Research Topics
| Thomas J DenglerSummaryAffiliation: University of Heidelberg Country: Germany Publications
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Detail Information
Publications
Non-invasive predictors of survival in cardiac amyloidosisArnt V Kristen
Department of Cardiology, Angiology, and Respiratory Medicine, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
Eur J Heart Fail 9:617-24. 2007..Patients with cardiac amyloidosis (CA) have increased mortality...- Stem cell therapy for the infarcted heart ("cellular cardiomyoplasty")Thomas J Dengler
Department of Cardiology, Internal Medical Clinic III, University of Heidelberg, Germany
Herz 27:598-610. 2002..Finally, a shortlist of central clinical and research goals is provided, which should be addressed by stringently designed patient trials... 
Staged heart transplantation and chemotherapy as a treatment option in patients with severe cardiac light-chain amyloidosisArnt V Kristen
Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg D 69120, Germany
Eur J Heart Fail 11:1014-20. 2009..The prognosis of advanced cardiac light-chain amyloidosis is poor. Heart transplantation might enable causative therapy and ultimately improve prognosis...- Ezetimibe effectively lowers LDL-cholesterol in cardiac allograft recipients on stable statin therapyMathias H Konstandin
Department of Cardiology, Internal Medicine, Ruprecht Karls University, Heidelberg, Germany
Clin Transplant 22:639-44. 2008..Extent of pre-treatment LDL-C and cardiac disorder prior to transplantation appear to correlate with the efficacy of ezetimibe therapy... - Effects of protein A immunoadsorption in patients with chronic dilated cardiomyopathyAndreas O Doesch
Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
J Clin Apher 25:315-22. 2010..The objective of this study was to investigate functional effects of immunoadsorption (IA) in patients with chronic nonfamilial dilated cardiomyopathy (DCM) regarding clinical and humoral markers of heart failure... - Rapid progression of left ventricular wall thickness predicts mortality in cardiac light-chain amyloidosisArnt V Kristen
Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
J Heart Lung Transplant 26:1313-9. 2007..Due to its high mortality, identification of patients at high risk is crucial for treatment strategies such as heart transplantation prior to chemotherapy for amyloid disease... - Heart rate reduction for 12 months with ivabradine reduces left ventricular mass in cardiac allograft recipientsAndreas O Doesch
Department of Cardiology, University of Heidelberg, Heidelberg, Germany
Transplantation 88:835-41. 2009..Currently, no 12-month data regarding effects of the novel I(f) channel antagonist ivabradine on heart rate control, effects on left ventricular mass, tolerability, and safety are available in patients after heart transplantation (HTX)... - Biomarkers after heart transplantation: nongenomicThomas J Dengler
University of Heidelberg, Heidelberg, Germany
Heart Fail Clin 3:69-81. 2007..Rather, multiple marker strategies, including gene-based tests, are likely to enhance future monitoring quality and enable individualized risk-adapted patient management... 
Green tea halts progression of cardiac transthyretin amyloidosis: an observational reportArnt V Kristen
Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Clin Res Cardiol 101:805-13. 2012..Thus, it might also halt progression of TTR amyloidosis. This is a single-center observational report on the effects of GT consumption in patients with ATTR cardiomopathy...- Prophylactic implantation of cardioverter-defibrillator in patients with severe cardiac amyloidosis and high risk for sudden cardiac deathArnt V Kristen
Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
Heart Rhythm 5:235-40. 2008..Cardiac light-chain amyloidosis carries a high risk for death predominantly from progressive cardiomyopathy or sudden death (SCD). Independent risk factors for SCD are syncope and complex nonsustained ventricular arrhythmias... - Negative pretransplant serostatus for Toxoplasma gondii is associated with impaired survival after heart transplantationAndreas O Doesch
Department of Cardiology, University of Heidelberg, Heidelberg, Germany
Transpl Int 23:382-9. 2010..The cause of impaired survival in Toxoplasma seronegative recipients is currently unclear; possible explanations include an alteration of immune-reactivity/-regulation or adverse effects of prophylactic medication... - Return to work after heart transplantation: discrepancy with subjective work abilityArnt V Kristen
Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
Transplantation 87:1001-5. 2009.... - Inhibition of IL-17A attenuates atherosclerotic lesion development in apoE-deficient miceChristian Erbel
Department of Cardiology, University of Heidelberg, Heidelberg, Germany
J Immunol 183:8167-75. 2009..The present data support a pathogenic role of IL-17A in the development of atherosclerosis by way of its widespread proinflammatory and proapoptotic effects on atherogenic cells... - Effects of protein A immunoadsorption in patients with advanced chronic dilated cardiomyopathyAndreas O Doesch
Department of Cardiology, University of Heidelberg, Heidelberg, Germany
J Clin Apher 24:141-9. 2009.... - Epstein-Barr virus load in whole blood is associated with immunosuppression, but not with post-transplant lymphoproliferative disease in stable adult heart transplant patientsAndreas O Doesch
Department of Cardiology, University of Heidelberg, Heidelberg, Germany
Transpl Int 21:963-71. 2008..EBV DNA viral load determination does not appear to be useful for risk prediction or early diagnosis of PTLD in adults after HTX, but an association of EBV DNA load with qualitative and quantitative immunosuppression is demonstrated... - Beneficial effect of omega-3 fatty acids on sirolimus- or everolimus-induced hypertriglyceridemia in heart transplant recipientsSultan Celik
Department of Cardiology, University of Heidelberg, Heidelberg, Germany
Transplantation 86:245-50. 2008..Omega-3 fatty acids (FAs) exert cardioprotective effects supporting a therapeutic role in cardiovascular conditions... - High prevalence of amyloid in 150 surgically removed heart valves--a comparison of histological and clinical data reveals a correlation to atheroinflammatory conditionsArnt V Kristen
Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany
Cardiovasc Pathol 19:228-35. 2010..The prevalence, pathophysiology, and clinical indicators of valvular amyloid deposition have not been clarified yet... - Assessment of disease severity and outcome in patients with systemic light-chain amyloidosis by the high-sensitivity troponin T assayArnt V Kristen
Department of Cardiology, Angiology, and Respiratory Medicine, Heidelberg University, Heidelberg, Germany
Blood 116:2455-61. 2010..Plasma levels of the hs-TnT assay are associated with the clinical, morphologic, and functional severity of cardiac AL amyloidosis and could provide useful information for clinicians on cardiac involvement and outcome... - Pharmacodynamic cyclosporine A-monitoring: relation of gene expression in lymphocytes to cyclosporine blood levels in cardiac allograft recipientsMathias H Konstandin
Department of Cardiology, Internal Medicine, Ruprecht Karls University, Heidelberg, Germany
Transpl Int 20:1036-43. 2007..It correlates better with the incidence of infections than measurement of CsA concentrations and might help in avoiding over-immunosuppression... - High-sensitive Troponin T measurements early after heart transplantation predict short- and long-term survivalChristian Erbel
Department of Cardiology, University of Heidelberg, Germany
Transpl Int 26:267-72. 2013..90, 95% CI: 0.81-1.00, P = 0.03). Cardiac troponin T concentrations early after transplantation as measured with a highly sensitive assay represent a strong and independent risk predictor of death after heart transplantation... - Endothelial progenitor cells possess monocyte-like antigen-presenting and T-cell-co-stimulatory capacityPatrick C Raemer
Department of Cardiology, University Hospital, University of Heidelberg, Germany
Transplantation 87:340-9. 2009..This study was performed to investigate the antigen-presenting capacity of peripheral blood mononuclear cells-derived EPC and their T-cell co-stimulatory capacity compared with human vascular endothelial cells (HUVEC) or monocytes... - Expression of IL-17A in human atherosclerotic lesions is associated with increased inflammation and plaque vulnerabilityChristian Erbel
Department of Cardiology, University of Heidelberg, Heidelberg, Germany
Basic Res Cardiol 106:125-34. 2011..05), but did not influence IL-17A. The association of IL-17A with ischemic symptoms and vulnerable plaque characteristics suggests that the pro-inflammatory cytokine IL-17A may contribute to atherosclerosis und plaque instability... - Skeletal scintigraphy indicates disease severity of cardiac involvement in patients with senile systemic amyloidosisArnt V Kristen
Department of Cardiology, Angiology, and Respiratory Medicine, Im Neuenheimer Feld 410, Heidelberg, Germany
Int J Cardiol 164:179-84. 2013..Senile systemic amyloidosis (SSA) is a common aging phenomenon in the elderly population. Nevertheless, pre-mortem diagnosis of SSA is rare. Thus, data on clinical characterization and disease severity are limited... - Who needs 'bridge' to transplantation in the presence of the Eurotransplant high-urgency heart transplantation program?Hiroyuki Kamiya
Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
Eur J Cardiothorac Surg 34:1129-33; discussion 1134-5. 2008..The purposes of this study are to identify a patient cohort that would benefit from the use of mechanical circulatory support (MCS) in the presence of the Eurotransplant high-urgency (HU) program... - Transthyretin valine-94-alanine, a novel variant associated with late-onset systemic amyloidosis with cardiac involvementArnt V Kristen
Department of Cardiology, Medical University of Heidelberg, Heidelberg, Germany
Amyloid 14:283-7. 2007..Final clinical assessment of severity of cardiac involvement in the present patient is rendered complex by possible concomitant or preceding idiopathic dilated cardiomyopathy... - Impact of pre-operative diabetes mellitus upon early and late survival after heart transplantation: a possible era effectRoland Klingenberg
Department of Cardiology, University Hospital Heidelberg, Heidelberg, Germany
J Heart Lung Transplant 24:1239-46. 2005..Diabetes-associated long-term survival appears to have improved in the recent era, supporting continued transplantation in diabetics under close surveillance and aggressive medical management... - Effects of oral valganciclovir prophylaxis for cytomegalovirus infection in heart transplant patientsAndreas O Doesch
Department of Cardiology, University of Heidelberg, Heidelberg
Drug Des Devel Ther 6:289-95. 2012..This study (June 2003-January 2010) retrospectively assessed the effects of oral valganciclovir prophylaxis in adult heart transplant recipients during the first year after transplantation... - Quantitative myocardial blush grade for the detection of cardiac allograft vasculopathyGrigorios Korosoglou
University of Heidelberg, Department of Cardiology, Heidelberg, Germany
Am Heart J 159:643-651.e2. 2010..The aim of our study was to investigate the ability of quantitative myocardial blush grade (MBG) to detect CAV... - Determinants of B-type natriuretic peptide plasma levels in the chronic phase after heart transplantationRoland Klingenberg
Department of Cardiology, University Hospital Heidelberg, Heidelberg, Germany
Transpl Int 18:169-76. 2005..In order to determine the value of BNP as a potential surrogate marker of TVP serial intraindividual measurements appear appropriate... - Immunomodulatory effects of poly(ADP-ribose) polymerase inhibition contribute to improved cardiac function and survival during acute cardiac rejectionGabor Szabo
Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
J Heart Lung Transplant 25:794-804. 2006..Therefore, we investigated whether PARP inhibition improves transplant outcome and the extent to which immunologic factors contribute to the effects of PARP inhibition... - Allograft rejection of ISHLT grade >/=3A occurring late after heart transplantation--a distinct entity?Roland Klingenberg
Department of Cardiology, University Hospital Heidelberg, Heidelberg, Germany
J Heart Lung Transplant 22:1005-13. 2003..The significance of International Society of Heart and Lung Transplantation (ISHLT) grade >/=3A rejection detected by routine endomyocardial biopsies beyond 2 years post-transplant remains uncertain... - Heart rate reduction after heart transplantation with beta-blocker versus the selective If channel antagonist ivabradineAndreas O Doesch
Department of Cardiology, University of Heidelberg, Heidelberg, Germany
Transplantation 84:988-96. 2007.... - High-dose melphalan with autologous stem cell transplantation after VAD induction chemotherapy for treatment of amyloid light chain amyloidosis: a single centre prospective phase II studyJolanta B Perz
Department of Haematology Oncology, Clinic of Internal Medicine, University of Heidelberg, 69120 Heidelberg, Germany
Br J Haematol 127:543-51. 2004..We could not show an additional benefit of VAD induction in terms of increasing haematological response rate; however the 13% mortality rate after HDM and ASCT in our series was lower than the previous report... - Serum levels of NT-proBNP as surrogate for cardiac amyloid burden: new evidence from gadolinium-enhanced cardiac magnetic resonance imaging in patients with amyloidosisStephanie Lehrke
Department of Medicine III, Division of Cardiology, University Hospital Heidelberg, Heidelberg, Germany
Amyloid 16:187-95. 2009..We aimed to use contrast enhanced cardiac magnetic resonance imaging (CMR) to identify functional and structural alterations related to levels of NT-proBNP better to understand the mechanisms of its release in cardiac amyloidosis... - Effectivity of a T-cell-adapted induction therapy with anti-thymocyte globulin (Sangstat)Achim Koch
Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
J Heart Lung Transplant 24:708-13. 2005..Therefore, we investigated whether reduced T-cell-adapted ATG induction therapy could be performed without increasing the risk of graft loss by rejection and whether reductions in infection rates and costs are possible... - Risk stratification in cardiac amyloidosis: novel approachesArnt V Kristen
Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
Transplantation 80:S151-5. 2005..Heart transplantation based on novel risk markers including NT-proBNP might be a suitable therapeutic approach for patients with manifest cardiac amyloidosis, but will require alternative patient selection and listing criteria... - Beta2-integrin activation on T cell subsets is an independent prognostic factor in unstable angina pectorisMathias H Konstandin
Dept of Cardiology, Ruprecht Karls University, Heidelberg, Germany
Basic Res Cardiol 104:341-51. 2009..Beta2-integrin mediated T cell recruitment plays a pivotal role in coronary atherosclerotic plaque rupture. The present study investigates beta2-integrin activation on T cell subsets as a risk marker in UA... - Late enhancement in cardiac amyloidosis: correlation of MRI enhancement pattern with histopathological findingsWaldemar Hosch
Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
Amyloid 15:196-204. 2008..LE seems to be associated with fibrosis due to ischemia of cardiomyocytes by small vessel amyloid deposition rather than with amyloid deposition in CA, suggesting that amyloid deposition might be present prior to LE detection... - Expression of platelet-derived growth factor and fibroblast growth factor in cryopreserved endomyocardial biopsies early and late after heart transplantAchim Koch
Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
Ann Thorac Surg 81:1372-8. 2006..The aim of the present study was, therefore, to examine the growth factor expression in the early and later periods, up to three years after transplant in the same patient cohort... - MR-relaxometry of myocardial tissue: significant elevation of T1 and T2 relaxation times in cardiac amyloidosisWaldemar Hosch
Department of Radiology, University Hospital Heidelberg, Heidelberg, Germany
Invest Radiol 42:636-42. 2007..Therefore, we measured T1 and T2 relaxation times (RT) of the left ventricular myocardium with magnetic resonance imaging at 1.5 T... - Influence of different implantation techniques on AV valve competence after orthotopic heart transplantationAchim Koch
Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
Eur J Cardiothorac Surg 28:717-23. 2005..We used this technique regularly since the year 1993 and report about our 10 years experience... - A comparison of measured trough levels and abbreviated AUC estimation by limited sampling strategies for monitoring mycophenolic acid exposure in stable heart transplant patients receiving cyclosporin A-containing and cyclosporin A-free immunosuppressive Andreas O Dösch
Department of Cardiology, University Hospital, University of Heidelberg, Heidelberg, Germany
Clin Ther 28:893-905. 2006..A reliable method of achieving effective and well-tolerated levels of NIMF-based immunosuppression would be of eminent interest... - Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient miceRoland Klingenberg
Department of Cardiology, University Hospital Heidelberg, Germany
Arterioscler Thromb Vasc Biol 27:2392-9. 2007..The sphingolipid analogue drug FTY720 mediates retrafficking of immune cells and inhibits their homing to inflammatory sites. We have evaluated the effect of FTY720 on atherogenesis and lipid metabolism... - Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantationGabor Szabo
Department of Cardiac Surgery, University of Heidelberg, Germany
Circ Res 90:100-6. 2002.... - Diagnostic efficiency of rejection monitoring after heart transplantation with cardiac troponin T is improved in specific patient subgroupsChristian A Gleissner
Department of Cardiology, University of Heidelberg, Germany
Clin Transplant 17:284-91. 2003..The clinical utility of these parameters was confirmed by longitudinal patient data and may help to select recipients most likely to benefit from cTnT rejection surveillance... - Proinflammatory and prothrombotic effects on human vascular endothelial cells of immune-cell-derived LIGHTS Celik
Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Eur J Med Res 14:147-56. 2009..Here, we compared the relative expression of LIGHT in different immune cells and the biological activity of immune cell-derived LIGHT on endothelial cells... - Induction of ILT expression on nonprofessional antigen presenting cells: Clinical applicationsChristian A Gleissner
Department of Cardiology, University of Heidelberg, Medizinische Universitaetsklinik III, Heidelberg, Germany
Hum Immunol 70:357-9. 2009..We here review mechanisms and effects of ILT3/ILT4 upregulation on endothelial cells and their potential significance in solid organ transplantation... - Role of erythropoietin in anemia after heart transplantationChristian A Gleissner
Department of Cardiology, Angiology and Pneumonology, University of Heidelberg, Im Neuenheimer Feld 410, D-69120 Heidelberg, Germany
Int J Cardiol 112:341-7. 2006..Erythropoietin may be a superior marker of functional renal impairment after heart transplantation; its therapeutic substitution allows effective anemia management and improves quality of life... - Morphometric changes of the right ventricle in the first two weeks after clinical heart transplantation: analysis of myocardial biopsies from patients with complicated versus uncomplicated courseAchim Koch
Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
Eur J Cardiothorac Surg 30:370-8. 2006..The question is if there are differences in development of MF and CH between patients with complicated versus patients with uncomplicated postoperative course... - A sensitive assay for the quantification of integrin-mediated adhesiveness of human stem cells and leukocyte subpopulations in whole bloodMathias H Konstandin
Department of Cardiology, Internal Medicine, Ruprecht Karls University, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
J Immunol Methods 327:30-9. 2007..Finally, the small blood volumes needed for adhesion analysis with the LC-AA allow the evaluation of multiple cell subpopulations in large sample collectives, e.g. required in clinical studies... - Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapyStefan Göser
Department of Internal Medicine III, University of Heidelberg, Germany
Circulation 112:3400-7. 2005..To determine their critical role in the pathogenesis of myocarditis, we inhibited mononuclear cell activation and migration to see if it would affect disease severity and disease prevalence in experimental autoimmune myocarditis (EAM)... - Indications for high-dose chemotherapy with autologous stem cell support in patients with systemic amyloid light chain amyloidosisStefan O Schonland
Department of Internal Medicine V Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany
Transplantation 80:S160-3. 2005..Here we review recent results of ASCT, eligibility criteria for HDM and report our own treatment results in 41 patients... - Reduced hemoglobin after heart transplantation is no independent risk factor for survival but is associated closely with impaired renal functionChristian A Gleissner
Department of Cardiology, Angiology and Pneumonology, University of Heidelberg, Heidelberg, Germany
Transplantation 77:710-7. 2004..Further studies will be required to investigate the role of post-HTX anemia as a sensitive indicator of functional renal impairment and the effects of anemia treatment on long-term survival... - Endothelial inducible costimulator ligand expression is increased during human cardiac allograft rejection and regulates endothelial cell-dependent allo-activation of CD8+ T cells in vitroRoland Klingenberg
Department of Cardiology, University Hospital Heidelberg, Heidelberg, Germany
Eur J Immunol 35:1712-21. 2005..04). Our data indicate a distinct role for ICOSL in EC-mediated CD8(+) T cell costimulation with implications for human cardiac allograft rejection... - IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cellsChristian A Gleissner
Department of Cardiology, University Hospital, University of Heidelberg, Heidelberg, Germany
Eur J Immunol 37:177-92. 2007..This identifies a novel action of IL-10 in EC and a potential therapeutical target for local immunomodulation... - Suspected cardiac amyloidosis: endomyocardial biopsy remains the diagnostic gold-standardArnt V Kristen
Am J Hematol 82:328. 2007 - Reduction of cyclosporine after introduction of mycophenolate mofetil improves chronic renal dysfunction in heart transplant recipients--the IMPROVED multi-centre studyChristiane E Angermann
Kardiologie Medizinische Poliklinik, Julius Maximilians Universitat Wurzburg, Klinikstrasse 6 8, 97070 Wurzburg, Germany
Eur Heart J 25:1626-34. 2004..This comparative prospective multi-centre study evaluated efficacy and safety of cyclosporine A downtitration in heart transplant recipients with chronic renal dysfunction potentially attributable to cyclosporine (n=161)... - Platelet-associated LIGHT (TNFSF14) mediates adhesion of platelets to human vascular endotheliumSultan Celik
Innere Medizin III, Universitat Heidelberg, Heidelberg, Germany
Thromb Haemost 98:798-805. 2007..LIGHT may thus be implicated in the pathogenesis of atherosclerosis and acute coronary syndrome, as evidenced by serum levels...