Eva L Decker

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. ncbi request reprint The moss bioreactor
    Eva L Decker
    Plant Biotechnology, University of Freiburg, Schaenzlstrasse 1, 79104 Freiburg, Germany
    Curr Opin Plant Biol 7:166-70. 2004
  2. ncbi request reprint Current achievements in the production of complex biopharmaceuticals with moss bioreactors
    Eva L Decker
    Plant Biotechnology, Faculty of Biology, Freiburg University, Schaenzlestr 1, 79104 Freiburg, Germany
    Bioprocess Biosyst Eng 31:3-9. 2008
  3. ncbi request reprint A novel aspartic proteinase is targeted to the secretory pathway and to the vacuole in the moss Physcomitrella patens
    Andreas Schaaf
    Plant Biotechnology, University of Freiburg, Freiburg, Germany
    Eur J Cell Biol 83:145-52. 2004
  4. pmc Use of endogenous signal sequences for transient production and efficient secretion by moss (Physcomitrella patens) cells
    Andreas Schaaf
    Department of Plant Biochemistry and Biotechnology, University of Munster, Hindenburgplatz 55, 48143 Münster, Germany
    BMC Biotechnol 5:30. 2005
  5. ncbi request reprint Filamentous temperature-sensitive Z (FtsZ) isoforms specifically interact in the chloroplasts and in the cytosol of Physcomitrella patens
    Louis Gremillon
    Plant Biotechnology, Faculty of Biology, University of Freiburg, Schaenzlestr 1, 79104 Freiburg, Germany
    New Phytol 176:299-310. 2007
  6. pmc Dual targeting of plastid division protein FtsZ to chloroplasts and the cytoplasm
    Justine Kiessling
    Plant Biotechnology, University of Freiburg, Schaenzlestrasse 1, D 79104 Freiburg, Germany
    EMBO Rep 5:889-94. 2004
  7. doi request reprint Moss-based production of asialo-erythropoietin devoid of Lewis A and other plant-typical carbohydrate determinants
    Juliana Parsons
    Plant Biotechnology, University of Freiburg, Freiburg, Germany
    Plant Biotechnol J 10:851-61. 2012
  8. doi request reprint Glycoprotein production in moss bioreactors
    Eva L Decker
    Plant Biotechnology, University of Freiburg, Schaenzlestr 1, 79104 Freiburg, Germany
    Plant Cell Rep 31:453-60. 2012
  9. ncbi request reprint Moss bioreactors producing improved biopharmaceuticals
    Eva L Decker
    Plant Biotechnology, Faculty of Biology, University of Freiburg, Schaenzlestr 1, D 79104 Freiburg, Germany
    Curr Opin Biotechnol 18:393-8. 2007
  10. doi request reprint Production of biologically active recombinant human factor H in Physcomitrella
    Annette Büttner-Mainik
    Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany
    Plant Biotechnol J 9:373-83. 2011

Collaborators

Detail Information

Publications15

  1. ncbi request reprint The moss bioreactor
    Eva L Decker
    Plant Biotechnology, University of Freiburg, Schaenzlstrasse 1, 79104 Freiburg, Germany
    Curr Opin Plant Biol 7:166-70. 2004
    ..Unlike all other plants, moss allows straightforward 'humanisation' of plant-derived pharmaceuticals...
  2. ncbi request reprint Current achievements in the production of complex biopharmaceuticals with moss bioreactors
    Eva L Decker
    Plant Biotechnology, Faculty of Biology, Freiburg University, Schaenzlestr 1, 79104 Freiburg, Germany
    Bioprocess Biosyst Eng 31:3-9. 2008
    ..By this means, moss strains with non-immunogenic humanized glycan patterns were created. Here we present an overview of the relevant aspects for establishing moss as a production system for recombinant biopharmaceuticals...
  3. ncbi request reprint A novel aspartic proteinase is targeted to the secretory pathway and to the vacuole in the moss Physcomitrella patens
    Andreas Schaaf
    Plant Biotechnology, University of Freiburg, Freiburg, Germany
    Eur J Cell Biol 83:145-52. 2004
    ..Above all the functionality of the secretory and the vacuolar targeting signals make them become useful tools for biotechnological approaches...
  4. pmc Use of endogenous signal sequences for transient production and efficient secretion by moss (Physcomitrella patens) cells
    Andreas Schaaf
    Department of Plant Biochemistry and Biotechnology, University of Munster, Hindenburgplatz 55, 48143 Münster, Germany
    BMC Biotechnol 5:30. 2005
    ..Though general features of secretion signals are conserved between plants and animals, the broad sequence variability among signal peptides suggests differing efficiency of signal peptide recognition...
  5. ncbi request reprint Filamentous temperature-sensitive Z (FtsZ) isoforms specifically interact in the chloroplasts and in the cytosol of Physcomitrella patens
    Louis Gremillon
    Plant Biotechnology, Faculty of Biology, University of Freiburg, Schaenzlestr 1, 79104 Freiburg, Germany
    New Phytol 176:299-310. 2007
    ....
  6. pmc Dual targeting of plastid division protein FtsZ to chloroplasts and the cytoplasm
    Justine Kiessling
    Plant Biotechnology, University of Freiburg, Schaenzlestrasse 1, D 79104 Freiburg, Germany
    EMBO Rep 5:889-94. 2004
    ..These findings comprise the first report on cytosolic localization of a eukaryotic FtsZ isoform, and indicate that this protein might connect cell and organelle division at least in moss...
  7. doi request reprint Moss-based production of asialo-erythropoietin devoid of Lewis A and other plant-typical carbohydrate determinants
    Juliana Parsons
    Plant Biotechnology, University of Freiburg, Freiburg, Germany
    Plant Biotechnol J 10:851-61. 2012
    ....
  8. doi request reprint Glycoprotein production in moss bioreactors
    Eva L Decker
    Plant Biotechnology, University of Freiburg, Schaenzlestr 1, 79104 Freiburg, Germany
    Plant Cell Rep 31:453-60. 2012
    ..Therapeutic antibodies produced in these strains exhibited antibody-dependent cellular cytotoxicity superior to the same molecules synthesized in mammalian cell lines...
  9. ncbi request reprint Moss bioreactors producing improved biopharmaceuticals
    Eva L Decker
    Plant Biotechnology, Faculty of Biology, University of Freiburg, Schaenzlestr 1, D 79104 Freiburg, Germany
    Curr Opin Biotechnol 18:393-8. 2007
    ..By targeted gene replacements, moss strains were created with non-immunogenic humanised glycan patterns. These were proven to be superior to currently used mammalian cell lines in producing antibodies with enhanced effectiveness...
  10. doi request reprint Production of biologically active recombinant human factor H in Physcomitrella
    Annette Büttner-Mainik
    Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany
    Plant Biotechnol J 9:373-83. 2011
    ..Ultimately, we show that the rFH displays complement regulatory activity comparable to FH purified from plasma...
  11. ncbi request reprint Diversification of ftsZ during early land plant evolution
    Stefan A Rensing
    University of Freiburg, Plant Biotechnology, Sonnenstr 5, D 79104 Freiburg, Germany
    J Mol Evol 58:154-62. 2004
    ..Comparison of sequence features and phylogenetic analyses confirm the presence of two clusters of paralogues in land plants and demonstrate that these genes were duplicated before the divergence of mosses, ferns and seed plants...
  12. pmc Quantitative promoter analysis in Physcomitrella patens: a set of plant vectors activating gene expression within three orders of magnitude
    Verena Horstmann
    University of Freiburg, Schaenzlestr, 1, 79104 Freiburg, Germany
    BMC Biotechnol 4:13. 2004
    ..To satisfy this requirement, a set of plant expression vectors was constructed and equipped with either heterologous or endogenous promoters...
  13. ncbi request reprint Cyclin D-knockout uncouples developmental progression from sugar availability
    Stefan Lorenz
    Freiburg University, Plant Biotechnology, Schaenzlestrasse 1, 79104 Freiburg, Germany
    Plant Mol Biol 53:227-36. 2003
    ..Thus, we conclude that Physcomitrella CycD might not be essential for cell-cycle regulation but is important for coupling the developmental progression to nutrient availability...
  14. ncbi request reprint Loss of GH3 function does not affect phytochrome-mediated development in a moss, Physcomitrella patens
    Nicole M Bierfreund
    University of Freiburg, Schaenzlestrsse, Freiburg, Germany
    J Plant Physiol 161:823-35. 2004
    ..No obvious differences between wild type and knockout plants could be detected under the examined conditions, indicating functional redundancy of the two genes...
  15. ncbi request reprint Isolation and characterisation of three moss-derived beta-tubulin promoters suitable for recombinant expression
    Wolfgang Jost
    Greenovation Biotech GmbH, Bötzinger Strasse 29b, 79111 Freiburg, Germany
    Curr Genet 47:111-20. 2005
    ..Expression rates were up to three times higher than those obtained with the 35S cauliflower mosaic virus (35S) promoter, which served as a reference...