Maura Dandri

Summary

Affiliation: University Medical Center Hamburg-Eppendorf
Country: Germany

Publications

  1. doi request reprint Experimental models and therapeutic approaches for HBV
    Maura Dandri
    Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Semin Immunopathol 35:7-21. 2013
  2. doi request reprint New insight in the pathobiology of hepatitis B virus infection
    Maura Dandri
    Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246, Hamburg, Germany
    Gut 61:i6-17. 2012
  3. doi request reprint The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus
    Tassilo Volz
    Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 58:861-7. 2013
  4. doi request reprint Virion half-life in chronic hepatitis B infection is strongly correlated with levels of viremia
    Maura Dandri
    Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Hepatology 48:1079-86. 2008
  5. doi request reprint In vivo proliferation of hepadnavirus-infected hepatocytes induces loss of covalently closed circular DNA in mice
    Marc Lutgehetmann
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Hepatology 52:16-24. 2010
  6. ncbi request reprint Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B
    Karsten Wursthorn
    Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Hepatology 44:675-84. 2006
  7. doi request reprint Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation
    Marc Lutgehetmann
    Department of Internal Medicine, University Medical Hospital Hamburg Eppendorf, Hamburg, Germany
    Hepatology 55:685-94. 2012
  8. doi request reprint Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice
    Marc Lutgehetmann
    Department of Internal Medicine, University Medical Hospital Hamburg Eppendorf, Hamburg, Germany
    Gastroenterology 140:2074-83, 2083.e1-2. 2011
  9. doi request reprint Strong antiviral activity of the new l-hydroxycytidine derivative, l-Hyd4FC, in HBV-infected human chimeric uPA/SCID mice
    Tassilo Volz
    Department of Internal Medicine, University Medical Center Hamburg, Hamburg, Germany
    Antivir Ther 17:623-31. 2012
  10. ncbi request reprint Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients
    Tassilo Volz
    Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Gastroenterology 133:843-52. 2007

Collaborators

Detail Information

Publications20

  1. doi request reprint Experimental models and therapeutic approaches for HBV
    Maura Dandri
    Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Semin Immunopathol 35:7-21. 2013
    ....
  2. doi request reprint New insight in the pathobiology of hepatitis B virus infection
    Maura Dandri
    Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246, Hamburg, Germany
    Gut 61:i6-17. 2012
    ....
  3. doi request reprint The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus
    Tassilo Volz
    Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 58:861-7. 2013
    ..We aimed at investigating the ability of the lipopeptide Myrcludex-B to block HBV spreading post-infection...
  4. doi request reprint Virion half-life in chronic hepatitis B infection is strongly correlated with levels of viremia
    Maura Dandri
    Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Hepatology 48:1079-86. 2008
    ..Notably, the lack of correlation between virion half-life and viremia in mice indicated that immune components significantly accelerate virion clearance rates in individuals with low titers...
  5. doi request reprint In vivo proliferation of hepadnavirus-infected hepatocytes induces loss of covalently closed circular DNA in mice
    Marc Lutgehetmann
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Hepatology 52:16-24. 2010
    ..5-log loss of intrahepatic cccDNA loads (P = 0.02). Intrahepatic viral DNA sequences persisting at the end of the study were mostly present as replicative intermediates and not as integrated virus...
  6. ncbi request reprint Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B
    Karsten Wursthorn
    Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Hepatology 44:675-84. 2006
    ..In conclusion, combination therapy with peg-IFN and ADV led to marked decreases in serum HBV-DNA and intrahepatic cccDNA, which was significantly correlated with reduced HBsAg...
  7. doi request reprint Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation
    Marc Lutgehetmann
    Department of Internal Medicine, University Medical Hospital Hamburg Eppendorf, Hamburg, Germany
    Hepatology 55:685-94. 2012
    ..Treatment with the HBV entry inhibitor Myrcludex-B, efficiently hindered the establishment of HDV infection in vivo...
  8. doi request reprint Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice
    Marc Lutgehetmann
    Department of Internal Medicine, University Medical Hospital Hamburg Eppendorf, Hamburg, Germany
    Gastroenterology 140:2074-83, 2083.e1-2. 2011
    ..We investigated whether HBV infection reduced IFN-α-mediated induction of antiviral defense mechanisms in human hepatocytes...
  9. doi request reprint Strong antiviral activity of the new l-hydroxycytidine derivative, l-Hyd4FC, in HBV-infected human chimeric uPA/SCID mice
    Tassilo Volz
    Department of Internal Medicine, University Medical Center Hamburg, Hamburg, Germany
    Antivir Ther 17:623-31. 2012
    ..The aim of this study was to determine the antiviral activity of l-Hyd4FC in HBV-infected human liver chimeric urokinase plasminogen activator (uPA)/SCID mice...
  10. ncbi request reprint Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients
    Tassilo Volz
    Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Gastroenterology 133:843-52. 2007
    ....
  11. pmc Multiplexing clonality: combining RGB marking and genetic barcoding
    Kerstin Cornils
    Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany, Institute for Medical Informatics and Biometry, Faculty of Medicine, Technische Universitat Dresden, Dresden 01307, Germany, ALS Automated Lab Solutions GmbH, Jena 07747, Germany, Department of Neuropathology, Hannover Medical School, Institute of Pathology, Hannover 30625, Germany, Department of Internal Medicine I, University Medical Center Hamburg Eppendorf, Hamburg 20246, Germany, Deep Sequencing Group SFB 655, Biotechnology Center, Technische Universitat Dresden, Dresden 01307, Germany
    Nucleic Acids Res 42:e56. 2014
    ..Moreover, the introduction of color-specific signatures in barcodes will facilitate studies on the impact of different variables (e.g. vector type, transgenes, culture conditions) in the context of competitive repopulation studies. ..
  12. doi request reprint Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration
    Lena Allweiss
    I Department of Medicine, Center for Internal Medicine, University Medical Center Hamburg Eppendorf, Germany
    J Hepatol 60:500-7. 2014
    ..Aim of the study was to investigate whether PegIFNα can induce sustained human hepatocyte responsiveness and substantial loss of circulating and intrahepatic viral antigen loads in a system lacking immune cell functions...
  13. doi request reprint Persistent hepatitis D virus mono-infection in humanized mice is efficiently converted by hepatitis B virus to a productive co-infection
    Katja Giersch
    I Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 60:538-44. 2014
    ..This study investigated whether HDV could persist intrahepatically in the absence of HBV in vivo and whether infectious HDV could subsequently be released following HBV super-infection...
  14. ncbi request reprint Morphological and functional analysis of rat hepatocyte spheroids generated on poly(L-lactic acid) polymer in a pulsatile flow bioreactor
    Eva Török
    Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Tissue Eng 12:1881-90. 2006
    ..Pulsatile flow culture on PLLA scaffolds is a promising new method of hepatic tissue engineering leading to liver neo-tissue formation...
  15. ncbi request reprint Chronic infection with hepatitis B viruses and antiviral drug evaluation in uPA mice after liver repopulation with tupaia hepatocytes
    Maura Dandri
    Department of Medicine, University of Hamburg, Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    J Hepatol 42:54-60. 2005
    ..Here we investigated the potential of primary hepatocytes from the tree shrew Tupaia belangeri that were shown to be susceptible to HBV infection...
  16. doi request reprint RGB marking facilitates multicolor clonal cell tracking
    Kristoffer Weber
    Research Department Cell and Gene Therapy, Clinic for Stem Cell Transplantation, University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Nat Med 17:504-9. 2011
    ..We conclude that RGB marking represents a useful tool for cell clonality studies in tissue regeneration and pathology...
  17. pmc Matrix Conditions and KLF2-Dependent Induction of Heme Oxygenase-1 Modulate Inhibition of HCV Replication by Fluvastatin
    Andrea Wuestenberg
    Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 9:e96533. 2014
    ..We investigated the mechanism, requirements and contribution of heme oxygenase-1(HO-1)-induction by statins to interference with HCV replication...
  18. doi request reprint Primary human hepatocytes from metabolic-disordered children recreate highly differentiated liver-tissue-like spheroids on alginate scaffolds
    Jeanette Bierwolf
    Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Tissue Eng Part A 18:1443-53. 2012
    ..Further, we demonstrate that livers from children with inherited metabolic disorders could serve as an alternative cell source for in vitro experiments...
  19. ncbi request reprint Increase in de novo HBV DNA integrations in response to oxidative DNA damage or inhibition of poly(ADP-ribosyl)ation
    Maura Dandri
    Heinrich Pette Institute for Experimental Virology and Immunology, University of Hamburg, Hamburg, Germany
    Hepatology 35:217-23. 2002
    ....
  20. doi request reprint Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression
    Janine Kah
    Institute of Experimental Immunology and Hepatology, Department of Medicine I, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Oncol Rep 28:1077-83. 2012
    ..Additionally, our results implicate that anti-tumor activity of statins requires cell proliferation and is reduced by p53 overexpression...