Philipp Diehl

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi request reprint [The role of microparticles in vascular diseases]
    P Diehl
    Abteilung für Innere Medizin III, Kardiologie und Angiologie, Medizinische Universitatsklinik, Hugstetter Strasse 55, Freiburg
    Hamostaseologie 28:203-6. 2008
  2. doi request reprint Discontinuation of long term clopidogrel therapy induces platelet rebound hyperaggregability between 2 and 6 weeks post cessation
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    Clin Res Cardiol 100:765-71. 2011
  3. doi request reprint Enhanced microparticles in ventricular assist device patients predict platelet, leukocyte and endothelial cell activation
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    Interact Cardiovasc Thorac Surg 11:133-7. 2010
  4. doi request reprint Increased platelet, leukocyte and endothelial microparticles predict enhanced coagulation and vascular inflammation in pulmonary hypertension
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    J Thromb Thrombolysis 31:173-9. 2011
  5. doi request reprint Increased levels of circulating microparticles in patients with severe aortic valve stenosis
    Philipp Diehl
    Dept for Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, D 79106 Freiburg, Germany
    Thromb Haemost 99:711-9. 2008
  6. doi request reprint Clopidogrel affects leukocyte dependent platelet aggregation by P2Y12 expressing leukocytes
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, 79106 Freiburg, Germany
    Basic Res Cardiol 105:379-87. 2010
  7. pmc BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1
    Thomas Helbing
    Department for Cardiology, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Arterioscler Thromb Vasc Biol 30:554-60. 2010
  8. ncbi request reprint Krüppel-like factor 15 regulates BMPER in endothelial cells
    Thomas Helbing
    Department of Cardiology, University of Freiburg, Hugstetter Str 55, 79106 Freiburg, Germany
    Cardiovasc Res 85:551-9. 2010
  9. ncbi request reprint [Is stent thrombosis the new Achilles heel of interventional cardiology? State of the Art clinical trials, causes and approaches for prevention]
    T Grumann
    Abteilung III für Kardiologie und Angiologie, Medizinische Universititäsklinik, Hugstetterstrasse 55, 79106 Freiburg
    Hamostaseologie 27:344-50. 2007
  10. doi request reprint Third generation P2Y12 antagonists inhibit platelet aggregation more effectively than clopidogrel in a myocardial infarction registry
    Christoph B Olivier
    Christoph Olivier, MD, Cardiology and Angiology I, Heart Center, Freiburg University, Hugstetter Str 55, 79106 Freiburg, Germany, Tel 49 761 270 34410, E mail
    Thromb Haemost 111:266-72. 2014

Collaborators

Detail Information

Publications10

  1. ncbi request reprint [The role of microparticles in vascular diseases]
    P Diehl
    Abteilung für Innere Medizin III, Kardiologie und Angiologie, Medizinische Universitatsklinik, Hugstetter Strasse 55, Freiburg
    Hamostaseologie 28:203-6. 2008
    ..They are detectable in many acute and chronic vascular diseases as a surrogate marker for disease activity but also play a role in the pathophysiology of vascular diseases...
  2. doi request reprint Discontinuation of long term clopidogrel therapy induces platelet rebound hyperaggregability between 2 and 6 weeks post cessation
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    Clin Res Cardiol 100:765-71. 2011
    ..Stent thrombosis occurs frequently within the first weeks after cessation of longterm clopidogrel therapy. We investigated if rebound platelet hyperreactivity occurs to provide a mechanism for this clinical observation...
  3. doi request reprint Enhanced microparticles in ventricular assist device patients predict platelet, leukocyte and endothelial cell activation
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    Interact Cardiovasc Thorac Surg 11:133-7. 2010
    ....
  4. doi request reprint Increased platelet, leukocyte and endothelial microparticles predict enhanced coagulation and vascular inflammation in pulmonary hypertension
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    J Thromb Thrombolysis 31:173-9. 2011
    ..02). PH patients have increased levels of platelet-, leukocyte- and endothelial MP indicating an increased vascular pro-coagulation and inflammation which might be related to thrombo-embolic complications as well as PH progression...
  5. doi request reprint Increased levels of circulating microparticles in patients with severe aortic valve stenosis
    Philipp Diehl
    Dept for Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, D 79106 Freiburg, Germany
    Thromb Haemost 99:711-9. 2008
    ....
  6. doi request reprint Clopidogrel affects leukocyte dependent platelet aggregation by P2Y12 expressing leukocytes
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, 79106 Freiburg, Germany
    Basic Res Cardiol 105:379-87. 2010
    ..This interaction is abolished by clopidogrel. Therefore, clopidogrel may act directly on leukocytes via the P2Y(12) receptor. (2) Clopidogrel may be under dosed in obese patients...
  7. pmc BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1
    Thomas Helbing
    Department for Cardiology, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Arterioscler Thromb Vasc Biol 30:554-60. 2010
    ..We set out to investigate the effect of statins on BMP endothelial cell precursor-derived regulator (BMPER), a novel member of the BMP pathway...
  8. ncbi request reprint Krüppel-like factor 15 regulates BMPER in endothelial cells
    Thomas Helbing
    Department of Cardiology, University of Freiburg, Hugstetter Str 55, 79106 Freiburg, Germany
    Cardiovasc Res 85:551-9. 2010
    ..BMPER is a key regulator of BMP4 activity and a prerequisite for BMP pathway activation by BMP4 in endothelial cells. Here, we characterize the BMPER promoter and elucidate mechanisms of BMPER regulation...
  9. ncbi request reprint [Is stent thrombosis the new Achilles heel of interventional cardiology? State of the Art clinical trials, causes and approaches for prevention]
    T Grumann
    Abteilung III für Kardiologie und Angiologie, Medizinische Universititäsklinik, Hugstetterstrasse 55, 79106 Freiburg
    Hamostaseologie 27:344-50. 2007
    ..Therefore, individual determination of platelet function in each patient undergoing stent implantation may help to avoid prothrombotic as well as bleeding complications...
  10. doi request reprint Third generation P2Y12 antagonists inhibit platelet aggregation more effectively than clopidogrel in a myocardial infarction registry
    Christoph B Olivier
    Christoph Olivier, MD, Cardiology and Angiology I, Heart Center, Freiburg University, Hugstetter Str 55, 79106 Freiburg, Germany, Tel 49 761 270 34410, E mail
    Thromb Haemost 111:266-72. 2014
    ..No significant difference in platelet inhibition was detected between prasugrel and ticagrelor. (registry for patients after Myocardial Infarction Treated with AntiPlatelet agents; DRKS00003146)...