hospital Essen, University Duisburg Essen, Hufelandstrase 55, 45147 Essen, Germany
    Trials 13:46. 2012
    ..We therefore designed a randomized controlled trial to evaluate the efficacy of aerobic endurance training versus relaxation training in patients with migraine (ARMIG)...
  5. ncbi Telmisartan on top of antihypertensive treatment does not prevent progression of cerebral white matter lesions in the prevention regimen for effectively avoiding second strokes (PRoFESS) MRI substudy
    Ralph Weber
    Department of Neurology, University Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Stroke 43:2336-42. 2012
    ..We investigated whether telmisartan prevents WML progression in the imaging substudy of the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial...
  6. doi [Neurostimulation for treatment of headaches]
    H C Diener
    Universitätsklinik für Neurologie und Westdeutsches Kopfschmerzzentrum, Universitatsklinikum Essen, Hufelandstr 55, 45147 Essen, Deutschland
    Nervenarzt 83:994-1000. 2012
    ....
  7. pmc Evaluating integrated headache care: a one-year follow-up observational study in patients treated at the Essen headache centre
    Charly Gaul
    Headache Centre, Department of Neurology, University Duisburg Essen, Essen, Germany
    BMC Neurol 11:124. 2011
    ..Outpatient integrated headache care was established in 2005 at the Essen Headache Centre in Germany. This paper reports outcome data for this approach...
  8. doi Headache classification by history has only limited predictive value for headache episodes treated in controlled trials with OTC analgesics
    H C Diener
    Department of Neurology, University Duisburg Essen, Essen, Germany
    Cephalalgia 29:188-93. 2009
    ..Symptom features of treated headaches should be captured to ensure that the attack is of the type targeted by the clinical trial. The International Headache Society Guidelines for controlled clinical trials should be updated accordingly...
  9. ncbi [Diagnosis and treatment of head and facial pain]
    H C Diener
    Klinik für Neurologie und Westdeutsches Kopfschmerzzentrum WKZ, Universitatsklinikum Essen, Hufelandstrasse 55, 45122, Essen, Deutschland
    Internist (Berl) 49:1343-8; quiz 1349-50. 2008
    ..This is followed by a brief summary on symptomatic headache caused by non-neurological diseases as well as on diagnostic procedures and management of headache in the emergency situation...
  10. ncbi [Diagnosis and treatment of head and facial pain]
    H C Diener
    Klinik für Neurologie und Westdeutsches Kopfschmerzzentrum, Universitatsklinikum Essen, Essen
    HNO 57:931-6; quiz 937-8. 2009
    ..This is followed by a brief summary on symptomatic headache caused by non-neurological diseases as well as on diagnostic procedures and management of headache in the emergency situation...
  11. ncbi NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II Trials
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Stroke 39:1751-8. 2008
    ..SAINT I and II were randomized, placebo-controlled, double-blind trials to investigate the efficacy of NXY-059 in patients with AIS...
  12. doi The efficacy and tolerability of a fixed combination of acetylsalicylic acid, paracetamol, and caffeine in patients with severe headache: a post-hoc subgroup analysis from a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel g
    H C Diener
    University Duisburg Essen, Germany
    Cephalalgia 31:1466-76. 2011
    ....
  13. ncbi OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 trial
    H C Diener
    University of Essen, Germany
    Cephalalgia 30:804-14. 2010
    ..This is the second of a pair of studies designed to evaluate the efficacy and safety of onabotulinumtoxinA (BOTOX) for prophylaxis of headaches in adults with chronic migraine...
  14. doi Antiplatelet therapy in secondary stroke prevention--state of the art
    Hans Christoph Diener
    Department of Neurology and Stroke Center, University Duisburg Essen, Essen, Germany
    J Cell Mol Med 14:2552-60. 2010
    ..For secondary stroke prevention in patients with atrial fibrillation, oral anticoagulation is more effective than aspirin or the combination of aspirin and clopidogrel...
  15. pmc Per-capita consumption of analgesics: a nine-country survey over 20 years
    H C Diener
    Department of Neurology, University Duisburg Essen, Essen, Germany
    J Headache Pain 9:225-31. 2008
    ..50 SU per capita per year. The prevalence of conditions inducing analgesic use shows appropriate analgesics use on an overall population level...
  16. ncbi DP-b99, a membrane-activated metal ion chelator, as neuroprotective therapy in ischemic stroke
    Hans Christoph Diener
    Department of Neurology, University Duisburg Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Stroke 39:1774-8. 2008
    ..We present the results of a multicenter, double-blind, placebo-controlled, randomized trial to assess the safety and potential protective effects of DP-b99 in acute ischemic stroke...
  17. pmc Migraine--the forgotten epidemic: development of the EHF/WHA Rome Declaration on Migraine
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45147, Essen, Germany
    J Headache Pain 7:433-7. 2006
    ..The key recommendation of the EHF/WHA Rome Declaration on Migraine is education of migraine sufferers, health professionals and health-policy makers...
  18. ncbi Effectiveness and satisfaction with zolmitriptan 5 mg nasal spray for treatment of migraine in real-life practice: results of a postmarketing surveillance study
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Clin Drug Investig 27:59-66. 2007
    ..Patient feedback can be collected in postmarketing surveillance (PMS) studies. The objective of this PMS study was to evaluate the efficacy and tolerability of zolmitriptan 5 mg nasal spray in the acute treatment of migraine attacks...
  19. ncbi Patent foramen ovale, stroke, and cardiovascular disease in migraine
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Curr Opin Neurol 20:310-9. 2007
    ..We will review the literature on the association between migraine with patent foramen ovale, stroke, and coronary heart disease...
  20. ncbi Patent foramen ovale and migraine
    Hans Christoph Diener
    Department of Neurology, University Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Curr Pain Headache Rep 11:236-40. 2007
    ..Until there is more evidence from ongoing large controlled trials, PFO closure should not be performed in clinical practice for the prophylaxis of migraine...
  21. ncbi Cessation versus continuation of 6-month migraine preventive therapy with topiramate (PROMPT): a randomised, double-blind, placebo-controlled trial
    Hans Christoph Diener
    Department of Neurology, Universitat Duisburg Essen, Germany
    Lancet Neurol 6:1054-62. 2007
    ..We assessed the effects of discontinuation of topiramate after a treatment period of 6 months...
  22. doi BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II study
    Hans Christoph Diener
    Department of Neurology and Headache Center, University Hospital Essen, University Duisburg Essen, Hufelandstrasse 55, Essen, Germany
    Cephalalgia 31:573-84. 2011
    ..The analysis included 341 subjects who took study medication...
  23. ncbi Update on the prophylaxis of migraine
    Markus Schürks
    Hans Christoph Diener, MD Department of Neurology, University Hospital Essen, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Curr Treat Options Neurol 10:20-9. 2008
    ..Acupuncture may be another alternative; although controlled trials have failed to differentiate its effect from placebo, it is at least innocuous. Botulinum toxin A is not effective in the prophylaxis of episodic migraine...
  24. ncbi Hypnic headache: clinical course and treatment
    Hans Christoph Diener
    Department of Neurology and Westgerman Headache Center Essen, University of Duisburg Essen, Hufelandstr 55, 45122, Essen, Germany
    Curr Treat Options Neurol 14:15-26. 2012
    ..Lithium has been reported to be effective in many patients, but it was often discontinued because of side effects. Indomethacin may be a viable option for third-line prophylactic therapy...
  25. doi [Consequent preventive therapy protects against stroke: EXPRESS study (Early use of Existing Preventive Strategies for Stroke)]
    H C Diener
    Klinik fur Neurologie, Universitatsklinikum Essen, Hufelandstrasse 55, Essen, Deutschland
    Internist (Berl) 49:635-6. 2008
  26. ncbi The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group st
    H C Diener
    Department of Neurology, University of Essen, Essen, Germany
    Cephalalgia 25:776-87. 2005
    ..All treatments were well tolerated. The incidence of adverse events observed was low...
  27. doi Gray matter changes related to chronic posttraumatic headache
    Mark Obermann
    Department of Neurology, University of Duisburg Essen, 45122 Essen, Germany
    Neurology 73:978-83. 2009
    ..Although up to 15% of patients with whiplash injury develop chronic headache, the basis and mechanisms of this posttraumatic headache are not well understood...
  28. ncbi Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene
    M Schurks
    Department of Neurology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Neurology 66:1917-9. 2006
    ..The genotype and allele distribution varied significantly between patients and controls. Homozygous carriers of the G-allele had a twofold increase in risk for CH (OR 1.97; 95% CI 1.32 to 2.92; p = 0.0007)...
  29. pmc Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFE
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Lancet Neurol 7:875-84. 2008
    ..The putative neuroprotective effects of antiplatelet compounds and the angiotensin II receptor antagonist telmisartan were investigated in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial...
  30. ncbi [Current diagnosis and treatment of migraine]
    H C Diener
    Universitätsklinik für Neurologie und Westdeutsches Kopfschmerzzentrum, Universitatsklinikum Essen, Hufelandstrasse 55, 45147, Essen, Germany
    Schmerz 22:51-8; quiz 59-60. 2008
    ..Nonpharmacologic treatment also plays an important role in migraine prevention. New medical care structures such as integrated headache care provide better support for patients with migraine, particularly those with chronic migraine...
  31. ncbi Clinical features of withdrawal headache following overuse of triptans and other headache drugs
    Z Katsarava
    Department of Neurology, University Hospital Essen, Germany
    Neurology 57:1694-8. 2001
    ..6 days for patients with tension-type headache and 8.5 days for patients with combination headache, p < 0.02). CONCLUSION: The duration and severity of withdrawal clearly depend on the type of overused headache drug only...
  32. ncbi Impaired trigeminal nociceptive processing in patients with trigeminal neuralgia
    M Obermann
    Department of Neurology, University Duisburg Essen, Essen, Germany
    Neurology 69:835-41. 2007
    ..Between the attacks the patient is usually asymptomatic, but a constant dull background pain may persist in some cases. The mechanisms associated with the development of this chronic pain are not well understood...
  33. ncbi Quantification of acute neck pain following whiplash injury by computer-aided pressure algesimetry
    P Stude
    Department of Neurology, University of Essen, Essen, Germany
    Cephalalgia 24:1067-75. 2004
    ..The computer-interactive pressure algesimetry enables a standardized and rater-independent quantification of the cervical syndrome with neck and shoulder pain caused by whiplash injury...
  34. doi Recurrent stroke after lobar and deep intracerebral hemorrhage: a hospital-based cohort study
    C Weimar
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Cerebrovasc Dis 32:283-8. 2011
    ..We therefore aimed to assess the patient characteristics and prognosis after deep and lobar ICH in a well-characterized, multicenter, hospital-based cohort...
  35. ncbi Prevalence of facial pain in migraine: a population-based study
    M S Yoon
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Cephalalgia 30:92-6. 2010
    ..23, P < 0.001). In one case isolated facial pain without headache was the leading symptom of migraine. Our results demonstrate that facial pain is not unusual in migraine, whereas isolated facial migraine is extremely rare...
  36. doi Electrically evoked nociceptive potentials for early detection of diabetic small-fiber neuropathy
    D Mueller
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Eur J Neurol 17:834-41. 2010
    ....
  37. doi Prevalence of migraine, tension-type headache and trigeminal neuralgia in multiple sclerosis
    N Putzki
    Department of Neurology, University Hospital Essen, Essen, Germany
    Eur J Neurol 16:262-7. 2009
    ..Prevalence rates of headache in multiple sclerosis (MS) patients varied widely in recent studies. This study aimed to investigate the 1 year prevalence of headache in MS compared with the general population...
  38. ncbi Experimental cranial pain elicited by capsaicin: a PET study
    A May
    Department of Neurology, University of Essen, Germany
    Pain 74:61-6. 1998
    ....
  39. doi [Current diagnosis and treatment of migraine]
    H C Diener
    Universitätsklinik für Neurologie und Westdeutsches Kopfschmerzzentrum, Universitatsklinikum Essen, Hufelandstrasse 55, 45147 Essen
    Ophthalmologe 105:501-8; quiz 509-10. 2008
    ..Nonpharmacologic treatment also plays an important role in migraine prevention. New medical care structures such as integrated headache care provide better support for patients with migraine, particularly those with chronic migraine...
  40. ncbi Abnormal habituation of 'nociceptive' blink reflex in migraine--evidence for increased excitability of trigeminal nociception
    Z Katsarava
    Department of Neurology, University of Essen, Germany
    Cephalalgia 23:814-9. 2003
    ..f. = 2, F = 12.4, P < 0.001). The demonstrated lack of habituation of the nBR responses indicates an abnormal trigeminal nociceptive processing in migraine patients outside the migraine attack...
  41. doi Current management and risk of recurrent stroke in cerebrovascular patients with right-to-left cardiac shunt
    C Weimar
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Cerebrovasc Dis 28:349-56. 2009
    ..We aimed to investigate the current management and prognosis in consecutive patients with RLS and otherwise cryptogenic cerebrovascular events...
  42. ncbi Identification of negative predictors of pain-free response to triptans: analysis of the eletriptan database
    H C Diener
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Cephalalgia 28:35-40. 2008
    ..placebo (all P < 0.01). Thus, eletriptan and sumatriptan are efficacious in difficult-to-treat patients at high risk for non-response to triptans...
  43. ncbi The G1246A polymorphism in the hypocretin receptor 2 gene is not associated with treatment response in cluster headache
    M Schurks
    Department of Neurology, University Hospital Essen, University Duisburg Essen, Essen, Germany
    Cephalalgia 27:363-7. 2007
    ..Our results do not support a role of the HCRTR2 G1246A polymorphism in drug responses in CH...
  44. ncbi Drug-induced headache: long-term follow-up of withdrawal therapy and persistence of drug misuse
    G Fritsche
    Department of Neurology, University of Essen, Germany
    Eur Neurol 45:229-35. 2001
    ..Under relapse conditions, the patients reached their former headache frequency level. The data show a higher relapse rate than previously assumed and that certain substance groups bear a higher relapse risk...
  45. pmc Fear conditioned potentiation of the acoustic blink reflex in patients with cerebellar lesions
    M Maschke
    Department of Neurology, University of Essen, Germany
    J Neurol Neurosurg Psychiatry 68:358-64. 2000
    ..To investigate whether the human cerebellum takes part in fear conditioned potentiation of the acoustic blink reflex...
  46. doi [The value of "migraine surgery". Overview of the pathophysiological concept and current evidence]
    C Gaul
    Westdeutsches Kopfschmerzzentrum, Neurologische Klinik, Universitatsklinikum Essen, 45147 Essen
    Nervenarzt 81:463-70. 2010
    ..In spite of the above, the study is frequently cited in the lay press. The surgical procedure as well as the study are critically discussed...
  47. doi Symptomatic intracranial atherosclerotic stenoses: prevalence and prognosis in patients with acute cerebral ischemia
    R Weber
    Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, Essen, Germany
    Cerebrovasc Dis 30:188-93. 2010
    ..In view of the increasing options for endovascular interventions, we sought to investigate the prevalence, risk for recurrent stroke and mortality in these patients...
  48. ncbi Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY trial): a randomised, open-label, blinded-endpoint trial
    Reinhard Dengler
    Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
    Lancet Neurol 9:159-66. 2010
    ..The EARLY trial aimed to compare outcome in patients given aspirin plus extended-release dipyridamole twice daily either within 24 h of stroke or TIA or after 7 days of aspirin monotherapy...
  49. ncbi Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo
    H C Diener
    Department of Neurology, University Essen, Germany
    Stroke 31:2543-51. 2000
    ..5 mg followed by a daily intravenous dose of 10 mg lubeluzole for 5 days in acute ischemic stroke patients...
  50. ncbi Features of medication overuse headache following overuse of different acute headache drugs
    V Limmroth
    Department of Neurology, University Hospital Essen, Germany
    Neurology 59:1011-4. 2002
    ....
  51. ncbi Topiramate reduces headache days in chronic migraine: a randomized, double-blind, placebo-controlled study
    H C Diener
    Department of Neurology, University of Duisburg Essen, Germany
    Cephalalgia 27:814-23. 2007
    ..This randomized, double-blind, placebo-controlled trial demonstrates that topiramate is effective and reasonably well tolerated when used for the preventive treatment of chronic migraine, even in the presence of medication overuse...
  52. ncbi Differences in clinical characteristics and frequency of accompanying migraine features in episodic and chronic cluster headache
    C Gaul
    Department of Neurology and Headache Centre, University Duisburg Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Cephalalgia 32:571-7. 2012
    ..Data on clinical differences between episodic (eCH) and chronic cluster headache (cCH) and accompanying migraine features are limited...
  53. doi Lateralized central facilitation of trigeminal nociception in cluster headache
    D Holle
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Neurology 78:985-92. 2012
    ..To investigate whether central facilitation of trigeminal pain processing is part of the pathophysiology of cluster headache (CH)...
  54. doi The Virtual International Stroke Trials Archive (VISTA): results and impact on future stroke trials and management of stroke patients
    C Weimar
    Department of Neurology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Int J Stroke 5:103-9. 2010
    ..The Virtual International Stroke Trials Archive was established to improve stroke care and trial design through the collation, categorization and potential access to data sets from clinical trials for the treatment of stroke...
  55. ncbi Reorganization of sensory and motor systems in hemiplegic stroke patients. A positron emission tomography study
    G Nelles
    Department of Neurology, University of Essen, Germany
    Stroke 30:1510-6. 1999
    ..We used positron emission tomography to study the functional reorganization of motor and sensory systems in hemiplegic stroke patients before motor recovery...
  56. ncbi A possible role of the human cerebellum in conditioning of the jaw-opening reflex
    M Maschke
    Department of Neurology, University of Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Neurosci Lett 285:213-7. 2000
    ..Thus, the intermediate cerebellum appears to be involved in classical conditioning of the jaw-opening reflex in humans...
  57. pmc Involvement of the human cerebellum during habituation of the acoustic startle response: a PET study
    D Timmann
    Department of Neurology, University of Essen, Germany
    J Neurol Neurosurg Psychiatry 65:771-3. 1998
    ..A significant decrease of rCBF was found in the medial cerebellum. These data are consistent with an involvement of the medial parts of the human cerebellum in non-associative learning as proposed by previous animal studies...
  58. ncbi Treatment of acute ischemic stroke with the low-molecular-weight heparin certoparin: results of the TOPAS trial. Therapy of Patients With Acute Stroke (TOPAS) Investigators
    H C Diener
    Neurologische Klinik und Poliklinik, Universit tsklinikum Essen, Hufelandstra e 55, 45122 Essen, Germany
    Stroke 32:22-9. 2001
    ..To study the safety and efficacy of the low-molecular-weight heparin certoparin, we performed a randomized, double-blind, dose-finding multicenter trial in patients with acute ischemic stroke (Therapy of Patients With Acute Stroke [TOPAS])...
  59. ncbi Cardiovascular safety of lubeluzole (Prosynap(R)) in patients with ischemic stroke
    W Hacke
    Department of Neurology, University of Heidelberg, Germany
    Cerebrovasc Dis 8:247-54. 1998
    ..In doses to 10 mg/day, lubeluzole has a favorable cardiovascular safety profile, as demonstrated by the lack of clinically relevant effects on heart rate, QT, QTc, and QTlc, and it was well tolerated by patients with ischemic stroke...
  60. ncbi Placebo-controlled comparison of effervescent acetylsalicylic acid, sumatriptan and ibuprofen in the treatment of migraine attacks
    H C Diener
    Department of Neurology, University Essen, Germany
    Cephalalgia 24:947-54. 2004
    ..Regarding pain-free at 2 h sumatriptan was most effective...
  61. ncbi [Treatment and prophylaxis of an acute migraine attack]
    H C Diener
    Universitätsklinik für Neurologie, Essen
    MMW Fortschr Med 146:41, 43-5. 2004
    ..Through nonmedicinal and medicinal prophylactic measures, the frequency and intensity of the migraine attacks can be reduced. Keeping a headache diary for documentation is essential...
  62. ncbi Prevalence of cluster headache in a population-based sample in Germany
    Z Katsarava
    Department of Neurology, University Hospital Essen, Essen, Germany
    Cephalalgia 27:1014-9. 2007
    ..7 +/- 12.7 years). All suspected cases (N = 182) were interviewed by a neurologist. Four subjects with CH (three men) were identified. The 1-year prevalence of CH was estimated to be 119/100,000 (95% confidence interval 3, 238/100,000)...
  63. ncbi Incidence and predictors for chronicity of headache in patients with episodic migraine
    Z Katsarava
    Department of Neurology, University Hospital Essen, Germany
    Neurology 62:788-90. 2004
    ..2 (95% CI 1.7 to 26.6) in patients with an "intermediate" (6 to 9 days/month) vs "low" headache frequency and 19.4 (95% CI 8.7 to 43.2) comparing patients with and without medication overuse...
  64. ncbi Population-based validation of a German-language self-administered headache questionnaire
    M S Yoon
    Department of Neurology, University of Essen, Hufelandstrasse 55, Essen, Germany
    Cephalalgia 28:605-8. 2008
    ....
  65. doi Predicting recovery after intracerebral hemorrhage--an external validation in patients from controlled clinical trials
    Christian Weimar
    Dept of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122, Essen, Germany
    J Neurol 256:464-9. 2009
    ..Here, we demonstrate the applicability of our models in an independent sample of ICH patients from controlled clinical trials...
  66. ncbi Prevalence of trigeminal autonomic symptoms in migraine: a population-based study
    M Obermann
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Cephalalgia 27:504-9. 2007
    ..Migraine patients with accompanying autonomic symptoms seem to experience their pain more unilateral and more severe than non-UA patients...
  67. ncbi Central sensitization of the trigeminal and somatic nociceptive systems in medication overuse headache mainly involves cerebral supraspinal structures
    I Ayzenberg
    Department of Neurology, University of Essen, Essen, Germany, and Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Cephalalgia 26:1106-14. 2006
    ..A transient facilitation was found of trigeminal and somatic nociceptive systems in MOH, which was more pronounced on a supraspinal level...
  68. ncbi G protein beta3 polymorphism and triptan response in cluster headache
    M Schurks
    Department of Neurology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Clin Pharmacol Ther 82:396-401. 2007
    ..e., drugs not directly affecting G proteins. We conclude that pain relief by triptans is significantly modulated by a common genetic GNB3 variant...
  69. ncbi Predictors of hazardous alcohol consumption among patients with cluster headache
    M Schurks
    Department of Neurology, University of Duisburg Essen, Essen, Germany, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Cephalalgia 26:623-7. 2006
    ..Moreover, predictors for hazardous alcohol consumption in CH patients are not different from the general population...
  70. ncbi One-year prevalence and socio-cultural aspects of chronic headache in Turkish immigrants and German natives
    I Kavuk
    Department of Neurology, University of Essen, Essen, Germany
    Cephalalgia 26:1177-81. 2006
    ..1, P = 0.014). The data from this cross-sectional study reveal a high prevalence of chronic headache as well as a very low utilization of adequate medical care in first-generation Turkish immigrants in Germany...
  71. ncbi Efficacy of pregabalin in the treatment of trigeminal neuralgia
    M Obermann
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Cephalalgia 28:174-81. 2008
    ..020). Concomitant chronic facial pain appears to be a clinical predictor of poor treatment outcome. PGB appears to be effective in the treatment of trigeminal neuralgia...
  72. ncbi Medication overuse headache: rates and predictors for relapse in a 4-year prospective study
    Z Katsarava
    Department of Neurology, University Hospital Essen, Essen, Germany
    Cephalalgia 25:12-5. 2005
    ..71%, P<or=0.001). The study suggests that the majority of relapses occur within the first year after withdrawal and that the long-term success of withdrawal depends on the type of primary headache and the type of overused medication...
  73. ncbi An in vivo rat model to study calcitonin gene related peptide release following activation of the trigeminal vascular system
    V Limmroth
    Department of Neurology, University of Essen, Essen, Germany
    Pain 92:101-6. 2001
    ....
  74. doi Natalizumab is effective as second line therapy in the treatment of relapsing remitting multiple sclerosis
    N Putzki
    Department of Neurology, University Hospital Essen, Essen, Germany
    Eur J Neurol 16:424-6. 2009
    ..Natalizumab has been recommended for the treatment of patients with relapsing remitting multiple sclerosis with insufficient response to interferon-beta (IFN-beta) or glatiramer acetate (GA)...
  75. ncbi The efficacy and safety of sc alniditan vs. sc sumatriptan in the acute treatment of migraine: a randomized, double-blind, placebo-controlled trial
    H C Diener
    Department of Neurology, University Hospital, University of Essen, Essen, Germany
    Cephalalgia 21:672-9. 2001
    ..4 mg for pain free at 2 h. The difference, however, was small and clinically not important. For alniditan, a dose-dependent adverse event relationship was seen. The safety profile of alniditan 1.4 mg was similar to that of sumatriptan...
  76. ncbi Seizure-associated headache in epilepsy
    T Leniger
    Department of Neurology, University of Essen, Essen, Germany
    Epilepsia 42:1176-9. 2001
    ..The purpose of this prospective study was to analyze frequency, classification, and characteristics of seizure-associated headache (SH) according to the criteria of the International Headache Society...
  77. ncbi Part IV: effects of zolmitriptan orally disintegrating tablet on migraine symptoms and ability to perform normal activities: a post-marketing surveillance study in Germany
    Hans Christoph Diener
    Department of Neurology, University Essen, Germany
    Curr Med Res Opin 21:S18-24. 2005
    ....
  78. ncbi Efficacy and safety of intravenous acetylsalicylic acid lysinate compared to subcutaneous sumatriptan and parenteral placebo in the acute treatment of migraine. A double-blind, double-dummy, randomized, multicenter, parallel group study. The ASASUMAMIG St
    H C Diener
    Department of Neurology, University Essen, Germany
    Cephalalgia 19:581-8; discussion 542. 1999
    ..6%, sumatriptan 37.8%). In conclusion, subcutaneous sumatriptan and lysine acetylsalicylate i.v. are effective treatments for patients suffering from migraine attacks. Sumatriptan is more effective, but resulted in more adverse events...
  79. ncbi Treatment of acute ischaemic stroke with the low-affinity, use-dependent NMDA antagonist AR-R15896AR. A safety and tolerability study
    Hans Christoph Diener
    Department of Neurology, University Essen, Hufelandstr 55, 45122 Essen, Germany
    J Neurol 249:561-8. 2002
    ..The aim of the present study was to examine the safety and tolerability of a new and higher dosage regimen that would enable acute stroke patients to achieve and maintain neuroprotective plasma concentrations...
  80. ncbi [Current aspects of secondary prevention of ischemic stroke]
    R Weber
    Klinik fur Neurologie, Universitatsklinikum Essen, Universitat Duisburg Essen
    Nervenarzt 78:1138-46. 2007
    ....
  81. ncbi Adult post-infectious thalamic encephalitis: acute onset and benign course
    M Gerwig
    Department of Neurology, University of Essen, Essen, Germany
    Eur J Neurol 11:135-9. 2004
    ..The cases and their relationship to possible post-infectious autoimmune inflammatory or toxic pathophysiological mechanisms are discussed and a review of the literature is provided...
  82. ncbi Antiplatelet agents in stroke prevention: acute and long-term treatment strategies
    R Weber
    Department of Neurology and Stroke Center, University Duisburg Essen, Essen, Germany
    Hamostaseologie 29:326-33. 2009
    ..Patients with symptomatic intracranial stenosis have a higher risk of intracerebral bleeding with oral anticoagulation compared to high dose aspirin. Aspirin is the recommended treatment in stroke patients with a patent foramen ovale...
  83. ncbi Trigeminal autonomic cephalalgias: a case of post-traumatic SUNCT syndrome?
    N Putzki
    Neurology, University of Essen, Essen, Germany
    Cephalalgia 25:395-7. 2005
  84. ncbi Analgesics
    H C Diener
    Department of Neurology, University of Essen, Germany
    Curr Med Res Opin 17:s13-6. 2001
    ..Few data on the efficacy of opioid drugs in the treatment of migraine are available. They seem to be effective but carry the risk of dependency and may cause drug-induced headache...
  85. ncbi Cyclandelate in the prophylaxis of migraine: a randomized, parallel, double-blind study in comparison with placebo and propranolol. The Study group
    H C Diener
    Department of Neurology, Universities of Essen, Germany
    Cephalalgia 16:441-7. 1996
    ..Both drugs were better than placebo, but not significantly so. Both active treatments were well tolerated...
  86. ncbi Rates and predictors for relapse in medication overuse headache: a 1-year prospective study
    Z Katsarava
    Department of Neurology, University Hospital Essen, Germany
    Neurology 60:1682-3. 2003
    ..001). The long-term success of withdrawal depends on the type of primary headache and the type of overused medication...
  87. ncbi Cardiac safety in the European Stroke Prevention Study 2 (ESPS2)
    H C Diener
    Dept of Neurology, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Int J Clin Pract 55:162-3. 2001
    ..Dipyridamole did not result in a higher number of cardiac events, e.g. angina pectoris, MI, or death from all causes. The combination of aspirin plus dipyridamole was superior to either drug alone in the prevention of stroke...
  88. ncbi Lack of neuroprotection by an ACTH (4-9) analogue. A randomized trial in patients treated with vincristine for Hodgkin's or non-Hodgkin's lymphoma
    S Koeppen
    Department of Neurology, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    J Cancer Res Clin Oncol 130:153-60. 2004
    ....
  89. ncbi Almotriptan in migraine patients who respond poorly to oral sumatriptan: a double-blind, randomized trial
    Hans Christoph Diener
    Department of Neurology, University Essen and Bayer Healthcare, Essen, Germany
    Headache 45:874-82. 2005
    ..To investigate the efficacy and tolerability of almotriptan 12.5 mg in migraine patients who respond poorly to sumatriptan 50 mg...
  90. ncbi Nitrous oxide modulator: lubeluzole
    Hans Christoph Diener
    Department of Neurology, University Essen, Germany
    Curr Med Res Opin 18:s23-6. 2002
    ..Phase II and early phase III trials indicated an improvement in neurological outcome, whereas a final large randomized and placebo controlled trial did not show superiority versus placebo...
  91. ncbi Prophylaxis of thrombotic and embolic events in acute ischemic stroke with the low-molecular-weight heparin certoparin: results of the PROTECT Trial
    Hans Christoph Diener
    University of Essen, Germany
    Stroke 37:139-44. 2006
    ....
  92. ncbi Complications following acute ischemic stroke
    Christian Weimar
    Department of Neurology, University of Essen, Essen, Germany
    Eur Neurol 48:133-40. 2002
    ..This study provides representative data on onset and severity of early neurological and medical complications as well as possible predictors for early recurrent cerebral ischemia following acute ischemic stroke...
  93. ncbi Predicting functional outcome and survival after acute ischemic stroke
    Christian Weimar
    Department of Neurology, University of Essen, Hufelandstr 55, Germany
    J Neurol 249:888-95. 2002
    ..We therefore developed prognostic models for functional dependence and death after 100 days in a large cohort of stroke patients...
  94. ncbi Efficacy of almotriptan 12.5 mg in achieving migraine-related composite endpoints: a double-blind, randomized, placebo-controlled study in patients controlled study in patients with previous poor response to sumatriptan 50 mg
    Hans Christoph Diener
    Department of Neurology, University of Essen, D 45145 Essen, Germany
    Curr Med Res Opin 21:1603-10. 2005
    ..Triptans are not identical and migraine sufferers respond differently to different triptans. Few studies have evaluated the efficacy of switching triptans in migraine patients who have shown poor response to another agent...
  95. ncbi Consistent efficacy, tolerability, and high levels of satisfaction with almotriptan 12.5 mg when used to treat multiple migraine attacks in routine clinical practice
    Hans Christoph Diener
    Department of Neurology, University of Essen, Hufelandstrasse 55, D 45145 Essen, Germany
    Headache 45:624-31. 2005
    ..To assess the efficacy, tolerability, and patient satisfaction with almotriptan 12.5 mg across multiple migraine attacks in routine clinical settings...
  96. ncbi Efficacy, tolerability and safety of oral eletriptan and ergotamine plus caffeine (Cafergot) in the acute treatment of migraine: a multicentre, randomised, double-blind, placebo-controlled comparison
    Hans Christoph Diener
    Department of Neurology, University of Essen, Essen, Germany
    Eur Neurol 47:99-107. 2002
    ..001) at 2 h. Adverse events were generally mild or moderate and transient. This randomised trial shows that oral eletriptan is more efficacious in the acute treatment of migraine than oral Cafergot and is well tolerated...
  97. ncbi Improving patient selection for clinical acute stroke trials
    Christian Weimar
    Department of Neurology, University of Essen, Essen, Germany
    Cerebrovasc Dis 21:386-92. 2006
    ..To optimize patient inclusion criteria for clinical acute stroke trials...
  98. ncbi The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria
    H C Diener
    Department of Neurology, University of Essen, Hufelandstrasse 55, DE 45122 Essen, Germany
    Eur Neurol 51:89-97. 2004
    ..Butterbur was well tolerated. This small trial indicates that butterbur may be effective in the prophylaxis of migraine...
  99. ncbi Efficacy of 1,000 mg effervescent acetylsalicylic acid and sumatriptan in treating associated migraine symptoms
    H C Diener
    Department of Neurology, University of Essen, Hufelandstrasse 55, DE 45147 Essen, Germany
    Eur Neurol 52:50-6. 2004
    ..The study showed that administration of effervescent ASA leads to remission of the migraine symptoms nausea, photophobia and phonophobia, reduces migraine headache and is comparable to sumatriptan...
  100. ncbi Adherence and quality of oral anticoagulation in cerebrovascular disease patients with atrial fibrillation
    C Weimar
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Eur Neurol 60:142-8. 2008
    ..We therefore sought to investigate the prescription patterns at discharge, adherence and quality of OAC in cerebrovascular disease patients with AF...
  101. ncbi Transcranial Doppler ultrasonographic features during drug withdrawal from drug-induced headache. A transcranial Doppler follow-up study
    C G Haase
    Department of Neurology, University Hospital Essen, Germany
    Headache 38:679-83. 1998
    ....