Thomas J Dengler

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Non-invasive predictors of survival in cardiac amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Eur J Heart Fail 9:617-24. 2007
  2. ncbi request reprint Stem cell therapy for the infarcted heart ("cellular cardiomyoplasty")
    Thomas J Dengler
    Department of Cardiology, Internal Medical Clinic III, University of Heidelberg, Germany
    Herz 27:598-610. 2002
  3. doi request reprint Staged heart transplantation and chemotherapy as a treatment option in patients with severe cardiac light-chain amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg D 69120, Germany
    Eur J Heart Fail 11:1014-20. 2009
  4. ncbi request reprint High-sensitive Troponin T measurements early after heart transplantation predict short- and long-term survival
    Christian Erbel
    Department of Cardiology, University of Heidelberg, Germany
    Transpl Int 26:267-72. 2013
  5. doi request reprint Ezetimibe effectively lowers LDL-cholesterol in cardiac allograft recipients on stable statin therapy
    Mathias H Konstandin
    Department of Cardiology, Internal Medicine, Ruprecht Karls University, Heidelberg, Germany
    Clin Transplant 22:639-44. 2008
  6. doi request reprint Effects of protein A immunoadsorption in patients with chronic dilated cardiomyopathy
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
    J Clin Apher 25:315-22. 2010
  7. pmc Increased adherence eight months after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1253-8. 2013
  8. doi request reprint Skeletal scintigraphy indicates disease severity of cardiac involvement in patients with senile systemic amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, Im Neuenheimer Feld 410, Heidelberg, Germany
    Int J Cardiol 164:179-84. 2013
  9. ncbi request reprint Rapid progression of left ventricular wall thickness predicts mortality in cardiac light-chain amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    J Heart Lung Transplant 26:1313-9. 2007
  10. doi request reprint Heart rate reduction for 12 months with ivabradine reduces left ventricular mass in cardiac allograft recipients
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transplantation 88:835-41. 2009

Detail Information

Publications61

  1. ncbi request reprint Non-invasive predictors of survival in cardiac amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Eur J Heart Fail 9:617-24. 2007
    ..Patients with cardiac amyloidosis (CA) have increased mortality...
  2. ncbi request reprint Stem cell therapy for the infarcted heart ("cellular cardiomyoplasty")
    Thomas J Dengler
    Department of Cardiology, Internal Medical Clinic III, University of Heidelberg, Germany
    Herz 27:598-610. 2002
    ..Finally, a shortlist of central clinical and research goals is provided, which should be addressed by stringently designed patient trials...
  3. doi request reprint Staged heart transplantation and chemotherapy as a treatment option in patients with severe cardiac light-chain amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg D 69120, Germany
    Eur J Heart Fail 11:1014-20. 2009
    ..The prognosis of advanced cardiac light-chain amyloidosis is poor. Heart transplantation might enable causative therapy and ultimately improve prognosis...
  4. ncbi request reprint High-sensitive Troponin T measurements early after heart transplantation predict short- and long-term survival
    Christian Erbel
    Department of Cardiology, University of Heidelberg, Germany
    Transpl Int 26:267-72. 2013
    ..90, 95% CI: 0.81-1.00, P = 0.03). Cardiac troponin T concentrations early after transplantation as measured with a highly sensitive assay represent a strong and independent risk predictor of death after heart transplantation...
  5. doi request reprint Ezetimibe effectively lowers LDL-cholesterol in cardiac allograft recipients on stable statin therapy
    Mathias H Konstandin
    Department of Cardiology, Internal Medicine, Ruprecht Karls University, Heidelberg, Germany
    Clin Transplant 22:639-44. 2008
    ..Extent of pre-treatment LDL-C and cardiac disorder prior to transplantation appear to correlate with the efficacy of ezetimibe therapy...
  6. doi request reprint Effects of protein A immunoadsorption in patients with chronic dilated cardiomyopathy
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
    J Clin Apher 25:315-22. 2010
    ..The objective of this study was to investigate functional effects of immunoadsorption (IA) in patients with chronic nonfamilial dilated cardiomyopathy (DCM) regarding clinical and humoral markers of heart failure...
  7. pmc Increased adherence eight months after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1253-8. 2013
    ....
  8. doi request reprint Skeletal scintigraphy indicates disease severity of cardiac involvement in patients with senile systemic amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, Im Neuenheimer Feld 410, Heidelberg, Germany
    Int J Cardiol 164:179-84. 2013
    ..Senile systemic amyloidosis (SSA) is a common aging phenomenon in the elderly population. Nevertheless, pre-mortem diagnosis of SSA is rare. Thus, data on clinical characterization and disease severity are limited...
  9. ncbi request reprint Rapid progression of left ventricular wall thickness predicts mortality in cardiac light-chain amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    J Heart Lung Transplant 26:1313-9. 2007
    ..Due to its high mortality, identification of patients at high risk is crucial for treatment strategies such as heart transplantation prior to chemotherapy for amyloid disease...
  10. doi request reprint Heart rate reduction for 12 months with ivabradine reduces left ventricular mass in cardiac allograft recipients
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transplantation 88:835-41. 2009
    ..Currently, no 12-month data regarding effects of the novel I(f) channel antagonist ivabradine on heart rate control, effects on left ventricular mass, tolerability, and safety are available in patients after heart transplantation (HTX)...
  11. ncbi request reprint Biomarkers after heart transplantation: nongenomic
    Thomas J Dengler
    University of Heidelberg, Heidelberg, Germany
    Heart Fail Clin 3:69-81. 2007
    ..Rather, multiple marker strategies, including gene-based tests, are likely to enhance future monitoring quality and enable individualized risk-adapted patient management...
  12. pmc Green tea halts progression of cardiac transthyretin amyloidosis: an observational report
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Clin Res Cardiol 101:805-13. 2012
    ..Thus, it might also halt progression of TTR amyloidosis. This is a single-center observational report on the effects of GT consumption in patients with ATTR cardiomopathy...
  13. doi request reprint Negative pretransplant serostatus for Toxoplasma gondii is associated with impaired survival after heart transplantation
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transpl Int 23:382-9. 2010
    ..The cause of impaired survival in Toxoplasma seronegative recipients is currently unclear; possible explanations include an alteration of immune-reactivity/-regulation or adverse effects of prophylactic medication...
  14. doi request reprint Return to work after heart transplantation: discrepancy with subjective work ability
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Transplantation 87:1001-5. 2009
    ....
  15. doi request reprint Prophylactic implantation of cardioverter-defibrillator in patients with severe cardiac amyloidosis and high risk for sudden cardiac death
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Heart Rhythm 5:235-40. 2008
    ..Cardiac light-chain amyloidosis carries a high risk for death predominantly from progressive cardiomyopathy or sudden death (SCD). Independent risk factors for SCD are syncope and complex nonsustained ventricular arrhythmias...
  16. doi request reprint Effects of protein A immunoadsorption in patients with advanced chronic dilated cardiomyopathy
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Clin Apher 24:141-9. 2009
    ....
  17. doi request reprint Inhibition of IL-17A attenuates atherosclerotic lesion development in apoE-deficient mice
    Christian Erbel
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Immunol 183:8167-75. 2009
    ..The present data support a pathogenic role of IL-17A in the development of atherosclerosis by way of its widespread proinflammatory and proapoptotic effects on atherogenic cells...
  18. doi request reprint High prevalence of amyloid in 150 surgically removed heart valves--a comparison of histological and clinical data reveals a correlation to atheroinflammatory conditions
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany
    Cardiovasc Pathol 19:228-35. 2010
    ..The prevalence, pathophysiology, and clinical indicators of valvular amyloid deposition have not been clarified yet...
  19. ncbi request reprint Pharmacodynamic cyclosporine A-monitoring: relation of gene expression in lymphocytes to cyclosporine blood levels in cardiac allograft recipients
    Mathias H Konstandin
    Department of Cardiology, Internal Medicine, Ruprecht Karls University, Heidelberg, Germany
    Transpl Int 20:1036-43. 2007
    ..It correlates better with the incidence of infections than measurement of CsA concentrations and might help in avoiding over-immunosuppression...
  20. doi request reprint Epstein-Barr virus load in whole blood is associated with immunosuppression, but not with post-transplant lymphoproliferative disease in stable adult heart transplant patients
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transpl Int 21:963-71. 2008
    ..EBV DNA viral load determination does not appear to be useful for risk prediction or early diagnosis of PTLD in adults after HTX, but an association of EBV DNA load with qualitative and quantitative immunosuppression is demonstrated...
  21. doi request reprint Beneficial effect of omega-3 fatty acids on sirolimus- or everolimus-induced hypertriglyceridemia in heart transplant recipients
    Sultan Celik
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transplantation 86:245-50. 2008
    ..Omega-3 fatty acids (FAs) exert cardioprotective effects supporting a therapeutic role in cardiovascular conditions...
  22. doi request reprint Assessment of disease severity and outcome in patients with systemic light-chain amyloidosis by the high-sensitivity troponin T assay
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, Heidelberg University, Heidelberg, Germany
    Blood 116:2455-61. 2010
    ..Plasma levels of the hs-TnT assay are associated with the clinical, morphologic, and functional severity of cardiac AL amyloidosis and could provide useful information for clinicians on cardiac involvement and outcome...
  23. pmc Effects of vildagliptin (Galvus®) therapy in patients with type 2 diabetes mellitus after heart transplantation
    Ibrahim Gueler
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:297-303. 2013
    ..Type 2 Diabetes mellitus (T2DM) is a common comorbidity in patients after heart transplantation (HTx) and is associated with adverse long-term outcomes...
  24. pmc Effects of oral valganciclovir prophylaxis for cytomegalovirus infection in heart transplant patients
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg
    Drug Des Devel Ther 6:289-95. 2012
    ..This study (June 2003-January 2010) retrospectively assessed the effects of oral valganciclovir prophylaxis in adult heart transplant recipients during the first year after transplantation...
  25. doi request reprint Expression of IL-17A in human atherosclerotic lesions is associated with increased inflammation and plaque vulnerability
    Christian Erbel
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Basic Res Cardiol 106:125-34. 2011
    ..05), but did not influence IL-17A. The association of IL-17A with ischemic symptoms and vulnerable plaque characteristics suggests that the pro-inflammatory cytokine IL-17A may contribute to atherosclerosis und plaque instability...
  26. doi request reprint Endothelial progenitor cells possess monocyte-like antigen-presenting and T-cell-co-stimulatory capacity
    Patrick C Raemer
    Department of Cardiology, University Hospital, University of Heidelberg, Germany
    Transplantation 87:340-9. 2009
    ..This study was performed to investigate the antigen-presenting capacity of peripheral blood mononuclear cells-derived EPC and their T-cell co-stimulatory capacity compared with human vascular endothelial cells (HUVEC) or monocytes...
  27. pmc Inhibition of B7-1 (CD80) by RhuDex(®) reduces lipopolysaccharide-mediated inflammation in human atherosclerotic lesions
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Germany
    Drug Des Devel Ther 8:447-57. 2014
    ..Costimulatory molecules and their receptors provide decisive signals for antigen-specific cell activation. The contribution of B7-related pathways to atherosclerosis has hardly been explored...
  28. doi request reprint Who needs 'bridge' to transplantation in the presence of the Eurotransplant high-urgency heart transplantation program?
    Hiroyuki Kamiya
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
    Eur J Cardiothorac Surg 34:1129-33; discussion 1134-5. 2008
    ..The purposes of this study are to identify a patient cohort that would benefit from the use of mechanical circulatory support (MCS) in the presence of the Eurotransplant high-urgency (HU) program...
  29. ncbi request reprint Transthyretin valine-94-alanine, a novel variant associated with late-onset systemic amyloidosis with cardiac involvement
    Arnt V Kristen
    Department of Cardiology, Medical University of Heidelberg, Heidelberg, Germany
    Amyloid 14:283-7. 2007
    ..Final clinical assessment of severity of cardiac involvement in the present patient is rendered complex by possible concomitant or preceding idiopathic dilated cardiomyopathy...
  30. ncbi request reprint Impact of pre-operative diabetes mellitus upon early and late survival after heart transplantation: a possible era effect
    Roland Klingenberg
    Department of Cardiology, University Hospital Heidelberg, Heidelberg, Germany
    J Heart Lung Transplant 24:1239-46. 2005
    ..The effect of pre- or post-operatively acquired diabetes mellitus on survival after heart transplantation remains controversial. The influence of transplant era on diabetes-associated survival is unknown...
  31. doi request reprint Quantitative myocardial blush grade for the detection of cardiac allograft vasculopathy
    Grigorios Korosoglou
    University of Heidelberg, Department of Cardiology, Heidelberg, Germany
    Am Heart J 159:643-651.e2. 2010
    ..The aim of our study was to investigate the ability of quantitative myocardial blush grade (MBG) to detect CAV...
  32. ncbi request reprint Immunomodulatory effects of poly(ADP-ribose) polymerase inhibition contribute to improved cardiac function and survival during acute cardiac rejection
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Heart Lung Transplant 25:794-804. 2006
    ..Therefore, we investigated whether PARP inhibition improves transplant outcome and the extent to which immunologic factors contribute to the effects of PARP inhibition...
  33. ncbi request reprint Allograft rejection of ISHLT grade >/=3A occurring late after heart transplantation--a distinct entity?
    Roland Klingenberg
    Department of Cardiology, University Hospital Heidelberg, Heidelberg, Germany
    J Heart Lung Transplant 22:1005-13. 2003
    ..The significance of International Society of Heart and Lung Transplantation (ISHLT) grade >/=3A rejection detected by routine endomyocardial biopsies beyond 2 years post-transplant remains uncertain...
  34. ncbi request reprint Determinants of B-type natriuretic peptide plasma levels in the chronic phase after heart transplantation
    Roland Klingenberg
    Department of Cardiology, University Hospital Heidelberg, Heidelberg, Germany
    Transpl Int 18:169-76. 2005
    ..In order to determine the value of BNP as a potential surrogate marker of TVP serial intraindividual measurements appear appropriate...
  35. ncbi request reprint Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice
    Roland Klingenberg
    Department of Cardiology, University Hospital Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 27:2392-9. 2007
    ..The sphingolipid analogue drug FTY720 mediates retrafficking of immune cells and inhibits their homing to inflammatory sites. We have evaluated the effect of FTY720 on atherogenesis and lipid metabolism...
  36. ncbi request reprint Heart rate reduction after heart transplantation with beta-blocker versus the selective If channel antagonist ivabradine
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transplantation 84:988-96. 2007
    ....
  37. ncbi request reprint High-dose melphalan with autologous stem cell transplantation after VAD induction chemotherapy for treatment of amyloid light chain amyloidosis: a single centre prospective phase II study
    Jolanta B Perz
    Department of Haematology Oncology, Clinic of Internal Medicine, University of Heidelberg, 69120 Heidelberg, Germany
    Br J Haematol 127:543-51. 2004
    ..We could not show an additional benefit of VAD induction in terms of increasing haematological response rate; however the 13% mortality rate after HDM and ASCT in our series was lower than the previous report...
  38. ncbi request reprint Effectivity of a T-cell-adapted induction therapy with anti-thymocyte globulin (Sangstat)
    Achim Koch
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Heart Lung Transplant 24:708-13. 2005
    ..Therefore, we investigated whether reduced T-cell-adapted ATG induction therapy could be performed without increasing the risk of graft loss by rejection and whether reductions in infection rates and costs are possible...
  39. ncbi request reprint Influence of different implantation techniques on AV valve competence after orthotopic heart transplantation
    Achim Koch
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Eur J Cardiothorac Surg 28:717-23. 2005
    ..We used this technique regularly since the year 1993 and report about our 10 years experience...
  40. ncbi request reprint Risk stratification in cardiac amyloidosis: novel approaches
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Transplantation 80:S151-5. 2005
    ..Heart transplantation based on novel risk markers including NT-proBNP might be a suitable therapeutic approach for patients with manifest cardiac amyloidosis, but will require alternative patient selection and listing criteria...
  41. doi request reprint Serum levels of NT-proBNP as surrogate for cardiac amyloid burden: new evidence from gadolinium-enhanced cardiac magnetic resonance imaging in patients with amyloidosis
    Stephanie Lehrke
    Department of Medicine III, Division of Cardiology, University Hospital Heidelberg, Heidelberg, Germany
    Amyloid 16:187-95. 2009
    ..We aimed to use contrast enhanced cardiac magnetic resonance imaging (CMR) to identify functional and structural alterations related to levels of NT-proBNP better to understand the mechanisms of its release in cardiac amyloidosis...
  42. ncbi request reprint Expression of platelet-derived growth factor and fibroblast growth factor in cryopreserved endomyocardial biopsies early and late after heart transplant
    Achim Koch
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Thorac Surg 81:1372-8. 2006
    ..The aim of the present study was, therefore, to examine the growth factor expression in the early and later periods, up to three years after transplant in the same patient cohort...
  43. doi request reprint Late enhancement in cardiac amyloidosis: correlation of MRI enhancement pattern with histopathological findings
    Waldemar Hosch
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
    Amyloid 15:196-204. 2008
    ..LE seems to be associated with fibrosis due to ischemia of cardiomyocytes by small vessel amyloid deposition rather than with amyloid deposition in CA, suggesting that amyloid deposition might be present prior to LE detection...
  44. doi request reprint Beta2-integrin activation on T cell subsets is an independent prognostic factor in unstable angina pectoris
    Mathias H Konstandin
    Dept of Cardiology, Ruprecht Karls University, Heidelberg, Germany
    Basic Res Cardiol 104:341-51. 2009
    ..Beta2-integrin mediated T cell recruitment plays a pivotal role in coronary atherosclerotic plaque rupture. The present study investigates beta2-integrin activation on T cell subsets as a risk marker in UA...
  45. ncbi request reprint MR-relaxometry of myocardial tissue: significant elevation of T1 and T2 relaxation times in cardiac amyloidosis
    Waldemar Hosch
    Department of Radiology, University Hospital Heidelberg, Heidelberg, Germany
    Invest Radiol 42:636-42. 2007
    ..Therefore, we measured T1 and T2 relaxation times (RT) of the left ventricular myocardium with magnetic resonance imaging at 1.5 T...
  46. ncbi request reprint A comparison of measured trough levels and abbreviated AUC estimation by limited sampling strategies for monitoring mycophenolic acid exposure in stable heart transplant patients receiving cyclosporin A-containing and cyclosporin A-free immunosuppressive
    Andreas O Dösch
    Department of Cardiology, University Hospital, University of Heidelberg, Heidelberg, Germany
    Clin Ther 28:893-905. 2006
    ..A reliable method of achieving effective and well-tolerated levels of NIMF-based immunosuppression would be of eminent interest...
  47. ncbi request reprint Diagnostic efficiency of rejection monitoring after heart transplantation with cardiac troponin T is improved in specific patient subgroups
    Christian A Gleissner
    Department of Cardiology, University of Heidelberg, Germany
    Clin Transplant 17:284-91. 2003
    ..The clinical utility of these parameters was confirmed by longitudinal patient data and may help to select recipients most likely to benefit from cTnT rejection surveillance...
  48. ncbi request reprint Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Germany
    Circ Res 90:100-6. 2002
    ....
  49. pmc Proinflammatory and prothrombotic effects on human vascular endothelial cells of immune-cell-derived LIGHT
    S Celik
    Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Eur J Med Res 14:147-56. 2009
    ..Here, we compared the relative expression of LIGHT in different immune cells and the biological activity of immune cell-derived LIGHT on endothelial cells...
  50. ncbi request reprint Induction of ILT expression on nonprofessional antigen presenting cells: Clinical applications
    Christian A Gleissner
    Department of Cardiology, University of Heidelberg, Medizinische Universitaetsklinik III, Heidelberg, Germany
    Hum Immunol 70:357-9. 2009
    ..We here review mechanisms and effects of ILT3/ILT4 upregulation on endothelial cells and their potential significance in solid organ transplantation...
  51. ncbi request reprint Role of erythropoietin in anemia after heart transplantation
    Christian A Gleissner
    Department of Cardiology, Angiology and Pneumonology, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Int J Cardiol 112:341-7. 2006
    ..Anemia after heart transplantation is common; however, there are scant data on etiology and treatment. This study evaluates type of anemia and the effects of erythropoietin therapy...
  52. ncbi request reprint Indications for high-dose chemotherapy with autologous stem cell support in patients with systemic amyloid light chain amyloidosis
    Stefan O Schonland
    Department of Internal Medicine V Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany
    Transplantation 80:S160-3. 2005
    ..Here we review recent results of ASCT, eligibility criteria for HDM and report our own treatment results in 41 patients...
  53. ncbi request reprint Morphometric changes of the right ventricle in the first two weeks after clinical heart transplantation: analysis of myocardial biopsies from patients with complicated versus uncomplicated course
    Achim Koch
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Eur J Cardiothorac Surg 30:370-8. 2006
    ..The question is if there are differences in development of MF and CH between patients with complicated versus patients with uncomplicated postoperative course...
  54. ncbi request reprint A sensitive assay for the quantification of integrin-mediated adhesiveness of human stem cells and leukocyte subpopulations in whole blood
    Mathias H Konstandin
    Department of Cardiology, Internal Medicine, Ruprecht Karls University, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    J Immunol Methods 327:30-9. 2007
    ..Finally, the small blood volumes needed for adhesion analysis with the LC-AA allow the evaluation of multiple cell subpopulations in large sample collectives, e.g. required in clinical studies...
  55. ncbi request reprint Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy
    Stefan Göser
    Department of Internal Medicine III, University of Heidelberg, Germany
    Circulation 112:3400-7. 2005
    ..To determine their critical role in the pathogenesis of myocarditis, we inhibited mononuclear cell activation and migration to see if it would affect disease severity and disease prevalence in experimental autoimmune myocarditis (EAM)...
  56. ncbi request reprint Endothelial inducible costimulator ligand expression is increased during human cardiac allograft rejection and regulates endothelial cell-dependent allo-activation of CD8+ T cells in vitro
    Roland Klingenberg
    Department of Cardiology, University Hospital Heidelberg, Heidelberg, Germany
    Eur J Immunol 35:1712-21. 2005
    ..04). Our data indicate a distinct role for ICOSL in EC-mediated CD8(+) T cell costimulation with implications for human cardiac allograft rejection...
  57. ncbi request reprint Reduced hemoglobin after heart transplantation is no independent risk factor for survival but is associated closely with impaired renal function
    Christian A Gleissner
    Department of Cardiology, Angiology and Pneumonology, University of Heidelberg, Heidelberg, Germany
    Transplantation 77:710-7. 2004
    ..Reduced hemoglobin (Hb) levels after heart transplantation (HTX) are common; however, there are only limited data on the association of posttransplant anemia with survival...
  58. ncbi request reprint IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells
    Christian A Gleissner
    Department of Cardiology, University Hospital, University of Heidelberg, Heidelberg, Germany
    Eur J Immunol 37:177-92. 2007
    ..This identifies a novel action of IL-10 in EC and a potential therapeutical target for local immunomodulation...
  59. ncbi request reprint Suspected cardiac amyloidosis: endomyocardial biopsy remains the diagnostic gold-standard
    Arnt V Kristen
    Am J Hematol 82:328. 2007
  60. ncbi request reprint Reduction of cyclosporine after introduction of mycophenolate mofetil improves chronic renal dysfunction in heart transplant recipients--the IMPROVED multi-centre study
    Christiane E Angermann
    Kardiologie Medizinische Poliklinik, Julius Maximilians Universitat Wurzburg, Klinikstrasse 6 8, 97070 Wurzburg, Germany
    Eur Heart J 25:1626-34. 2004
    ..This comparative prospective multi-centre study evaluated efficacy and safety of cyclosporine A downtitration in heart transplant recipients with chronic renal dysfunction potentially attributable to cyclosporine (n=161)...
  61. ncbi request reprint Platelet-associated LIGHT (TNFSF14) mediates adhesion of platelets to human vascular endothelium
    Sultan Celik
    Innere Medizin III, Universitat Heidelberg, Heidelberg, Germany
    Thromb Haemost 98:798-805. 2007
    ..LIGHT may thus be implicated in the pathogenesis of atherosclerosis and acute coronary syndrome, as evidenced by serum levels...