Research Topics
Genomes and GenesSpecies | Volker DanielSummaryAffiliation: University of Heidelberg Country: Germany Publications
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Publications
CD4+ CD25+ Foxp3+ IFNγ+ CD178+ human induced Treg (iTreg) contribute to suppression of alloresponses by apoptosis of responder cellsVolker Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
Hum Immunol 74:151-62. 2013....- CD4(+)CD25(+)Foxp3(+)IFNγ(+) Treg are immunosuppressive in vitro and increase with intensity of the alloresponse in pretransplant MLCVolker Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
Transpl Immunol 27:114-21. 2012..Quantity of induced IFNγ(+) iTreg depends on the strength of the alloresponse and both parameters are inversely associated with long-term graft outcome... 
In-vitro inhibition of IFNγ+ iTreg mediated by monoclonal antibodies against cell surface determinants essential for iTreg functionVolker Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Germany
BMC Immunol 13:47. 2012..To study the mechanism of immunosuppression, we attempted to block cell surface receptors and thereby inhibited the function of this iTreg subset in-vitro using monoclonal antibodies and recombinant proteins...- Clinical relevance of immune monitoring in solid organ transplantationVolker Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Int Rev Immunol 28:155-84. 2009..A multiparametric immune monitoring program, performed frequently and lifelong, might be the appropriate approach to predict dysfunction of the graft before clinical symptoms occur... - Association of high IFN-gamma plasma levels with low B-cell counts in renal transplant recipients with stable long-term graft functionVolker Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Clin Transplant 24:281-9. 2010..High IFN-gamma plasma levels might prevent the development of an immunological alloresponse and thereby contribute to the maintenance of graft acceptance... - Observational support for an immunoregulatory role of CD3+CD4+CD25+IFN-gamma+ blood lymphocytes in kidney transplant recipients with good long-term graft outcomeVolker Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transpl Int 21:646-60. 2008..Our data support an immunoregulatory role of CD3+CD4+CD25+Foxp3+IFN-gamma+ cells in a subgroup of transplant recipients with good graft acceptance... 
Association of IL-12+ DC with High CD3+CD4-DR+ lymphocyte counts in long-term HIV-infected hemophilia patients with clinically stable diseaseVolker Daniel
Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
J Clin Immunol 28:58-72. 2008..These data suggest that long-term HIV-infected hemophilia patients with clinically stable disease have normal levels of functional IL-10(+) DC and IL-12(+) DC that might be involved in halting the progression of disease...- Association of circulating interleukin (IL)-12- and IL-10-producing dendritic cells with time posttransplant, dose of immunosuppression, and plasma cytokines in renal-transplant recipientsVolker Daniel
Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, S 69120 Heidelberg, Germany
Transplantation 79:1498-506. 2005..We investigated DC and plasma cytokine patterns early and late after transplantation... - Increased peripheral blood leukocyte subsets with regulatory phenotype in clinically stable long-term HIV-infected hemophilia patients on HAART may be beneficial and contribute to a decrease in autoimmunityVolker Daniel
Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Viral Immunol 23:87-97. 2010..Increased immunoregulatory T PBL might decrease autoimmunity, thereby contributing to immunological reconstitution and stabilization of long-term HIV-infected hemophilia patients on HAART... - Normal or even increased dendritic cell and peripheral blood lymphocyte subsets with regulatory phenotype in clinically stable long-term HIV-infected patients with hemophilia on highly active antiretroviral therapyVolker Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
J Acquir Immune Defic Syndr 47:1-15. 2008..Increased CD8 PBL counts imply immunocompetence. Increased CD8 PBL counts and normal or even upregulated immunoregulatory cells might stabilize our long-term HIV-infected patients with hemophilia clinically... - CD4+CD25+Foxp3+IFN-γ+ human induced T regulatory cells are induced by interferon-γ and suppress alloresponses nonspecificallyVolker Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Hum Immunol 72:699-707. 2011..Circulating CD4(+)CD25(+)Foxp3(+)IFN-γ(+) PBL could suppress allogeneic T-cell responses in patients and may be involved in inhibition of the posttransplant alloresponse... - Associations of dichlorodiphenyltrichloroethane (DDT) 4.4 and dichlorodiphenyldichloroethylene (DDE) 4.4 blood levels with plasma IL-4Volker Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Arch Environ Health 57:541-7. 2002..The authors hypothesized that clinical symptoms, such as the frequent infections reported by many patients, could be a consequence of these immunological abnormalities... - Proteasome inhibition suppresses essential immune functions of human CD4+ T cellsCarsten Berges
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Immunology 124:234-46. 2008..Thus, the proteasome is required for essential immune functions of activated CD4(+) T cells and can be defined as a molecular target for the suppression of deregulated and unwanted T-cell-mediated immune responses... - Short communication: decreasing soluble CD30 and increasing IFN-gamma plasma levels are indicators of effective highly active antiretroviral therapyMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
AIDS Res Hum Retroviruses 23:886-90. 2007..Our data suggest that decreasing sCD30 and increasing IFN-gamma plasma levels are indicators of effective HAART treatment and CD4 Th1 cell recovery in HIV-infected patients... - Decreasing plasma soluble IL-1 receptor antagonist and increasing monocyte activation early post-transplant may be involved in pathogenesis of delayed graft function in renal transplant recipientsMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
Clin Transplant 24:415-23. 2010..Blocking of monocyte activity after renal transplantation may be considered a potential approach for improving graft outcome... - Association of pretransplant soluble glycoprotein 130 (sgp130) plasma levels and posttransplant acute tubular necrosis in renal transplant recipientsMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
Transplantation 88:266-71. 2009..Previously, we reported that high pretransplant sIL-6R plasma levels are associated with posttransplant acute tubular necrosis (ATN). In this study, we examined associations of pretransplant plasma levels of sgp130 with ATN... - Proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+ T cellsCarsten Berges
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
J Cell Biochem 108:935-46. 2009..These results provide novel insights into the mechanisms of apoptosis induced by proteasome inhibition in activated T cells and underscore the future use of proteasome inhibitors for immunosuppression... - Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruriaMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 88:1109-16. 2009..BKV-associated nephropathy develops in approximately 5% to 8% of renal transplant recipients, and its prognosis is poor. The relationship between urine cytokines and BK viruria in kidney recipients has not been defined... - Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanismsCarsten Berges
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
Mol Immunol 46:2892-901. 2009..Thus, helenalin can be defined as a new immunosuppressive compound suited for the treatment of deregulated and unwanted T cell-mediated immune responses... - Dissociation of CD4(+) cell counts from viral load and association with immune complexes in HIV(+) hemophilia patientsMahmoud Sadeghi
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D-69120, Heidelberg, Germany
Immunol Lett 91:23-32. 2004..CONCLUSION: These data suggest that HIV regulates and mediates CD4 depletion in part by the induction of autoreactive ICs against CD4(+) lymphocytes, especially complement-fixing autoreactive IgG and gp120/IgG complexes... - Evidence for IFN-gamma up- and IL-4 downregulation late post-transplant in patients with good kidney graft outcomeMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Clin Transplant 21:449-59. 2007..These data suggest that increased plasma IFN-gamma and decreased plasma IL-4 late post-transplant might be involved in the induction of mechanisms that facilitate good long-term graft outcome... - Increased pretransplantation plasma kynurenine levels do not protect from but predict acute kidney allograft rejectionImad Lahdou
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Hum Immunol 71:1067-72. 2010..Although informative in overall terms, at the present stage, Kyn levels do not allow the concise risk differentiation of individual patients... - Dysregulated cytokine responses during cytomegalovirus infection in renal transplant recipientsMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 86:275-85. 2008..The aim of this study was to examine whether there are differences in plasma cytokine levels pretransplant, before and during CMV replication in renal transplant recipients... - Epidemiology of pretransplant EBV and CMV serostatus in relation to posttransplant non-Hodgkin lymphomaGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 88:962-7. 2009..CMV serostatus was not independently associated with risk of NHL after kidney transplantation. Surprisingly, in liver transplantation, the risk of NHL was virtually unaffected by EBV serostatus... - Proteasomal chymotrypsin-like peptidase activity is required for essential functions of human monocyte-derived dendritic cellsCord Naujokat
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Immunology 120:120-32. 2007.... - Strong inflammatory cytokine response in male and strong anti-inflammatory response in female kidney transplant recipients with urinary tract infectionMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transpl Int 18:177-85. 2005.... - Antithymocyte globulins suppress dendritic cell function by multiple mechanismsCord Naujokat
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 83:485-97. 2007..Although immunosuppressive mechanisms of ATGs on T cells are well studied, less is known about their impact on dendritic cells (DCs)... - Increased expression and altered subunit composition of proteasomes induced by continuous proteasome inhibition establish apoptosis resistance and hyperproliferation of Burkitt lymphoma cellsDominik Fuchs
Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
J Cell Biochem 103:270-83. 2008.... - Strong association of phenylalanine and tryptophan metabolites with activated cytomegalovirus infection in kidney transplant recipientsMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, D 69117 Heidelberg, Germany
Hum Immunol 73:186-92. 2012..Moreover, tryptophan metabolite levels correlate with disease severity. Measurement of these amino acids is an inexpensive and fast method expected to complete conventional diagnostic assays... - High urine sIL-6R as a predictor of late graft failure in renal transplant recipientsMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany. mahmoud.sadeghi@ med.uni-heidelberg.de
Transplantation 76:1190-4. 2003..003 and P=0.01, respectively). Serum creatinine levels were not associated with increased urine sIL-6R. CONCLUSION: High urine sIL-6R appears to be predictive of late graft failure in renal transplant recipients... - Association of high pretransplant sIL-6R plasma levels with acute tubular necrosis in kidney graft recipientsMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 81:1716-24. 2006.... - Cytokine expression during early and late phase of acute Puumala hantavirus infectionMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
BMC Immunol 12:65. 2011..An immune-mediated pathogenesis is discussed for both syndromes. The aim of our study was to investigate cytokine expression during the course of acute Puumala hantavirus infection... - Pharmacokinetics and immunodynamics of basiliximab in pediatric renal transplant recipients on mycophenolate mofetil comedicationBritta Höcker
Department of Pediatrics I, University Children s Hospital Heidelberg, Heidelberg, Germany
Transplantation 86:1234-40. 2008.... - HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathwayDominik Fuchs
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
Biochem Biophys Res Commun 374:309-14. 2008..Thus, simvastatin overcomes bortezomib-induced apoptosis resistance by inhibiting synthesis of GGPP and disrupting a GGPP-dependent survival pathway... - Evaluation of hepatocyte growth factor as a sensitive marker for early detection of acute renal allograft rejectionKhaled Mahmoud
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 83:1035-40. 2007..In the present study we investigated whether HGF can serve as a marker for detection of acute rejection in the early posttransplantation period... - Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cellsDominik Fuchs
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
Biochem Biophys Res Commun 390:743-9. 2009..Thus, salinomycin should be considered as a novel and effective anticancer agent that overcomes multiple mechanisms of apoptosis resistance in human cancer cells... - Plasmapheresis adjusts inflammatory responses in potential kidney transplant recipientsMahmoud Sadeghi
1 Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany 2 Department of Nephrology, University of Heidelberg, Heidelberg, Germany 3 Department of General and Transplant Surgery, University of Heidelberg, Heidelberg, Germany 4 Address correspondence to Mahmoud Sadeghi, M D, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, Heidelberg, Germany
Transplantation 95:1021-9. 2013..The effect of PP on lymphocyte subpopulations, plasma neopterin, and cytokines in renal transplant recipients was investigated in this study... - Disassociation between risk of graft loss and risk of non-Hodgkin lymphoma with induction agents in renal transplant recipientsGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 81:1227-33. 2006..It is widely assumed that the graft-enhancing properties of antilymphocyte induction agents and their lymphoma-inducing potential are intimately related... - Effect of cytomegalovirus prophylaxis with immunoglobulin or with antiviral drugs on post-transplant non-Hodgkin lymphoma: a multicentre retrospective analysisGerhard Opelz
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Lancet Oncol 8:212-8. 2007..No reliable methods for the prevention of EBV infection and lymphoma are available. We aimed to elucidate the effect of prophylactic treatment for cytomegalovirus (CMV) infection on the incidence of post-transplant lymphomas... - Cell cycle- and activation-dependent regulation of cyclosporin A-induced T cell apoptosisCord Naujokat
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
Biochem Biophys Res Commun 310:347-54. 2003.... - Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosisImad Lahdou
Department of Transplantation Immunology, University of Heidelberg, Germany
Hum Immunol 74:60-6. 2013..Here we investigate whether the degree of systemic inflammation (QuinA, neopterin, CRP and IL-6) correlates with clinical liver dysfunction according to the MELD Score... - A cell line model for the differentiation of human dendritic cellsCarsten Berges
Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D-69120 Heidelberg, Germany
Biochem Biophys Res Commun 333:896-907. 2005.... - Longitudinal analysis of T-helper cell phenotypes in renal-transplant recipients undergoing growth hormone therapyAnette Melk
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 78:1792-801. 2004..We therefore evaluated the immune phenotypes of pediatric renal-transplant recipients and controls in response to rhGH with regard to a possible shift toward a T-helper (TH)1-type response... - Effectivity of a T-cell-adapted induction therapy with anti-thymocyte globulin (Sangstat)Achim Koch
Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
J Heart Lung Transplant 24:708-13. 2005..Therefore, we investigated whether reduced T-cell-adapted ATG induction therapy could be performed without increasing the risk of graft loss by rejection and whether reductions in infection rates and costs are possible... - The collaborative transplant study registryGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany Electronic address
Transplant Rev (Orlando) 27:43-5. 2013..Participation is voluntary and the study has strictly scientific objectives. Analyses of the CTS database serve as an international reference source in the field of solid organ transplantation... - The role of IL-8 in patients with fibromyalgia: a prospective longitudinal study of 6 monthsHaili Wang
Department of Orthopedic Surgery, Ruprecht Karls University of Heidelberg, Heidelberg, Germany
Clin J Pain 25:1-4. 2009.... - Evaluation of posttransplantation soluble CD30 for diagnosis of acute renal allograft rejectionSteffen Pelzl
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 75:421-3. 2003..CONCLUSIONS: sCD30 measured on posttransplantation days 3 to 5 offers a noninvasive means for differentiating patients with impending acute allograft rejection from patients with an uncomplicated course or with acute tubular necrosis... - Mycophenolate mofetil-based immunosuppression and cytokine genotypes: effects on monokine secretion and antigen presentation in long-term renal transplant recipientsRolf Weimer
Department of Internal Medicine, University of Giessen, Giessen, Germany
Transplantation 75:2090-9. 2003..It has been suggested that increased monocyte responses might play a role in chronic allograft rejection... - Role of the ubiquitin-proteasome pathway in the diagnosis of human diseasesJakub Golab
Department of Immunology, Center of Biostructure Research, The Medical University of Warsaw, Warsaw, Poland
Clin Chim Acta 340:27-40. 2004..Future research should lead to an improved understanding of the pathophysiology of the ubiquitin-proteasome pathway with the aim of allowing the development of subtle diagnostic strategies... - ATG induction therapy: long-term effects on Th1 but not on Th2 responsesRolf Weimer
Department of Internal Medicine, University of Giessen, Giessen, Germany
Transpl Int 18:226-36. 2005....