S Dhein

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Signal transduction and transcriptional control of cardiac connexin43 up-regulation after alpha 1-adrenoceptor stimulation
    Aida Salameh
    Department of Pediatric Cardiology, University of Leipzig, Heart Centre, 04289 Leipzig, Germany
    J Pharmacol Exp Ther 326:315-22. 2008
  2. doi request reprint Local effects and mechanisms of antiarrhythmic peptide AAP10 in acute regional myocardial ischemia: electrophysiological and molecular findings
    Joanna Jozwiak
    Herzzentrum, Klinik fur Herzchirurgie, Universitat Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 378:459-70. 2008
  3. pmc Inverse Relationship between Tumor Proliferation Markers and Connexin Expression in a Malignant Cardiac Tumor Originating from Mesenchymal Stem Cell Engineered Tissue in a Rat in vivo Model
    Cathleen Spath
    Translational Centre for Regenerative Medicine Leipzig, Germany
    Front Pharmacol 4:42. 2013
  4. doi request reprint Allium ursinum L.: bioassay-guided isolation and identification of a galactolipid and a phytosterol exerting antiaggregatory effects
    Dina Sabha
    King Hussein Medical Centre, Amman, Jordan
    Pharmacology 89:260-9. 2012
  5. ncbi request reprint Cardiac ischemia and uncoupling: gap junctions in ischemia and infarction
    Stefan Dhein
    Klinik fur Herzchirurgie, Herzzentrum, Universitat Leipzig, Leipzig, Germany
    Adv Cardiol 42:198-212. 2006
  6. ncbi request reprint Ischemic and inflammatory lung impairment by extracorporeal circulation: effect of PARP-inhibition by INO1001
    S Dhein
    Clinic for Cardiac Surgery, Heart Centre Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Pharmacol Res 58:332-9. 2008
  7. pmc Effects of autologous bone marrow stem cell transplantation on beta-adrenoceptor density and electrical activation pattern in a rabbit model of non-ischemic heart failure
    Stefan Dhein
    Clinic for Cardiac Surgery, Heart Centre Leipzig, University of Leipzig, Germany
    J Cardiothorac Surg 1:17. 2006
  8. ncbi request reprint Pharmacological modulation and differential regulation of the cardiac gap junction proteins connexin 43 and connexin 40
    Stefan Dhein
    Clinic for Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Struempellstr 39, 04289, Leipzig, Germany
    Biol Cell 94:409-22. 2002
  9. ncbi request reprint Pharmacology of gap junctions in the cardiovascular system
    Stefan Dhein
    Clinic for Cardiac Surgery, Heart Centre Leipzig, University of Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Cardiovasc Res 62:287-98. 2004
  10. doi request reprint An in vitro model for assessment of drug-induced torsade de pointes arrhythmia : effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia
    Stefan Dhein
    Clinic for Cardiac Surgery, University of Leipzig, Struempellstr 39, 04289, Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 378:631-44. 2008

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint Signal transduction and transcriptional control of cardiac connexin43 up-regulation after alpha 1-adrenoceptor stimulation
    Aida Salameh
    Department of Pediatric Cardiology, University of Leipzig, Heart Centre, 04289 Leipzig, Germany
    J Pharmacol Exp Ther 326:315-22. 2008
    ..Therefore, we conclude that alpha(1)-adrenoceptor stimulation up-regulates cardiac Cx43 expression via a PKC p38- and p42/44 MAPK-regulated pathway, possibly involving AP1...
  2. doi request reprint Local effects and mechanisms of antiarrhythmic peptide AAP10 in acute regional myocardial ischemia: electrophysiological and molecular findings
    Joanna Jozwiak
    Herzzentrum, Klinik fur Herzchirurgie, Universitat Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 378:459-70. 2008
    ..The AAP10 action seems confined to the ischemic area...
  3. pmc Inverse Relationship between Tumor Proliferation Markers and Connexin Expression in a Malignant Cardiac Tumor Originating from Mesenchymal Stem Cell Engineered Tissue in a Rat in vivo Model
    Cathleen Spath
    Translational Centre for Regenerative Medicine Leipzig, Germany
    Front Pharmacol 4:42. 2013
    ..This implicates that gap junction communication between tumor and normal tissue is reduced or absent, which could mean that growth and differentiation signals can not be exchanged...
  4. doi request reprint Allium ursinum L.: bioassay-guided isolation and identification of a galactolipid and a phytosterol exerting antiaggregatory effects
    Dina Sabha
    King Hussein Medical Centre, Amman, Jordan
    Pharmacology 89:260-9. 2012
    ....
  5. ncbi request reprint Cardiac ischemia and uncoupling: gap junctions in ischemia and infarction
    Stefan Dhein
    Klinik fur Herzchirurgie, Herzzentrum, Universitat Leipzig, Leipzig, Germany
    Adv Cardiol 42:198-212. 2006
    ..In the chronic phase, remodeling processes also involve gap junctions and lead to highly heterogeneous non-uniform tissue which may serve as an arrhythmogenic trigger...
  6. ncbi request reprint Ischemic and inflammatory lung impairment by extracorporeal circulation: effect of PARP-inhibition by INO1001
    S Dhein
    Clinic for Cardiac Surgery, Heart Centre Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Pharmacol Res 58:332-9. 2008
    ..We investigated whether extracorporeal circulation may induce biochemical and histological changes in the lungs which may help to explain this development...
  7. pmc Effects of autologous bone marrow stem cell transplantation on beta-adrenoceptor density and electrical activation pattern in a rabbit model of non-ischemic heart failure
    Stefan Dhein
    Clinic for Cardiac Surgery, Heart Centre Leipzig, University of Leipzig, Germany
    J Cardiothorac Surg 1:17. 2006
    ..Since only little is known on stem cell therapy in non-ischemic heart failure we wanted to know whether a long-term improvement of cardiac function in non-ischemic heart failure can be achieved by stem cell transplantation...
  8. ncbi request reprint Pharmacological modulation and differential regulation of the cardiac gap junction proteins connexin 43 and connexin 40
    Stefan Dhein
    Clinic for Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Struempellstr 39, 04289, Leipzig, Germany
    Biol Cell 94:409-22. 2002
    ..Interestingly, it appears that the expression of Cx43 and Cx40 can be differentially regulated...
  9. ncbi request reprint Pharmacology of gap junctions in the cardiovascular system
    Stefan Dhein
    Clinic for Cardiac Surgery, Heart Centre Leipzig, University of Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Cardiovasc Res 62:287-98. 2004
    ..This review describes the various substances affecting these parameters and outlines the possible pharmacological use of such drugs...
  10. doi request reprint An in vitro model for assessment of drug-induced torsade de pointes arrhythmia : effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia
    Stefan Dhein
    Clinic for Cardiac Surgery, University of Leipzig, Struempellstr 39, 04289, Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 378:631-44. 2008
    ..896, p < 0.001) The model seems suitable to identify a pharmacological risk for TdP in vitro within a limited number of animals...
  11. ncbi request reprint Protein kinase Calpha mediates the effect of antiarrhythmic peptide on gap junction conductance
    S Dhein
    Institute of Pharmacology, University of Halle, Germany
    Cell Commun Adhes 8:257-64. 2001
    ..In conclusion; AAP10 increases Gj in both adult cardiomyocytes and transfected HeLa-Cx43 cells. AAP10 leads to enhanced phosphorylation of Cx43 via activation of PKCalpha. A membrane receptor exists for antiarrhythmic peptides...
  12. ncbi request reprint Peptides acting at gap junctions
    Stefan Dhein
    Clinic for Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Peptides 23:1701-9. 2002
    ..Thus, intercellular communication can be controlled using peptide drugs...
  13. ncbi request reprint Role of connexins in atrial fibrillation
    Stefan Dhein
    Klinik fur Herzchirurgie, Herzzentrum, Universitat Leipzig, Leipzig, Germany
    Adv Cardiol 42:161-74. 2006
    ..New studies point to a modulating role of angiotensin II in this process and a possible therapeutic role for ACE inhibitors or AT(1) antagonists...
  14. doi request reprint A new role for extracellular Ca2+ in gap-junction remodeling: studies in humans and rats
    S Dhein
    Klinik fur Herzchirurgie, Herzzentrum, Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 377:125-38. 2008
    ..Moreover, cyclosporin A completely abolished the Ca(2+)-induced changes, while verapamil was ineffective. We conclude that extracellular calcium (24 h exposure) seems to up-regulate Cx40 but not Cx43...
  15. doi request reprint Improving cardiac gap junction communication as a new antiarrhythmic mechanism: the action of antiarrhythmic peptides
    Stefan Dhein
    Clinic for Cardiac Surgery, University of Leipzig, Struempellstr 39, 04289, Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 381:221-34. 2010
    ..The present review outlines the development of this group of peptides and derivatives, their mode of action and molecular mechanisms, and discusses their possible therapeutic potential...
  16. ncbi request reprint Effects of the new antiarrhythmic peptide ZP123 on epicardial activation and repolarization pattern
    Stefan Dhein
    Clinic for Cardiac Surgery, University of Leipzig, Heart Center, Leipzig, Germany
    Cell Commun Adhes 10:371-8. 2003
    ..We conclude that AAP10 and ZP123 have similar effects in vitro, but the superior enzymatic stability of ZP123 makes this compound the preferred substance for in vivo studies of antiarrhythmic peptides...
  17. pmc Effects of metoprolol therapy on cardiac gap junction remodelling and conduction in human chronic atrial fibrillation
    S Dhein
    Clinic for Cardiac Surgery, University of Leipzig, Leipzig, Germany
    Br J Pharmacol 164:607-16. 2011
    ..We investigated the influence of metoprolol on gap junction proteins connexin43 (Cx43) and connexin40 (Cx40) in atrial tissue from patients with/without atrial fibrillation (AF)...
  18. ncbi request reprint Antiarrhythmic and electrophysiological effects of long-chain omega-3 polyunsaturated fatty acids
    Stefan Dhein
    Clinic for Cardiac Surgery, University of Leipzig, Heart Center, Struempellstrasse 39, 04289 Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 371:202-11. 2005
    ..Anisotropy was not significantly changed. EPA and ALA did not exhibit a systematic effect on V(L) or V(T). These results clearly demonstrate that DHA, EPA, and ALA exhibit direct electrophysiological effects with different profiles...
  19. ncbi request reprint New sialyl-Lewis-X analogues antagonize leukocyte-induced ischemia-reperfusion arrhythmia--a mapping study
    S Dhein
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Thorac Cardiovasc Surg 52:102-9. 2004
    ..Leukocytes infiltrating the ischemic region play an important pathophysiological role. The effects of soluble sialyl-Lewis-X analogues Hoe934553 and Hoe943644, which may inhibit leukocyte-endothelial interaction, were investigated...
  20. ncbi request reprint Pharmacodynamics of T-cell function for monitoring immunosuppression
    M J Barten
    Department of Cardiac Surgery, Heart Center Leipzip, Leipzig, Germany
    Cell Prolif 40:50-63. 2007
    ..Thus, in this study we have monitored the PD properties of immunosuppressants on diverse T-cell functions in heart transplant (HTx) recipients...
  21. pmc Effects of the gap junction uncoupler palmitoleic acid on the activation and repolarization wavefronts in isolated rabbit hearts
    S Dhein
    Institute of Pharmacology, University of Halle, Germany
    Br J Pharmacol 128:1375-84. 1999
    ..As important arrhythmogenic effects of uncoupling enhancement of dispersion with concomitant disturbation of the normal activation pattern and slowing of conduction might be considered...
  22. ncbi request reprint Pharmacodynamic monitoring of the conversion of cyclosporine to tacrolimus in heart and lung transplant recipients
    M J Barten
    University Leipzig, Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany
    Transplant Proc 37:4532-4. 2005
    ..Therefore, we used our PD assays of lymphocyte function to monitor the conversion of CsA to TRL in heart (HTx) and lung (LTx) transplant recipients...
  23. ncbi request reprint The aging heart: changes in the pharmacodynamic electrophysiological response to verapamil in aged rabbit hearts
    A Salameh
    Heart Centre, Department of Paediatric Cardiology, University of Leipzig, Leipzig, Germany
    J Physiol Pharmacol 61:141-51. 2010
    ..L) (reduced maximum conductance, a shift of the steady state inactivation) in the aged heart which may influence the response to verapamil...
  24. ncbi request reprint Acetylsalicylic acid enhances arrhythmogeneity in a model of local ischemia of isolated rabbit hearts
    S Dhein
    Institute of Pharmacology, University of Cologne, Germany
    Eur J Pharmacol 339:129-39. 1997
    ..Thus, in acute myocardial ischemia, acetylsalicylic acid may have (besides the well known and desired antiaggregatory effects) electrophysiologic side effects which seem to be proarrhythmic in regional ischemia at least in this model...
  25. ncbi request reprint Structure-activity relationships of novel peptides related to the antiarrhythmic peptide AAP10 which reduce the dispersion of epicardial action potential duration
    R Grover
    Institute of Pharmacology, University of Cologne, Gleuelerstr. 24, 50931 Cologne, Germany
    Peptides 22:1011-21. 2001
    ..Among these new synthetic peptides various including the cyclopeptide cAAP10RG, cyclo[CF(3)C(OH)-Gly-Ala-Gly-Hyp-Pro-Tyr] showed promising activities. (supported by the DFG and Köln-Fortune)..
  26. ncbi request reprint Differential pattern of endothelin-1-induced inotropic effects in right atria and left ventricles of the human heart
    S Dhein
    Department of Pharmacology, University of Halle, Germany
    J Cardiovasc Pharmacol 36:564-9. 2000
    ..We conclude that, because ET-1 inhibits adenylylcyclase and causes negative inotropic effects in atria but not in ventricles, adenylylcyclase inhibition might be responsible for the transient negative inotropic effect of ET-1...
  27. ncbi request reprint Pharmacological modification of gap junction coupling by an antiarrhythmic peptide via protein kinase C activation
    Stephan Weng
    Clinic for Cardiac Surgery, University of Leipzig, Heart Center, 04289 Leipzig, Germany
    FASEB J 16:1114-6. 2002
    ....
  28. ncbi request reprint Different effects of the beta-adrenoceptor antagonists celiprolol and metoprolol on vascular structure and function in long-term type I diabetic rats
    A Olbrich
    Institute of Pharmacology, University of Cologne, Germany
    J Cardiovasc Pharmacol 33:193-203. 1999
    ..We conclude that celiprolol can exert antiangiopathic effects in diabetic rats and that both beta-adrenoceptor antagonists did not aggravate diabetic angiopathy and metabolic derangement...
  29. doi request reprint Cardioprotective effects of low-dose cyclosporin A added to histidine-tryptophan-ketoglutarate cardioplegia solution prior to total myocardial ischemia: an in vitro rabbit heart study
    P Pritzwald-Stegmann
    Heart Centre Leipzig, Leipzig, Germany
    Pharmacology 88:167-73. 2011
    ..We investigated whether low-dose CsA added to histidine-tryptophan-ketoglutarate (HTK) cardioplegia solution could improve myocardial protection during longer periods of global myocardial ischemia as encountered during cardiac surgery...
  30. pmc The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta-adrenoceptors
    A Salameh
    Department of Paediatric Cardiology, University of Leipzig, Heart Centre, Leipzig, Germany
    Br J Pharmacol 158:198-208. 2009
    ..As the beta-adrenoceptor is involved in many cardiac diseases, we wanted to clarify the pathway by which beta-adrenoceptor stimulation may control Cx43 expression...
  31. ncbi request reprint Chronic effects of endothelin 1 and angiotensin II on gap junctions and intercellular communication in cardiac cells
    Lioudmilla Polontchouk
    Institute of Pharmacology, Martin Luther University of Halle Wittenberg, D 06097 Halle, Germany
    FASEB J 16:87-9. 2002
    ..Thus, stimulation of the ERK and p38 signal pathways via ETA and AT1 receptors may partcipate in the regulation of cardiac gap junctions under (patho)physiological conditions...
  32. doi request reprint Alpha-1-adrenoceptor subtype selective regulation of connexin 43 expression in rat cardiomyocytes
    Diana Marcela Rojas Gomez
    Clinic for Cardiac Surgery, University of Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 377:77-85. 2008
    ..Thus, we conclude that cardiac Cx43 expression seems to be regulated via alpha(1)-adrenoceptors predominantly by subtype alpha(1D)-adrenoceptors, while other proteins like beta-actin seem to be regulated via alpha(1A)-adrenoceptors...
  33. ncbi request reprint Ultrastructural findings in porcine hearts after extracorporeal long-term preservation with a modified Langendorff perfusion system
    H Aupperle
    Institut für Veterinär Pathologie, Universitat Leipzig, An den Tierkliniken 33, 04103 Leipzig, Germany
    J Vet Med A Physiol Pathol Clin Med 54:230-7. 2007
    ..This is a promising model for extracorporeal heart perfusion. However, ultrastructural findings indicated that some necessary modifications to prevent cellular damages during reperfusion were needed...
  34. ncbi request reprint Subchronic alpha- and beta-adrenergic regulation of cardiac gap junction protein expression
    A Salameh
    Medizinische Klinik I, Abteilung Kardiologie, Universitätsklinik Leipzig, Leipzig, Germany
    FASEB J 20:365-7. 2006
    ..Adrenergic stimulation of cardiomyocytes can enhance Cx43 expression thereby increasing cellular coupling, indicating a possible role for catecholamines in the regulation of cardiac gap junction expression in cardiac disease...
  35. doi request reprint Olea europaea leaf extract exerts L-type Ca(2+) channel antagonistic effects
    A Scheffler
    Klinik fur Herzchirurgie, Herzzentrum Leipzig, Strümpellstr 39, 04289 Leipzig, Germany
    J Ethnopharmacol 120:233-40. 2008
    ..Cardiovascular diseases are still the leading causes of morbidity and mortality in industrialized countries with hypertension being one of the main risk factors...
  36. doi request reprint Postoperative development of aspirin resistance following coronary artery bypass
    J Kempfert
    Department of Cardiac Surgery, Heartcenter, University of Leipzig, Leipzig, Germany
    Eur J Clin Invest 39:769-74. 2009
    ..Rates of perioperative aspirin resistance cited in the literature are up to 50% and could be influenced by extracorporeal circulation. Thus, aspirin resistance after CABG may have a significant clinical relevance...
  37. ncbi request reprint Increase in gap junction conductance by an antiarrhythmic peptide
    A Muller
    Institute of Pharmacology, University of Koln, Germany
    Eur J Pharmacol 327:65-72. 1997
    ..We conclude that AAP10 increases gap junction conductance, i.e., cellular coupling in the heart. This finding might be the first step towards the development of a new class of antiarrhythmic agents...
  38. ncbi request reprint Effects of the I(K.ATP) blockers glibenclamide and HMR1883 on cardiac electrophysiology during ischemia and reperfusion
    S Dhein
    Institute of Pharmacology, University of Halle, Magdeburger Str 4, 06097 Saale, Halle, Germany
    Eur J Pharmacol 398:273-84. 2000
    ..Furthermore, unlike glibenclamide HMR1883 does not interfere with postischemic hyperemia...
  39. ncbi request reprint Long-term effects of the endothelin(A) receptor antagonist LU 135252 and the angiotensin-converting enzyme inhibitor trandolapril on diabetic angiopathy and nephropathy in a chronic type I diabetes mellitus rat model
    S Dhein
    Institute of Pharmacology, University of Halle, Halle, Germany
    J Pharmacol Exp Ther 293:351-9. 2000
    ....
  40. ncbi request reprint Interaction between simvastatin and metoprolol with respect to cardiac beta-adrenoceptor density, catecholamine levels and perioperative catecholamine requirements in cardiac surgery patients
    A Franka Nette
    Clinic for Cardiac Surgery, Heart Centre Leipzig, University of Leipzig, Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 372:115-24. 2005
    ..Additional simvastatin therapy did not reduce post-operative catecholamine consumption...
  41. ncbi request reprint Blunted cardiac responses to receptor activation in subjects with Thr164Ile beta(2)-adrenoceptors
    O E Brodde
    Department of Pharmacology, University of Halle, Germany
    Circulation 103:1048-50. 2001
    ..CONCLUSIONS: These data show that humans with the Ile164 genotype show blunted cardiac beta(2)-AR responsiveness, which may help explain the decreased survival of patients with this genotype in the setting of congestive heart failure...
  42. doi request reprint Activation of cardiomyocytes depending on their proximity to human bone marrow stem cells
    F Roeske
    Clinic for Cardiac Surgery, University of Leipzig, Leipzig, Germany
    Thorac Cardiovasc Surg 59:78-84. 2011
    ..Thus, a small number of BMC can affect a larger number of cardiomyocytes by activating an intracellular signaling cascade and enhancing β-adrenoceptor density...
  43. ncbi request reprint C0h/C2h monitoring of the pharmacodynamics of cyclosporin plus mycophenolate mofetil in human heart transplant recipients
    M J Barten
    University Leipzig, Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany
    Transplant Proc 37:1360-1. 2005
    ....
  44. doi request reprint Immunological monitoring of extracorporeal photopheresis after heart transplantation
    M T Dieterlen
    Department of Cardiac Surgery, Heart Center, University Hospital Leipzig, Leipzig, Germany
    Clin Exp Immunol 176:120-8. 2014
    ..We recommend a monitoring strategy that includes the quantification and analysis of T(regs), pDCs and the immune balance status before and up to 12 months after starting ECP...
  45. doi request reprint Cardiac fibroblasts inhibit β-adrenoceptor-dependent connexin43 expression in neonatal rat cardiomyocytes
    A Salameh
    Clinic for Paediatric Cardiology, University of Leipzig, Heart Centre, Struempellstr 39, 04289 Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 386:421-33. 2013
    ..Thus, our study indicates that cardiac fibroblasts inhibit β-adrenoceptor-dependent Cx43 signalling in CM involving angiotensin II...
  46. ncbi request reprint Epicardial treatment of atrial fibrillation using cryoablation in an acute off-pump sheep model
    N Doll
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    Thorac Cardiovasc Surg 51:267-73. 2003
    ..Irvine, California, USA) for linear epicardial treatment of atrial fibrillation in an acute off-pump sheep model...
  47. ncbi request reprint Aspects of the intercellular communication in aged hearts: effects of the gap junction uncoupler palmitoleic acid
    S Dhein
    Institute of Pharmacology, University of Halle, Magdeburger Strasse 4, 06097 Halle, Saale, Germany
    Naunyn Schmiedebergs Arch Pharmacol 364:397-408. 2001
    ..The functional age-dependent changes can be mimicked in young hearts by the gap junction uncoupler palmitoleic acid...
  48. ncbi request reprint Pharmacodynamics of the immunosuppressive effects of the combination of tacrolimus with mycophenolate mofetil
    M J Barten
    Leipzig Heartcenter, Department of Cardiac Surgery, University Leipzig, Leipzig, Germany
    Transplant Proc 34:2372-3. 2002
  49. ncbi request reprint Assessment of immunosuppression by lymphocyte functions in human blood
    M J Barten
    Department of Cardiac Surgery, Leipzig Heartcenter, University Leipzig, Leipzig, Germany
    Transplant Proc 34:2876-7. 2002
  50. pmc Fibrosis in left atrial tissue of patients with atrial fibrillation with and without underlying mitral valve disease
    A Boldt
    Heart Centre, Cardiovascular Surgery, University of Leipzig, Leipzig, Germany
    Heart 90:400-5. 2004
    ..To examine the hypothesis that major extracellular matrix (ECM) proteins are expressed differently in the left atrial tissue of patients in sinus rhythm (SR), lone atrial fibrillation (AF), and AF with underlying mitral valve disease (MVD)...
  51. ncbi request reprint Inositolphosphate formation in thoracic and abdominal rat aorta following Gq/11-coupled receptor stimulation
    S Dhein
    Institute of Pharmacology, University of Halle Wittenberg, Halle Saale, Germany
    Naunyn Schmiedebergs Arch Pharmacol 363:322-9. 2001
    ..ET-1 effects on IP formation are mediated by ETA-receptors and U 46619 effects by TP-receptors. NA effects are mediated by alpha1D- and alpha1A-adrenoceptors; alpha1B-adrenoceptors seem to play a minor role...
  52. ncbi request reprint Effects of autologous stem cells on immunohistochemical patterns and gene expression of metalloproteinases and their tissue inhibitors in doxorubicin cardiomyopathy in a rabbit model
    H Aupperle
    Institut für Veterinär Pathologie, An den Tierkliniken 33, 04103 Leipzig, Germany
    Vet Pathol 44:494-503. 2007
    ..MSCs injection into the LV resulted in marked differences of collagen content and MMP/TIMP expression in the whole heart, although significant numbers of living MSCs were not detected after 4 weeks...
  53. ncbi request reprint Chronic regulation of the expression of the gap junction protein connexin 43 in transfected HeLa cells
    A Salameh
    Medizinische Klinik I, Abteilung Kardiologie, Universitätsklinik Leipzig, Johannisallee 32, 04103 Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 368:33-40. 2003
    ..From these results we conclude that 1.Cx43 content can be regulated via AC/cAMP/PKA, PKC and TNF alpha-receptor-dependent pathways 2. Activation of p38 MAP kinase is a common pathway for regulation of Cx43 content in HeLa cells..
  54. ncbi request reprint Left ventricular reverse remodeling after surgical therapy for aortic stenosis: correlation to Renin-Angiotensin system gene expression
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Leipzig, Germany
    Circulation 106:I23-6. 2002
    ..Surgical therapy for aortic stenosis leads to reverse remodeling, with normalization of left ventricular hypertrophy (LVH). The aim of this study was to examine Renin-Angiotensin system (RAS) gene expression in this setting...
  55. doi request reprint Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43
    Aida Salameh
    Clinic for Pediatric Cardiology, University of Leipzig, Heart Centre, Struempellstr 39, 04289 Leipzig, Germany
    Circ Res 106:1592-602. 2010
    ..Cyclic mechanical stretch (CMS) is an important physiological and pathological factor in the heart...
  56. doi request reprint Functional, metabolic, and morphological aspects of continuous, normothermic heart preservation: effects of different preparation and perfusion techniques
    Jens Garbade
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Germany
    Tissue Eng Part C Methods 15:275-83. 2009
    ..The use of a lower perfusion pressure, as well as avoiding cardioplegia and hypothermia, led to significantly better and longer preservation of perfused hearts...
  57. ncbi request reprint Selective arterialization of a cardiac vein in a model of cardiac microangiopathy and macroangiopathy in sheep
    Michaela Elisabeth Resetar
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    J Thorac Cardiovasc Surg 133:1252-6. 2007
    ..We investigated the benefit of arterialization of a cardiac vein under these circumstances in an acute animal model...
  58. doi request reprint Human cardiac gap-junction coupling: effects of antiarrhythmic peptide AAP10
    Anja Hagen
    Clinic for Cardiac Surgery, University of Leipzig, Heart Centre, Strümpellstr 39, 04289 Leipzig, Germany
    Cardiovasc Res 83:405-15. 2009
    ....
  59. doi request reprint Cardiac gap junction channels are upregulated by metoprolol: an unexpected effect of beta-blockers
    Aida Salameh
    Clinic for Pediatric Cardiology, University of Leipzig, Leipzig, Germany
    Pharmacology 85:203-10. 2010
    ....
  60. doi request reprint Mechanical strain and the aortic valve: influence on fibroblasts, extracellular matrix, and potential stenosis
    Sven Lehmann
    Department for Heart Surgery, Universitat Leipzig, Heart Center, Leipzig, Germany
    Ann Thorac Surg 88:1476-83. 2009
    ..Mechanical strain may affect aortic valve cusp, leading to an altered extracellular matrix ultrastructure and eventually aortic stenosis. The aim of this study was to evaluate the affect of these potential relationships on human tissue...
  61. ncbi request reprint Role of the cardiac Na(+)/H(+)exchanger in [Ca(2+)](i)and [Na(+)](i)handling during intracellular acidosis. Effect of cariporide (Hoe 642)
    Aida Salameh
    Medizinische Klinik I, Abt Kardiologie, Universitat Leipzig, Johannisallee 32, 04103 Leipzig, Germany
    Pharmacol Res 45:35-41. 2002
    ..The effect of cariporide (Hoe 642) in intracellular acidosis seems to be based on antagonization of the rise in intracellular sodium rather than calcium in this model...
  62. doi request reprint Cardiac and electrophysiological effects of primary and refined extracts from Leonurus cardiaca L. (Ph.Eur.)
    Malte Ritter
    Clinic for Cardiac Surgery, University of Leipzig, Leipzig, Germany
    Planta Med 76:572-82. 2010
    ..Thus, LCRE acts on multiple electrophysiological targets, specifically I(Ca.L), I(K.r), and I(f), observed both at whole organ and single cell level...
  63. doi request reprint Bone marrow-derived stem cells attenuate impaired contractility and enhance capillary density in a rabbit model of Doxorubicin-induced failing hearts
    Jens Garbade
    Department of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Leipzig, Germany
    J Card Surg 24:591-9. 2009
    ..This study evaluates the effects of BMC transplantation on contractility and remote capillary density of doxorubicin-induced failing hearts...
  64. ncbi request reprint Pharmacodynamic monitoring of the immunosuppressive therapy in patients after heart transplantation: whole blood flow cytometric analysis of lymphocyte function
    Markus J Barten
    Department of Cardiac Surgery, University of Leipzig, Heart Center Leipzig, 04289 Leipzig, Germany
    Comput Biol Med 37:1367-73. 2007
    ..The information from both pharmacokinetic and pharmacodynamic monitoring has the potential to increase the efficacy and safety of individual immunosuppressive therapy after HTx...
  65. ncbi request reprint Cytokine analysis to predict immunosuppression
    Markus J Barten
    Department of Cardiac Surgery, University of Leipzig, Heart Center Leipzig, 04289 Leipzig, Germany
    Cytometry A 69:155-7. 2006
    ..However, there is still an incessant need to explore assay conditions and techniques of analyzing cytokines, which are specific and reliable for monitoring drug efficacy...
  66. ncbi request reprint Chronic regulation of the expression of gap junction proteins connexin40, connexin43, and connexin45 in neonatal rat cardiomyocytes
    Aida Salameh
    Medizinische Klinik I, Abteilung Kardiologie, Universitätsklinik Leipzig, Johannisallee 32, 04103 Leipzig, Germany
    Eur J Pharmacol 503:9-16. 2004
    ..This may contribute to the changes observed in heart failure with regard to the formation of an arrhythmogenic substrate...
  67. ncbi request reprint Morphological, electrophysiological and coupling characteristics of bone marrow-derived mononuclear cells-an in vitro-model
    Ardawan Julian Rastan
    Department of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 27:104-10. 2005
    ..However, it is unknown whether or not cardiomyocytes and BMCs can form functioning cell-to-cell coupling and develop adequate electrophysiological properties...
  68. ncbi request reprint Mycophenolic acid interaction with cyclosporine and tacrolimus in vitro and in vivo: evaluation of additive effects on rat blood lymphocyte function
    Markus J Barten
    University of Leipzig, Department of Cardiac Surgery, Heart Center Leipzig, Struempellstrasse 39, 04289 Leipzig, Germany
    Ther Drug Monit 27:123-31. 2005
    ....
  69. ncbi request reprint Sub-chronic nicotine exposure induces intercellular communication failure and differential down-regulation of connexins in cultured human endothelial cells
    Stephan Haussig
    Clinic for Cardiac Surgery, University of Leipzig, Heart Centre, Strümpellstr 39, D 04289 Leipzig, Germany
    Atherosclerosis 196:210-8. 2008
    ..Tobacco abuse is still among the most important cardiovascular risk factors in modern society. We investigated whether sub-chronic nicotine exposure can induce endothelial dysfunction and communication failure...
  70. ncbi request reprint Assessment of immunosuppressive drug interactions: inhibition of lymphocyte function in peripheral human blood
    Markus J Barten
    Department of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, 04289 Leipzig, Germany
    J Immunol Methods 283:99-114. 2003
    ..The assay also permits pharmacological analysis of drug interactions, which will lead to improved safety and therapeutic efficacy in transplanted patients...
  71. ncbi request reprint Agonist-independent alteration in beta-adrenoceptor-G-protein-adenylate cyclase system in an equine model of recurrent airway obstruction
    Getu Abraham
    Institute of Pharmacology, Pharmacy and Toxicology, Leipzig University, Germany
    Pulm Pharmacol Ther 19:218-29. 2006
    ....
  72. ncbi request reprint Fusion of bone marrow-derived stem cells with cardiomyocytes in a heterologous in vitro model
    Jens Garbade
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 28:685-91. 2005
    ..However, the identity of BMCs as true cardiomyocytes is still ambiguous. Therefore, we investigated the fate of transplanted fluorescence labeled BMCs and cardiomyocytes in co-culture...
  73. ncbi request reprint Pharmacology of gap junctions. New pharmacological targets for treatment of arrhythmia, seizure and cancer?
    Aida Salameh
    Clinic I for Internal Medicine, Department of Cardiology, University of Leipzig, Johannisallee 32, 04103 Leipzig, Germany
    Biochim Biophys Acta 1719:36-58. 2005
    ..GJIC can be affected acutely by changing gap junction conductance or--more chronic--by altering connexin expression and membrane localisation. This review gives an overview on drugs affecting GJIC...
  74. ncbi request reprint Comparing the ultrastructural effects of two different cardiac preparation- and perfusion-techniques in a porcine model of extracorporal long-term preservation
    Heike Aupperle
    Institute of Pathology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 33, 04103 Leipzig, Germany
    Eur J Cardiothorac Surg 31:214-21. 2007
    ..In heart transplantation a well-preserved myocardial ultrastructure is an important precondition for functional regeneration. Aim of the study is to optimize the conditions in this new established model of extracorporeal cardiac perfusion...
  75. ncbi request reprint Pharmacological and biochemical characterization of the beta-adrenergic signal transduction pathway in different segments of the respiratory tract
    Getu Abraham
    Faculty of Veterinary Medicine, Institute of Pharmacology, Pharmacy and Toxicology, Leipzig University, An den Tierkliniken 15, 04103 Leipzig, Germany
    Biochem Pharmacol 66:1067-81. 2003
    ..Thus, it is speculated that this could have important therapeutic consequences in beta-adrenoceptor agonist-induced receptor regulation in bronchial asthma...
  76. doi request reprint Opposing and synergistic effects of cyclic mechanical stretch and α- or β-adrenergic stimulation on the cardiac gap junction protein Cx43
    Aida Salameh
    Clinic for Paediatric Cardiology, University of Leipzig, Germany
    Pharmacol Res 62:506-13. 2010
    ..However, CMS and adrenergic stimulation differentially affected Cx43-protein/mRNA ratio and Cx43-phosphorylation...
  77. doi request reprint Adrenergic control of cardiac gap junction function and expression
    Aida Salameh
    Clinic for Paediatric Cardiology, Heart Centre, University of Leipzig, Strümpellstraße 39, 04289, Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 383:331-46. 2011
    ..They probably are involved in the formation of an arrhythmogenic substrate in certain heart diseases...
  78. ncbi request reprint Affects of immunosuppression on circulating dendritic cells: an adjunct to therapeutic drug monitoring after heart transplantation
    Markus J Barten
    University of Leipzig, Department of Cardiac Surgery, Heart Center Leipzig, 04289 Leipzig, Germany
    Int Immunopharmacol 6:2011-7. 2006
    ....
  79. ncbi request reprint Synergistic effects of sirolimus with cyclosporine and tacrolimus: analysis of immunosuppression on lymphocyte proliferation and activation in rat whole blood
    Markus J Barten
    University of Leipzig, Department of Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
    Transplantation 77:1154-62. 2004
    ....
  80. ncbi request reprint Muscarinic receptors in the mammalian heart
    S Dhein
    Institute of Pharmacology, University of Halle Wittenberg, Germany
    Pharmacol Res 44:161-82. 2001
    ..M-ChR are subject to regulation by G-protein-coupled-receptor kinase. Alterations of cardiac M(2)-ChR in age and various kinds of disease are discussed...
  81. ncbi request reprint Structural myocardial changes after coronary artery surgery
    F Eberhardt
    University of Cologne, University of Halle, Germany
    Eur J Clin Invest 30:938-46. 2000
    ..In the present study we sought to determine if and to what extent clinical, structural and histochemical evidence of myocardial changes associated with stunning could be found in patients after CABG and cold crystalloid cardioplegia...
  82. ncbi request reprint Dual mode of action of dihydropyridine calcium antagonists: a role for nitric oxide
    S Dhein
    Institute of Pharmacology, University of Halle, Germany
    Drugs 58:397-404. 1999
    ..In addition, NO release from both vascular endothelium and platelets may contribute to the antiatherosclerotic and antithrombotic effects described for certain dihydropyridines...
  83. ncbi request reprint Effect of chronic treatment with vitamin E on endothelial dysfunction in a type I in vivo diabetes mellitus model and in vitro
    S Dhein
    University of Leipzig, Heart Centre Leipzig, Clinic for Cardiac Surgery, Leipzig, Germany
    J Pharmacol Exp Ther 305:114-22. 2003
    ....
  84. ncbi request reprint Expression of angiotensin II receptors in human left and right atrial tissue in atrial fibrillation with and without underlying mitral valve disease
    Andreas Boldt
    University of Leipzig, Heart Center, Cardiovascular Surgery, Cardiology, Leipzig, Germany
    J Am Coll Cardiol 42:1785-92. 2003
    ..TIVES: We postulated a change of angiotensin II receptor subtype expression in patients with lone atrial fibrillation (AF) and AF with underlying mitral valve disease (MVD) both compared with sinus rhythm (SR)...
  85. doi request reprint Functional pathology of the ovaries and uteri of premature female piglets exposed to distinct amounts of zearalenone
    A Reischauer
    Institute of Veterinary Pathology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 33, D 04103, Leipzig
    Mycotoxin Res 21:143-6. 2005
    ..Nevertheless, compared to the group I, statistical analyses of all parameters investigated revealed significance only in the increased mitotic activity of muscle cells in the uterinelamina muscularis in treatment group V...
  86. ncbi request reprint In-vivo studies do not support a major functional role for the Gly389Arg beta 1-adrenoceptor polymorphism in humans
    R Buscher
    Institute of Pharmacology and Toxicology, University of Halle, Magdeburger Strasse 4, D 06097 Halle Saale, Germany
    Pharmacogenetics 11:199-205. 2001
    ..In conclusion, our data do not support the idea that the reduced responsiveness of Gly389 against agonist-induced stimulation observed in vitro is of major functional importance in vivo...
  87. ncbi request reprint Pharmacodynamics of sirolimus and cyclosporine combination therapy
    M J Barten
    Department of Cardiac Surgery, Leipzig Heartcenter, University Leipzig, Leipzig, Germany
    Transplant Proc 34:2878. 2002
  88. ncbi request reprint Segment-dependent expression of muscarinic acetylcholine receptors and G-protein coupling in the equine respiratory tract
    G Abraham
    Institute of Pharmacology, Pharmacy and Toxicology, Leipzig University, Leipzig
    Vet Res Commun 31:207-26. 2007
    ..These receptors might contribute to the pathogenesis of COPD in the horse and could provide potential drug targets for the therapeutic use of anticholinergics in this species...
  89. ncbi request reprint Effect of a beta 2-adrenoceptor stimulation on hyperglycemia-induced endothelial dysfunction
    Armin Kabat
    Institute for Pharmacology, University of Halle, Germany
    J Pharmacol Exp Ther 308:564-73. 2004
    ..We conclude that hyperglycemia in PAEC induces endothelial dysfunction with impaired nitric oxide release and that this can be prevented by beta(2)-adrenoceptor stimulation...
  90. ncbi request reprint Modeling of temperature mapping for quantitative dynamic infrared coronary angiography for intraoperative graft patency control
    Jens Garbade
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    J Thorac Cardiovasc Surg 131:1344-51. 2006
    ..The aim of this study was to develop a heat-transfer model for quantitative flow estimation in an experimental setup. The first clinical results in coronary artery bypass grafting are reported...
  91. ncbi request reprint L-arginine supplementation prevents the development of endothelial dysfunction in hyperglycaemia
    Armin Kabat
    Institute of Pharmacology, University of Halle, Faculty of Medicine, Halle, Germany
    Pharmacology 76:185-91. 2006
    ..L-Arginine utilisation may be impaired in hyperglycaemia and L-arginine supplementation might be an interesting additional therapeutic tool in diabetic patients...
  92. ncbi request reprint Rapid detection of the R389G polymorphism of ADRB1 by real time PCR using fluorescence resonance energy transfer
    Matthias Sauer
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Germany
    Clin Lab 55:128-36. 2009
    ..DNA sequencing confirmed a 100% concordance. This alternative technique is significantly less time consuming than traditional PCR-RFLP and facilitates the analysis of a large numbers of samples...
  93. ncbi request reprint Age-dependent changes of cardiac neuronal noradrenaline reuptake transporter (uptake1) in the human heart
    Kirsten Leineweber
    Institute of Pharmacology, Martin Luther University of Halle Wittenberg, Halle, Germany
    J Am Coll Cardiol 40:1459. 2002
    ..The purpose of this study was to elucidate whether the neuronal noradrenaline reuptake transporter (uptake1) undergoes age-dependent regulation in the human heart...
  94. doi request reprint The equine endometrosis: new insights into the pathogenesis
    Christine Hoffmann
    Institute of Pathology, University of Leipzig, Germany
    Anim Reprod Sci 111:261-78. 2009
    ..It can be concluded that the various types of endometrosis represent different stages in the fibrotic process, possibly leading to the destruction of the glands and subsequently resulting in the development of a stromal fibrosis...
  95. ncbi request reprint Changes in alpha(1)-adrenergic vascular reactivity in monocrotaline-treated rats
    Stefan Dhein
    Institute of Pharmacology, University of Halle Wittenberg, Magdeburger Strasse 4, 06097 Halle Saale, Germany
    Naunyn Schmiedebergs Arch Pharmacol 365:87-95. 2002
    ....
  96. ncbi request reprint Pharmacology of cardiovascular gap junctions
    Jean Claude Hervé
    Equipe, Interactions et Communications Cellulaires, IPBC, CNRS Université de Poitiers, Poitiers, France
    Adv Cardiol 42:107-31. 2006
    ..On the other hand, drugs affecting these mediators may influence GJ networking and may thus open new therapeutic horizons...
  97. ncbi request reprint Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts
    Wolfram Hubertus Zimmermann
    Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg Eppendorf, Germany
    Nat Med 12:452-8. 2006
    ..Thus, our study provides evidence that large contractile cardiac tissue grafts can be constructed in vitro, can survive after implantation and can support contractile function of infarcted hearts...
  98. ncbi request reprint Forming the network-gap junctions in the cardiovascular system
    Stefan Dhein
    Cardiovasc Res 62:225-7. 2004
  99. ncbi request reprint The influence of immunosuppressive drugs on T- and B-cell apoptosis via p53-mediated pathway in vitro and in vivo
    Andreas Boldt
    University of Leipzig Heart Center, Department of Cardiac Surgery and Cardiology, Germany
    Transplantation 82:422-7. 2006
    ..This study was designed to assess the effects of calcineurin and inosine-5-monophosphate-dehydrogenase inhibitors on p53-mediated-apoptosis in T- and B-cells in vitro and in human heart-transplanted recipients (HTx-R)...
  100. ncbi request reprint New, emerging roles for cardiac connexins. Mitochondrial Cx43 raises new questions
    Stefan Dhein
    Cardiovasc Res 67:179-81. 2005
  101. doi request reprint Neonatal rat cardiomyocytes show characteristics of nonhomotypic gap junction channels
    Jan Sebastian Schulte
    Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Munster, Munster, Germany
    Cell Commun Adhes 15:13-25. 2008
    ..In conclusion the authors assume the additional presence of heterotypic and possibly even heteromeric gap junction channels in neonatal rat cardiomyocytes...