M Daffertshofer

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint [Heparin during acute ischemic stroke. Present data and clinical situation]
    M Daffertshofer
    Neurologische Klinik, Universitatsklinikum Mannheim, Ruprecht Karls Universitat, Heidelberg
    Nervenarzt 74:307-19. 2003
  2. ncbi request reprint Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: results of a phase II clinical trial
    Michael Daffertshofer
    Department of Neurology, Universitatsklinikum Mannheim, Germany
    Stroke 36:1441-6. 2005
  3. ncbi request reprint Transient ischemic attacks are more than "ministrokes"
    Michael Daffertshofer
    Department of Neurology, University Heidelberg, Universitatsklinikum Mannheim, Mannheim, Germany
    Stroke 35:2453-8. 2004
  4. ncbi request reprint Therapeutic ultrasound in ischemic stroke treatment: experimental evidence
    Michael Daffertshofer
    Department of Neurology, University of Heidelberg, University Hospital Mannheim, Theodor Kutzer Ufer, 68135, Mannheim, Germany
    Eur J Ultrasound 16:121-30. 2002
  5. ncbi request reprint Potential use of therapeutic ultrasound in ischemic stroke treatment
    S Behrens
    Department of Neurology, University of Heidelberg, University Hospital Mannheim, Theodor Kutzer Ufer, 68135 Mannheim, Germany
    Echocardiography 18:259-63. 2001
  6. ncbi request reprint Low-frequency, low-intensity ultrasound accelerates thrombolysis through the skull
    S Behrens
    Department of Neurology, University Hospital Mannheim, University of Heidelberg, Germany
    Ultrasound Med Biol 25:269-73. 1999
  7. ncbi request reprint Transcranial ultrasound-improved thrombolysis: diagnostic vs. therapeutic ultrasound
    S Behrens
    Department of Neurology, Universitaetsklinikum Mannheim, University of Heidelberg, 68135 Mannheim, Germany
    Ultrasound Med Biol 27:1683-9. 2001
  8. ncbi request reprint High-intensity transient signals in patients with cerebral ischemia
    M Daffertshofer
    Department of Neurology, University Heidelberg, Klinikum Mannheim, Germany
    Stroke 27:1844-9. 1996
  9. ncbi request reprint Improvement in stroke quality management by an educational programme
    Stephan Behrens
    Department of Neurology, University of Heidelberg, Universitatsklinikum Mannheim, Germany
    Cerebrovasc Dis 13:262-6. 2002
  10. doi request reprint Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY trial): a randomised, open-label, blinded-endpoint trial
    Reinhard Dengler
    Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
    Lancet Neurol 9:159-66. 2010

Detail Information

Publications36

  1. ncbi request reprint [Heparin during acute ischemic stroke. Present data and clinical situation]
    M Daffertshofer
    Neurologische Klinik, Universitatsklinikum Mannheim, Ruprecht Karls Universitat, Heidelberg
    Nervenarzt 74:307-19. 2003
    ..g.observational trials, continuous registers, etc.) addressing the adaptation of study-related conditions to the much more complex situation of daily routine (with risk/benefit, safety, and economic variables)...
  2. ncbi request reprint Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: results of a phase II clinical trial
    Michael Daffertshofer
    Department of Neurology, Universitatsklinikum Mannheim, Germany
    Stroke 36:1441-6. 2005
    ..We therefore conducted the first multicenter clinical trial to investigate safety of tPA plus low-frequency ultrasound (300 kHz)...
  3. ncbi request reprint Transient ischemic attacks are more than "ministrokes"
    Michael Daffertshofer
    Department of Neurology, University Heidelberg, Universitatsklinikum Mannheim, Mannheim, Germany
    Stroke 35:2453-8. 2004
    ..Transient ischemic attacks (TIAs) are warning signs of stroke. Recently, the hypothesis was raised that TIA bears a significant risk for death and dependence and requires the same complex diagnostic workup as a complete stroke...
  4. ncbi request reprint Therapeutic ultrasound in ischemic stroke treatment: experimental evidence
    Michael Daffertshofer
    Department of Neurology, University of Heidelberg, University Hospital Mannheim, Theodor Kutzer Ufer, 68135, Mannheim, Germany
    Eur J Ultrasound 16:121-30. 2002
    ..The experimental data so far help to characterize the optimal US settings for sonothrombolysis and support the hypothesis that this combined treatment is a prospective advance in optimizing thrombolytic therapy in acute stroke...
  5. ncbi request reprint Potential use of therapeutic ultrasound in ischemic stroke treatment
    S Behrens
    Department of Neurology, University of Heidelberg, University Hospital Mannheim, Theodor Kutzer Ufer, 68135 Mannheim, Germany
    Echocardiography 18:259-63. 2001
    ..This combined treatment is one perspective in optimizing therapy in acute stroke within the acute phase and may be applied easily with few limitations...
  6. ncbi request reprint Low-frequency, low-intensity ultrasound accelerates thrombolysis through the skull
    S Behrens
    Department of Neurology, University Hospital Mannheim, University of Heidelberg, Germany
    Ultrasound Med Biol 25:269-73. 1999
    ..01) for US treatment in combination with rt-PA vs. rt-PA alone. Results suggest that US increases rt-PA-mediated thrombolysis through the skull and may improve benefits of thrombolytic stroke treatment in vivo...
  7. ncbi request reprint Transcranial ultrasound-improved thrombolysis: diagnostic vs. therapeutic ultrasound
    S Behrens
    Department of Neurology, Universitaetsklinikum Mannheim, University of Heidelberg, 68135 Mannheim, Germany
    Ultrasound Med Biol 27:1683-9. 2001
    ..Results suggest efficacy and safety of the 185-kHz transducer, which is superior to diagnostic US. Such a novel US probe may be able to optimize thrombolytic stroke treatment...
  8. ncbi request reprint High-intensity transient signals in patients with cerebral ischemia
    M Daffertshofer
    Department of Neurology, University Heidelberg, Klinikum Mannheim, Germany
    Stroke 27:1844-9. 1996
    ..This study investigated the diagnostic relevance of transcranial Doppler monitoring for the detection of high-intensity transient signals (HITS) in patients with recent cerebral ischemic events of various origins...
  9. ncbi request reprint Improvement in stroke quality management by an educational programme
    Stephan Behrens
    Department of Neurology, University of Heidelberg, Universitatsklinikum Mannheim, Germany
    Cerebrovasc Dis 13:262-6. 2002
    ..01) by 69 min after the EP, with increasing numbers of patients suitable for acute stroke therapies within a 0- to 3-hour treatment window...
  10. doi request reprint Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY trial): a randomised, open-label, blinded-endpoint trial
    Reinhard Dengler
    Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
    Lancet Neurol 9:159-66. 2010
    ..The EARLY trial aimed to compare outcome in patients given aspirin plus extended-release dipyridamole twice daily either within 24 h of stroke or TIA or after 7 days of aspirin monotherapy...
  11. ncbi request reprint Assessment of T2- and T1-weighted MRI brain lesion load in patients with subcortical vascular encephalopathy
    A Gass
    Neurologische Universitatsklinik, Klinikum Mannheim der Universit├Ąt Heidelberg, Germany
    Neuroradiology 40:503-6. 1998
    ..We suggest that T1- and T2-weighted MRI lesion loads demonstrate relevant structural abnormality in patients with SVE...
  12. ncbi request reprint [Current controversies in the diagnosis and management of cerebral venous and dural sinus thrombosis]
    S Schwarz
    Neurologische Universitatsklinik, Klinikum Mannheim, Mannheim
    Nervenarzt 74:639-53. 2003
    ..Both methods have a high sensitivity for cerebral venous thrombosis. Local fibrinolytic therapy or other aggressive recanalizing methods can not be generally recommended...
  13. ncbi request reprint [Subcortical vascular encephalopathy]
    H Baezner
    Neurologische Universitatsklinik, Klinikum Mannheim, Ruprecht Karls Universitat Heidelberg, Mannheim
    Ther Umsch 60:541-52. 2003
    ..This review delineates diagnostic milestones, discusses etiological and pathophysiological mechanisms, and displays therapeutical options...
  14. ncbi request reprint Improvement of sensitivity and interrater reliability to detect acute stroke by dynamic perfusion computed tomography and computed tomography angiography
    Johann Scharf
    Department of Neuroradiology, University Hospital Mannheim, Mannheim, Germany
    J Comput Assist Tomogr 30:105-10. 2006
    ..To assess the benefits of additional computed tomography perfusion (CTP) and computed tomography angiography (CTA) on the detection of early stroke, vessel occlusion, estimated infarct size, and interrater reliability...
  15. ncbi request reprint Infrared spectroscopy: a new diagnostic tool in Alzheimer disease
    Martin Griebe
    Department of Neurology, Universitaetsklinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Neurosci Lett 420:29-33. 2007
    ..Larger sample numbers for ANN training and validation could increase diagnostic accuracy and thus prove to be a useful screening tool...
  16. ncbi request reprint Hemodynamic reserve and high-intensity transient signals in moyamoya disease
    Peter Horn
    Department of Neurosurgery, University of Heidelberg, Universitatsklinikum Mannheim, Mannheim, Germany
    Cerebrovasc Dis 19:141-6. 2005
    ..The incidence of high-intensity transient signals (HITS) and the degree of hemodynamic compromise were studied in symptomatic patients with MMD...
  17. doi request reprint Early spontaneous recanalization following acute carotid occlusion
    Kristina Szabo
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    J Neuroimaging 18:148-53. 2008
    ..Occlusion of the internal carotid artery (ICA) and stroke may be the consequence of either local thrombosis due to atherosclerosis or massive embolism. Up to date, there are only few reports of subsequent recanalization...
  18. ncbi request reprint Ultrasound and arterial wall disease
    Michael Hennerici
    Department of Neurology, University of Heidelberg, Universitatsklinikum Mannheim, Mannheim, Germany
    Cerebrovasc Dis 17:19-33. 2004
    ....
  19. ncbi request reprint Brain temperature during 340-kHz pulsed ultrasound insonation: a safety study for sonothrombolysis
    Marc Fatar
    Department of Neurology, Klinikum Mannheim, University of Heidelberg, Germany
    Stroke 37:1883-7. 2006
    ....
  20. ncbi request reprint Ultrasound in the treatment of ischaemic stroke
    Michael Daffertshofer
    Department of Neurology, University of Heidelberg, University Hospital Mannheim, Germany
    Lancet Neurol 2:283-90. 2003
    ..Controlled clinical trials to test safety management and effectiveness of both strategies are in progress...
  21. ncbi request reprint Efficacy of sonothrombolysis in a rat model of embolic ischemic stroke
    M Daffertshofer
    Department of Neurology, University of Heidelberg, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Neurosci Lett 361:115-9. 2004
    ..05). There were five intracranial bleedings giving a bleeding rate of 9.3%. In summary: ultrasound treatment in addition to rt-PA is more effective than single rt-PA treatment in reducing infarct volume and safe with regard to bleeding...
  22. ncbi request reprint Arterial gas embolism after decompression: correlation with right-to-left shunting
    S Ries
    Department of Neurology, University of Heidelberg, Klinikum Mannheim, Germany
    Neurology 52:401-4. 1999
    ..The pathway of spontaneous paradoxical embolism was tracked for the first time, supporting the concept of paradoxical gas embolism as a cause of early neurologic sequelae after decompression in at-risk divers...
  23. ncbi request reprint Vasoneuronal coupling in migraineurs after subcutaneous sumatriptan: a TCD study
    H Baezner
    Department of Neurology, University Heidelberg, Klinikum Mannheim, 68135, Mannheim, Germany
    J Neurol Sci 167:50-5. 1999
    ..These results provide evidence against the hypothesis that sumatriptan produces vasoconstriction in the intracranial human arterial circulation as a potential risk of cerebral ischemia...
  24. ncbi request reprint [Comparison between German and Turkish descent in ischemic stroke. Risk factors, initial findings, rehabilitative therapy, and social consequences]
    C Kayhan
    Neurologische Klinik, Universitatsklinikum Mannheim, Universitat Heidelberg
    Nervenarzt 78:188-92. 2007
    ..Until now no data has been available on possible specific features of the Turkish minority in Germany with respect to stroke...
  25. ncbi request reprint Stroke recurrences in patients with symptomatic vs asymptomatic middle cerebral artery disease
    R Kern
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, 68135 Mannheim, Germany
    Neurology 65:859-64. 2005
    ..Although the natural history of extracranial carotid artery disease has been investigated systematically, limited data are available on the course of middle cerebral artery (MCA) disease...
  26. ncbi request reprint Spermidine: A predictor for neurological outcome and infarct size in focal cerebral ischemia?
    T Els
    Department of Neurology, University of Freiburg, Germany
    Stroke 32:43-6. 2001
    ..The aim of our study was to investigate whether the elevation of polyamines in the blood of patients with focal cerebral ischemia correlates with the clinical outcome and the infarct volume...
  27. ncbi request reprint [Retrospective analysis of neurological patients on a medical intensive care unit]
    M Fatar
    Neurologische Klinik, Universitatsklinikum Mannheim, Universitat Heidelberg
    Anasthesiol Intensivmed Notfallmed Schmerzther 41:14-20. 2006
    ..The aim of this study was to evaluate number and kind of neurological patients in comparison with other patients on a medical ICU...
  28. ncbi request reprint Stroke treatment guided by transcranial Doppler monitoring in a patient unresponsive to standard regimens
    S Behrens
    Department of Neurology, Klinikum Mannheim, University of Heidelberg, Germany
    Cerebrovasc Dis 9:175-7. 1999
    ..Detection of high-intensity transient signals by TCM provided a useful guidance of pathophysiologically oriented treatment in this patient...
  29. ncbi request reprint Simultaneous assessment of brain tissue oxygenation and cerebral perfusion during orthostatic stress
    K Krakow
    Department of Neurology, University of Heidelberg, Klinikum Mannheim, Germany
    Eur Neurol 43:39-46. 2000
    ..The results indicate that the combination of TCD and NIRS increases the understanding of hemodynamic and metabolic changes during orthostatic stress, which may lead to individually suited therapeutic procedures...
  30. ncbi request reprint Sonothrombolysis: experimental evidence
    Michael Daffertshofer
    Department of Neurology, University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Front Neurol Neurosci 21:140-9. 2006
    ..The current experimental data helps to identify the optimal ultrasound characteristics for sonothrombolysis and supports the hypothesis combined treatment being a perspective in optimizing thrombolytic therapy in acute stroke...
  31. ncbi request reprint Assessment of gait in subcortical vascular encephalopathy by computerized analysis: a cross-sectional and longitudinal study
    H Bazner
    Department of Neurology, University of Heidelberg, Universitatsklinikum Mannheim, Theodor Kutzer Ufer, 68167 Mannheim, Germany
    J Neurol 247:841-9. 2000
    ..4 +/- 4.5 vs. 8.4 +/- 5.5, P < 0.05). This study shows the value of a new and practicable gait analysis system for the evaluation of gait disorders and it quantifies the deterioration of gait in SVE patients...
  32. ncbi request reprint Tirofiban for the treatment of ischaemic stroke
    Simone C Bukow
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Germany
    Expert Opin Pharmacother 7:73-9. 2006
    ..In recent years, increasing effort in studying glycoprotein IIb/IIIa antagonists has been made, mostly for treatment with abciximab. However, there is one Phase II trial that investigated treatment with tirofiban...
  33. ncbi request reprint Supratentorial age-related white matter changes predict outcome in cerebellar stroke
    Eva Grips
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Stroke 36:1988-93. 2005
    ..Based on an index patient, we hypothesized that age and pre-existent WMLs rather than infarct volume and topography determine outcome...
  34. doi request reprint Clinical and angiographic risk factors for stroke and death within 30 days after carotid endarterectomy and stent-protected angioplasty: a subanalysis of the SPACE study
    Robert Stingele
    Department of Neurology, University Hospital Schleswig Holstein, Kiel, Germany
    Lancet Neurol 7:216-22. 2008
    ..Better knowledge of risk factors could improve assignment of patients to these procedures and reduce overall risk. We aimed to assess the risk of stroke or death associated with CEA and CAS in patients with different risk factors...
  35. ncbi request reprint Common carotid artery intima-media thickness in patients with brain infarction and intracerebral haemorrhage
    Konstantinos N Vemmos
    Department of Clinical Therapeutics, University of Athens, Alexandra Hospital, Athens, Greece
    Cerebrovasc Dis 17:280-6. 2004
    ..1 mm CCA-IMT increase was 1.29 (95% CI: 1.03-1.61). The present results demonstrate the possible predictive power of non-invasive measurement of the CCA-IMT with respect to BI versus ICH and deserve further investigation...
  36. ncbi request reprint Pulse pressure in acute stroke is an independent predictor of long-term mortality
    Konstantinos N Vemmos
    Department of Clinical Therapeutics, University of Athens, Alexandra Hospital, Athens, Greece
    Cerebrovasc Dis 18:30-6. 2004
    ..This may have implications in acute stroke BP management and warrants further investigation...