Gunther Deuschl

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. doi request reprint Subthalamic neurostimulation for Parkinson's disease with early fluctuations: balancing the risks and benefits
    Gunther Deuschl
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Kiel Campus, Christian Albrechts University, Kiel, Germany Electronic address
    Lancet Neurol 12:1025-34. 2013
  2. pmc Mapping the EQ-5D index by UPDRS and PDQ-8 in patients with Parkinson's disease
    Judith Dams
    Department of Neurology, Philipps University, Marburg, Germany
    Health Qual Life Outcomes 11:35. 2013
  3. doi request reprint Stimulation of the subthalamic nucleus at an earlier disease stage of Parkinson's disease: concept and standards of the EARLYSTIM-study
    Gunther Deuschl
    Department of Neurology, Universitatsklinikum Schleswig Holstein, Christian Albrechts University, Kiel, Germany
    Parkinsonism Relat Disord 19:56-61. 2013
  4. pmc Can Zipf's law be adapted to normalize microarrays?
    Tim Lu
    Department of Medicine, Christian Albrechts University, Kiel, Germany
    BMC Bioinformatics 6:37. 2005
  5. ncbi request reprint Deep brain stimulation for tremor [correction of trauma]: patient selection and evaluation
    Gunther Deuschl
    Department of Neurology, Christian Albrechts University Kiel, Germany
    Mov Disord 17:S102-11. 2002
  6. doi request reprint Essential tremor--neurodegenerative or nondegenerative disease towards a working definition of ET
    Gunther Deuschl
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 24:2033-41. 2009
  7. ncbi request reprint Deep-brain stimulation for Parkinson's disease
    G Deuschl
    Department of Neurology, Christian Albrechts Universitat Kiel, Niemannsweg 147, 24105 Kiel, Germany
    J Neurol 249:III/36-9. 2002
  8. ncbi request reprint A randomized trial of deep-brain stimulation for Parkinson's disease
    Gunther Deuschl
    Christian Albrechts University, Kiel, Germany
    N Engl J Med 355:896-908. 2006
  9. ncbi request reprint Deep brain stimulation of the subthalamic nucleus for Parkinson's disease: a therapy approaching evidence-based standards
    G Deuschl
    Department of Neurology, Christian Albrechts Universitat Kiel, Niemannsweg 147, 24105 Kiel, Germany
    J Neurol 250:I43-6. 2003
  10. ncbi request reprint Deep brain stimulation: postoperative issues
    Gunther Deuschl
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 21:S219-37. 2006

Detail Information

Publications159 found, 100 shown here

  1. doi request reprint Subthalamic neurostimulation for Parkinson's disease with early fluctuations: balancing the risks and benefits
    Gunther Deuschl
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Kiel Campus, Christian Albrechts University, Kiel, Germany Electronic address
    Lancet Neurol 12:1025-34. 2013
    ..As mobility is consistently improved during the times with poor mobility by reducing fluctuations and delaying levodopa-sensitive complications, we propose that this treatment changes the disease course. ..
  2. pmc Mapping the EQ-5D index by UPDRS and PDQ-8 in patients with Parkinson's disease
    Judith Dams
    Department of Neurology, Philipps University, Marburg, Germany
    Health Qual Life Outcomes 11:35. 2013
    ..We aimed to develop an estimation algorithm for EuroQol- 5 dimensions (EQ-5D)-based utilities from the clinical UPDRS or disease-specific HrQoL data in the absence of original utilities estimates...
  3. doi request reprint Stimulation of the subthalamic nucleus at an earlier disease stage of Parkinson's disease: concept and standards of the EARLYSTIM-study
    Gunther Deuschl
    Department of Neurology, Universitatsklinikum Schleswig Holstein, Christian Albrechts University, Kiel, Germany
    Parkinsonism Relat Disord 19:56-61. 2013
    ....
  4. pmc Can Zipf's law be adapted to normalize microarrays?
    Tim Lu
    Department of Medicine, Christian Albrechts University, Kiel, Germany
    BMC Bioinformatics 6:37. 2005
    ..A computationally simple and intuitively appealing technique based on this observation is presented...
  5. ncbi request reprint Deep brain stimulation for tremor [correction of trauma]: patient selection and evaluation
    Gunther Deuschl
    Department of Neurology, Christian Albrechts University Kiel, Germany
    Mov Disord 17:S102-11. 2002
    ..The patient needs to be well informed about his individual risk-benefit ratio and of alternative treatments, before undergoing stereotactic surgery...
  6. doi request reprint Essential tremor--neurodegenerative or nondegenerative disease towards a working definition of ET
    Gunther Deuschl
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 24:2033-41. 2009
    ..Lacking such a standard, we propose a subclassification of ET into three categories: hereditary ET, sporadic ET, and senile ET, which we believe will help researchers resolve many of the controversies in this field...
  7. ncbi request reprint Deep-brain stimulation for Parkinson's disease
    G Deuschl
    Department of Neurology, Christian Albrechts Universitat Kiel, Niemannsweg 147, 24105 Kiel, Germany
    J Neurol 249:III/36-9. 2002
    ..However, prospective studies for this procedure are lacking and some clinical problems may be more easily solved with targeting the internal pallidum or the thalamus. Despite major progress in this field, much work remains to be done...
  8. ncbi request reprint A randomized trial of deep-brain stimulation for Parkinson's disease
    Gunther Deuschl
    Christian Albrechts University, Kiel, Germany
    N Engl J Med 355:896-908. 2006
    ..Neurostimulation of the subthalamic nucleus reduces levodopa-related motor complications in advanced Parkinson's disease. We compared this treatment plus medication with medical management...
  9. ncbi request reprint Deep brain stimulation of the subthalamic nucleus for Parkinson's disease: a therapy approaching evidence-based standards
    G Deuschl
    Department of Neurology, Christian Albrechts Universitat Kiel, Niemannsweg 147, 24105 Kiel, Germany
    J Neurol 250:I43-6. 2003
    ..Further studies should specifically address the questions of efficacy and side effects as well as the impact on quality of life...
  10. ncbi request reprint Deep brain stimulation: postoperative issues
    Gunther Deuschl
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 21:S219-37. 2006
    ..The report has been endorsed by the Scientific Issues Committee of the Movement Disorder Society and the American Society of Stereotactic and Functional Neurosurgery...
  11. doi request reprint The phenomenology of parkinsonian tremor
    Gunther Deuschl
    Department of Neurology, Christian Albrechts University Kiel, Germany
    Parkinsonism Relat Disord 18:S87-9. 2012
    ..Several differential diagnoses like rest tremor in ET, dystonic tremor, psychogenic tremor and Holmes' tremor may be misinterpreted as PD-tremor. Tests and clinical clues to separate them are presented...
  12. ncbi request reprint Dystonic tremor
    G Deuschl
    Department of Neurology, Christian Albrechts University Kiel, Germany
    Rev Neurol (Paris) 159:900-5. 2003
    ..The pathophysiology is unknown. Reciprocal inhibition and other inhibitory reflex pathways at various levels seem to be reduced at least in some cases with dystonic tremors...
  13. doi request reprint [Parkinson's disease - the future of invasive therapy]
    G Deuschl
    Neurologische Klinik der Christian Albrechts Universität zu Kiel, Kiel
    Fortschr Neurol Psychiatr 78:S16-9. 2010
    ..Further promising interventions for invasive therapy of Parkinson's disease are transplantation of foetal cells and stem cells, gene therapy and the use of duo-dopa and apomorhine...
  14. doi request reprint Treatment of patients with essential tremor
    Gunther Deuschl
    Department of Neurology, Christian Albrechts University Kiel, Kiel, Germany
    Lancet Neurol 10:148-61. 2011
    ..Better drugs are needed, and controlled trials are required to determine the safety and efficacy of DBS in the nucleus ventrointermedius and neighbouring subthalamic structures...
  15. ncbi request reprint Pathophysiology of nonparkinsonian tremors
    Gunther Deuschl
    Department of Neurology, Christian Albrechts Universitat, Kiel, Germany
    Mov Disord 17:S41-8. 2002
    ..Unlike the case of Parkinson's disease, functional neurosurgery of nonparkinsonian tremors is not yet based on a solid pathophysiological background...
  16. ncbi request reprint Clinical spectrum and physiology of palatal tremor
    Gunther Deuschl
    Department of Neurology, Christian Albrechts University Kiel, Kiel, Germany
    Mov Disord 17:S63-6. 2002
  17. ncbi request reprint Essential tremor and cerebellar dysfunction clinical and kinematic analysis of intention tremor
    G Deuschl
    Department of Neurology, Christian Albrechts University of Kiel, Germany
    Brain 123:1568-80. 2000
    ..ET(IT) patients have abnormalities of their upper limb function compatible with cerebellar disease. This suggests that patients with more advanced ET show abnormalities of cerebellar functions...
  18. ncbi request reprint The pathophysiology of tremor
    G Deuschl
    Department of Neurology, Christian Albrechts Universitat, Niemannsweg 147, D 24105 Kiel, Germany
    Muscle Nerve 24:716-35. 2001
    ..Modern neurology needs to develop and test such hypotheses, because this is the only way to develop rational medical and surgical therapies...
  19. pmc Spontaneous and reflex activity of facial muscles in dystonia, Parkinson's disease, and in normal subjects
    G Deuschl
    Department of Neurology, University of Kiel, Germany
    J Neurol Neurosurg Psychiatry 64:320-4. 1998
    ..The present study was undertaken to collect data on the age dependent development of this index and on possible abnormalities in Parkinson's disease and dystonia...
  20. ncbi request reprint [Therapy of Parkinson's disease 2008]
    G Deuschl
    Klinik fur Neurologie, UK SH, Campus Kiel
    MMW Fortschr Med 150:60-3. 2008
  21. ncbi request reprint Efficacy and tolerability of Entacapone versus Cabergoline in parkinsonian patients suffering from wearing-off
    Gunther Deuschl
    Department of Neurology, Christian Albrechts Universitat, Kiel, Germany
    Mov Disord 22:1550-5. 2007
    ..ENT and CBG reduced the patient's motor complications effectively and to a similar degree. The clinical benefit was more quickly apparent with ENT, which also showed a more favorable AE profile than CBG...
  22. ncbi request reprint Tremor
    G Deuschl
    Department of Neurology, Christian Albrechts Universitat, Kiel, Germany
    Curr Opin Neurol 13:437-43. 2000
    ..Gabapentine has been assessed for efficacy in some tremors, and deep brain stimulation of the ventrolateral thalamus has been shown to be safer and more effective for severe essential and parkinsonian tremor than thalamotomy...
  23. ncbi request reprint The pathophysiology of parkinsonian tremor: a review
    G Deuschl
    Department of Neurology, Christian Albrechts Universitat Kiel
    J Neurol 247:V33-48. 2000
    ..Assuming the oscillator within the basal ganglia pathway, the mechanism of stereotactic surgery might be a desynchronization of the activity of the basal ganglia-thalamo-cortical or the cerebello-thalamo-cortical pathway...
  24. ncbi request reprint Corticomuscular coherence in the 6-15 Hz band: is the cortex involved in the generation of physiologic tremor?
    Jan Raethjen
    Department of Neurology, University of Kiel, Niemannsweg 147, 24105 Kiel, Germany
    Exp Brain Res 142:32-40. 2002
    ..We conclude that cortical networks are involved in the generation of physiologic tremor...
  25. ncbi request reprint Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements
    Roland Wenzelburger
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 18:1162-9. 2003
    ..Other akinesia items and the time for build-up of lifting force were equally improved in both conditions. This suggests that routine STN-DBS might not be equally effective on all aspects of fine motor functions...
  26. ncbi request reprint Dyskinesias and grip control in Parkinson's disease are normalized by chronic stimulation of the subthalamic nucleus
    Roland Wenzelburger
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Ann Neurol 52:240-3. 2002
    ..Grip force overflow is a promising parameter to study the desensitizing effect of chronic deep-brain stimulation on levodopa-induced dyskinesias...
  27. ncbi request reprint Improved sensory gating of urinary bladder afferents in Parkinson's disease following subthalamic stimulation
    Jan Herzog
    Department of Neurology, Christian Albrechts University Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
    Brain 131:132-45. 2008
    ..Furthermore, this is the first imaging study, which shows an effect of STN-DBS on sensory gating in PD patients and its neural basis...
  28. doi request reprint Is improvement in the quality of life after subthalamic nucleus stimulation in Parkinson's disease predictable?
    Christine Daniels
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 26:2516-21. 2011
    ..Improvement in QoL after STN-DBS is also correlated with changes in motor functions and changes in depression and anxiety...
  29. doi request reprint Negative impact of borderline global cognitive scores on quality of life after subthalamic nucleus stimulation in Parkinson's disease
    Karsten Witt
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Neurol Sci 310:261-6. 2011
    ....
  30. ncbi request reprint Differential effects of L-dopa and subthalamic stimulation on depressive symptoms and hedonic tone in Parkinson's disease
    Karsten Witt
    Department of Neurology, University Schleswig Holstein, Kiel, Germany
    J Neuropsychiatry Clin Neurosci 18:397-401. 2006
    ..These results demonstrate a single dissociation of depressive symptoms and anhedonia in response to an acute L-dopa and STN-stimulation challenge...
  31. ncbi request reprint Time delay and partial coherence analyses to identify cortical connectivities
    R B Govindan
    Department of Neurology, Christian Albrechts University of Kiel, Schittenhelmstrasse 10, D 24105, Kiel, Germany
    Biol Cybern 94:262-75. 2006
    ..Biologically plausible cortico-muscular and cortico-cortical connections are identified by these methods...
  32. doi request reprint Relation of lead trajectory and electrode position to neuropsychological outcomes of subthalamic neurostimulation in Parkinson's disease: results from a randomized trial
    Karsten Witt
    Department of Neurology, Kiel University, Kiel, Germany
    Brain 136:2109-19. 2013
    ..This study also stresses the importance of precise positioning of the active stimulating contact within the subthalamic volume to avoid adverse effects on semantic verbal fluency and response inhibition. ..
  33. doi request reprint Stimulation site within the MRI-defined STN predicts postoperative motor outcome
    Fritz Wodarg
    Department of Neurology, Christian Albrechts University Kiel, Kiel, Germany
    Mov Disord 27:874-9. 2012
    ..Precise targeting of the lateral region of the STN is essential for achieving sufficient stimulation efficacy. Preoperative T2-weighted MRI might be a useful component of the targeting procedure to improve the outcome of PD patients...
  34. doi request reprint The atypical subthalamic nucleus--an anatomical variant relevant for stereotactic targeting
    Rene Reese
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 27:544-8. 2012
    ..The improvement of PD motor symptoms by DBS of the STN depends on exact targeting...
  35. doi request reprint Gait ataxia in essential tremor is differentially modulated by thalamic stimulation
    Alfonso Fasano
    Department of Neurology, Christian Albrechts University, 24105 Kiel, Germany
    Brain 133:3635-48. 2010
    ....
  36. doi request reprint Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study
    Karsten Witt
    Christian Albrechts University, Kiel, Germany
    Lancet Neurol 7:605-14. 2008
    ..To assess the neuropsychiatric consequences of DBS in patients with PD we did an ancillary protocol as part of a randomised study that compared DBS with the best medical treatment...
  37. doi request reprint Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease
    Christine Daniels
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 25:1583-9. 2010
    ....
  38. doi request reprint Cortical correlates of the basic and first harmonic frequency of Parkinsonian tremor
    Jan Raethjen
    Department of Neurology, University of Kiel, Schittenhelmstr 10, 24105 Kiel, Germany
    Clin Neurophysiol 120:1866-72. 2009
    ..It has been hypothesized that the basic and first harmonic frequency of Parkinsonian tremor are somewhat independent oscillations the biological basis of which remains unclear...
  39. ncbi request reprint Kinematic analysis of thalamic versus subthalamic neurostimulation in postural and intention tremor
    Jan Herzog
    Department of Neurology, Christian Albrechts University Kiel, Germany
    Brain 130:1608-25. 2007
    ..The better efficacy of stimulation within the STA compared to thalamus proper favours the concept of a modulation of cerebello-thalamic projections underlying the improvement of these symptoms...
  40. doi request reprint Influence of deep brain stimulation and levodopa on sensory signs in Parkinson's disease
    Janne Gierthmühlen
    Department of Neurology, Division of Neurological Pain Research and Therapy, Universitatsklinikum Schleswig Holstein, Kiel, Germany
    Mov Disord 25:1195-202. 2010
    ....
  41. doi request reprint Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs
    Monika Pötter-Nerger
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Neurophysiol 102:3180-90. 2009
    ..These results provide evidence for a homeostatic response pattern in the human M1(HAND) that integrates acute plastic changes evoked through different "input channels."..
  42. doi request reprint Manual activity shapes structure and function in contralateral human motor hand area
    Oliver Granert
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Neuroimage 54:32-41. 2011
    ..This bi-directional structural plasticity is functionally relevant as local grey matter changes are mirrored by changes in regional excitability...
  43. ncbi request reprint Most effective stimulation site in subthalamic deep brain stimulation for Parkinson's disease
    Jan Herzog
    Department of Neurology, Christian Albrechts Universitat Kiel, Germany
    Mov Disord 19:1050-4. 2004
    ..g., zona incerta, were significantly less effective. We suggest that the dorsolateral STN border should be covered by STN-DBS...
  44. ncbi request reprint Two-year follow-up of subthalamic deep brain stimulation in Parkinson's disease
    Jan Herzog
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 18:1332-7. 2003
    ..The current series demonstrates efficacy and safety of STN-DBS beyond the first year after surgical procedure. Complications of STN-DBS comprise a wide range of psychiatric adverse events which, however, were temporary...
  45. ncbi request reprint Is the rhythm of physiological tremor involved in cortico-cortical interactions?
    Jan Raethjen
    Department of Neurology, University of Kiel, Kiel, Germany
    Mov Disord 19:458-65. 2004
    ..We conclude that the cortical correlates of physiological tremor may be involved in linking different cortical motor centers and might therefore play a role in cortical motor planning...
  46. ncbi request reprint Manic episode with psychotic symptoms induced by subthalamic nucleus stimulation in a patient with Parkinson's disease
    Jan Herzog
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 18:1382-4. 2003
    ..A manic episode with psychotic symptoms induced by STN-DBS occurred in a previously psychiatrically healthy patient, focusing on the role of STN-DBS in influencing not only motor but also emotional behaviour...
  47. doi request reprint LINGO1 polymorphisms are associated with essential tremor in Europeans
    Sandra Thier
    Department of Neurology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Mov Disord 25:717-23. 2010
    ..Our study gives further evidence that LINGO1 acts as a susceptibility gene for ET...
  48. doi request reprint Influence of subthalamic deep brain stimulation versus levodopa on motor perseverations in Parkinson's disease
    Jan Herzog
    Department of Neurology, Christian Albrechts University, Schittenhelmstr 10, Kiel, Germany
    Mov Disord 24:1206-10. 2009
    ..7 +/- 2.6 (P < 0.001) whereas levodopa had no impact (R(2) reduction 3.7 +/- 1.6, P = 0.081). This demonstrates that STN-DBS, by reducing motor perseveration, influences higher order aspects of motor behavior of patients with PD...
  49. doi request reprint Cortical representation of rhythmic foot movements
    Jan Raethjen
    Department of Neurology, University of Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
    Brain Res 1236:79-84. 2008
    ..A similar cortical contribution may be important also for gait control in humans...
  50. doi request reprint LINGO1 is not associated with Parkinson's disease in German patients
    Stephan Klebe
    Department of Neurology, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 3, Kiel, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:1173-8. 2010
    ..SNPs in the LINGO1 gene associated with ET could not be shown to be associated with PD in our study population, despite a postulated overlap between both diseases...
  51. ncbi request reprint Feedback-based versus observational classification learning in healthy aging and Parkinson's disease
    Julia Schmitt-Eliassen
    Department of Neurology, University Medical Center Schleswig Holstein, Campus Kiel, Kiel, Germany
    Brain Res 1142:178-88. 2007
    ..This finding questions the general role of the striatum in feedback-based learning and demonstrates that healthy aging particularly affects feedback-based learning...
  52. doi request reprint Botulinum neurotoxin treatment improves force regulation in writer's cramp
    Kirsten E Zeuner
    Department of Neurology, Kiel University, Neurozentrum, Arnold Heller Strasse 3, Haus 41, 24105 Kiel, Germany
    Parkinsonism Relat Disord 19:611-6. 2013
    ..In conclusion, force regulation was disturbed in patients and improved after BoNT treatment. This is not compatible with a simple muscle weakening and might thus reflect improved sensorimotor integration...
  53. ncbi request reprint Prevalence of gait disorders in hospitalized neurological patients
    Henning Stolze
    Department of Neurology, Universitatsklinikum Kiel, Kiel, Germany
    Mov Disord 20:89-94. 2005
    ..A decline of cognitive function was accompanied by a reduction of walking speed. According to these results, gait disorders are among the most frequent symptoms in neurology...
  54. ncbi request reprint Deep brain stimulation of the subthalamic nucleus improves cognitive flexibility but impairs response inhibition in Parkinson disease
    Karsten Witt
    Department of Neurology, Christian Albrechts University Kiel, Kiel, Germany
    Arch Neurol 61:697-700. 2004
    ....
  55. doi request reprint Subcortical substrates of TMS induced modulation of the cortico-cortical connectivity
    Sergiu Groppa
    Department of Neurology, Christian Albrechts University, Schittenhelmstr 10, Kiel 24105, Germany
    Brain Stimul 6:138-46. 2013
    ..g. the alpha rhythm. It has been hypothesized that this effect is not limited to the stimulated region but involves subcortical and distant cortical areas...
  56. doi request reprint Continuous theta-burst stimulation of the primary motor cortex in essential tremor
    Helge Hellriegel
    Department of Neurology, Christian Albrechts University Kiel, Germany
    Clin Neurophysiol 123:1010-5. 2012
    ..We investigated whether essential tremor (ET) can be altered by suppressing the corticospinal excitability in the primary motor cortex (M1) with transcranial magnetic stimulation...
  57. pmc Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease
    Janne Ludwig
    Division of Neurological Pain Research and Therapy, University of Kiel, Kiel, Germany
    J Neurol Neurosurg Psychiatry 78:742-5. 2007
    ..Since less pharmacotherapy is needed after STN stimulation, reduced levodopa intake results in relative improvement of autonomic function in deep brain stimulated PD patients...
  58. doi request reprint Cost-effectiveness of deep brain stimulation in patients with Parkinson's disease
    Judith Dams
    Department of Neurology, Philipps University Marburg, Marburg, Germany
    Mov Disord 28:763-71. 2013
    ..Our data support adopting and reimbursing deep brain stimulation within the German health care system...
  59. ncbi request reprint Falls in frequent neurological diseases--prevalence, risk factors and aetiology
    Henning Stolze
    Department of Neurology, Universitatsklinikum Kiel, Niemannsweg 147, 24105 Kiel, Germany
    J Neurol 251:79-84. 2004
    ..Falls in neurological patients are particularly linked to medication and disorders affecting gait and balance...
  60. doi request reprint White matter microstructural changes of thalamocortical networks in photosensitivity and idiopathic generalized epilepsy
    Sergiu Groppa
    Department of Neurology, University Hospital Schleswig Holstein, University of Kiel, Kiel, Germany
    Epilepsia 53:668-76. 2012
    ..Recent studies revealed a functional network consisting of occipital, parietal, and precentral areas that might be implicated in PPR. Herein, we investigate the microstructural changes associated with PPR...
  61. doi request reprint Motor re-training does not need to be task specific to improve writer's cramp
    Kirsten E Zeuner
    Department of Neurology, Christian Albrechts University Kiel, Kiel, Germany
    Mov Disord 23:2319-27. 2008
    ..We conclude that re-training does not need to specifically focus on the task affected by dystonia to be clinically effective...
  62. doi request reprint Modulation of gait coordination by subthalamic stimulation improves freezing of gait
    Alfonso Fasano
    Departments of Neurology and Neurosurgery, Christian Albrechts University, Kiel, Germany
    Mov Disord 26:844-51. 2011
    ..This identifies poor leg coordination as a risk factor for causing freezing of gait...
  63. doi request reprint Subthalamic deep brain stimulation increases pallidal firing rate and regularity
    Rene Reese
    Department of Neurology, University Hospitals Schleswig Holstein, Kiel, Germany
    Exp Neurol 229:517-21. 2011
    ..The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD...
  64. pmc Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: evaluation of active electrode contacts
    W Hamel
    Department of Neurosurgery, Christian Albrechts University, Kiel, Germany
    J Neurol Neurosurg Psychiatry 74:1036-46. 2003
    ..The site of permanent stimulation is the subject of ongoing debate, as stimulation both within and adjacent to the subthalamic nucleus may be effective...
  65. doi request reprint Subthalamic nucleus stimulation restores corticospinal facilitation in Parkinson's disease
    Monika Pötter-Nerger
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 23:2210-5. 2008
    ..01). STN-HFS restores the normal facilitatory drive of a transcranially evoked motor cortical response to the spinal motoneuron pool. In addition to subcortical routes, STN-DBS also alters spinal excitability via transcortical pathways...
  66. ncbi request reprint Subthalamic stimulation modulates cortical control of urinary bladder in Parkinson's disease
    Jan Herzog
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Brain 129:3366-75. 2006
    ..The data suggest that STN-DBS ameliorates bladder dysfunction and that this modulation may result from facilitated processing of afferent bladder information...
  67. pmc Transient filament occlusion of the middle cerebral artery in rats: does the reperfusion method matter 24 hours after perfusion?
    Jian Ren Liu
    Department of Neurology, University of Schleswig Holstein, Campus Kiel, Christian Albrechts University Kiel, Kiel, Germany
    BMC Neurosci 13:154. 2012
    ..Of the two methods, UNICAR is easier to perform. This study was designed to comprehensively compare the two reperfusion methods to determine if there are any differences in outcomes...
  68. doi request reprint Neuronal networks in west syndrome as revealed by source analysis and renormalized partial directed coherence
    Natia Japaridze
    Department of Neuropediatrics, Pediatric Hospital, Christian Albrechts University, Kiel, Germany
    Brain Topogr 26:157-70. 2013
    ..This study supports the theory that hypsarrhythmia results from ascending brainstem pathways that project widely to basal ganglia and cerebral cortex...
  69. doi request reprint Provocation of Parkinsonian tremor
    Jan Raethjen
    Department of Neurology, University of Kiel, Schittenhelmstr 10, Kiel, Germany
    Mov Disord 23:1019-23. 2008
    ..We therefore suggest that each assessment of Parkinsonian rest tremor should include a systematic provocation and this should be formally included in future versions of the UPDRS...
  70. doi request reprint Effect of cabergoline on parkinsonian tremor assessed by long-term actigraphy
    Sabine Binder
    Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 10, Kiel, Germany
    Eur Neurol 61:149-53. 2009
    ..One reason is the substantial fluctuation of tremor severity over time, which is difficult to capture and may render momentary clinical assessments unreliable...
  71. doi request reprint Impact of subthalamic stimulation and medication on proximal and distal bradykinesia in Parkinson's disease
    M Pötter-Nerger
    Department of Neurology, Christian Albrecht University, Kiel, Germany
    Eur Neurol 62:114-9. 2009
    ..To evaluate the usefulness of a new instrument for bedside testing of proximal arm and distal finger tapping performance in patients with Parkinson's disease (PD)...
  72. pmc Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor
    Sandra Thier
    Department of Neurology, University Hospital Schleswig Holstein, Kiel, Germany
    Neurology 79:243-8. 2012
    ..Despite high heritability, the genetic determinants of ET are largely unknown. We performed the second genome-wide association study (GWAS) for ET to elucidate genetic risk factors of ET...
  73. doi request reprint Deep brain stimulation in Parkinson's disease following fetal nigral transplantation
    Jan Herzog
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 23:1293-6. 2008
    ..These findings, based on two case reports, highlight the pivotal role of the GPi in mediating dyskinesia-related neural activity within the basal ganglia loop...
  74. ncbi request reprint The motor system shows adaptive changes in complex regional pain syndrome
    Christian Maihofner
    Department of Neurology, Institute for Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    Brain 130:2671-87. 2007
    ..In summary, the results of this study suggest that substantial adaptive changes within the central nervous system may contribute to motor symptoms in CRPS...
  75. doi request reprint Camptocormia in idiopathic Parkinson's disease: a focal myopathy of the paravertebral muscles
    Nils G Margraf
    Department of Neurology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Mov Disord 25:542-51. 2010
    ..The cause of camptocormia in idiopathic PD is a focal myopathy. Our findings suggest that the myopathy has a progressive course, which finally leads to degeneration of the paravertebral muscles...
  76. pmc Associative stimulation of the supraorbital nerve fails to induce timing-specific plasticity in the human blink reflex
    Kirsten E Zeuner
    Department of Neurology, Christian Albrechts University Kiel, Kiel, Germany
    PLoS ONE 5:e13602. 2010
    ....
  77. doi request reprint Effects of deep brain stimulation of the cerebellothalamic pathways on the sense of smell
    M Kronenbuerger
    Department of Neurology, Medical Faculty, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Exp Neurol 222:144-52. 2010
    ..We propose that the impairment of the odor threshold with DBS is related to effects on an olfacto-motor loop, while disturbed odor discrimination may be related to effects of DBS on short-term memory...
  78. ncbi request reprint Selective affection of hippocampal CA-1 neurons in patients with transient global amnesia without long-term sequelae
    T Bartsch
    Department of Neurology, University Hospital Schleswig Holstein Kiel, Germany
    Brain 129:2874-84. 2006
    ..The TGA can be considered a model for a focal transient perturbation of memory circuits in the temporo-mesial region...
  79. pmc Source analysis of beta-synchronisation and cortico-muscular coherence after movement termination based on high resolution electroencephalography
    Muthuraman Muthuraman
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    PLoS ONE 7:e33928. 2012
    ..Whereas PMBS seems to reset the supraspinal sensorimotor network, cortico-muscular coherence may represent the recalibration of cortico-motoneuronal and spinal systems...
  80. doi request reprint A clinical test for the alcohol sensitivity of essential tremor
    Karina Knudsen
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 26:2291-5. 2011
    ..Here we describe the controlled measurements of tremor severity after alcohol ingestion and the practicability of using it as a home test...
  81. doi request reprint A new diagnostic test to distinguish tremulous Parkinson's disease from advanced essential tremor
    Muthuraman Muthuraman
    Department of Neurology, University of Kiel, Kiel, Germany
    Mov Disord 26:1548-52. 2011
    ..Clinical distinction between advanced essential tremor and tremulous Parkinson's disease can be difficult...
  82. doi request reprint The oscillating central network of Essential tremor
    Jan Raethjen
    Department of Neurology, University of Kiel, University Hospital Schleswig Holstein, Campus Kiel, Schittenhelmstr 10, 24105 Kiel, Germany
    Clin Neurophysiol 123:61-4. 2012
    ..And this may be the basis for the selective effect of deep brain stimulation on tremor...
  83. doi request reprint Subthreshold depression in Parkinson's disease
    Julia Reiff
    Department of Psychiatry, Zentrum für Integrative Psychiatrie, Kiel, Germany
    Mov Disord 26:1741-4. 2011
    ..Quality of life in Parkinson patients with subthreshold depression could be improved if the prevalence and symptom profile were better understood...
  84. doi request reprint Evaluation of a screening instrument for essential tremor
    Delia Lorenz
    Department of Neurology, Christian Albrechts University Kiel, Germany
    Mov Disord 23:1006-12. 2008
    ..We present an easy to use and reliable screening instrument that is effective to identify patients with ET but not able to exclude patients with other tremor forms...
  85. ncbi request reprint Cortical involvement in the generation of essential tremor
    Jan Raethjen
    Dept of Neurology, University of Kiel, 24105 Kiel, Germany
    J Neurophysiol 97:3219-28. 2007
    ..Thus the tremor rhythm is intermittently relayed only in different cortical motor areas. We hypothesize that tremor oscillations build up in different subcortical and subcortico-cortical circuits only temporarily entraining each other...
  86. ncbi request reprint Eye-hand coordination in essential tremor
    Peter Trillenberg
    Department of Neurology, University Hospital of Schleswig Holstein, Lubeck, Germany
    Mov Disord 21:373-9. 2006
    ..These changes might be related to cerebellar disease but they are independent of the intention tremor component and saccade performance...
  87. ncbi request reprint The impact of normal aging and Parkinson's disease on response preparation in task-switching behavior
    Karsten Witt
    Department of Neurology, University Medical Center Schleswig Holstein Campus Kiel, Schittenhelmstrasse 10, D 24105 Kiel, Germany
    Brain Res 1114:173-82. 2006
    ..This argues for different mechanisms that underlie the changes in task-switching behavior in healthy aging and PD...
  88. doi request reprint Neuronal activity of the human subthalamic nucleus in the parkinsonian and nonparkinsonian state
    F Steigerwald
    Department of Neurology, Christian Albrechts Universitat Kiel, Schittenhelmstr 10, D 24105 Kiel, Germany
    J Neurophysiol 100:2515-24. 2008
    ..In addition, they emphasize abnormalities in the patterning and dynamics of neuronal discharges in the parkinsonian STN, which support current concepts of abnormal motor loop oscillations in Parkinson's disease...
  89. doi request reprint Accuracy and distortion of deep brain stimulation electrodes on postoperative MRI and CT
    M O Pinsker
    Department of Neurosurgery, UK SH, Kiel, Germany
    Zentralbl Neurochir 69:144-7. 2008
    ..The goal of this study was to determine the relation and size of these artefacts to the electrodes by comparing the position of the electrodes in postoperative MR and CT imaging...
  90. ncbi request reprint Gait analysis of sporadic and hereditary spastic paraplegia
    S Klebe
    Neurologische Klinik, Christian Albrechts Universitat, Niemannsweg 147, 24105, Kiel, Germany
    J Neurol 251:571-8. 2004
    ..Spastic paraparesis is the major and most disabling clinical symptom and was assessed with gait analysis using a three-dimensional infrared movement analysis system...
  91. ncbi request reprint Effects of bilateral subthalamic nucleus stimulation on parkinsonian gait
    H Stolze
    Department of Neurology, , Germany
    Neurology 57:144-6. 2001
    ..In two patients with freezing during the "on" period, subthalamic nucleus stimulation failed to reduce this symptom effectively...
  92. doi request reprint Incidental findings are frequent in young healthy individuals undergoing magnetic resonance imaging in brain research imaging studies: a prospective single-center study
    Gesa Hartwigsen
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Comput Assist Tomogr 34:596-600. 2010
    ..There are currently no established guidelines regarding their management...
  93. doi request reprint The correlation between quantitative T2' and regional cerebral blood flow after acute brain ischemia in early reperfusion as demonstrated in a middle cerebral artery occlusion/reperfusion model of the rat
    Ulf R Jensen
    Institute of Neuroradiology, University of Schleswig Hostein, Campus Kiel, Kiel, Germany
    J Neurosci Methods 178:55-8. 2009
    ..No correlation between rCBF and qT2' has been performed to date. In this study a correlation between rCBF and qT2' was performed in a temporary middle cerebral occlusion-reperfusion model of the rat...
  94. ncbi request reprint Neuropsychological consequences of endarterectomy and endovascular angioplasty with stent placement for treatment of symptomatic carotid stenosis: a prospective randomised study
    Karsten Witt
    Department of Neurology, University Medical Center Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
    J Neurol 254:1524-32. 2007
    ..The clinical relevance of these differences remains unknown. We therefore compared the neuropsychological consequences of CAS and CEA and additionally measured the S100beta protein, a marker of cerebral damage...
  95. pmc Dopamine receptor D3 gene and essential tremor in large series of German, Danish and French patients
    Delia Lorenz
    Department of Neurology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Eur J Hum Genet 17:766-73. 2009
    ..We did not find a significant association of the DRD3 variant with ET nor linkage to the DRD3 receptor in German, Danish and French ET patients and families, suggesting that it is unlikely to be a causal factor for ET...
  96. ncbi request reprint Patients with Parkinson's disease learn to control complex systems-an indication for intact implicit cognitive skill learning
    Karsten Witt
    Department of Neurology, University Medical Center Schleswig Holstein, Campus Kiel, Germany
    Neuropsychologia 44:2445-51. 2006
    ..These results demonstrate a functional independence of implicit cognitive skill learning and certain aspects of executive functions...
  97. doi request reprint Failure of deep brain stimulation of the posterior inferior hypothalamus in chronic cluster headache - report of two cases and review of the literature
    M O Pinsker
    Department of Neurosurgery, UK SH, Kiel, Kiel, Germany
    Zentralbl Neurochir 69:76-9. 2008
    ..Recently, deep brain stimulation of the posterior hypothalamus has been shown to be effective in the treatment of drug-resistant chronic cluster headache...
  98. doi request reprint [Deep brain stimulation for Parkinson's disease]
    J Herzog
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 10, Kiel, Germany
    Nervenarzt 81:669-79. 2010
    ..Future studies will prospectively compare the clinical effects of STN and pallidal DBS. Alternative targets for treatment of PD have to be considered including the pedunculopontine nucleus, thalamic CM/Pf complex and zona incerta...
  99. ncbi request reprint Deep brain stimulation in the subthalamic area is more effective than nucleus ventralis intermedius stimulation for bilateral intention tremor
    W Hamel
    Department of Neurosurgery, Christian Albrechts University, Kiel, Germany
    Acta Neurochir (Wien) 149:749-58; discussion 758. 2007
    ..The ventro-lateral thalamus is the stereotactic target of choice for severe intention tremor. Nevertheless, the optimal target area has remained controversial, and targeting of the subthalamic area has been suggested to be superior...
  100. ncbi request reprint From theory to therapy: implications from an in vitro model of ramified microglia
    P Rosenstiel
    Department of Anatomy, Christian-Albrechs-University, Kiel, Germany
    Microsc Res Tech 54:18-25. 2001
    ..The second part reviews experiments with microglia cell cultures to elucidate underlying signalling pathways and summarizes recent advances of our knowledge in microglial molecular pathways that may ultimately lead to neurodegeneration...
  101. ncbi request reprint Parkinsonian action tremor: interference with object manipulation and lacking levodopa response
    J Raethjen
    Department of Neurology, University of Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
    Exp Neurol 194:151-60. 2005
    ..It does not show a clear levodopa response but affects dextrous movement coordination when associated with clinically severe overall akinesia...