Martin Dichgans

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Genetic association studies in stroke: methodological issues and proposed standard criteria
    Martin Dichgans
    Department of Neurology, Klinikum Grosshadern, Munich, Germany
    Stroke 36:2027-31. 2005
  2. ncbi request reprint Strategic role of frontal white matter tracts in vascular cognitive impairment: a voxel-based lesion-symptom mapping study in CADASIL
    Marco Duering
    Institute for Stroke and Dementia Research, Ludwig Maximilians University, Munich, Germany
    Brain 134:2366-75. 2011
  3. pmc The carotid plaque imaging in acute stroke (CAPIAS) study: protocol and initial baseline data
    Anna Bayer-Karpinska
    Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    BMC Neurol 13:201. 2013
  4. pmc Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
    Joanna M Wardlaw
    Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK
    Lancet Neurol 12:822-38. 2013
  5. ncbi request reprint Update on the genetics of stroke and cerebrovascular disease 2006
    Martin Dichgans
    Neurologische Klinik, Klinikum Grosshadern, Ludwig Maximilians Universitat, Marchioninistrasse 15, Munchen, Germany D 81377
    Stroke 38:216-8. 2007
  6. ncbi request reprint Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL
    Martin Dichgans
    Department of Neurology, Grosshadern Clinic, Ludwig Maximilian University, Munich, Germany
    Lancet Neurol 7:310-8. 2008
  7. ncbi request reprint Cognition in CADASIL
    Martin Dichgans
    Department of Neurology, Ludwig Maximilians Universitat, Klinikum Grobetahadern, Marchionistr 15, D 81377 Munchen, Germany
    Stroke 40:S45-7. 2009
  8. ncbi request reprint Genetics of ischaemic stroke
    Martin Dichgans
    Department of Neurology, Neurologische Klinik, Klinikum Grosshadern, Ludwig Maximilians University, D 81377 Munchen, Germany
    Lancet Neurol 6:149-61. 2007
  9. ncbi request reprint Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine
    Martin Dichgans
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians Universitat, 81377 Munchen, Germany
    Lancet 366:371-7. 2005
  10. doi request reprint Multimodal recanalization therapy in acute basilar artery occlusion: long-term functional outcome and quality of life
    Caroline Ottomeyer
    Department of Neurology, Klinikum Grosshadern, University of Munich, Munich, Germany
    Stroke 43:2130-5. 2012

Detail Information

Publications94

  1. ncbi request reprint Genetic association studies in stroke: methodological issues and proposed standard criteria
    Martin Dichgans
    Department of Neurology, Klinikum Grosshadern, Munich, Germany
    Stroke 36:2027-31. 2005
    ..A large number of candidate gene association studies have attempted to identify genes implicated in stroke, but there have been few replicable and robust associations reported...
  2. ncbi request reprint Strategic role of frontal white matter tracts in vascular cognitive impairment: a voxel-based lesion-symptom mapping study in CADASIL
    Marco Duering
    Institute for Stroke and Dementia Research, Ludwig Maximilians University, Munich, Germany
    Brain 134:2366-75. 2011
    ..Together these findings provide strong support for a central role of frontal-subcortical circuits in cerebral small vessel disease and vascular cognitive impairment...
  3. pmc The carotid plaque imaging in acute stroke (CAPIAS) study: protocol and initial baseline data
    Anna Bayer-Karpinska
    Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    BMC Neurol 13:201. 2013
    ....
  4. pmc Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
    Joanna M Wardlaw
    Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK
    Lancet Neurol 12:822-38. 2013
    ..This Position Paper summarises the main outcomes of this international effort to provide the STandards for ReportIng Vascular changes on nEuroimaging (STRIVE). ..
  5. ncbi request reprint Update on the genetics of stroke and cerebrovascular disease 2006
    Martin Dichgans
    Neurologische Klinik, Klinikum Grosshadern, Ludwig Maximilians Universitat, Marchioninistrasse 15, Munchen, Germany D 81377
    Stroke 38:216-8. 2007
  6. ncbi request reprint Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL
    Martin Dichgans
    Department of Neurology, Grosshadern Clinic, Ludwig Maximilian University, Munich, Germany
    Lancet Neurol 7:310-8. 2008
    ..We did a multicentre, 18-week, placebo-controlled, double-blind, randomised parallel-group trial to determine whether the cholinesterase inhibitor donepezil improves cognition in patients with CADASIL...
  7. ncbi request reprint Cognition in CADASIL
    Martin Dichgans
    Department of Neurology, Ludwig Maximilians Universitat, Klinikum Grobetahadern, Marchionistr 15, D 81377 Munchen, Germany
    Stroke 40:S45-7. 2009
    ..This article highlights some of the advances on cognition in CADASIL...
  8. ncbi request reprint Genetics of ischaemic stroke
    Martin Dichgans
    Department of Neurology, Neurologische Klinik, Klinikum Grosshadern, Ludwig Maximilians University, D 81377 Munchen, Germany
    Lancet Neurol 6:149-61. 2007
    ..This approach will contribute to the identification of additional genes, novel pathways, and eventually novel therapeutic approaches to ischaemic stroke...
  9. ncbi request reprint Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine
    Martin Dichgans
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians Universitat, 81377 Munchen, Germany
    Lancet 366:371-7. 2005
    ..So far, mutations in two genes regulating ion translocation-CACNA1A and ATP1A2-have been identified in pedigrees with this disease...
  10. doi request reprint Multimodal recanalization therapy in acute basilar artery occlusion: long-term functional outcome and quality of life
    Caroline Ottomeyer
    Department of Neurology, Klinikum Grosshadern, University of Munich, Munich, Germany
    Stroke 43:2130-5. 2012
    ..A substantial subset of treated patients survives with only minor or moderate functional handicap. However, long-term functional outcome and quality of life in these patients have rarely been systematically analyzed...
  11. ncbi request reprint Staged escalation therapy in acute basilar artery occlusion: intravenous thrombolysis and on-demand consecutive endovascular mechanical thrombectomy: preliminary experience in 16 patients
    Thomas Pfefferkorn
    Klinikum Grosshadern, Department of Neurology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Stroke 39:1496-500. 2008
    ..The combination of IVT with consecutive on-demand EMT may allow for early treatment initiation with high recanalization rates but has never been systematically tested in patients with BAO...
  12. ncbi request reprint Vascular integrin immunoreactivity is selectively lost on capillaries during rat focal cerebral ischemia and reperfusion
    Dorothe Burggraf
    Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Brain Res 1189:189-97. 2008
    ..The prominent capillary vulnerability contributes significantly to the impairment of the microvascular integrity and after ischemia and reperfusion...
  13. doi request reprint Education modifies the relation of vascular pathology to cognitive function: cognitive reserve in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Nikola Zieren
    Institute for Stroke and Dementia Research, Medical Center, Ludwig Maximilians University, Marchioninistr 15, Munich, Germany
    Neurobiol Aging 34:400-7. 2013
    ..The results extend the concept of CR to VCI...
  14. pmc Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies
    Rainer Malik
    From the Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat, Munich, Germany R M, M D Stroke and Dementia Research Centre, St George s University of London, London, United Kingdom S B, H S M Laboratory of Neurogenetics M A N and Laboratory of Epidemiology and Population Sciences L J L, National Institute on Aging, National Institutes of Health, Bethesda, MD Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health E G H and Center for Translational Neuroscience and Mental Health Research C L, University of Newcastle, Callaghan, NSW, Australia Center for Bioinformatics, Biomarker Discovery and Information Based Medicine, Hunter Medical Research Institute, New Lambton, NSW, Australia E G H Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA W J D, J R Department of Medicine, University of Maryland School of Medicine, Baltimore, MD Y C C, B D M Department of Veterans Affairs and Veterans Affairs Medical Center, Baltimore Geriatric Research, Education, and Clinical Center GRECC, Baltimore, MD Y C C, B D M Department of Epidemiology C A I V, B F J V, Baltimore
    Stroke 45:394-402. 2014
    ..We aimed to generate a multilocus genetic risk score (GRS) for IS based on genome-wide association studies data from clinical-based samples and to establish its external validity in prospective population-based cohorts...
  15. pmc Characteristics of carotid atherosclerotic plaques of chronic lipid apheresis patients as assessed by in vivo high-resolution CMR--a comparative analysis
    Jochen M Grimm
    Institute for Clinical Radiology, Ludwig Maximilians University Hospital Munich, Pettenkoferstrasse 8a, Munich, Germany
    J Cardiovasc Magn Reson 14:80. 2012
    ..The purpose of this study was to evaluate the influence of chronic lipid apheresis (LA) on the composition of atherosclerotic carotid plaques...
  16. ncbi request reprint Drip, ship, and retrieve: cooperative recanalization therapy in acute basilar artery occlusion
    Thomas Pfefferkorn
    Department of Neurology, Klinikum Grosshadern, University of Munich, Munich, Germany
    Stroke 41:722-6. 2010
    ....
  17. doi request reprint Enhanced L-arginine-induced vasoreactivity suggests endothelial dysfunction in CADASIL
    Nils Peters
    Dept of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377, Munich, Germany
    J Neurol 255:1203-8. 2008
    ..Vasoreactivity induced by L-arginine, which is the substrate for endothelial nitric oxide synthase, is a parameter of endothelial function and has been shown to be altered in patients with cerebrovascular disease...
  18. ncbi request reprint rt-PA causes a dose-dependent increase in the extravasation of cellular and non-cellular blood elements after focal cerebral ischemia
    Dorothe Burggraf
    Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Brain Res 1164:55-62. 2007
    ..Despite various benefits, rt-PA is responsible for a dose-dependent increase of edema and hemorrhage after cerebral ischemia. Clinicians should consider using the lowest effective dose of rt-PA in stroke patients...
  19. pmc Hippocampal volume is an independent predictor of cognitive performance in CADASIL
    Mike O'Sullivan
    Neurologische Klinik, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninstrasse 15, 81377 Munich, Germany
    Neurobiol Aging 30:890-7. 2009
    ..These findings strengthen the view that hippocampal atrophy is an important pathway of cognitive impairment in vascular as well as degenerative disease...
  20. ncbi request reprint Pravastatin reduces microvascular basal lamina damage following focal cerebral ischemia and reperfusion
    Andreas Trinkl
    Department of Neurology, Experimental Stroke Research, Ludwig Maximillians University, Munich, Klinikum Grosshadern, Marchioninistr 15, D 81377 Munich, Germany
    Eur J Neurosci 24:520-6. 2006
    ..553 +/- 47%, P < 0.01). Pravastatin pretreatment resulted in a reduction of microvascular basal lamina damage and hemoglobin extravasation following transient ischemia. Pravastatin seems to protect the cerebral microvascular system...
  21. ncbi request reprint Matrix metalloproteinase (MMP) induction and inhibition at different doses of recombinant tissue plasminogen activator following experimental stroke
    Dorothe Burggraf
    Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany
    Thromb Haemost 98:963-9. 2007
    ..This strongly supports use of the lowest effective dosage of rt-PA available...
  22. ncbi request reprint Effects of short term atorvastatin treatment on cerebral hemodynamics in CADASIL
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
    J Neurol Sci 260:100-5. 2007
    ..CADASIL is a monogenic form of SVD caused by mutations in the Notch3 gene. Treatment options are limited and little is known about the therapeutic role of statins in CADASIL...
  23. ncbi request reprint MRI in acute cerebral ischemia of the young: the Stroke in Young Fabry Patients (sifap1) Study
    Franz Fazekas
    From the Departments of Neurology F F, C E, R S, S R and Radiology C E, Division of Neuroradiology, Medical University of Graz, Austria Institute for Stroke and Dementia Research M D, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat, Munchen, Germany Department of Biostatistics and Clinical Epidemiology B G, M H, P M, Charite Universitatsmedizin, and Robert Koch Institut B G, Berlin Department of Neurology and Center for Stroke Research Berlin G J J, Charité Universitätsmedizin Berlin Department of Neurology M G H, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim Institute of Clinical Epidemiology and Biometry P H, Comprehensive Heart Failure Center, University of Wurzburg, and Centre for Clinical Studies, University Hospital Würzburg Justus Liebig University M K, C T, Giessen Department of Neurology C K, University of Greifswald, Germany Department of Neurology J P, T T, Helsinki University Central Hospital, Helsinki, Finland Department of Clinical Neuroscience B N, Lund University Hospital, Lund, Sweden and Albrecht Kossel Institute for Neuroregeneration A R, University of Rostock
    Neurology 81:1914-21. 2013
    ..We focused on cerebral imaging findings in a large cohort of young patients with a symptomatic ischemic cerebrovascular event (CVE) to extract relevant pathophysiologic and clinical information...
  24. ncbi request reprint Diffusion magnetic resonance histograms as a surrogate marker and predictor of disease progression in CADASIL: a two-year follow-up study
    Markus Holtmannspotter
    Abteilung fur Neuroradiologie, Klinikum Grosshadern, Ludwig Maximilians Universitat, Munich, Germany
    Stroke 36:2559-65. 2005
    ..In this study, we assessed the role of quantitative MRI (T2-lesion volume and diffusion tensor imaging [DTI]-derived metrics) in monitoring and predicting disease progression...
  25. ncbi request reprint Protection of cerebral microvasculature after moderate hypothermia following experimental focal cerebral ischemia in mice
    Jan Burk
    Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Brain Res 1226:248-55. 2008
    ..These protective effects in an additional animal model of ischemia and reperfusion strongly recommend hypothermia as a potential beneficial treatment for stroke...
  26. ncbi request reprint Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patients
    Christian Opherk
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Brain 127:2533-9. 2004
    ..Our findings suggest possible genotype-phenotype correlations with regard to disease progression. The data presented may serve as source material for counselling CADASIL patients and for designing future interventional trials...
  27. pmc Strategic white matter tracts for processing speed deficits in age-related small vessel disease
    Marco Duering
    From the Institute for Stroke and Dementia Research M Duering, B G, M G, M Dichgans, Klinikum der Universitat Munchen, Munich, Germany the Department of Neurology S S, L P, E H, S R, R S, Medical University of Graz the Institute for Medical Informatics, Statistics and Documentation E H, Graz, Austria the Department of Neurology E J, H C, CHU Lariboisière, Assistance Publique des Hôpitaux de Paris Neurospin E D, CEA Saclay, Gif sur Yvette, France the German Center for Neurodegenerative Diseases DZNE, Munich M Dichgans and Munich Cluster for Systems Neurology SyNergy M Dichgans, Munich, Germany
    Neurology 82:1946-50. 2014
    ..We investigated the impact of lesion location on processing speed in age-related small vessel disease...
  28. ncbi request reprint Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL
    Christian Opherk
    From Institute for Stroke and Dementia Research C O, M G, M Duering, R M, M Dichgans, and Department of Neurology C O, Klinikum der Universitat Munchen, Ludwig Maximilians University, Munich, Germany Department of Neurology, DHU NeuroVasc, Hopital Lariboisiere, APHP, Paris, France E J, H C Université Paris Diderot, Sorbonne Paris Cité, Génétique des Maladies Vasculaires, INSERM UMR S740, Paris, France D H, E T L Stroke and Dementia Research Centre, St George s University of London, London, United Kingdom P A S, S B Neurology Division and Molecular Medicine Section, Mazzoni Hospital, Ascoli Piceno, Italy L P, S S, M R Department of Medicine, Surgery and Neurosciences, University of Siena, Italy M T D, N D S, Department of Physiology and Cell Biology
    Stroke 45:968-72. 2014
    ..The current study searched for genetic modifiers of WMH volume in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a monogenic small vessel disease...
  29. doi request reprint Superficial siderosis is a warning sign for future intracranial hemorrhage
    Jennifer Linn
    Department of Neuroradiology, University Hospital Munich, Marchioninistrasse 15, 81377, Munich, Germany
    J Neurol 260:176-81. 2013
    ..SS can be considered a warning sign of future ICH or SAH, which frequently occur adjacent to pre-existing SS. Prospective studies are needed to confirm these findings...
  30. ncbi request reprint Intrafamilial variability in fragile X-associated tremor/ataxia syndrome
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University Munich, Munich, Germany
    Mov Disord 21:98-102. 2006
    ..Also, their family history suggests further evidence of possible manifestation of FXTAS in women...
  31. doi request reprint Black blood MRI in suspected large artery primary angiitis of the central nervous system
    Thomas Pfefferkorn
    Department of Neurology, University of Munich, Germany
    J Neuroimaging 23:379-83. 2013
    ..In this single-center observational pilot study we prospectively investigated the value of BB-MRI in the diagnosis of large artery PACNS...
  32. doi request reprint Preceding intravenous thrombolysis facilitates endovascular mechanical recanalization in large intracranial artery occlusion
    Thomas Pfefferkorn
    Department of Neurology, Klinikum Grosshadern, University of Munich, Munich, Germany
    Int J Stroke 7:14-8. 2012
    ..To test this hypothesis, we analyzed the influence of intravenous thrombolysis on net intervention time in subsequent endovascular mechanical recanalization...
  33. ncbi request reprint The pattern of cognitive performance in CADASIL: a monogenic condition leading to subcortical ischemic vascular dementia
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
    Am J Psychiatry 162:2078-85. 2005
    ..Mutation carriers almost invariably develop cognitive deficits and eventually dementia. The current study describes the profile of cognitive abnormalities in CADASIL subjects...
  34. ncbi request reprint A new approach to reduce the number of animals used in experimental focal cerebral ischemia models
    Dorothe Burggraf
    Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Neurosci Lett 386:88-93. 2005
    ..Thus, this method increases the validity of data comparisons and reduces significantly the number of animals needed in various experimental settings...
  35. doi request reprint Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis
    Marco Duering
    Institute for Stroke and Dementia Research, Ludwig Maximilians University, 81377 Munich, Germany
    Hum Mol Genet 20:3256-65. 2011
    ..These findings in combination with a new assay for single-molecule aggregation analysis provide novel opportunities for the development of therapeutic strategies...
  36. doi request reprint The Determinants of Dementia After Stroke (DEDEMAS) Study: protocol and pilot data
    Frank A Wollenweber
    Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians University, Munich, Germany
    Int J Stroke 9:387-92. 2014
    ..About 20% of stroke patients develop dementia within a few months after their event, but the determinants and mechanisms of poststroke dementia are insufficiently understood...
  37. doi request reprint Incident lacunes preferentially localize to the edge of white matter hyperintensities: insights into the pathophysiology of cerebral small vessel disease
    Marco Duering
    Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians University, Marchioninistrase 15, 81377 Munich, Germany
    Brain 136:2717-26. 2013
    ..Our observations further support and refine the concept of the white matter hyperintensity penumbra. ..
  38. ncbi request reprint A two-year clinical follow-up study in 80 CADASIL subjects: progression patterns and implications for clinical trials
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Stroke 35:1603-8. 2004
    ..The aim of this study was to explore the patterns of clinical progression in CADASIL, to check for prognostic variables, and to provide sample size estimates for future therapeutic trials...
  39. doi request reprint Incident subcortical infarcts induce focal thinning in connected cortical regions
    Marco Duering
    Institute for Stroke and Dementia Research, Ludwig Maximilians University, Munich, Germany
    Neurology 79:2025-8. 2012
    ..Brain atrophy is common in subcortical ischemic vascular disease, but the underlying mechanisms are poorly understood. We set out to examine the effects of incident subcortical infarcts on cortical morphology...
  40. ncbi request reprint Clinical features, course and outcome in deep cerebral venous system thrombosis: an analysis of 32 cases
    Thomas Pfefferkorn
    Klinikum Grosshadern, Department of Neurology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    J Neurol 256:1839-45. 2009
    ..While most patients stabilize and have a good recovery, progressing coma associated with poor outcome is seen in a subset of patients who may thus require other treatment options, such as endovascular therapy...
  41. ncbi request reprint Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: phenotypic and mutational spectrum
    Martin Dichgans
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians Universitat, Marchioninistrasse 15, D 81377, Munich, Germany
    J Neurol Sci 203:77-80. 2002
    ..This article gives a brief overview on the phenotypic spectrum of the disease and discusses some of the relevant disease mechanisms that lead from Notch3 mutations to ischemic infarcts...
  42. doi request reprint Ischemic stroke of the cortical "hand knob" area: stroke mechanisms and prognosis
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    J Neurol 256:1146-51. 2009
    ..It mostly reflects first ever ischemic stroke, and follow-up data suggest a rather benign course...
  43. ncbi request reprint Heritability of MRI lesion volume in CADASIL: evidence for genetic modifiers
    Christian Opherk
    Neurologische Klinik, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munchen, Germany
    Stroke 37:2684-9. 2006
    ..However, little is known about the factors that underlie this variability. We sought to quantify the contribution of modifying genetic effects to individual differences in the volume of cerebral ischemic lesions...
  44. doi request reprint Cortical vein thrombosis: the diagnostic value of different imaging modalities
    Jennifer Linn
    Department of Neuroradiology, University Hospital Munich, Marchioninistr 15, 81377, Munich, Germany
    Neuroradiology 52:899-911. 2010
    ..Cortical vein thrombosis (CVT) is a rare disorder, and its diagnosis is challenging. The aim of our study was to evaluate the value of different imaging modalities for the detection of CVT...
  45. ncbi request reprint CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Exp Cell Res 299:454-64. 2004
    ..Moreover, the data suggest that ligand-induced receptor shedding may not be required for N3ECD deposition in CADASIL...
  46. ncbi request reprint Spectrum of mutations in biopsy-proven CADASIL: implications for diagnostic strategies
    Nils Peters
    Department of Neurology, Neurogenetics Laboratory, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Arch Neurol 62:1091-4. 2005
    ..Mutations are typically located within epidermal growth factor-like repeat domains in the extracellular part of the Notch3 receptor. Identification of the mutation is critical for genetic counseling and testing of relatives at risk...
  47. ncbi request reprint Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia
    Dorothe Burggraf
    Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Neurobiol Dis 25:506-13. 2007
    ..Hemoglobin extravasation was also significantly reduced. Our results suggest that doxycycline may have a potential use as an anti-ischemic compound since it provides microvascular protection by inhibiting the plasminogen system...
  48. doi request reprint Endovascular mechanical recanalisation of acute carotid-T occlusions: a single-center retrospective analysis
    Gunther Fesl
    Department of Neuroradiology, University of Munich, Klinikum Grosshadern, Munich, Germany
    Cardiovasc Intervent Radiol 34:280-6. 2011
    ..Acute carotid-T occlusion generally responds poorly to thrombolysis. Endovascular mechanical thrombectomy (EMT) seems to be a promising alternative. However, there are few data on EMT in carotid-T occlusions...
  49. doi request reprint CADASIL mutations enhance spontaneous multimerization of NOTCH3
    Christian Opherk
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    Hum Mol Genet 18:2761-7. 2009
    ..Taken together, our results for the first time provide experimental evidence for N3 self-association and strongly argue for a neomorphic effect of CADASIL mutations in disease pathogenesis...
  50. pmc Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
    Martin Dichgans
    From the Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat, Munich, Germany M D, R Malik Munich Cluster for Systems Neurology SyNergy, Munich, Germany M D Institut für Medizinische Biometrie und Statistik I R K, and Institut für integrative und experimentelle Genomik J E, Universitat zu Lubeck, Lubeck, Germany Universitätsklinikum Schleswig Holstein, Campus Lubeck, Germany I R K Department of Neurology and Center for Human Genetic Research J R, and Cardiology Division C J O D, Massachusetts General Hospital, Boston Harvard Medical School, Boston, MA J R Program in Medical and Population Genetics J R, and Program in Medical and Population Genetics S K, Broad Institute of Harvard and MIT, Cambridge, MA Clinical Trial Service Unit and Epidemiological Studies Unit R C, J C H, Wellcome Trust Centre for Human Genetics H W, M Farrall, Department of Cardiovascular Medicine M Farrall, and Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience P M R, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom deCODE Genetics, Reykjavik, Iceland S G, G T, U T
    Stroke 45:24-36. 2014
    ..Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases...
  51. doi request reprint Reversible cerebral vasoconstriction syndrome with concurrent bilateral carotid artery dissection
    Anna Bayer-Karpinska
    Institute for Stroke and Dementia Research, Ludwig Maximilians University, Munich, Germany
    Cephalalgia 33:491-5. 2013
    ..So far, only single cases of unilateral carotid artery dissection and reversible cerebral vasoconstriction syndrome have been reported...
  52. doi request reprint Vessel wall inflammation in spontaneous cervical artery dissection: a prospective, observational positron emission tomography, computed tomography, and magnetic resonance imaging study
    Thomas Pfefferkorn
    Klinikum Grosshadern, Department of Neurology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Stroke 42:1563-8. 2011
    ..We used contrast-enhanced high-resolution MRI (hrMRI) and positron emission tomography CT (PET-CT) to systematically investigate VWI in spontaneous CAD...
  53. ncbi request reprint Prevalence of nonstenosing, complicated atherosclerotic plaques in cryptogenic stroke
    Tobias M Freilinger
    Department of Neurology, Ludwig Maximilians University Munich, Klinikum Groshadern, Munich, Germany
    JACC Cardiovasc Imaging 5:397-405. 2012
    ..Our goal was to assess the prevalence of complicated American Heart Association (AHA) lesion type VI plaques in the carotid arteries of patients with cryptogenic stroke...
  54. ncbi request reprint Matrix metalloproteinase induction by EMMPRIN in experimental focal cerebral ischemia
    Dorothe Burggraf
    Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Eur J Neurosci 22:273-7. 2005
    ..These results raise the possibility that the increased expression of EMMPRIN, the increase in MMPs and the damage of the basal lamina following cerebral ischemia are connected and part of a network of related changes...
  55. ncbi request reprint Ischemic stroke and peripheral arterial thromboembolism in a patient with Crohn's disease: a case presentation
    Tobias Freilinger
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    J Neurol Sci 266:177-9. 2008
    ..A pathophysiological model explaining this cooccurrence as well as the significance of prothrombotic risk factors ("hypercoaguable state") in the setting of inflammatory bowel disease and stroke are discussed...
  56. ncbi request reprint Long-term outcome after suboccipital decompressive craniectomy for malignant cerebellar infarction
    Thomas Pfefferkorn
    Department of Neurology, Klinikum Grosshadern, University of Munich, Munich, Germany
    Stroke 40:3045-50. 2009
    ..Suboccipital decompressive craniectomy (SDC) is a life-saving intervention for patients with malignant cerebellar infarction. However, long-term outcome has not been systematically analyzed...
  57. ncbi request reprint Role of subvoxel free fluid on diffusion parameters in brain tissue with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy and its correlation with physical disability: histogram analysis of standard and fluid-atte
    Martin Dichgans
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians Universitat, AG NMR, D 80804 Munich, Germany
    AJNR Am J Neuroradiol 24:1083-9. 2003
    ....
  58. doi request reprint Prevalence of cortical superficial siderosis in patients with cognitive impairment
    Frank Arne Wollenweber
    Institute for Stroke and Dementia Research, Ludwig Maximilians University, Marchioninistr 15, 81377, Munich, Germany
    J Neurol 261:277-82. 2014
    ..cSS is common in patients with cognitive impairment. It is associated with lower cognitive scores, white matter hyperintensities and microbleeds and can be the only imaging sign for CAA in this patient group. ..
  59. ncbi request reprint Prolonged cerebral transit time in CADASIL: a transcranial ultrasound study
    Martin Liebetrau
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munchen, Germany
    Stroke 33:509-12. 2002
    ..In this study, we measured the arteriovenous cerebral transit time (CTT) to identify changes related to the microangiopathy in CADASIL...
  60. ncbi request reprint CADASIL: a monogenic condition causing stroke and subcortical vascular dementia
    Martin Dichgans
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Cerebrovasc Dis 13:37-41. 2002
    ..CADASIL has opened a new perspective in studying basic mechanisms of vessel wall degeneration and ischemic tissue damage related to small vessel disease...
  61. ncbi request reprint Measurement of brain atrophy in subcortical vascular disease: a comparison of different approaches and the impact of ischaemic lesions
    Mike O'Sullivan
    Neurologische Klinik, Klinikum Grobetahadern, Ludwig Maximilians University, Munich, Germany
    Neuroimage 43:312-20. 2008
    ..Choice of analysis approach for this kind of clinical question will be determined by factors other than their robustness and precision, such as a desire to explore subtle localised changes using extensions of these processing tools...
  62. ncbi request reprint Cortical hypometabolism and crossed cerebellar diaschisis suggest subcortically induced disconnection in CADASIL: an 18F-FDG PET study
    Klaus Tatsch
    Department of Nuclear Medicine, Klinikum Grosshadern, Ludwig Maximilians University Munich, Munich, Germany
    J Nucl Med 44:862-9. 2003
    ..The purpose of this study was to evaluate with (18)F-FDG PET whether regional cerebral metabolic rate of glucose (rCMRglc) is altered in CADASIL patients and, if so, whether there is evidence of subcortically induced disconnection...
  63. pmc Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes
    James F Meschia
    From the Mayo Clinic Jacksonville, FL J F M University of Alabama at Birmingham D K A, L A M Mayo Clinic Rochester, MN R D B Massachusetts General Hospital, Boston, MA H A, J R, O W University of British Columbia, Vancouver, British Columbia, Canada O R B University of Maryland School of Medicine and Veterans Administration Medical Center, Baltimore, MD J W C, P F M, B D M, A R S, S J K University Medical Center Utrecht, Utrecht, The Netherlands P I W d B Brigham and Women s Hospital, Harvard Medical School, Boston, MA P I W d B Broad Institute of Harvard, MIT, Cambridge, MA P I W d B Klinikum der Universität München, Ludwig Maximilians University, Munich, Germany M D Johns Hopkins University, Baltimore, MD K F D University of Texas Health Science Center at Houston M F Saint Francis Medical Center, Lynwood, CA R P G NINDS Neurogenetics Cluster, Bethesda, MD K G IMIM Hospital Universitari del Mar, Barcelona, Spain J J C University of Florida, College of Pharmacy, Gainesville, FL J A J Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Germany
    Stroke 44:2694-702. 2013
    ..The National Institute of Neurological Disorders and Stroke SiGN (Stroke Genetics Network) contributes substantially to meta-analyses that focus on specific subtypes of stroke...
  64. doi request reprint Subclinical hyperthyroidism is a risk factor for poor functional outcome after ischemic stroke
    Frank Arne Wollenweber
    Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    Stroke 44:1446-8. 2013
    ..Subclinical hyperthyroidism is associated with adverse cardiovascular events, including stroke and atrial fibrillation. However, its impact on functional outcome after stroke remains unexplored...
  65. pmc Genome-wide analysis of blood pressure variability and ischemic stroke
    Sunaina Yadav
    From the Imperial College Cerebrovascular Research Unit ICCRU S Y, I C, M S K, N H, M P, P E R, P S and International Centre for Circulatory Health P S, Imperial College London, London, United Kingdom Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health E G H, M M, J A, School of Nursing and Midwifery J M M, and School of Biomedical Sciences and Pharmacy R J S, University of Newcastle, Newcastle, New South Wales, Australia Hunter Medical Research Institute, Newcastle, New South Wales, Australia E G H, J M M, M M, R J S, J A Institute for Stroke and Dementia Research ISD, Medical Centre, Klinikum der Universitat Munchen, Ludwig Maximilians University, Munich, Germany R M, M D Munich Cluster for Systems Neurology SyNergy, Munich, Germany R M, M D Stroke and Dementia Research Centre, St George s University of London, London, Germany
    Stroke 44:2703-9. 2013
    ..We sought to determine whether such variability has genetic causes and whether genetic variants associated with BP variability are also associated with ischemic stroke...
  66. pmc Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke
    Andreas Gschwendtner
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians Universitat, Marchioninistrasse 15, Munich, Germany
    Ann Neurol 65:531-9. 2009
    ..3. Stroke, in particular, ischemic stroke caused by atherosclerotic disease, shares common mechanisms with myocardial infarction. We investigated whether the 9p21 region contributes to ischemic stroke risk...
  67. ncbi request reprint Monogenic causes of stroke
    Martin Dichgans
    Neurologische Klinik, Klinikum Grosshadern, Munich, Germany
    Int Psychogeriatr 15:15-22. 2003
    ....
  68. ncbi request reprint Subarachnoid hemorrhage and diplopia as initial presentation of polycythemia vera
    Christian Opherk
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    Cerebrovasc Dis 19:279-80. 2005
  69. ncbi request reprint Lifestyle risk factors for ischemic stroke and transient ischemic attack in young adults in the Stroke in Young Fabry Patients study
    Bettina von Sarnowski
    Department of Neurology, University Medicine, Ferdinand Sauerbruch Straße, D 17475 Greifswald, Germany
    Stroke 44:119-25. 2013
    ..Although many stroke patients are young or middle-aged, risk factor profiles in these age groups are poorly understood...
  70. pmc Genome-wide association analysis identifies susceptibility loci for migraine without aura
    Tobias Freilinger
    Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Munich, Germany
    Nat Genet 44:777-82. 2012
    ..This study identifies the first susceptibility loci for migraine without aura, thereby expanding our knowledge of this debilitating neurological disorder...
  71. ncbi request reprint Cerebral microbleeds in CADASIL: a gradient-echo magnetic resonance imaging and autopsy study
    Martin Dichgans
    Department of NeurologyKlinikum Grosshadern, Ludwig Maximilians University, Munchen, Germany
    Stroke 33:67-71. 2002
    ..Our purposes were (1) to determine the frequency, extent, and pattern of MBs in CADASIL; (2) to analyze the relationship between MBs and T2-hyperintense lesions; and (3) to evaluate the histopathology of brain tissue affected by MBs...
  72. ncbi request reprint Complex segregation analysis of restless legs syndrome provides evidence for an autosomal dominant mode of inheritance in early age at onset families
    Juliane Winkelmann
    Section of Neurology, Max Planck Institute of Psychiatry, Munich, Germany
    Ann Neurol 52:297-302. 2002
    ..The segregation pattern found in our families argues for an autosomal allele acting dominantly in RLS families with an early age at onset of symptoms and suggests that RLS is a causative heterogeneous disease...
  73. ncbi request reprint Admission facility is associated with outcome of basilar artery occlusion
    Robert Muller
    Department of Neurology, Klinikum Harlaching, Städtisches Klinikum München GmbH, Munich, Germany
    Stroke 38:1380-3. 2007
    ..We investigated whether initial admission to telemedically linked general hospitals with subsequent stroke-center transfer is related to poorer outcome than direct admission to stroke centers...
  74. ncbi request reprint Histopathological abnormalities in ocular blood vessels of CADASIL patients
    Christos Haritoglou
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Am J Ophthalmol 138:302-5. 2004
    ..To assess histopathological findings in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)...
  75. ncbi request reprint Blurring of the vessels of the interhemispheric fissure in multislice CT angiography: a sign of meningeal carcinomatosis
    Birgit B Ertl-Wagner
    Klinikum Grosshadern, Institute of Clinical Radiology, University of Munich, Marchioninistr 15, 81377 Munich, Germany
    Eur Radiol 14:673-8. 2004
    ..This sign may serve as an indicator of meningeal carcinomatosis and should raise the suspicion of this disease entity...
  76. ncbi request reprint A new cause of hereditary small vessel disease: angiopathy of retina and brain
    Martin Dichgans
    Neurology 60:8-9. 2003
  77. ncbi request reprint Diagnostic criteria of vascular dementia in CADASIL
    Sarah Benisty
    Department of Geriatric Medicine, University Paris 7, 2 rue Ambroise Pare, 75010 Paris, France
    Stroke 39:838-44. 2008
    ..Application of these criteria in CADASIL, a genetic model of SIVD, may help to better assess their significance. The aim of this study was to compare different sets of diagnostic criteria of VaD in a population of CADASIL patients...
  78. ncbi request reprint Variation in the PDE4D gene and ischemic stroke risk: a systematic review and meta-analysis on 5200 cases and 6600 controls
    Steve Bevan
    Centre for Clinical Neuroscience, St George s, University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Stroke 39:1966-71. 2008
    ..Meta-analysis provides a method to combine this data and determine in a larger sample size whether the association with PDE4D can be replicated...
  79. doi request reprint Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations
    Steve Bevan
    Centre for Clinical Neuroscience, St Georges University of London, Cranmer Terrace, Tooting, London, SW17 0RE, UK
    Stroke 39:1109-14. 2008
    ..Using a case control replication methodology, all members of the leukotriene synthesis pathway and their receptors were examined for genetic variants, which may act as risk factors for all ischemic stroke and stroke subtypes...
  80. ncbi request reprint Cortical changes in cerebral small vessel diseases: a 3D MRI study of cortical morphology in CADASIL
    Eric Jouvent
    Department of Neurology, INSERM UMR 740 and Université Paris VII, France
    Brain 131:2201-8. 2008
    ..These results suggest that the examination of cortical morphology may be of high clinical relevance in SVDB...
  81. ncbi request reprint Thrombolysis of basilar artery occlusion--intra-arterial or intravenous: is there really no difference?
    Gernot Schulte-Altedorneburg
    Stroke 38:9; author reply 10-11. 2007
  82. pmc Divergent sodium channel defects in familial hemiplegic migraine
    Kristopher M Kahlig
    Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN 37240, USA
    Proc Natl Acad Sci U S A 105:9799-804. 2008
    ..1 defects can cause FHM3. Our results also emphasize the complex relationship between migraine and epilepsy and provide further evidence that both disorders may share common molecular mechanisms...
  83. ncbi request reprint National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards
    Vladimir Hachinski
    London Health Sciences Centre, University Campus, London, Ontario, Canada
    Stroke 37:2220-41. 2006
    ....
  84. ncbi request reprint Blood pressure and haemoglobin A1c are associated with microhaemorrhage in CADASIL: a two-centre cohort study
    Anand Viswanathan
    Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, Paris, France
    Brain 129:2375-83. 2006
    ..These lesions have a potential clinical impact in CADASIL. These findings further suggest that modulation of blood pressure and glucose levels might influence the course of the disease...
  85. ncbi request reprint CADASIL presenting with a movement disorder: a clinical study of a Chilean kindred
    Marcelo Miranda
    Department of Neurology, Nuclear Medicine and Dermatology, Clinica Las Condes and Universidad de Chile, Santiago, Chile
    Mov Disord 21:1008-12. 2006
    ..Our report emphasizes that CADASIL must be considered in the study of patients with secondary dystonia...
  86. ncbi request reprint ALOX5AP gene and the PDE4D gene in a central European population of stroke patients
    Elin Lõhmussaar
    Institutes of Human Genetics, GSF National Research Institute for Environment and Health, Neuherberg, Germany
    Stroke 36:731-6. 2005
    ..The aim of the present study was to explore the role of these genes in a central European population of stroke patients...
  87. ncbi request reprint The novel p.L1649Q mutation in the SCN1A epilepsy gene is associated with familial hemiplegic migraine: genetic and functional studies. Mutation in brief #957. Online
    Kaate R J Vanmolkot
    Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    Hum Mutat 28:522. 2007
    ..Our findings establish the role of neuronal Na(v)1.1 sodium channels in FHM and reinforce the involvement of ion channel dysfunction in the pathogenesis of this episodic brain disorder...
  88. ncbi request reprint C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy
    Anna Richards
    Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 39:1068-70. 2007
    ..These data have implications for the maintenance of vascular integrity in the degenerative cerebral microangiopathies leading to stroke and dementias...
  89. ncbi request reprint Brain atrophy is related to lacunar lesions and tissue microstructural changes in CADASIL
    Eric Jouvent
    Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, and Université Paris VII, Paris, France
    Stroke 38:1786-90. 2007
    ..The contribution of subcortical cerebral lesions in this process remains undetermined. The aim of this study was to investigate the relationships between cerebral volume and different types of subcortical MRI lesions in CADASIL...
  90. doi request reprint Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with an increased risk of ischemic stroke in white Europeans
    Andreas Gschwendtner
    Stroke 39:1593-6. 2008
    ..Genetic variation in the EPHX2 gene region has been reported to influence susceptibility to ischemic stroke in blacks. We assessed the role of this gene region in white Europeans and performed analyses with regard to stroke subtypes...
  91. ncbi request reprint Rare missense variants in ATP1A2 in families with clustering of common forms of migraine
    Unda Todt
    Institut fur Humangenetik, Universitatsklinikum Bonn, Bonn, Germany
    Hum Mutat 26:315-21. 2005
    ....
  92. ncbi request reprint Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neurosci Lett 440:68-71. 2008
    ..15). We found a SORL1 haplotype which was associated with CSF levels of amyloid-beta cleavage products, measured as altered levels of Abeta42. Thus our data suggest that SORL1 gene variants might influence AD pathology...
  93. ncbi request reprint Familial carpal tunnel syndrome: further evidence for a genetic contribution
    Matthias Elstner
    Clin Genet 69:179-82. 2006