Dhein S, Perlitz F, Mohr F. An in vitro model for assessment of drug-induced torsade de pointes arrhythmia : effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia. Naunyn Schmiedebergs Arch Pharmacol. 2008;378:631-44 pubmed publisher
..896, p < 0.001) The model seems suitable to identify a pharmacological risk for TdP in vitro within a limited number of animals. ..
Dhein S, Rothe S, Busch A, Rojas Gomez D, Boldt A, Reutemann A, et al. Effects of metoprolol therapy on cardiac gap junction remodelling and conduction in human chronic atrial fibrillation. Br J Pharmacol. 2011;164:607-16 pubmed publisher
..We investigated the influence of metoprolol on gap junction proteins connexin43 (Cx43) and connexin40 (Cx40) in atrial tissue from patients with/without atrial fibrillation (AF)...