Jennifer Diedler

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Decompressive surgery for severe brain edema
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    J Intensive Care Med 24:168-78. 2009
  2. ncbi request reprint Bilateral facial palsy: Epstein-Barr virus, not Lyme disease
    J Diedler
    Department of Neurology, Institute of Hygiene, University of Heidelberg, Germany
    Eur J Neurol 13:1029-30. 2006
  3. doi request reprint The limitations of near-infrared spectroscopy to assess cerebrovascular reactivity: the role of slow frequency oscillations
    Jennifer Diedler
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    Anesth Analg 113:849-57. 2011
  4. doi request reprint Autoregulation and brain metabolism in the perihematomal region of spontaneous intracerebral hemorrhage: an observational pilot study
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neurol Sci 295:16-22. 2010
  5. pmc Low hemoglobin is associated with poor functional outcome after non-traumatic, supratentorial intracerebral hemorrhage
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany
    Crit Care 14:R63. 2010
  6. doi request reprint Intensive care management of acute stroke: general management
    J Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg 69120, Germany
    Int J Stroke 4:365-78. 2009
  7. doi request reprint Quantitative EEG correlates of low cerebral perfusion in severe stroke
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Neurocrit Care 11:210-6. 2009
  8. doi request reprint Auditory processing in children with language-based learning problems: a magnetencephalography study
    Jennifer Diedler
    Department of Neurology, Section of Biomagnetism, University of Heidelberg, Heidelberg, Germany
    Neuroreport 20:844-8. 2009
  9. doi request reprint C-reactive-protein levels associated with infection predict short- and long-term outcome after supratentorial intracerebral hemorrhage
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 27:272-9. 2009
  10. doi request reprint Impaired cerebral vasomotor activity in spontaneous intracerebral hemorrhage
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 40:815-9. 2009

Detail Information

Publications36

  1. doi request reprint Decompressive surgery for severe brain edema
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    J Intensive Care Med 24:168-78. 2009
    ..Although there is increasing evidence for the efficacy of decompressive surgery in reducing intracranial pressure and even mortality, a critical point remains the definition of good or acceptable outcome...
  2. ncbi request reprint Bilateral facial palsy: Epstein-Barr virus, not Lyme disease
    J Diedler
    Department of Neurology, Institute of Hygiene, University of Heidelberg, Germany
    Eur J Neurol 13:1029-30. 2006
    ..Bilateral facial palsy is frequently linked with lyme disease. We report a patient with bilateral facial palsy due to Epstein-Barr virus infection but with Borrelia burgdorferi IgM in serum caused by polyclonal B-lymphocyte stimulation...
  3. doi request reprint The limitations of near-infrared spectroscopy to assess cerebrovascular reactivity: the role of slow frequency oscillations
    Jennifer Diedler
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    Anesth Analg 113:849-57. 2011
    ..In the current study, we investigated the role of slow oscillations of total hemoglobin for NIRS-based cerebrovascular reactivity monitoring...
  4. doi request reprint Autoregulation and brain metabolism in the perihematomal region of spontaneous intracerebral hemorrhage: an observational pilot study
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neurol Sci 295:16-22. 2010
    ..A study in a larger population is needed to clarify the relationship between PRx and ORx in ICH patients, the local metabolic effects of autoregulatory failure and its relation to brain edema formation and clinical outcome...
  5. pmc Low hemoglobin is associated with poor functional outcome after non-traumatic, supratentorial intracerebral hemorrhage
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany
    Crit Care 14:R63. 2010
    ..Here, we assessed the relationship between hemoglobin (HB) levels and clinical outcome after ICH...
  6. doi request reprint Intensive care management of acute stroke: general management
    J Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg 69120, Germany
    Int J Stroke 4:365-78. 2009
    ..In part II of the review, surgical management options for acute stroke will be discussed in detail...
  7. doi request reprint Quantitative EEG correlates of low cerebral perfusion in severe stroke
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Neurocrit Care 11:210-6. 2009
    ..We aimed to identify parameters that may be used for continuous monitoring even in patients with a burst-suppression baseline EEG pattern...
  8. doi request reprint Auditory processing in children with language-based learning problems: a magnetencephalography study
    Jennifer Diedler
    Department of Neurology, Section of Biomagnetism, University of Heidelberg, Heidelberg, Germany
    Neuroreport 20:844-8. 2009
    ..These findings provide evidence for a diminished neuronal representation of short auditory stimuli in the primary auditory cortex of LP children...
  9. doi request reprint C-reactive-protein levels associated with infection predict short- and long-term outcome after supratentorial intracerebral hemorrhage
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 27:272-9. 2009
    ..The aim of the current study was to assess the occurrence of infection and its impact on the short- and long-term outcome of patients with supratentorial intracerebral hemorrhage (ICH)...
  10. doi request reprint Impaired cerebral vasomotor activity in spontaneous intracerebral hemorrhage
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 40:815-9. 2009
    ..In the current study, we aimed to investigate cerebrovascular reactivity and its significance for outcome in spontaneous intracerebral hemorrhage...
  11. ncbi request reprint Endovascular cooling in a patient with neuroleptic malignant syndrome
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Germany
    J Neurol Sci 264:163-5. 2008
    ..However, upon withdrawl of endovascular temperature control there was a relapse. This is the first case where endovascular cooling was applied successfully in neuroleptic malignant syndrome...
  12. ncbi request reprint Auditory temporal resolution in children assessed by magnetoencephalography
    Jennifer Diedler
    Department of Neurology, Section of Biomagnetism, University of Heidelberg, Heidelberg, Germany
    Neuroreport 18:1691-5. 2007
    ..AEFs thus provide an objective tool to assess auditory temporal resolution in children. Children's neuromagnetic response patterns differed significantly from the adult responses under the same experimental conditions...
  13. doi request reprint EEG power spectrum to predict prognosis after hemicraniectomy for space-occupying middle cerebral artery infarction
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany jennifer diedler med uni heidelberg de
    Cerebrovasc Dis 29:162-9. 2010
    ..Here we applied spectral EEG analysis to determine the prognosis early after hemicraniectomy, while the patient is still treated in the intensive care unit...
  14. doi request reprint Intensive care management of acute stroke: surgical treatment
    Marek Sykora
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Int J Stroke 5:170-7. 2010
    ..Most recently, hopeful preliminary data have emerged on new approaches in the treatment of intraventricular haemorrhage. In this article, we review the current neurosurgical options in acute ischaemic and haemorrhagic stroke...
  15. doi request reprint Blood pressure course in acute stroke relates to baroreflex dysfunction
    Marek Sykora
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 30:172-9. 2010
    ..Baroreflex dysfunction has repeatedly been reported in stroke patients. We hypothesize that blood pressure (BP) derangements in the acute phase relate to the impairment of baroreflex...
  16. doi request reprint Baroreflex sensitivity to predict malignant middle cerebral artery infarction
    Marek Sykora
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 43:714-9. 2012
    ..We aimed to investigate the predictive potential of baroreflex sensitivity (BRS) as a marker of autonomic balance for calculating the course of large middle cerebral artery infarction...
  17. doi request reprint Baroreflex: a new therapeutic target in human stroke?
    Marek Sykora
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 40:e678-82. 2009
    ....
  18. doi request reprint Autonomic shift and increased susceptibility to infections after acute intracerebral hemorrhage
    Marek Sykora
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 42:1218-23. 2011
    ..However, the underlying pathophysiology remains unclear. The aim of the current study was to investigate the role of autonomic shift in increased susceptibility to infection after acute intracerebral hemorrhage (ICH)...
  19. doi request reprint Cerebral oxygen transport failure?: decreasing hemoglobin and hematocrit levels after ischemic stroke predict poor outcome and mortality: STroke: RelevAnt Impact of hemoGlobin, Hematocrit and Transfusion (STRAIGHT)--an observational study
    Lars Kellert
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 42:2832-7. 2011
    ..Although conceivably relevant for penumbra oxygenation, the optimal levels of hemoglobin (Hb) and hematocrit (Hct) in patients with acute ischemic stroke are unknown...
  20. doi request reprint Subacute perihematomal edema in intracerebral hemorrhage is associated with impaired blood pressure regulation
    Marek Sykora
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neurol Sci 284:108-12. 2009
    ..The aims of our study were therefore to explore the effects of impaired baroreflex on edema in acute ICH and to evaluate the effects of perihematomal edema on early neurologic deterioration...
  21. doi request reprint Induction of cooling with a passive head and neck cooling device: effects on brain temperature after stroke
    Sven Poli
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 44:708-13. 2013
    ..We conducted this study to investigate the relationship between surface head/neck cooling and brain temperature...
  22. doi request reprint Time constant of the cerebral arterial bed in normal subjects
    Magdalena Kasprowicz
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    Ultrasound Med Biol 38:1129-37. 2012
    ..C(a) was negatively correlated with mean ABP (R(partial) = -0.68, p < 0.000001). In summary, the time constant shortens with increasing EtCO(2). Its potential role in cerebrovascular investigations needs further studies...
  23. doi request reprint Pressure reactivity index correlates with metabolic dysfunction in a porcine model of intracerebral hemorrhage
    Edgar Santos
    Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany
    Acta Neurochir Suppl 114:363-7. 2012
    ..We correlated oxygen, flow, and pressure indices of cerebrovascular reactivity (CR) with extracellular cerebral metabolite concentrations in a porcine model of intracerebral hemorrhage (ICH)...
  24. doi request reprint Autonomic effects of intraventricular extension in intracerebral hemorrhage
    Marek Sykora
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Neurocrit Care 16:102-8. 2012
    ..The pathophysiology of autonomic impairment after intracerebral hemorrhage (ICH) is unknown. This study examined the relationship between intraventricular hemorrhage extension (IVH) and autonomic dysregulation after ICH...
  25. doi request reprint Impaired baroreceptor reflex sensitivity in acute stroke is associated with insular involvement, but not with carotid atherosclerosis
    Marek Sykora
    Department of Neurology, University of Heidelberg, Germany
    Stroke 40:737-42. 2009
    ..The insula may play a central role in baroreflex modulation. The aim of the study was therefore to examine BRS in patients with acute stroke with regard to carotid atherosclerosis and insular involvement...
  26. doi request reprint Impact of statin use and lipid profile on symptomatic intracerebral haemorrhage, outcome and mortality after intravenous thrombolysis in acute stroke
    Andrea Rocco
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 33:362-8. 2012
    ..The aim of the current study was to assess the impact of statin use and lipid profile on sICH, outcome and mortality following thrombolysis in acute stroke...
  27. doi request reprint Low-frequency sampling for PRx calculation does not reduce prognostication and produces similar CPPopt in intracerebral haemorrhage patients
    Edgar Santos
    Department of Neurosurgery, University of Heidelberg, Germany
    Acta Neurochir (Wien) 153:2189-95. 2011
    ..We compared PRx with a different calculation method [low-frequency PRx (L-PRx)], where rapid fluctuations of MAP and ICP are cancelled (waves with frequencies greater than 0.01 Hz)...
  28. doi request reprint Impaired baroreflex sensitivity predicts outcome of acute intracerebral hemorrhage
    Marek Sykora
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Crit Care Med 36:3074-9. 2008
    ..Baroreflex sensitivity (BRS) in spontaneous intracerebral hemorrhage has not been investigated. We sought to examine BRS in patients with intracerebral hemorrhage and evaluate the relationship between BRS and short-term outcome measures...
  29. doi request reprint Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 41:288-94. 2010
    ..Antiplatelets (APs) may increase the risk of symptomatic intracerebral hemorrhage (ICH) following intravenous thrombolysis after ischemic stroke...
  30. doi request reprint Glycosylated hemoglobin A1 predicts risk for symptomatic hemorrhage after thrombolysis for acute stroke
    Andrea Rocco
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 44:2134-8. 2013
    ..Symptomatic intracerebral hemorrhage (sICH) is the most feared acute complication after intravenous thrombolysis. The aim of this study was to determine the predictive value of parameters of glycosylated hemoglobin A1 (HbA1c) on sICH...
  31. doi request reprint Microalbuminuria in cerebrovascular disease: a modifiable risk factor?
    A Rocco
    Department of Neurology, Ruprecht Karls University Heidelberg, Heidelberg, Germany
    Int J Stroke 5:30-4. 2010
    ..This review focuses on the importance of microalbuminuria for cerebrovascular disease, stressing the clinical and therapeutic implications using antihypertensive therapy to control the urinary albumin excretion...
  32. doi request reprint Is the maximum dose of 90 mg alteplase sufficient for patients with ischemic stroke weighing >100 kg?
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 42:1615-20. 2011
    ..We investigated if the lower per-kilogram dose is associated with poor early neurological improvement and worse outcome after thrombolysis...
  33. doi request reprint Intrapulmonary right-left shunts in Guillain-Barré syndrome with severe dysautonomia
    Marek Sykora
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Neurocrit Care 9:374-7. 2008
    ..To our knowledge, increased intrapulmonary shunts in association with GBS have not yet been reported...
  34. doi request reprint Autonomic impairment in tetanus: delayed baroreflex involvement
    Marek Sykora
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    J Neurol Sci 270:201-4. 2008
    ..Blood pressure instability could not be explained by baroreflex dynamics. We suggest that a shift towards sympathetic activity possibly overruled the effects of decreased baroreflex sensitivity on blood pressure regulation...
  35. ncbi request reprint Effect of analgesics and sedatives on the occurrence of spreading depolarizations accompanying acute brain injury
    Daniel N Hertle
    Department of Neurosurgery, University of Heidelberg, University Hospital Heidelberg, 69120 Heidelberg, Germany
    Brain 135:2390-8. 2012
    ..05). Our findings suggest that ketamine-or another N-methyl-d-aspartate receptor antagonist-may represent a viable treatment for patients at risk for spreading depolarizations. This hypothesis will be tested in a prospective study...
  36. pmc Repetitive asystole in right insular haemorrhage
    Marek Sykora
    J Neurol Neurosurg Psychiatry 78:1282-3. 2007