M Dichgans

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Quantitative MRI in CADASIL: correlation with disability and cognitive performance
    M Dichgans
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Neurology 52:1361-7. 1999
  2. ncbi Small in-frame deletions and missense mutations in CADASIL: 3D models predict misfolding of Notch3 EGF-like repeat domains
    M Dichgans
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Eur J Hum Genet 8:280-5. 2000
  3. ncbi Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY trial): a randomised, open-label, blinded-endpoint trial
    Reinhard Dengler
    Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
    Lancet Neurol 9:159-66. 2010
  4. ncbi Polymorphisms in the receptor for GDNF (RET) are not associated with Parkinson's disease in Southern Germany
    C B Lücking
    Department of Neurology, Ludwig Maximilians University, Marchioninistr 15, 81377 Munchen, Germany
    Neurobiol Aging 31:167-8. 2010
  5. ncbi A novel mutation in CACNA1A associated with hemiplegic migraine, cerebellar dysfunction and late-onset cognitive decline
    T Freilinger
    Department of Neurology, Klinikum Groshadern, Ludwig Maximilians Universitat, Munich, Germany
    J Neurol Sci 300:160-3. 2011
  6. ncbi NOTCH3 mutation involving three cysteine residues in a family with typical CADASIL
    M Dichgans
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians Universitat, Munich, Germany
    Neurology 57:1714-7. 2001
  7. ncbi Reduced cerebrovascular CO(2) reactivity in CADASIL: A transcranial Doppler sonography study
    T Pfefferkorn
    Department of Neurology, Klinikum Grosshadern,
    Stroke 32:17-21. 2001
  8. ncbi Internal carotid artery dissection and ischemic cerebral infarction in the setting of essential thrombocythemia
    T Freilinger
    Department of Neurology, Ludwig Maximilians Universitat, Klinikum Groshadern, Munich, Germany
    Clin Appl Thromb Hemost 17:E138-40. 2011
  9. ncbi Altered white and gray matter metabolism in CADASIL: a proton MR spectroscopy and 1H-MRSI study
    D P Auer
    Max Planck Institut fur Psychiatrie, AG NMR, Munich, Germany
    Neurology 56:635-42. 2001
  10. ncbi Expansion of the phenotypic spectrum of the CACNA1A T666M mutation: a family with familial hemiplegic migraine type 1, cerebellar atrophy and mental retardation
    T Freilinger
    Department of Neurology, , Klinikum Grosshadern, Munich, Germany
    Cephalalgia 28:403-7. 2008

Detail Information

Publications40

  1. ncbi Quantitative MRI in CADASIL: correlation with disability and cognitive performance
    M Dichgans
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Neurology 52:1361-7. 1999
    ....
  2. ncbi Small in-frame deletions and missense mutations in CADASIL: 3D models predict misfolding of Notch3 EGF-like repeat domains
    M Dichgans
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Eur J Hum Genet 8:280-5. 2000
    ..To study the potential effects of these mutations 3D homology models of the first six EGF domains were generated on the basis of NMR data from human fibrillin-1. These models predict domain misfolding for a subset of mutations...
  3. ncbi Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY trial): a randomised, open-label, blinded-endpoint trial
    Reinhard Dengler
    Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
    Lancet Neurol 9:159-66. 2010
    ..The EARLY trial aimed to compare outcome in patients given aspirin plus extended-release dipyridamole twice daily either within 24 h of stroke or TIA or after 7 days of aspirin monotherapy...
  4. ncbi Polymorphisms in the receptor for GDNF (RET) are not associated with Parkinson's disease in Southern Germany
    C B Lücking
    Department of Neurology, Ludwig Maximilians University, Marchioninistr 15, 81377 Munchen, Germany
    Neurobiol Aging 31:167-8. 2010
    ....
  5. ncbi A novel mutation in CACNA1A associated with hemiplegic migraine, cerebellar dysfunction and late-onset cognitive decline
    T Freilinger
    Department of Neurology, Klinikum Groshadern, Ludwig Maximilians Universitat, Munich, Germany
    J Neurol Sci 300:160-3. 2011
    ..This suggests a possible causal link between cerebellar and cognitive disturbances in this patient; in addition to these pathophysiological aspects, we review of the role of the cerebellum in cognition...
  6. ncbi NOTCH3 mutation involving three cysteine residues in a family with typical CADASIL
    M Dichgans
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians Universitat, Munich, Germany
    Neurology 57:1714-7. 2001
    ..These data are consistent with the hypothesis that the change toward an odd number of cysteine residues within a given EGF repeat and therefore an unpaired, reactive cysteine residue is the common and critical molecular event in CADASIL...
  7. ncbi Reduced cerebrovascular CO(2) reactivity in CADASIL: A transcranial Doppler sonography study
    T Pfefferkorn
    Department of Neurology, Klinikum Grosshadern,
    Stroke 32:17-21. 2001
    ..The reduction of CO(2) reactivity in nondisabled CADASIL individuals suggests an early role of impaired cerebral vasoreactivity in the evolution of the disease...
  8. ncbi Internal carotid artery dissection and ischemic cerebral infarction in the setting of essential thrombocythemia
    T Freilinger
    Department of Neurology, Ludwig Maximilians Universitat, Klinikum Groshadern, Munich, Germany
    Clin Appl Thromb Hemost 17:E138-40. 2011
    ..In particular, we speculate that ET may increase the susceptibility of cervical vessels to spontaneous dissection, for example, by disturbing the microcirculation within the vessel wall...
  9. ncbi Altered white and gray matter metabolism in CADASIL: a proton MR spectroscopy and 1H-MRSI study
    D P Auer
    Max Planck Institut fur Psychiatrie, AG NMR, Munich, Germany
    Neurology 56:635-42. 2001
    ..To further characterize the cerebral pathology in vivo we analyzed metabolite concentrations in normal and abnormal appearing brain tissue using single and multiple voxel proton MR spectroscopy (1H-MRS and 1H-MRSI)...
  10. ncbi Expansion of the phenotypic spectrum of the CACNA1A T666M mutation: a family with familial hemiplegic migraine type 1, cerebellar atrophy and mental retardation
    T Freilinger
    Department of Neurology, , Klinikum Grosshadern, Munich, Germany
    Cephalalgia 28:403-7. 2008
  11. ncbi Noncontrast CT in deep cerebral venous thrombosis and sinus thrombosis: comparison of its diagnostic value for both entities
    J Linn
    Department of Neuroradiology, University Hospital Munich, Munich, Germany
    AJNR Am J Neuroradiol 30:728-35. 2009
    ..Because noncontrast cranial CT (NCCT) is still the imaging technique of choice in most emergency departments, we aimed to investigate its value in the diagnosis of SVT and DVT...
  12. ncbi Retinal vascular abnormalities in CADASIL
    C Haritoglou
    Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany
    Neurology 62:1202-5. 2004
    ..Findings included bilateral peripapillary arteriolar sheathing (30%), arteriolar narrowing (80%), and arteriovenous nicking (90%). No retinal infarcts, vascular occlusions, exudation, or hypoperfusion of affected vessels were found...
  13. ncbi Brain volume changes in CADASIL: a serial MRI study in pure subcortical ischemic vascular disease
    N Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany
    Neurology 66:1517-22. 2006
    ..Age and systolic blood pressure are risk factors for brain volume loss during follow-up. Percent brain volume change seems promising as an adjunct outcome measure in future interventional trials...
  14. ncbi Familial hemiplegic migraine with cerebellar ataxia and paroxysmal psychosis
    M Spranger
    Department of Neurology, University of Heidelberg, Germany
    Eur Neurol 41:150-2. 1999
    ....
  15. ncbi High-resolution black-blood contrast-enhanced T1 weighted images for the diagnosis and follow-up of intracranial arteritis
    T Saam
    Department of Clinical Radiology, University of Munich, Grosshadern Campus, Munich, Germany
    Br J Radiol 83:e182-4. 2010
    ..Therefore, brain biopsies are often needed to confirm the diagnosis. Recent reports have shown that MRI is able to visualise contrast enhancement in subjects with known primary CNS arteritis...
  16. ncbi Subarachnoid hemosiderosis and superficial cortical hemosiderosis in cerebral amyloid angiopathy
    J Linn
    Department of Neuroradiology, University of Munich, Munich, Germany
    AJNR Am J Neuroradiol 29:184-6. 2008
    ..Thus, we propose that these 2 findings might be valuable as noninvasive diagnostic markers for CAA...
  17. ncbi Opening of the blood-brain barrier preceding cortical edema in a severe attack of FHM type II
    J P Dreier
    Department of Neurology, Charite University Medicine, 10117 Berlin, Germany
    Neurology 64:2145-7. 2005
    ..The findings suggest that the delayed cortical edema was vasogenic in the severe migraine aura variant of this ATP1A2 mutation carrier...
  18. ncbi Inherited Myoclonus-dystonia syndrome: narrowing the 7q21-q31 locus in German families
    F Asmus
    Neurologische Klinik, Klinikum Grosshadern, , , Germany
    Ann Neurol 49:121-4. 2001
    ..99. The observation of key recombinations in one family refined the disease locus to a 7.2 cM region flanked by the markers D7S652 and D7S2480...
  19. ncbi A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias
    M Strupp
    Department of Neurology, Friedrich Baur Institute and IFB LMU, University of Munich, Campus Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Neurology 77:269-75. 2011
    ..The therapeutic effects of 4-aminopyridine (4AP) were investigated in a randomized, double-blind, crossover trial in 10 subjects with familial episodic ataxia with nystagmus...
  20. ncbi Clinical characteristics and frequency of the hereditary restless legs syndrome in a population of 300 patients
    J Winkelmann
    Max Planck Institute of Psychiatry, Section of Neurology, Munich, Germany
    Sleep 23:597-602. 2000
    ..1% vs. 2.6%, p < 0.05). Our study shows that patients with hereditary RLS may experience an earlier onset of the disease. Hereditary and non-hereditary RLS present with similiar clinical signs and symptoms...
  21. ncbi 1H-MRS alterations in the cerebellum of patients with familial hemiplegic migraine type 1
    M Dichgans
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Neurology 64:608-13. 2005
    ..Genetic studies have established an association with mutations in the CACNA1A gene. However, the mechanisms underlying cerebellar involvement are largely unknown...
  22. ncbi Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFE
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Lancet Neurol 7:875-84. 2008
    ..The putative neuroprotective effects of antiplatelet compounds and the angiotensin II receptor antagonist telmisartan were investigated in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial...
  23. ncbi Successful bilateral pallidal stimulation for Meige syndrome and spasmodic torticollis
    C Opherk
    Department of Neurology, Klinikum Grosshadern Marchioninistr. 15, D-81377 Munich, Germany
    Neurology 66:E14. 2006
  24. ncbi Systematic analysis of three FHM genes in 39 sporadic patients with hemiplegic migraine
    B de Vries
    Departments of Human Genetics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Neurology 69:2170-6. 2007
    ..It will also facilitate the often difficult differential diagnosis from other causes of transient hemiparesis...
  25. ncbi [Genetics of migraine]
    T Freilinger
    Neurologische Klinik und Poliklinik, Klinikum Grosshadern der Ludwig Maximilians Universität München, Marchioninistrasse 23, 81377, Munchen
    Nervenarzt 77:1186, 1188-95. 2006
    ..We further discuss the roles of CACNA1A, ATP1A2, and SCN1A in the pathophysiology of cortical spreading depression, which is the likely correlate of migraine aura...
  26. ncbi Variability of familial hemiplegic migraine with novel A1A2 Na+/K+-ATPase variants
    K Jurkat-Rott
    Department of Applied Physiology, Ulm University, Germany
    Neurology 62:1857-61. 2004
    ..D718N and P979L may predispose to seizures and mental retardation. A1A2 does not play a major role in sporadic HM; only one variant, R383H, occurred in 1 of 24 cases...
  27. ncbi [Susac syndrome: case reports and review of the literature]
    I W Reiniger
    Augenklinik, Klinikum der Universitat Munchen
    Klin Monbl Augenheilkd 223:161-7. 2006
    ..Susac syndrome is a rare disease of unknown pathogenesis. It consists of retinal arterial occlusion, hearing loss and encephalopathy (triad)...
  28. ncbi Correlations between clinical findings and magnetization transfer imaging metrics of tissue damage in individuals with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    G Iannucci
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy
    Stroke 32:643-8. 2001
    ..Brain tissue outside PD abnormalities is also damaged. This study suggests that the extent and the severity of the brain tissue damage are critical factors in determining clinical status in CADASIL...
  29. ncbi [Diagnosis and therapy of basilar artery occlusion]
    T Pfefferkorn
    Neurologische Klinik, Klinikum Grosshadern, Ludwigs Maximilians Universität München
    Nervenarzt 77:416-22. 2006
    ..This review focuses on current developments in the diagnosis and treatment of acute basilar artery occlusion...
  30. ncbi Treatment of episodic ataxia type 2 with the potassium channel blocker 4-aminopyridine
    M Strupp
    Department of Neurology, University of Munich, Germany
    Neurology 62:1623-5. 2004
    ..Attacks recurred after treatment was stopped; subsequent treatment alleviated the symptoms (mean follow-up time 6 months). These effects might be due to an improvement of the impaired functioning of Purkinje cells...
  31. ncbi A magnetic resonance imaging study of the cervical cord of patients with CADASIL
    M A Rocca
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 56:1392-4. 2001
    ..A significant correlation was found between the extent of brain lesions and cord MTR, suggesting wallerian degeneration as the substrate of the cord MTR changes...
  32. ncbi Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: decrease in regional cerebral blood volume in hyperintense subcortical lesions inversely correlates with disability and cognitive performance
    R Bruening
    Institute of Clinical Radiology, Klinikum Grossadern, Ludwig-Maximilians University, Marchioninstrasse 15, D-81377 Munich, Germany
    AJNR Am J Neuroradiol 22:1268-74. 2001
    ..rCBV did not correlate with age. CONCLUSION: rCBV measured in the hyperintense subcortical white matter in individuals with CADASIL was decreased and inversely correlated with disability and cognitive impairment...
  33. ncbi Reversible coma with raised intracranial pressure: an unusual clinical manifestation of CADASIL
    F Feuerhake
    Department of Neuropathology, University of Freiburg, 79106 Freiburg, Germany
    Acta Neuropathol 103:188-92. 2002
    ..We suggest that a transient disturbance of the blood-brain barrier related to the underlying vascular pathology may have caused this unusual presentation of CADASIL...
  34. ncbi [Diagnostic evaluation of the craniocervical vascular system with a 16-slice multi-detector row spiral CT. Protocols and first experiences]
    B Ertl-Wagner
    Institut fur Klinische Radiologie, Klinikum der Universitat Munchen, Grosshadern, Germany
    Radiologe 42:728-32. 2002
    ..We aim to describe our first experiences with this novel technology in the diagnostic imaging of the craniocervical vascular system...
  35. ncbi RLS3: fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity
    K M Liebetanz
    Department of Clinical Neurophysiology, Georg-August-University, Goettingen, Germany
    Neurology 67:320-1. 2006
    ..P values were 0.0054 for marker D9S1810 for TDT and 0.0009 for the affecteds-only linkage analysis, providing a confirmation of RLS3. This study narrows the region containing the autosomal dominant RLS3 locus to 11.1 cM (16.6 Mbp)...
  36. ncbi The pathogenesis of CADASIL: an update
    R N Kalaria
    Institute for Ageing and Health, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, NE4 6 BE, UK
    J Neurol Sci 226:35-9. 2004
    ..This report summarizes some of the highlights of the satellite symposium on CADASIL at Vas-Cog 2003...
  37. ncbi Peripheral nerve and skeletal muscle involvement in CADASIL
    J M Schroder
    Department of Neuropathology University Hospital, RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Acta Neuropathol 110:587-99. 2005
    ....
  38. ncbi Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL
    A Viswanathan
    Departments of Neurology, Centre Hospitalier Universitaire Lariboisière, Assistance Publique des Hopitaux de Paris, France
    Neurology 69:172-9. 2007
    ..Our purpose was to examine the influence of the visible MRI markers in the disease, including the load of lacunar lesions on cognitive impairment and disability in CADASIL...
  39. ncbi Malignant posterior cerebral artery infarction
    Th Pfefferkorn
    J Neurol 253:1640-1. 2006
  40. ncbi Genomic sequences of aldolase C (Zebrin II) direct lacZ expression exclusively in non-neuronal cells of transgenic mice
    E U Walther
    Neurologische Klinik, Marchioninstrasse 15, 81377 Munich, Germany
    Proc Natl Acad Sci U S A 95:2615-20. 1998
    ..The absence of Purkinje cell staining suggests that the cis elements required for this expression must be located outside of the sequences used in this study...