Holger Diedrichs

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. doi request reprint Delta-glycated hemoglobin: a novel independent risk factor for cardiovascular events in patients without diabetes mellitus
    H Diedrichs
    Clinic III for Internal Medicine, Cologne Heart Centre, University of Cologne, Cologne, Germany
    J Endocrinol Invest 32:564-7. 2009
  2. ncbi request reprint Activation of the calcineurin/NFAT signalling cascade starts early in human hypertrophic myocardium
    H Diedrichs
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine, University of Cologne, Cologne, Germany
    J Int Med Res 35:803-18. 2007
  3. ncbi request reprint An increase in HbA1c after percutaneous coronary intervention raises the risk for restenosis in patients without Type 2 diabetes mellitus
    H Diedrichs
    Clinic III for Internal Medicine, University of Koln, Cologne, Germany
    Diabet Med 25:228-31. 2008
  4. ncbi request reprint Calcineurin independent development of myocardial hypertrophy in transgenic rats overexpressing the mouse renin gene, TGR(mREN2)27
    H Diedrichs
    Laboratory for Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    J Mol Med (Berl) 82:688-95. 2004
  5. ncbi request reprint [Increased myocardial blood flow after spinal cord stimulation in patients with refractory angina pectoris]
    Holger Diedrichs
    Klinik III fur Innere Medizin, Universitat zu Koln, Cologne
    Med Klin (Munich) 98:146-50. 2003
  6. ncbi request reprint Altered tension cost in (TG(mREN-2)27) rats overexpressing the mouse renin gene
    Carsten Zobel
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmann Str 9, 50924, Cologne, Germany
    Eur J Appl Physiol 99:121-32. 2007
  7. ncbi request reprint Mechanisms of Ca2+-dependent calcineurin activation in mechanical stretch-induced hypertrophy
    Carsten Zobel
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Cologne, Germany
    Cardiology 107:281-90. 2007
  8. doi request reprint NT-pro-BNP for differential diagnosis in patients with syncope
    Roman Pfister
    Department III of Internal Medicine, University of Cologne, Cologne, Germany
    Int J Cardiol 133:51-4. 2009
  9. ncbi request reprint Increased functional importance of the Na,Ca-exchanger in contracting failing human myocardium but unchanged activity in isolated vesicles
    Holger Diedrichs
    Clinic III for Internal Medicine, University of Cologne, Cologne, Germany
    Int Heart J 48:755-66. 2007
  10. ncbi request reprint Increased regulatory activity of the calcineurin/NFAT pathway in human heart failure
    Holger Diedrichs
    Laboratory of Muscle Research and Molecular Cardiology, University of Cologne, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Eur J Heart Fail 6:3-9. 2004

Detail Information

Publications14

  1. doi request reprint Delta-glycated hemoglobin: a novel independent risk factor for cardiovascular events in patients without diabetes mellitus
    H Diedrichs
    Clinic III for Internal Medicine, Cologne Heart Centre, University of Cologne, Cologne, Germany
    J Endocrinol Invest 32:564-7. 2009
    ..We hypothesized that dynamic changes in HbA1c (Delta-HbA1c) would better predict cardiovascular outcome than a single value...
  2. ncbi request reprint Activation of the calcineurin/NFAT signalling cascade starts early in human hypertrophic myocardium
    H Diedrichs
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine, University of Cologne, Cologne, Germany
    J Int Med Res 35:803-18. 2007
    ..Already present in compensated hypertrophy it showed a tendency to a further increase following transition to decompensated hypertrophy...
  3. ncbi request reprint An increase in HbA1c after percutaneous coronary intervention raises the risk for restenosis in patients without Type 2 diabetes mellitus
    H Diedrichs
    Clinic III for Internal Medicine, University of Koln, Cologne, Germany
    Diabet Med 25:228-31. 2008
    ..Therefore, the rate of restenosis was investigated after elective PCI in 101 consecutive patients without diabetes mellitus in relation to dynamic changes of HbA(1c) levels...
  4. ncbi request reprint Calcineurin independent development of myocardial hypertrophy in transgenic rats overexpressing the mouse renin gene, TGR(mREN2)27
    H Diedrichs
    Laboratory for Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    J Mol Med (Berl) 82:688-95. 2004
    ..Thus GATA-4 seems to be a marker of hypertrophy independently of calcineurin activation, possibly activated by various pathways...
  5. ncbi request reprint [Increased myocardial blood flow after spinal cord stimulation in patients with refractory angina pectoris]
    Holger Diedrichs
    Klinik III fur Innere Medizin, Universitat zu Koln, Cologne
    Med Klin (Munich) 98:146-50. 2003
    ..In spite of great progresses in surgical and catheter interventional techniques there is an increasing number of patients with coronary heart disease not suitable for these conventional treatment strategies...
  6. ncbi request reprint Altered tension cost in (TG(mREN-2)27) rats overexpressing the mouse renin gene
    Carsten Zobel
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph Stelzmann Str 9, 50924, Cologne, Germany
    Eur J Appl Physiol 99:121-32. 2007
    ..The present study demonstrates that cardiac hypertrophy, induced by an activation of the renin-angiotensin system, leads to adapting alterations on the level of the contractile filaments, which reduce tension cost...
  7. ncbi request reprint Mechanisms of Ca2+-dependent calcineurin activation in mechanical stretch-induced hypertrophy
    Carsten Zobel
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Cologne, Germany
    Cardiology 107:281-90. 2007
    ....
  8. doi request reprint NT-pro-BNP for differential diagnosis in patients with syncope
    Roman Pfister
    Department III of Internal Medicine, University of Cologne, Cologne, Germany
    Int J Cardiol 133:51-4. 2009
    ..Syncope is a frequent diagnosis and establishing the etiology is often elaborate. Aim of this study was to evaluate the diagnostic value of NT-pro-BNP in patients with syncope...
  9. ncbi request reprint Increased functional importance of the Na,Ca-exchanger in contracting failing human myocardium but unchanged activity in isolated vesicles
    Holger Diedrichs
    Clinic III for Internal Medicine, University of Cologne, Cologne, Germany
    Int Heart J 48:755-66. 2007
    ....
  10. ncbi request reprint Increased regulatory activity of the calcineurin/NFAT pathway in human heart failure
    Holger Diedrichs
    Laboratory of Muscle Research and Molecular Cardiology, University of Cologne, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Eur J Heart Fail 6:3-9. 2004
    ..As reported from animal experiments, the Ca(2+)-calmodulin activated phosphatase calcineurin and its downstream transcriptional effector NFAT have been implicated as transducers of the hypertrophic response...
  11. ncbi request reprint In vivo uptake of azithromycin in human coronary plaques
    C A Schneider
    Klinik III fur Innere Medizin, Universitat zu Koln, Germany
    Am J Cardiol 86:789-91, A9. 2000
    ..Azithromycin was found in all plaque samples with a median concentration of 284 ng/ml (95% confidence interval 163 to 517 ng/ml)...
  12. doi request reprint Prognostic impact of NT-proBNP and renal function in comparison to contemporary multi-marker risk scores in heart failure patients
    Roman Pfister
    Department III of Internal Medicine, University of Cologne, Germany
    Eur J Heart Fail 10:315-20. 2008
    ..Multi-marker risk scores accurately predict prognosis in heart failure patients but calculation is complex...
  13. ncbi request reprint Phosphodiesterase type 5 inhibitor sildenafil citrate does not potentiate the vasodilative properties of nebivolol in rat aorta
    Stephan Rosenkranz
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Kerpener Str 62, D 50924 Cologne, Germany
    Life Sci 78:1103-7. 2006
    ....
  14. doi request reprint Inhibition of the alpha1beta1 isoform of the Na, K-ATPase by 8-methoxycoumestrol without positive inotropic effect in human myocardium--novel aspects of cardiac glycoside pharmacology
    T Potter
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Köln 50924, Germany
    J Cardiovasc Pharmacol 54:10-5. 2009
    ....