Sebastien Couillard-Despres

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. doi request reprint Ageing abolishes the effects of fluoxetine on neurogenesis
    S Couillard-Despres
    Department of Neurology, University of Regensburg, Regensburg D 93053, Germany
    Mol Psychiatry 14:856-64. 2009
  2. ncbi request reprint In vivo optical imaging of neurogenesis: watching new neurons in the intact brain
    Sebastien Couillard-Despres
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Mol Imaging 7:28-34. 2008
  3. pmc Human in vitro reporter model of neuronal development and early differentiation processes
    Sebastien Couillard-Despres
    Department of Neurology, University of Regensburg, Universitatsstr, 84, 93053 Regensburg, Germany
    BMC Neurosci 9:31. 2008
  4. ncbi request reprint Doublecortin expression levels in adult brain reflect neurogenesis
    Sebastien Couillard-Despres
    Volkswagen Foundation Junior Group, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Eur J Neurosci 21:1-14. 2005
  5. doi request reprint Dopaminergic lesion enhances growth factor-induced striatal neuroblast migration
    Beate Winner
    Department of Neurology, University of Regensburg, Regensburg, Germany
    J Neuropathol Exp Neurol 67:105-16. 2008
  6. ncbi request reprint Transient expression of doublecortin during adult neurogenesis
    Jason P Brown
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    J Comp Neurol 467:1-10. 2003
  7. ncbi request reprint Targeted transgene expression in neuronal precursors: watching young neurons in the old brain
    Sebastien Couillard-Despres
    Volkswagen Foundation Junior Group, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Eur J Neurosci 24:1535-45. 2006
  8. ncbi request reprint Physical activity fails to rescue hippocampal neurogenesis deficits in the R6/2 mouse model of Huntington's disease
    Zacharias Kohl
    Department of Neurology, University of Regensburg, Universitätsstr 84, Regensburg, Germany
    Brain Res 1155:24-33. 2007
  9. doi request reprint Oligodendrogenesis of adult neural progenitors: differential effects of ciliary neurotrophic factor and mesenchymal stem cell derived factors
    Francisco J Rivera
    Department of Neurology, University of Regensburg, Regensburg, Germany
    J Neurochem 107:832-43. 2008
  10. ncbi request reprint Mitotic impairment by doublecortin is diminished by doublecortin mutations found in patients
    Sebastien Couillard-Despres
    Department of Neurology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Neurogenetics 5:83-93. 2004

Collaborators

Detail Information

Publications24

  1. doi request reprint Ageing abolishes the effects of fluoxetine on neurogenesis
    S Couillard-Despres
    Department of Neurology, University of Regensburg, Regensburg D 93053, Germany
    Mol Psychiatry 14:856-64. 2009
    ....
  2. ncbi request reprint In vivo optical imaging of neurogenesis: watching new neurons in the intact brain
    Sebastien Couillard-Despres
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Mol Imaging 7:28-34. 2008
    ..Hence, our DCX-promo-luciferase transgenic model constitutes an effective tool that answers the pressing need for rapid investigation of the impact on neurogenesis of a large number of candidate compounds waiting to be tested...
  3. pmc Human in vitro reporter model of neuronal development and early differentiation processes
    Sebastien Couillard-Despres
    Department of Neurology, University of Regensburg, Universitatsstr, 84, 93053 Regensburg, Germany
    BMC Neurosci 9:31. 2008
    ....
  4. ncbi request reprint Doublecortin expression levels in adult brain reflect neurogenesis
    Sebastien Couillard-Despres
    Volkswagen Foundation Junior Group, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Eur J Neurosci 21:1-14. 2005
    ....
  5. doi request reprint Dopaminergic lesion enhances growth factor-induced striatal neuroblast migration
    Beate Winner
    Department of Neurology, University of Regensburg, Regensburg, Germany
    J Neuropathol Exp Neurol 67:105-16. 2008
    ..Similar mechanisms may be involved in the increased numbers of dopaminergic neurons observed in the olfactory bulbs of PD patients and their functional olfactory deficits...
  6. ncbi request reprint Transient expression of doublecortin during adult neurogenesis
    Jason P Brown
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    J Comp Neurol 467:1-10. 2003
    ..This assumption is further supported by our observation that the number of DCX-expressing cells in the dentate gyrus was decreased with age according to the reduction of neurogenesis in the aging dentate gyrus previously reported...
  7. ncbi request reprint Targeted transgene expression in neuronal precursors: watching young neurons in the old brain
    Sebastien Couillard-Despres
    Volkswagen Foundation Junior Group, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Eur J Neurosci 24:1535-45. 2006
    ..Therefore, maintenance of the fundamental properties of neuronal precursors even at advanced age suggests that stimulation of neurogenesis may constitute a valid strategy to counteract age-related neuronal loss and cognitive declines...
  8. ncbi request reprint Physical activity fails to rescue hippocampal neurogenesis deficits in the R6/2 mouse model of Huntington's disease
    Zacharias Kohl
    Department of Neurology, University of Regensburg, Universitätsstr 84, Regensburg, Germany
    Brain Res 1155:24-33. 2007
    ..Future studies need to decipher the molecular pathways involved in repressing the generation of new neurons after physical activity in huntingtin transgenic rodents...
  9. doi request reprint Oligodendrogenesis of adult neural progenitors: differential effects of ciliary neurotrophic factor and mesenchymal stem cell derived factors
    Francisco J Rivera
    Department of Neurology, University of Regensburg, Regensburg, Germany
    J Neurochem 107:832-43. 2008
    ..In summary, this work provides evidence for differential effects of ciliary neurotrophic factor and mesenchymal stem cells-derived activity on oligodendrogenesis of adult neural progenitor cells...
  10. ncbi request reprint Mitotic impairment by doublecortin is diminished by doublecortin mutations found in patients
    Sebastien Couillard-Despres
    Department of Neurology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Neurogenetics 5:83-93. 2004
    ..The magnitude of this decrease is proportional to the severity of the mutation-associated clinical symptoms, thereby providing a cell-based assay for the prognosis of DCX-associated neuronal migration disorders...
  11. doi request reprint Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein
    Franz Marxreiter
    Department of Neurology, University of Regensburg, Universitatsstrasse 84, 93053 Regensburg, Germany
    Eur J Neurosci 29:879-90. 2009
    ..This finding suggests that interfering with alpha-synuclein pathology can rescue newly generated neurons, possibly leading to new targets for therapeutic interventions in synucleinopathies...
  12. ncbi request reprint Inhibition of Smad7, a negative regulator of TGF-beta signaling, suppresses autoimmune encephalomyelitis
    Ingo Kleiter
    Department of Neurology, University of Regensburg, Universitaetsstr 84, 93053 Regensburg, Germany
    J Neuroimmunol 187:61-73. 2007
    ..Smad7 inhibition thus represents a novel systemic treatment strategy for autoimmune CNS inflammation, targeting TGF-beta signaling without TGF-beta-associated toxicity...
  13. ncbi request reprint Transforming growth factor-beta1 is a negative modulator of adult neurogenesis
    Frank Peter Wachs
    Department of Neurology, University of Regensburg, Regensburg, Germany
    J Neuropathol Exp Neurol 65:358-70. 2006
    ..This might have potential implications for neurogenesis in a variety of TGF-beta1-associated CNS diseases and pathologic conditions...
  14. ncbi request reprint Neuronal precursor-specific activity of a human doublecortin regulatory sequence
    Claudia Karl
    Volkswagen Foundation Research Group, University of Regensburg, Regensburg, Germany
    J Neurochem 92:264-82. 2005
    ..Moreover, application of neurogenesis-related growth factors in the neuronal precursor cultures suggested the lack of direct signalling of these factors on the DCX promoter construct...
  15. pmc Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis
    Beate Winner
    Department of Neurology, University of Regensburg, Universitaetsstr 84, 93053 Regensburg, Germany
    Neurobiol Aging 29:913-25. 2008
    ..The impaired neurogenesis in the olfactory bulb of different transgenic alpha-synuclein mice during aging highlights the need to further explore the interplay between olfactory dysfunction and neurogenesis in Parkinson disease...
  16. ncbi request reprint Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells
    Francisco J Rivera
    Volkswagen Foundation Research Group, University of Regensburg, Regensburg, Germany
    Stem Cells 24:2209-19. 2006
    ..This work might have major implications for the development of future transplantation strategies for the treatment of degenerative diseases in the CNS...
  17. ncbi request reprint Transforming growth factor-β1 primes proliferating adult neural progenitor cells to electrophysiological functionality
    Sabrina Kraus
    Department of Experimental Ophthalmology, Eye Clinic, University Medical Center Regensburg, Regensburg, Germany
    Glia 61:1767-83. 2013
    ..In summary, stimulation of NPCs by TGF-β1 fosters a functional neuronal phenotype, which will be of relevance for future cell replacement strategies in neurodegenerative diseases or acute CNS lesions...
  18. ncbi request reprint The neurogenic competence of progenitors from the postnatal rat retina in vitro
    Maren Engelhardt
    Volkswagen Foundation Research Group, Department of Neurology, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    Exp Eye Res 78:1025-36. 2004
    ..In addition, major differences in growth and differentiation potential of adult neural stem cells and postnatal and adult retinal progenitors are presented...
  19. ncbi request reprint Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb
    Beate Winner
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Exp Neurol 197:113-21. 2006
    ..This study supports the accumulating evidence that neurotransmitters play a crucial role in determining survival and differentiation of newly generated neurons...
  20. doi request reprint A nuclear magnetic resonance biomarker for neural progenitor cells: is it all neurogenesis?
    Paul Ramm
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Stem Cells 27:420-3. 2009
    ..However, this requires further experimental evidence. The present work clearly urges the identification of additional biomarkers for NPCs and for neurogenesis...
  21. ncbi request reprint Lactation-induced reduction in hippocampal neurogenesis is reversed by repeated stress exposure
    Katharina M Hillerer
    Department of Behavioural and Molecular Neurobiology, University of Regensburg, Regensburg, Germany Department of Obstetrics and Gynaecology, Salzburger Landeskrankenhaus SALK, Paracelsus Medical University, Salzburg, Austria
    Hippocampus 24:673-83. 2014
    ..This study assessed the effect of stress during lactation on hippocampal neurogenesis and indicates that stress interferes with important peripartum adaptations at the level of the hippocampus...
  22. ncbi request reprint Sex-dependent regulation of hippocampal neurogenesis under basal and chronic stress conditions in rats
    Katharina M Hillerer
    Department of Behavioural and Molecular Neurobiology, University of Regensburg, Germany
    Hippocampus 23:476-87. 2013
    ....
  23. ncbi request reprint High efficacy of clonal growth and expansion of adult neural stem cells
    Frank Peter Wachs
    Volkswagen Foundation Junior Group, University of Regensburg, Germany
    Lab Invest 83:949-62. 2003
    ..This work provides an important step toward the development of standardized protocols for highly efficient in vitro expansion of NSCs from the adult central nervous system to move more closely to the clinical use of NSCs...
  24. pmc Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis
    Andre M Mueller
    Department of Neurology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    J Neuroinflammation 5:20. 2008
    ....