Roland S Croner

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc TGF-beta receptor 2 downregulation in tumour-associated stroma worsens prognosis and high-grade tumours show more tumour-associated macrophages and lower TGF-beta1 expression in colon carcinoma: a retrospective study
    David Bacman
    Institute of Pathology, St, Vincentius hospital, Karlsruhe, Germany
    BMC Cancer 7:156. 2007
  2. ncbi request reprint Intravenous glycine after cecal ligation and puncture has no effect on impaired hepatic microperfusion, leukocyte adhesion, and mortality in septic rats
    R S Croner
    Department of Surgery, University of Erlangen, Germany
    Microvasc Res 69:71-8. 2005
  3. ncbi request reprint C1-inhibitor reduces hepatic leukocyte-endothelial interaction and the expression of VCAM-1 in LPS-induced sepsis in the rat
    Roland S Croner
    Department of Surgery, University of Heidelberg, D 69120 Heidelburg, Germany
    Microvasc Res 67:182-91. 2004
  4. ncbi request reprint Tissue preparation for gene expression profiling of colorectal carcinoma: three alternatives to laser microdissection with preamplification
    Roland S Croner
    Department of Surgery, University of Erlangen, Germany
    J Lab Clin Med 143:344-51. 2004
  5. ncbi request reprint Common denominator genes that distinguish colorectal carcinoma from normal mucosa
    Roland S Croner
    Department of Surgery, University of Erlangen, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Int J Colorectal Dis 20:353-62. 2005
  6. pmc Age and manifestation related symptoms in familial adenomatous polyposis
    Roland S Croner
    Department of Surgery, University of Erlangen, Maximilliansplatz 1, D 91054 Erlangen, Germany
    BMC Cancer 5:24. 2005
  7. pmc Hepatic platelet and leukocyte adherence during endotoxemia
    Roland S Croner
    Department of Surgery, University of Erlangen Nuernberg, Germany
    Crit Care 10:R15. 2006
  8. ncbi request reprint Microarray versus conventional prediction of lymph node metastasis in colorectal carcinoma
    Roland S Croner
    Department of Surgery, University of Erlangen, Erlangen, Germany
    Cancer 104:395-404. 2005
  9. pmc Comparability of microarray data between amplified and non amplified RNA in colorectal carcinoma
    Roland S Croner
    Department of Surgery, Friedrich Alexander University, Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    J Biomed Biotechnol 2009:837170. 2009
  10. ncbi request reprint IFN-γ-driven intratumoral microenvironment exhibits superior prognostic effect compared with an IFN-α-driven microenvironment in patients with colon carcinoma
    Sandra Grenz
    Division of Molecular and Experimental Surgery, Department of Surgery, University Medical Center Erlangen, Erlangen, Germany
    Am J Pathol 183:1897-909. 2013

Collaborators

Detail Information

Publications41

  1. pmc TGF-beta receptor 2 downregulation in tumour-associated stroma worsens prognosis and high-grade tumours show more tumour-associated macrophages and lower TGF-beta1 expression in colon carcinoma: a retrospective study
    David Bacman
    Institute of Pathology, St, Vincentius hospital, Karlsruhe, Germany
    BMC Cancer 7:156. 2007
    ..Disruption of transforming growth factor beta (TGF-beta) signalling in tumour cells is related to more aggressive clinical behaviour. Expression data of components of this pathway in tumour-associated stroma is limited...
  2. ncbi request reprint Intravenous glycine after cecal ligation and puncture has no effect on impaired hepatic microperfusion, leukocyte adhesion, and mortality in septic rats
    R S Croner
    Department of Surgery, University of Erlangen, Germany
    Microvasc Res 69:71-8. 2005
    ..Our animal model does not support the use of glycine in patients...
  3. ncbi request reprint C1-inhibitor reduces hepatic leukocyte-endothelial interaction and the expression of VCAM-1 in LPS-induced sepsis in the rat
    Roland S Croner
    Department of Surgery, University of Heidelberg, D 69120 Heidelburg, Germany
    Microvasc Res 67:182-91. 2004
    ..The purpose of this study was to investigate the influence of C1-INH on microcirculation and LEI in the liver in a rat model of sepsis...
  4. ncbi request reprint Tissue preparation for gene expression profiling of colorectal carcinoma: three alternatives to laser microdissection with preamplification
    Roland S Croner
    Department of Surgery, University of Erlangen, Germany
    J Lab Clin Med 143:344-51. 2004
    ..All 3 methods provided enough RNA, of sufficient quality, for gene-expression microarray analysis in colorectal carcinoma. Cross-methodologic analyses of array data should not be performed uncritically...
  5. ncbi request reprint Common denominator genes that distinguish colorectal carcinoma from normal mucosa
    Roland S Croner
    Department of Surgery, University of Erlangen, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Int J Colorectal Dis 20:353-62. 2005
    ..On the basis of our own and other investigators' microarray data, our goal was to identify a common denominator gene cluster distinguishing CRC from MC...
  6. pmc Age and manifestation related symptoms in familial adenomatous polyposis
    Roland S Croner
    Department of Surgery, University of Erlangen, Maximilliansplatz 1, D 91054 Erlangen, Germany
    BMC Cancer 5:24. 2005
    ..Except for those identified via FAP registers, the majority of patients are symptomatic at the time of diagnosis...
  7. pmc Hepatic platelet and leukocyte adherence during endotoxemia
    Roland S Croner
    Department of Surgery, University of Erlangen Nuernberg, Germany
    Crit Care 10:R15. 2006
    ..The time course and reciprocal influences of ongoing microcirculatory events during endotoxemia have not been clarified...
  8. ncbi request reprint Microarray versus conventional prediction of lymph node metastasis in colorectal carcinoma
    Roland S Croner
    Department of Surgery, University of Erlangen, Erlangen, Germany
    Cancer 104:395-404. 2005
    ..Currently, postoperative histology results are needed to determine lymph node status. Reliable preoperative information would be useful to advance treatment strategies...
  9. pmc Comparability of microarray data between amplified and non amplified RNA in colorectal carcinoma
    Roland S Croner
    Department of Surgery, Friedrich Alexander University, Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    J Biomed Biotechnol 2009:837170. 2009
    ..In conclusion microarray data resulting from different pre-processing regarding RNA pre-amplification can not be compared within one analysis...
  10. ncbi request reprint IFN-γ-driven intratumoral microenvironment exhibits superior prognostic effect compared with an IFN-α-driven microenvironment in patients with colon carcinoma
    Sandra Grenz
    Division of Molecular and Experimental Surgery, Department of Surgery, University Medical Center Erlangen, Erlangen, Germany
    Am J Pathol 183:1897-909. 2013
    ....
  11. pmc One step nucleic acid amplification (OSNA) - a new method for lymph node staging in colorectal carcinomas
    Roland S Croner
    Department of Surgery, University of Erlangen Nuremberg, Germany
    J Transl Med 8:83. 2010
    ..A molecular method called OSNA (One Step Nucleic Acid Amplification) may be suitable to determine the metastatic status of the complete LN and therefore improve staging...
  12. doi request reprint Cdc2 as prognostic marker in stage UICC II colon carcinomas
    Alexander Meyer
    Department of Surgery, Friedrich Alexander University, Erlangen Nuremberg, Germany
    Eur J Cancer 45:1466-73. 2009
    ..It might play a crucial role during tumour progression in colon carcinomas (CCA). Thus, the prognostic value of cdc2 expression and connected markers relevant for proliferation and apoptosis has to be evaluated...
  13. doi request reprint Molecular signature for lymphatic metastasis in colorectal carcinomas
    Roland S Croner
    Department of Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Surg 247:803-10. 2008
    ..Microarray techniques provide a promising tool to identify stage-specific molecular signatures on primary tumor biopsies...
  14. doi request reprint Anorectal gastrointestinal stromal tumors: a retrospective multicenter analysis of 15 cases emphasizing their high local recurrence rate and the need for standardized therapeutic approach
    Abbas Agaimy
    Institute of Pathology, University Hospital Erlangen, Krankenhausstraße 8 10, 91054 Erlangen, Germany
    Int J Colorectal Dis 28:1057-64. 2013
    ..This study aims to report our multicenter experience with diagnosis, management, and prognosis of anorectal gastrointestinal stromal tumors (GIST)...
  15. pmc Molecular mechanisms of lymphatic metastasis in solid tumors of the gastrointestinal tract
    Melanie C Langheinrich
    Department of Surgery, University Hospital Erlangen, Germany
    Int J Clin Exp Pathol 5:614-23. 2012
    ..This article will briefly describe the lymphatic system and then provide an overview of the molecular players involved in tumor lymphangiogenesis...
  16. doi request reprint Hepatic gene expression during endotoxemia
    Roland S Croner
    Department of Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    J Surg Res 154:126-34. 2009
    ..The interaction of the different hepatic cell types during these processes is not completely understood and may be clarified by microarray technology...
  17. doi request reprint A novel complex KIT mutation in a gastrointestinal stromal tumor of the vermiform appendix
    Nikolaos Vassos
    Department of Surgery, University Hospital Erlangen, 91054 Erlangen, Germany
    Hum Pathol 44:651-5. 2013
    ..The patient is currently alive without evidence of progression 27 months after surgery...
  18. ncbi request reprint Differences in the gene expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in primary colorectal tumors and their synchronous liver metastases
    Bernhard Gentner
    Department of Medicine, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Anticancer Res 29:67-74. 2009
    ..We wanted to specifically define their role in established colorectal cancer liver metastases...
  19. ncbi request reprint Expression and localization of axin 2 in colorectal carcinoma and its clinical implication
    Ute Schaal
    Division of Molecular and Experimental Surgery, University Medical Center Erlangen, Erlangen, Germany
    Int J Colorectal Dis 28:1469-78. 2013
    ..Here, we investigated RNA- and protein expression of axin 2 in CRC tissues at the single cell level. Moreover, the association of axin 2 with prognosis and survival was investigated in a large cohort of CRC patients (n = 280)...
  20. doi request reprint Tumor-associated fibroblasts isolated from colorectal cancer tissues exhibit increased ICAM-1 expression and affinity for monocytes
    Vera S Schellerer
    Department of Surgery, University Medical Center Erlangen, D 91054 Erlangen, Germany
    Oncol Rep 31:255-61. 2014
    ..Therefore, these isolated fibroblasts are a useful tool for further functional investigation of desmoplastic tissue reactions in CRC...
  21. pmc Gastrointestinal manifestations of neurofibromatosis type 1 (Recklinghausen's disease): clinicopathological spectrum with pathogenetic considerations
    Abbas Agaimy
    Institute of Pathology, University Hospital, Erlangen, Germany
    Int J Clin Exp Pathol 5:852-62. 2012
    ..In addition, this review underlines the great value of specific gastrointestinal findings in uncovering undiagnosed or missed NF-1 cases...
  22. doi request reprint GBP-1 acts as a tumor suppressor in colorectal cancer cells
    Nathalie Britzen-Laurent
    Division of Molecular and Experimental Surgery, Department of Surgery, University Medical Center Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 10, 91054 Erlangen, Germany
    Carcinogenesis 34:153-62. 2013
    ..Altogether, these results suggested that GBP-1 acts directly as a tumor suppressor in CRC and the loss of GBP-1 expression might indicate tumor evasion from the IFN-γ-dominated Th1 immune response...
  23. doi request reprint Molecular characterization of peripheral arterial disease in proximal extremity arteries
    Roland S Croner
    Department of Surgery, University Hospital Erlangen, Erlangen, Germany
    J Surg Res 178:1046-58. 2012
    ..Molecular pathways that could be targeted have not been identified so far. To address this issue, we compared the molecular profiles of healthy versus PAD proximal femoral arteries...
  24. doi request reprint Is coagulation factor VIII a useful marker for colorectal carcinoma?
    Vera S Schellerer
    Department of Surgery, University Hospital, Friedrich Alexander University, Erlangen, Germany
    Int J Biol Markers 27:20-6. 2012
    ..In the following pilot study, we investigated the usefulness of coagulation factor VIII (FVIII) as a possible prognostic marker in patients with colorectal carcinoma (CRC)...
  25. doi request reprint Isolation of endothelial cells from human tumors
    Elisabeth Naschberger
    Division of Molecular and Experimental Surgery, University Medical Center Erlangen, Erlangen, Germany
    Methods Mol Biol 731:209-18. 2011
    ..The isolated endothelial cell cultures may provide a useful in vitro model system to elucidate epigenetic effects on angiogenesis in cancer and to optimize antiangiogenic therapy...
  26. doi request reprint Combined multi-gene analysis at the RNA and protein levels in single FFPE tissue sections
    Christian Ostalecki
    Department of Dermatology, Universitatsklinikum Erlangen, Erlangen, Germany
    Exp Mol Pathol 95:1-6. 2013
    ..This may provide new perspectives for the determination of pathogenic gene expression in the framework of individualized medicine. ..
  27. ncbi request reprint Non-compliance in surveillance for patients with previous resection of large (> or = 1 cm) colorectal adenomas
    Wolfgang M Brueckl
    Department of Medicine 1, University Hospital of Erlangen, Ulmenweg 18, 91054 Erlangen, Germany
    World J Gastroenterol 12:7313-8. 2006
    ..To assess the extent and reasons of non-compliance in surveillance for patients undergoing polypectomy of large (> or = 1 cm) colorectal adenomas...
  28. ncbi request reprint DNA stool test for colorectal cancer: hypermethylation of the secreted frizzled-related protein-1 gene
    Wei Zhang
    Department of Surgery, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    Dis Colon Rectum 50:1618-26; discussion 1626-7. 2007
    ..To investigate a potential mode of noninvasive screening for colorectal cancer, we evaluated the hypermethylation of the secreted frizzled-related protein-1 gene promoter in human stool DNA...
  29. ncbi request reprint Alterations in the tissue inhibitor of metalloproteinase-3 (TIMP-3) are found frequently in human colorectal tumours displaying either microsatellite stability (MSS) or instability (MSI)
    Wolfgang M Brueckl
    Department of Internal Medicine I, Friedrich Alexander University Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    Cancer Lett 223:137-42. 2005
    ..TIMP-3 fulfils all important criteria for being a target gene in the mutator pathway. Thus, TIMP-3 might be a factor of general importance for colorectal carcinogenesis...
  30. doi request reprint Extraabdominal lymph node metastasis in gastrointestinal stromal tumors (GIST)
    Nikolaos Vassos
    Department of Surgery, University Hospital, University of Erlangen, Krankenhausstrasse 12, 91054 Erlangen, Germany
    J Gastrointest Surg 15:1232-6. 2011
    ..Accordingly, nodal dissection is generally not recommended for GISTs' surgical treatment...
  31. doi request reprint Multivisceral resection for colon carcinoma
    Roland S Croner
    Department of Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Dis Colon Rectum 52:1381-6. 2009
    ..The purpose of this study was to investigate the value of multivisceral resection in primary colon carcinomas and factors influencing its success...
  32. pmc Solid-pseudopapillary neoplasm (SPN) of the pancreas: case series and literature review on an enigmatic entity
    Nikolaos Vassos
    Department of Surgery, University Hospital, Erlangen, Germany
    Int J Clin Exp Pathol 6:1051-9. 2013
    ..SPN possesses a low malignant potential and complete surgical resection with clear margins is the treatment of choice. Following R0 resection, SPN has an excellent prognosis...
  33. pmc Deep-seated huge hibernoma of soft tissue: a rare differential diagnosis of atypical lipomatous tumor/well differentiated liposarcoma
    Nikolaos Vassos
    Department of Surgery, University Hospital Erlangen, Germany
    Int J Clin Exp Pathol 6:2178-84. 2013
    ..Mainly young adults are affected, usually without significant clinical symptoms...
  34. pmc Hepatic angiomyolipoma: a series of six cases with emphasis on pathological-radiological correlations and unusual variants diagnosed by core needle biopsy
    Abbas Agaimy
    Institute of Pathology, University Hospital, Erlangen, Germany
    Int J Clin Exp Pathol 5:512-21. 2012
    ..Awareness of their diverse morphological spectrum in liver biopsy is necessary to avoid misdiagnosis as hepatocellular carcinoma, metastatic melanoma or other malignant neoplasms...
  35. pmc Impact of serosal involvement/extramural growth on the risk of synchronous and metachronous peritoneal spread in gastrointestinal stromal tumors: proposal for a macroscopic classification of GIST
    Abbas Agaimy
    Institute of Pathology, University Hospital, Erlangen, Germany
    Int J Clin Exp Pathol 5:12-22. 2012
    ..Peritoneal and hepatic metastases are the main routes of spread of gastrointestinal stromal tumors (GIST). However, criteria to predict the site and pattern of recurrence in individual cases are still lacking...
  36. doi request reprint Angiostatic immune reaction in colorectal carcinoma: Impact on survival and perspectives for antiangiogenic therapy
    Elisabeth Naschberger
    Division of Molecular and Experimental Surgery, Department of Surgery, University of Erlangen Nuremberg, Schwabachanlage 10, Erlangen, Germany
    Int J Cancer 123:2120-9. 2008
    ..Moreover, the induction of a Th-1-like angiostatic immune reaction may be a promising approach for the clinical treatment of CRC...
  37. ncbi request reprint Coexistence of gastrointestinal stromal tumours (GIST) and malignant neoplasms of different origin: prognostic implications
    Nikolaos Vassos
    Department of Surgery, University Hospital, Erlangen, Germany Electronic address
    Int J Surg 12:371-7. 2014
    ..However, their coexistence with other malignancies of different histogenetic origin remains a challenging issue...
  38. doi request reprint A novel chip-based parallel transfection assay to evaluate paracrine cell interactions
    Elisabeth Kuhn
    Division of Molecular and Experimental Surgery, Department of Surgery, University Medical Center Erlangen, Schwabachanlage 10, 91054 Erlangen, Germany
    Lab Chip 12:1363-72. 2012
    ....
  39. ncbi request reprint Prognostic significance of microsatellite instability in curatively resected adenocarcinoma of the small intestine
    Wolfgang M Brueckl
    Department of Internal Medicine I, Friedrich Alexander University, Ulmenweg 18, Erlangen Nuremberg, D 91054 Erlangen, Germany
    Cancer Lett 203:181-90. 2004
    ..005 and P<0.001) for an increased survival in multivariate analysis. Therefore, it is suggested that analysis of the MSI status might prove useful in discerning prognosis within cancers of the same stage...
  40. doi request reprint An unusual and potentially misleading phenotypic change in a primary gastrointestinal stromal tumour (GIST) under imatinib mesylate therapy
    Nikolaos Vassos
    Department of Surgery, University Hospital, Erlangen, Germany
    Virchows Arch 458:363-9. 2011
    ..Awareness of this phenomenon would help to avoid diagnostic confusion when evaluating post-treatment resections from GISTs...
  41. ncbi request reprint Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, The University Texas Medical Branch, Galveston Burns Unit, 815 Market Street, Galveston, TX 77550, USA
    J Hepatol 42:870-9. 2005
    ..The aim of the present study was to determine whether insulin exerts positive effects on hepatic homeostasis and function during endotoxemia...