Carl Erik Dempfle

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi D-dimer assays: the current status and new assay technologies
    Carl Erik Dempfle
    Thromb Res 118:569-71. 2006
  2. ncbi Prothrombin complex concentrate (Octaplex) in patients requiring immediate reversal of oral anticoagulation
    Hanno B Riess
    Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Thromb Res 121:9-16. 2007
  3. ncbi The fibrin assay comparison trial (FACT): correlation of soluble fibrin assays with D-dimer
    C E Dempfle
    University of Heidelberg, Mannheim University Hospital, I Department of Medicine, Germany
    Thromb Haemost 86:1204-9. 2001
  4. ncbi Use of soluble fibrin antigen instead of D-dimer as fibrin-related marker may enhance the prognostic power of the ISTH overt DIC score
    Carl Erik Dempfle
    University Hospital of Mannheim, I Department of Medicine, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Thromb Haemost 91:812-8. 2004
  5. doi Demonstration of heterodimeric fibrinogen molecules partially conjugated with albumin in a novel dysfibrinogen: fibrinogen Mannheim V
    Carl Erik Dempfle
    Department of Medicine, University Hospital of Mannheim, Mannheim, Germany
    Thromb Haemost 102:29-34. 2009
  6. ncbi D-dimer testing and venous thromboembolism: four view points
    C E Dempfle
    University Hospital of Mannheim, I Department of Medicine, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Thromb Haemost 3:377-9. 2005
  7. ncbi [Perioperative coagulation diagnostics]
    C E Dempfle
    I Medizinische Klinik, Universitatsklinikum Mannheim
    Anaesthesist 54:167-75; quiz 176-7. 2005
  8. ncbi Changes in fibrinogen and fibrin induced by a peptide analog of fibrinogen gamma365-380
    C E Dempfle
    I Department of Medicine, University Hospital of Mannheim, Mannheim, Germany
    J Thromb Haemost 5:1707-14. 2007
  9. doi Impact of fibrinogen concentration in severely ill patients on mechanical properties of whole blood clots
    Carl Erik Dempfle
    First Department of Medicine, Germany bDepartment of Anaesthesiology and Operative Intensive Care, University Hospital of Mannheim, Mannheim, Germany
    Blood Coagul Fibrinolysis 19:765-70. 2008
  10. doi Point of care coagulation tests in critically ill patients
    Carl Erik Dempfle
    I Department of Medicine, University Hospital of Mannheim, Mannheim, Germany
    Semin Thromb Hemost 34:445-50. 2008

Collaborators

Detail Information

Publications68

  1. ncbi D-dimer assays: the current status and new assay technologies
    Carl Erik Dempfle
    Thromb Res 118:569-71. 2006
  2. ncbi Prothrombin complex concentrate (Octaplex) in patients requiring immediate reversal of oral anticoagulation
    Hanno B Riess
    Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Thromb Res 121:9-16. 2007
    ..e. rapid correction of international normalized ratio (INR)...
  3. ncbi The fibrin assay comparison trial (FACT): correlation of soluble fibrin assays with D-dimer
    C E Dempfle
    University of Heidelberg, Mannheim University Hospital, I Department of Medicine, Germany
    Thromb Haemost 86:1204-9. 2001
    ..Since SF assays react with crosslinked fibrin derivatives, it is not possible to clearly distinguish between acute fibrin formation, and fibrin dissolution on the basis of the results of current SF assays...
  4. ncbi Use of soluble fibrin antigen instead of D-dimer as fibrin-related marker may enhance the prognostic power of the ISTH overt DIC score
    Carl Erik Dempfle
    University Hospital of Mannheim, I Department of Medicine, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Thromb Haemost 91:812-8. 2004
    ..The present data on the distribution of values may provide a basis for the selection of appropriate cutoff points for assigning 2, and 3 points in the score...
  5. doi Demonstration of heterodimeric fibrinogen molecules partially conjugated with albumin in a novel dysfibrinogen: fibrinogen Mannheim V
    Carl Erik Dempfle
    Department of Medicine, University Hospital of Mannheim, Mannheim, Germany
    Thromb Haemost 102:29-34. 2009
    ..This new fibrinogen mutation, leads to a balanced array of homo- and heterodimeric fibrinogen molecules, some of which are conjugated to albumin...
  6. ncbi D-dimer testing and venous thromboembolism: four view points
    C E Dempfle
    University Hospital of Mannheim, I Department of Medicine, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Thromb Haemost 3:377-9. 2005
  7. ncbi [Perioperative coagulation diagnostics]
    C E Dempfle
    I Medizinische Klinik, Universitatsklinikum Mannheim
    Anaesthesist 54:167-75; quiz 176-7. 2005
    ..Preoperative laboratory diagnostics for thrombophilia are not necessary in most cases. The decision for intensified antithrombotic measures is made according to patient history and the postoperative clinical course...
  8. ncbi Changes in fibrinogen and fibrin induced by a peptide analog of fibrinogen gamma365-380
    C E Dempfle
    I Department of Medicine, University Hospital of Mannheim, Mannheim, Germany
    J Thromb Haemost 5:1707-14. 2007
    ..The effects of synthetic peptides with sequences derived from the gamma-chain of fibrinogen on the functional properties of fibrinogen and fibrin were investigated...
  9. doi Impact of fibrinogen concentration in severely ill patients on mechanical properties of whole blood clots
    Carl Erik Dempfle
    First Department of Medicine, Germany bDepartment of Anaesthesiology and Operative Intensive Care, University Hospital of Mannheim, Mannheim, Germany
    Blood Coagul Fibrinolysis 19:765-70. 2008
    ....
  10. doi Point of care coagulation tests in critically ill patients
    Carl Erik Dempfle
    I Department of Medicine, University Hospital of Mannheim, Mannheim, Germany
    Semin Thromb Hemost 34:445-50. 2008
    ....
  11. ncbi [Sepsis-associated coagulation disorders]
    C E Dempfle
    Universitatsklinikum Mannheim, I Medizinische Klinik Theodor Kutzer Ufer 1 3, 68167 Mannheim
    Hamostaseologie 25:183-9. 2005
    ..Its use is not limited to patients with sepsis-induced disseminated intravascular coagulation, although these patients appear to benefit especially from this therapy...
  12. ncbi [Avoiding emergency situations under anticoagulant therapy with vitamin K antagonists]
    C E Dempfle
    I Medizinische Klinik, Universitatsklinikum Mannheim
    Internist (Berl) 46:1006-10, 1012-3. 2005
    ..Unfractionated or low molecular weight heparin is given when INR levels are below therapeutic range. Patients with contraindications to heparin may be treated with alternative anticoagulants such as danaparoid, lepirudin or fondaparinux...
  13. doi Heptest-STAT, a new assay for monitoring of low-molecular-weight heparins, is not influenced by pregnancy-related changes of blood plasma
    Carl Erik Dempfle
    University Hospital of Mannheim, I Department of Medicine, D 68167 Mannheim, Germany
    Thromb Haemost 102:1001-6. 2009
    ..Heptest-STAT can be used with the same standard calibration for non-pregnant and pregnant patients and for all LMWHs under investigation, including fondparinux. No individual calibrations are necessary...
  14. ncbi Coagulopathy of sepsis
    Carl Erik Dempfle
    University Hospital of Mannheim, I Department of Medicine, Mannheim, Germany
    Thromb Haemost 91:213-24. 2004
    ..Based on case reports, treatment with drotrecogin alfa (activated) or substitution of protein C have been recommended for adjuvant treatment of sepsis-related purpura fulminans...
  15. ncbi [The TAFI system. The new role of fibrinolysis]
    C E Dempfle
    Universitatsklinikum Mannheim, I Medizinische Klinik, Theodor Kutzer Ufer 1 3, 68167 Mannheim
    Hamostaseologie 27:278-81. 2007
    ..TAFIa-inhibitors are currently being developed for the treatment of throboembolic disorders or hypofibrinolytic DIC. Enhancement of TAFIa-activity may be helpful in patients with bleeding...
  16. ncbi Sensitivity and specificity of a quantitative point of care D-dimer assay using heparinized whole blood, in patients with clinically suspected deep vein thrombosis
    Carl Erik Dempfle
    1st Department of Medicine, Mannheim University Hospital, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Thromb Haemost 96:79-83. 2006
    ..The new whole blood POC D-dimer assay is a reliable tool for exclusion of DVT in symptomatic outpatients, displaying a comparable diagnostic performance as VIDAS D-dimer and Tina-quant D-dimer assays...
  17. ncbi Course of indicators of thrombin activity in the early phase of acute myocardial infarction: effect of fibrinolytic therapy and acute percutaneous coronary angioplasty
    Carl Erik Dempfle
    University Hospital of Mannheim, I Department of Medicine, Mannheim, Germany
    Thromb Haemost 90:147-54. 2003
    ....
  18. ncbi What role does the measurement of fibrinogen and its derivatives have in the diagnosis of disseminated intravascular coagulation?
    Carl Erik Dempfle
    I Department of Medicine, Mannheim University Hospital, Mannheim, Germany
    Blood Rev 16:S23-8. 2002
    ..New assays using monoclonal antibodies directed against epitopes specific for elastase-mediated fibrin degradation may add valuable diagnostic information in patients with septic conditions...
  19. ncbi Performance evaluation of a new rapid quantitative assay system for measurement of D-dimer in plasma and whole blood: PATHFAST D-dimer
    Carl Erik Dempfle
    Mannheim University Hospital, I Department of Medicine, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Thromb Res 120:591-6. 2007
    ..005 microg/ml FEU. In conclusion, the PATHFAST D-dimer assay is the first automated fully quantitative D-dimer assay, which can use plasma and whole blood as sample materials in parallel...
  20. ncbi Influence of receptor activator of nuclear factor kappa B on human aortic valve myofibroblasts
    Jens J Kaden
    Department of Medicine Cardiology, Angiology, Pneumology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Exp Mol Pathol 78:36-40. 2005
    ..These results support the concept that MMPs are involved in the connective tissue remodeling during calcific aortic valve stenosis. RANKL might regulate this process by promoting cell proliferation and MMP expression and activation...
  21. doi Effect of atorvastatin on haemostasis, fibrinolysis and inflammation in normocholesterolaemic patients with coronary artery disease: a post hoc analysis of data from a prospective, randomized, double-blind study
    Thomas Walter
    University Medical Center Mannheim, First Department of Medicine, Mannheim, Germany
    Clin Drug Investig 30:453-60. 2010
    ..Treatment with HMG-CoA reductase inhibitors (statins) reduces the morbidity and mortality of coronary artery disease (CAD). In addition to their lipid-lowering actions, pleiotropic effects of statins have been demonstrated...
  22. ncbi Enhanced expression of platelet CD40-ligand by in vitro lipopolysaccharide-challenge in patients with ventricular fibrillation complicating acute myocardial infarction
    Thorsten Kälsch
    Department of Cardiology, 1st Department of Medicine, University Hospital Mannheim, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Int J Cardiol 107:350-5. 2006
    ..A role of inflammatory stimulation on platelets as a potential risk factor for ventricular fibrillation during acute myocardial infarction has not been described yet...
  23. doi Platelet and monocyte activation in acute ischemic stroke--is there a correlation with stroke etiology?
    Tom Oberheiden
    1st Department of Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Germany
    Clin Appl Thromb Hemost 18:87-91. 2012
    ..047). In conclusion, patients with acute ischemic stroke show an upregulation of platelet CD40L and an activation of cellular coagulation with highest activation in the large artery disease subgroup...
  24. ncbi Sex-based differences in clinical and angiographic outcomes in patients with ST-elevation myocardial infarction treated with concomitant use of glycoprotein IIb/IIIa inhibitors
    Stefan Kralev
    1st Departmet of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Cardiol J 17:580-6. 2010
    ..The purpose of the present prospective study was to compare the clinical outcome of women and men presenting with ST-elevation myocardial infarction (STEMI) undergoing primary PCI with concomitant usage of GP IIb/IIIa inhibitors...
  25. ncbi Thrombogenicity of sirolimus-eluting stents and bare metal stents: evaluation in the early phase after stent implantation
    Thomas Walter
    University Medical Centre Mannheim, First Department of Medicine Cardiology, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    In Vivo 24:635-9. 2010
    ..Thrombogenicitiy of drug-eluting stents is a matter of controversial debate. The aim of this study was to evaluate the thrombogenicity of sirolimus-eluting stents (SES) compared to bare metal stents (BMS) in a standardised in vitro model...
  26. ncbi Endotoxin-induced effects on platelets and monocytes in an in vivo model of inflammation
    Thorsten Kälsch
    1st Department of Medicine, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Basic Res Cardiol 102:460-6. 2007
    ..The aim of this study was to investigate the direct and short-term effects of inflammation on platelet and monocyte activation with an in vivo model of endotoxemia in healthy volunteers...
  27. ncbi Effects of alimentary lipemia and inflammation on platelet CD40-ligand
    Thorsten Kälsch
    1st Department of Medicine, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Thromb Res 120:703-8. 2007
    ..Our aim was to describe the role of postprandial lipemia and inflammatory stimulation on platelet and monocyte activation and CD40-ligand (CD40L) levels...
  28. ncbi Activation of coagulation during alimentary lipemia under real-life conditions
    Elif Elmas
    I Department of Medicine, University Hospital of Mannheim, Theodor Kutzer Ufer 1 3, D 68167, Mannheim, Germany
    Int J Cardiol 114:172-5. 2007
    ..9+/-94.6 to 273.6+/-122.5 mg/dl in coronary heart disease patients. Fat-rich meals may cause procoagulant episodes, which may promote vascular complications such as myocardial infarction, transient ischemia attacks in susceptible persons...
  29. ncbi Valproate-associated coagulopathies are frequent and variable in children
    Thorsten Gerstner
    Department of Pediatrics, Mannheim University Hospital, University of Heidelberg, Heidelberg, Germany
    Epilepsia 47:1136-43. 2006
    ..The clinical relevance of coagulopathies, known as side effects of VPA therapy, especially thrombocytopenia, von Willebrand disease, and a decrease of factor XIII, is still unclear...
  30. ncbi Interleukin-1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis
    Jens J Kaden
    1st Department of Medicine Cardiology, Angiology, and Pneumology, University Hospital of Mannheim, Mannheim, Germany
    Atherosclerosis 170:205-11. 2003
    ..Cell proliferation was increased by IL-1 beta as determined by bromodesoxyuridine incorporation. Thus, IL-1 beta may regulate remodeling of the extracellular matrix in calcific AS...
  31. ncbi Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis
    Jens J Kaden
    1st Department of Medicine Cardiology, Angiology, and Pneumology, University Hospital of Mannheim, Germany
    J Heart Valve Dis 13:560-6. 2004
    ..Their pathogenetic role in calcific aortic stenosis is unknown...
  32. doi The reduced anticoagulant effect of fondaparinux at low antithrombin levels
    Carl Erik Dempfle
    I Department of Medicine, University Medical Centre Mannheim, Mannheim, Germany
    Anesth Analg 109:712-6. 2009
    ..Low antithrombin levels may compromise the anticoagulant effect of heparin and heparin-related compounds, such as fondaparinux...
  33. ncbi High plasma levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) and interleukin-8 (IL-8) characterize patients prone to ventricular fibrillation complicating myocardial infarction
    Elif Elmas
    1st Department of Medicine, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
    Clin Chem Lab Med 45:1360-5. 2007
    ..The aim of the present study was to assess potential differences of levels of MMP-9, TIMP-1 and IL-8 in postmyocardial infarction patients with or without VF complicating acute MI...
  34. ncbi Assessment of markers of thrombin generation in patients with acute myocardial infarction complicated by ventricular fibrillation
    Elif Elmas
    Department of Cardiology, First Department of Medicine, University of Heidelberg, Mannheim, Germany
    Clin Cardiol 29:165-9. 2006
    ....
  35. ncbi Time-dependent changes in the plasma concentration of matrix metalloproteinase 9 after acute myocardial infarction
    Jens J Kaden
    1st Department of Medicine Cardiology, Angiology and Pulmonology, University Hospital of Mannheim, Mannheim, Germany
    Cardiology 99:140-4. 2003
    ..The ratio of MMP-9 to TIMP-1 was significantly increased on admission in both groups and returned to baseline at 48 h. These data suggest that MMP-9 might play a pathophysiologic role during the early phase of acute MI...
  36. ncbi Pathogenetic role of Chlamydia pneumoniae in calcific aortic stenosis: immunohistochemistry study and review of the literature
    Jens J Kaden
    1st Department of Medicine Cardiology, Angiology, and Pneumology, University Hospital of Mannheim, University of Heidelberg, Germany
    J Heart Valve Dis 12:447-53. 2003
    ..An association with Chlamydia pneumoniae infection has been discussed, but previous studies have yielded divergent results...
  37. doi Activation of platelets and cellular coagulation in cerebral small-vessel disease
    Tom Oberheiden
    1st Department of Medicine, Germany
    Blood Coagul Fibrinolysis 21:729-35. 2010
    ..Patients with cSVD show an up-regulation of the platelet CD40L and CD62P system and an activation of cellular coagulation which might contribute to the initiation and progression of cSVD...
  38. ncbi Coagulation activation and expression of CD40 ligand on platelets upon in vitro lipopolysaccharide-challenge in patients with unstable angina
    Thorsten Kälsch
    University Hospital Mannheim, 1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Int J Cardiol 111:217-23. 2006
    ..A role of inflammatory stimulation on coagulation time and expression of CD40 ligand on platelets in acute coronary syndromes has not been described yet...
  39. ncbi Midregional pro-atrial natriuretic peptide is a useful indicator for the detection of impaired left ventricular function in patients with coronary artery disease
    Elif Elmas
    1st Department of Medicine, Medical Faculty Mannheim of the University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Int J Cardiol 128:244-9. 2008
    ....
  40. ncbi Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis
    Jens J Kaden
    1st Department of Medicine Cardiology, Angiology, Pneumology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Cardiovasc Pathol 14:80-7. 2005
    ....
  41. ncbi Coagulation activation is associated with interleukin-6 plasma levels in patients with mechanical prosthetic heart valves
    Volker Liebe
    First Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    In Vivo 20:427-30. 2006
    ..Here, anticoagulation efficiency was assessed by sensitive techniques and potential determinants of coagulation activation were identified...
  42. ncbi Alimentary lipemia enhances procoagulatory effects of inflammation in patients with a history of acute myocardial infarction complicated by ventricular fibrillation
    Thorsten Kälsch
    1st Department of Medicine, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Int J Cardiol 123:131-7. 2008
    ..The role of acute alimentary lipemia and inflammation in the occurrence of ventricular arrhythmias in acute myocardial infarction has not been described yet...
  43. doi Factor V Leiden mutation enhances fibrin formation and dissolution in vivo in a human endotoxemia model
    Elif Elmas
    Department of Medicine I, University Medical Center Mannheim, Mannheim, Germany
    Blood 116:801-5. 2010
    ....
  44. ncbi Correlation of degree of aortic valve stenosis by Doppler echocardiogram to quantity of calcium in the valve by electron beam tomography
    Jens J Kaden
    Department of Internal Medicine I Cardiology, Angiology, and Pneumology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Am J Cardiol 90:554-7. 2002
  45. ncbi Evaluation of the automated coagulation analyzer Sysmex CA-7000
    Alexandra Dorn-Beineke
    Institute for Clinical Chemistry, Faculty for Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim 68167, Germany
    Thromb Res 116:171-9. 2005
    ..The aim of the present study was to evaluate the analytical and technical performance of the Sysmex CA-7000 coagulation analyzer under routine laboratory conditions...
  46. ncbi Validation, calibration, and specificity of quantitative D-dimer assays
    Carl Erik Dempfle
    I Department of Medicine, University Hospital of Mannheim, Mannheim, Germany
    Semin Vasc Med 5:315-20. 2005
    ..Assay technologies include manual latex agglutination assays, automated latex-enhanced light-scattering immunoassays, enzyme-linked immunoassays, and others...
  47. ncbi Clinical outcome of patients with diabetes presenting with ST-elevation myocardial infarction and treated with concomitant use of glycoprotein IIb/IIIa inhibitors
    Stefan Kralev
    1st Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Cardiol J 16:234-40. 2009
    ..This study aims to compare the clinical outcome of patients with and without diabetes, presenting with STEMI undergoing primary PCI with concomitant usage of GP IIb/IIIa inhibitors in real clinical practice...
  48. ncbi Effect of atorvastatin on cellular adhesion molecules on leukocytes in patients with normocholesterolemic coronary artery disease
    Thomas Walter
    University Medical Centre Mannheim, First Department of Medicine, D 68167 Mannheim, Germany
    In Vivo 24:189-93. 2010
    ..The aim of the present study was to assess whether atorvastatin therapy has an impact on the expression of cellular adhesion molecules on leukocytes in patients with normocholesterolemic CAD...
  49. ncbi Factor XIII deficiency associated with valproate treatment
    Martin Teich
    Department of Pediatrics, Mannheim University Hospital, University of Heidelberg, Heidelberg, Germany
    Epilepsia 45:187-9. 2004
    ..We present two children who developed a deficiency of factor XIII with valproate (VPA) treatment. This coagulation disorder has not been described in association with VPA treatment in children, and only very recently in one adult patient...
  50. doi The G534E-polymorphism of the gene encoding the factor VII-activating protease is a risk factor for venous thrombosis and recurrent events
    Parviz Ahmad-Nejad
    Institute for Clinical Chemistry, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Germany
    Thromb Res 130:441-4. 2012
    ....
  51. doi In vivo clot lysis of human thrombus with intravenous abciximab immunobubbles and ultrasound
    Angelika Alonso
    Department of Neurology, University Hospital of Mannheim, Germany
    Thromb Res 124:70-4. 2009
    ..2 MHz ultrasound in combination with abciximab immunobubbles induces thrombolysis without lytic agents that is superior to insonation of non-specific immunobubbles...
  52. ncbi Enhanced coagulation activation by in vitro lipopolysaccharide challenge in patients with ventricular fibrillation complicating acute myocardial infarction
    Thorsten Kälsch
    1st Department of Medicine, University Hospital Mannheim, Germany
    J Cardiovasc Electrophysiol 16:858-63. 2005
    ..Indicators of coagulation and inflammation are elevated in patients with coronary heart disease. A role of coagulation activation in ventricular fibrillation during acute myocardial infarction has not been described...
  53. ncbi Phenprocoumon-induced hepatitis as an immunologically mediated drug allergic complication of antithrombotic therapy
    Alexandra Dorn-Beineke
    Institute of Clinical Chemistry, Laboratory for Haematology and Immunology, Faculty of Clinical Medicine Mannheim, University Heidelberg, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
    Thromb Haemost 90:1210-3. 2003
  54. doi High incidence of vaproate-induced coagulation disorders in children receiving valproic acid: a prospective study
    Stephan Koenig
    Department of Pediatrics, Germany, Mannheim University Hospital, University of Heidelberg, Germany
    Blood Coagul Fibrinolysis 19:375-82. 2008
    ..Acquired von Willebrand's disease and hypofibrinogenemia may become relevant in patients with surgery or trauma. Particular attention should be paid to factor-XIII deficiency, which is especially seen with valproate therapy...
  55. ncbi Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcification
    Jens J Kaden
    First Department of Medicine Cardiology, Angiology, and Pneumology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theordor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Mol Cell Cardiol 36:57-66. 2004
    ..quot;Receptor Activator of Nuclear factor kappaB Ligand" (RANKL) and osteoprotegerin (OPG) are members of a cytokine system involved in bone turnover and vascular calcification. Their role in calcific AS is not known...
  56. ncbi In vitro models for assessing transcranial ultrasound-enhanced thrombolysis
    Stephen Meairs
    Stroke 36:929-30; author reply 930-1. 2005
  57. doi The hidden sepsis marker: aPTT waveform analysis
    Carl Erik Dempfle
    Thromb Haemost 100:9-10. 2008
  58. ncbi D-dimer: standardization versus harmonization
    Carl Erik Dempfle
    Thromb Haemost 95:399-400. 2006
  59. ncbi Acidosis and impaired blood coagulation: what and how to correct before using recombinant human factor VIIa
    Carl Erik Dempfle
    Crit Care Med 35:1627-9. 2007
  60. ncbi Hypersensitivity to the pentasaccharide fondaparinux in patients with delayed-type heparin allergy
    Jochen Utikal
    Thromb Haemost 94:895-6. 2005
  61. ncbi Do we need thrombin generation assays for monitoring anticoagulation?
    Carl Erik Dempfle
    Thromb Haemost 100:179-80. 2008
  62. ncbi Lipoprotein complexed C-reactive protein in patients with coronary heart disease
    Elif Elmas
    Thromb Haemost 94:1111-2. 2005
  63. ncbi New disseminated intravascular coagulation score: A useful tool to predict mortality in comparison with Acute Physiology and Chronic Health Evaluation II and Logistic Organ Dysfunction scores
    Matthias W A Angstwurm
    Medizinische Klinik, Department of Internal Intensive Care Unit, Standort Innenstadt der Ludwig Maximilans Universitat Muenchen, Muenchen, Germany
    Crit Care Med 34:314-20; quiz 328. 2006
    ....
  64. ncbi Hypofibrinogenaemia associated with a novel heterozygous gamma289 Ala -->Val substitution (fibrinogen Dorfen)
    Amy Dear
    Molecular Pathology Laboratory, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Thromb Haemost 92:1291-5. 2004
    ..This case suggests that the highly conserved Ala(289) is important in maintaining structure of the "a" polymerization site via hydrogen bonding to Thr(371)...
  65. ncbi Theme issue: fibrinogen and fibrin--structure, function, interactions and clinical applications
    Carl Erik Dempfle
    Thromb Haemost 89:599-600. 2003
  66. ncbi [Sepsis diagnosis: hemostatic imbalance and role of activated protein C]
    Carl Erik Dempfle
    Krankenpfl J 40:316. 2002
  67. ncbi [Clinical assessment of potential fields of application of recombinant factor VIIa in internal and pediatric diseases. Recommendations of an expert group]
    Carl Erik Dempfle
    Hämostaseologie, Klinikum Mannheim gGmbH, Mannheim
    Med Klin (Munich) 102:70-81. 2007
    ..In factor VII deficiency lower dosages of 15-30 microg/kg body weight of rFVIIa are given every 4-6 h, whereas higher doses of 150-200 microg/kg body weight are used in neonates...
  68. ncbi Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients
    Katrin Tefs
    Hospital for Children and Adolescents, University of Leipzig, Oststrasse 21 25, D 04317 Leipzig, Germany
    Blood 108:3021-6. 2006
    ..These results demonstrate impaired secretion of mutant PLG proteins as a common molecular pathomechanism in type I PLG deficiency...