S E Combs

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc In vitro evaluation of photon and raster-scanned carbon ion radiotherapy in combination with gemcitabine in pancreatic cancer cell lines
    Rami A El Shafie
    Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Radiat Res 54:i113-9. 2013
  2. doi Intensity modulated radiotherapy as neoadjuvant chemoradiation for the treatment of patients with locally advanced pancreatic cancer. Outcome analysis and comparison with a 3D-treated patient cohort
    S E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Strahlenther Onkol 189:738-44. 2013
  3. pmc Phase I study evaluating the treatment of patients with locally advanced pancreatic cancer with carbon ion radiotherapy: the PHOENIX-01 trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 13:419. 2013
  4. doi [Translational uroradio-oncology]
    S E Combs
    RadioOnkologie und Strahlentherapie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland
    Urologe A 52:1276-82. 2013
  5. pmc The stability of osseous metastases of the spine in lung cancer--a retrospective analysis of 338 cases
    Harald Rief
    Department of Radiation Oncology, German Bone Research Group, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 8:200. 2013
  6. pmc Hypofractionated carbon ion therapy delivered with scanned ion beams for patients with hepatocellular carcinoma - feasibility and clinical response
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, INF 400, Heidelberg 69120, Germany
    Radiat Oncol 8:59. 2013
  7. pmc Long term toxicity and prognostic factors of radiation therapy for secreting and non-secreting pituitary adenomas
    Stefan Rieken
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 8:18. 2013
  8. pmc Chemoradiation in patients with isolated recurrent pancreatic cancer - therapeutical efficacy and probability of re-resection
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany
    Radiat Oncol 8:27. 2013
  9. pmc First experiences in treatment of low-grade glioma grade I and II with proton therapy
    Henrik Hauswald
    Department of Radiation Oncology, University of Heidelberg, INF 400, Heidelberg, 69120, Germany
    Radiat Oncol 7:189. 2012
  10. pmc Efficacy and toxicity of whole brain radiotherapy in patients with multiple cerebral metastases from malignant melanoma
    Henrik Hauswald
    Department of Radiation Oncology, University of Heidelberg, INF 400, Heidelberg, 69120, Germany
    Radiat Oncol 7:130. 2012

Detail Information

Publications89

  1. pmc In vitro evaluation of photon and raster-scanned carbon ion radiotherapy in combination with gemcitabine in pancreatic cancer cell lines
    Rami A El Shafie
    Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Radiat Res 54:i113-9. 2013
    ....
  2. doi Intensity modulated radiotherapy as neoadjuvant chemoradiation for the treatment of patients with locally advanced pancreatic cancer. Outcome analysis and comparison with a 3D-treated patient cohort
    S E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Strahlenther Onkol 189:738-44. 2013
    ..To evaluate outcome after intensity modulated radiotherapy (IMRT) compared to 3D conformal radiotherapy (3D-RT) as neoadjuvant treatment in patients with locally advanced pancreatic cancer (LAPC)...
  3. pmc Phase I study evaluating the treatment of patients with locally advanced pancreatic cancer with carbon ion radiotherapy: the PHOENIX-01 trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 13:419. 2013
    ..16 and 2.46 depending on the pancreatic cancer cell line as well as the endpoint analyzed. Japanese Data on the evaluation of carbon ion radiation therapy showed promising results for patients with pancreatic cancer...
  4. doi [Translational uroradio-oncology]
    S E Combs
    RadioOnkologie und Strahlentherapie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland
    Urologe A 52:1276-82. 2013
    ..In urological oncology, radiotherapy can be offered as a valid treatment alternative for a number of tumors, such as prostate cancer or urothelial cancer/bladder cancer...
  5. pmc The stability of osseous metastases of the spine in lung cancer--a retrospective analysis of 338 cases
    Harald Rief
    Department of Radiation Oncology, German Bone Research Group, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 8:200. 2013
    ....
  6. pmc Hypofractionated carbon ion therapy delivered with scanned ion beams for patients with hepatocellular carcinoma - feasibility and clinical response
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, INF 400, Heidelberg 69120, Germany
    Radiat Oncol 8:59. 2013
    ..Furthermore, carbon ions have an increased relative biological effectiveness (RBE) compared to photons...
  7. pmc Long term toxicity and prognostic factors of radiation therapy for secreting and non-secreting pituitary adenomas
    Stefan Rieken
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 8:18. 2013
    ..This study was initiated to investigate long-term toxicity, treatment outcome and prognostic factors after radiotherapy (RT) in patients with pituitary adenomas...
  8. pmc Chemoradiation in patients with isolated recurrent pancreatic cancer - therapeutical efficacy and probability of re-resection
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany
    Radiat Oncol 8:27. 2013
    ..In the present retrospective analysis we analysed the therapeutic outcome of a set of patients, who were treated with chemoradiation (CRT) for recurrent pancreatic cancer (RPC) in a single institution...
  9. pmc First experiences in treatment of low-grade glioma grade I and II with proton therapy
    Henrik Hauswald
    Department of Radiation Oncology, University of Heidelberg, INF 400, Heidelberg, 69120, Germany
    Radiat Oncol 7:189. 2012
    ..To retrospectively assess feasibility and toxicity of proton therapy in patients with low-grade glioma (WHO °I/II)...
  10. pmc Efficacy and toxicity of whole brain radiotherapy in patients with multiple cerebral metastases from malignant melanoma
    Henrik Hauswald
    Department of Radiation Oncology, University of Heidelberg, INF 400, Heidelberg, 69120, Germany
    Radiat Oncol 7:130. 2012
    ..To retrospectively access outcome and toxicity of whole brain radiotherapy (WBRT) in patients with multiple brain metastases (BM) from malignant melanoma (MM)...
  11. doi Comparison of carbon ion radiotherapy to photon radiation alone or in combination with temozolomide in patients with high-grade gliomas: explorative hypothesis-generating retrospective analysis
    Stephanie E Combs
    University Hospital of Heidelberg, Department of Radiation Oncology, Germany
    Radiother Oncol 108:132-5. 2013
    ..To compare retrospectively outcome after photon radiotherapy alone, radiochemotherapy with temozolomide (TMZ), and carbon ion radiotherapy in patients with high-grade gliomas and to generate a hypothetical outcome curve for C12 and TMZ...
  12. doi Hearing preservation after radiotherapy for vestibular schwannomas is comparable to hearing deterioration in healthy adults and is accompanied by local tumor control and a highly preserved quality of life (QOL) as patients' self-reported outcome
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Radiother Oncol 106:175-80. 2013
    ..To evaluate long-term results and patients' self-reported outcome of high-precision photon radiotherapy for the treatment of patients with vestibular schwannoma (VS)...
  13. doi Skull base meningiomas: Long-term results and patient self-reported outcome in 507 patients treated with fractionated stereotactic radiotherapy (FSRT) or intensity modulated radiotherapy (IMRT)
    Stephanie E Combs
    University Hospital of Heidelberg, Germany
    Radiother Oncol 106:186-91. 2013
    ..To evaluate long-term outcome of high-precision photon radiotherapy in 507 patients with skull base meningiomas...
  14. doi Clinical controversies: proton radiation therapy for brain and skull base tumors
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Semin Radiat Oncol 23:120-6. 2013
    ....
  15. pmc State-of-the-art treatment alternatives for base of skull meningiomas: complementing and controversial indications for neurosurgery, stereotactic and robotic based radiosurgery or modern fractionated radiation techniques
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 7:226. 2012
    ..In this review we evaluate different treatment options, the outcome of modern irradiation techniques as well as the clinical results available, and establish recommendations for the treatment of patients with skull-base meningiomas...
  16. doi Generation and validation of a prognostic score to predict outcome after re-irradiation of recurrent glioma
    Stephanie E Combs
    University Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, Germany
    Acta Oncol 52:147-52. 2013
    ..In the present work, we developed a practical prognostic score to predict survival outcome after re-irradiation...
  17. pmc Treatment of pediatric patients and young adults with particle therapy at the Heidelberg Ion Therapy Center (HIT): establishment of workflow and initial clinical data
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany
    Radiat Oncol 7:170. 2012
    ..To report on establishment of workflow and clinical results of particle therapy at the Heidelberg Ion Therapy Center...
  18. pmc Connection of European particle therapy centers and generation of a common particle database system within the European ULICE-framework
    Kerstin A Kessel
    Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 7:115. 2012
    ....
  19. pmc Neoadjuvant chemoradiation with Gemcitabine for locally advanced pancreatic cancer
    Daniel Habermehl
    Department of Radiation Oncology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 7:28. 2012
    ..To evaluate efficacy and secondary resectability in patients with locally advanced pancreatic cancer (LAPC) treated with neoadjuvant chemoradiotherapy (CRT)...
  20. pmc Proton and carbon ion radiotherapy for primary brain tumors delivered with active raster scanning at the Heidelberg Ion Therapy Center (HIT): early treatment results and study concepts
    Stefan Rieken
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 7:41. 2012
    ..This study was set up in order to investigate toxicity and response after proton and carbon ion therapy for gliomas and meningiomas...
  21. pmc Monitoring of patients treated with particle therapy using positron-emission-tomography (PET): the MIRANDA study
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Germany
    BMC Cancer 12:133. 2012
    ..The purpose of this clinical study is to investigate the clinical feasibility and effectiveness of offline Positron-Emission-Tomography (PET) quality assurance for promoting the accuracy of proton and carbon ion beam therapy...
  22. pmc Comparison of intensity modulated radiotherapy (IMRT) with intensity modulated particle therapy (IMPT) using fixed beams or an ion gantry for the treatment of patients with skull base meningiomas
    Katsura Kosaki
    Department of Radiology, Nagoya City University Hospital, Nagoya, Japan
    Radiat Oncol 7:44. 2012
    ..To examine the potential improvement in treatment planning for patients with skull base meningioma using IMRT compared to carbon ion or proton beams with and without a gantry...
  23. pmc Phase I/II trial evaluating carbon ion radiotherapy for the treatment of recurrent rectal cancer: the PANDORA-01 trial
    Stephanie E Combs
    Deparment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    BMC Cancer 12:137. 2012
    ..Moreover, these patients are likely to benefit from the enhanced biological efficacy of carbon ions...
  24. doi Improved correlation of the neuropathologic classification according to adapted world health organization classification and outcome after radiotherapy in patients with atypical and anaplastic meningiomas
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 81:1415-21. 2011
    ..To evaluate the correlation between the 1993 and 2000/2007 World Health Organization (WHO) classification with the outcome in patients with high-grade meningiomas...
  25. pmc In vitro evaluation of photon and carbon ion radiotherapy in combination with chemotherapy in glioblastoma cells
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 7:9. 2012
    ..To evaluate the cytotoxic effect of carbon ion radiotherapy and chemotherapy in glioblastoma cells in vitro...
  26. pmc Targeting ανβ3 and ανβ5 inhibits photon-induced hypermigration of malignant glioma cells
    Stefan Rieken
    University Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, Germany
    Radiat Oncol 6:132. 2011
    ..This study was set up to describe mechanisms underlying increased glioma cell migration through photon irradiation and to analyse the modifiability of photon-altered glioma cell motility by integrin inhibition...
  27. pmc Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM)
    Sebastian Adeberg
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany
    Radiat Oncol 6:117. 2011
    ..We analyzed our long-term experience with fractionated stereotactic radiotherapy (FSRT) in patients with meningioma of the optic nerve sheath (ONSM)...
  28. pmc Randomised trial of proton vs. carbon ion radiation therapy in patients with low and intermediate grade chondrosarcoma of the skull base, clinical phase III study
    Anna V Nikoghosyan
    Dept of Clinical Radiology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    BMC Cancer 10:606. 2010
    ..However, high-LET (linear energy transfer) beams such as carbon ions theoretically offer advantages by enhanced biologic effectiveness in slow-growing tumours...
  29. pmc Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma
    Claudia Blattmann
    Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 154, 69120 Heidelberg, Germany
    BMC Cancer 10:96. 2010
    ..They achieve a higher relative biological effectiveness. Phase I/II dose escalation studies of HIT in adults with non-resectable bone and soft tissue sarcomas have already shown favorable results...
  30. pmc Randomised trial of proton vs. carbon ion radiation therapy in patients with chordoma of the skull base, clinical phase III study HIT-1-Study
    Anna V Nikoghosyan
    Dept of Clinical Radiology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    BMC Cancer 10:607. 2010
    ..Proton therapy is the gold standard in the treatment of skull base chordomas. However, high-LET beams such as carbon ions theoretically offer biologic advantages by enhanced biologic effectiveness in slow-growing tumors...
  31. pmc Outcome and prognostic factors of desmoplastic medulloblastoma treated within a multidisciplinary treatment concept
    Stefan Rieken
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 10:450. 2010
    ..This study was set up to investigate treatment outcome and prognostic factors after radiation therapy in patients with desmoplastic medulloblastomas...
  32. pmc Randomised phase I/II study to evaluate carbon ion radiotherapy versus fractionated stereotactic radiotherapy in patients with recurrent or progressive gliomas: the CINDERELLA trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 10:533. 2010
    ..First Japanese Data on the evaluation of carbon ion radiation therapy for the treatment of primary high-grade gliomas showed promising results in a small and heterogeneous patient collective...
  33. ncbi Heidelberg Ion Therapy Center (HIT): Initial clinical experience in the first 80 patients
    Stephanie E Combs
    University Hospital of Heidelberg, Department of Radiation Oncology, 69120 Heidelberg, Germany
    Acta Oncol 49:1132-40. 2010
    ..In this report we present the first 80 patients treated with proton and carbon ion radiotherapy and describe patient selection, treatment planning and daily treatment for different indications...
  34. pmc Randomized phase II study evaluating a carbon ion boost applied after combined radiochemotherapy with temozolomide versus a proton boost after radiochemotherapy with temozolomide in patients with primary glioblastoma: the CLEOPATRA trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 10:478. 2010
    ..Protons, however, offer an RBE which is comparable to photons. First Japanese Data on the evaluation of carbon ion radiation therapy showed promising results in a small and heterogeneous patient collective...
  35. pmc Treatment of patients with atypical meningiomas Simpson grade 4 and 5 with a carbon ion boost in combination with postoperative photon radiotherapy: the MARCIE trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 10:615. 2010
    ..First data obtained within the Phase I/II trial performed at GSI in Darmstadt on carbon ion radiotherapy for patients with high-risk meningiomas has shown safety, and treatment results are promising...
  36. pmc Phase i study evaluating the treatment of patients with hepatocellular carcinoma (HCC) with carbon ion radiotherapy: the PROMETHEUS-01 trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 11:67. 2011
    ..Japanese Data on the evaluation of carbon ion radiation therapy showed promising results for patients with HCC...
  37. pmc Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: one step forward, and one step back?
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Radiat Oncol 6:115. 2011
    ..IDH-1 mutations were significantly associated with increased overall survival...
  38. doi Long-term outcome of high-precision radiotherapy in patients with brain stem gliomas: results from a difficult-to-treat patient population using fractionated stereotactic radiotherapy
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Radiother Oncol 91:60-6. 2009
    ..To assess long-term outcome in 85 patients with brain stem gliomas treated with fractionated stereotactic radiation therapy (FSRT)...
  39. doi Helical tomotherapy for meningiomas of the skull base and in paraspinal regions with complex anatomy and/or multiple lesions
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Tumori 97:484-91. 2011
    ..To evaluate helical tomotherapy for the treatment of complex-shaped uni- or multifocal meningiomas...
  40. doi [Strategies for preoperative downsizing in patients with local nonresectable pancreatic cancer]
    S E Combs
    Abteilung Radioonkologie und Strahlentherapie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland
    Chirurg 82:981-8. 2011
    ..Additionally, molecular markers may help to stratify patients for different treatment schedules...
  41. doi Carbon ion radiotherapy performed as re-irradiation using active beam delivery in patients with tumors of the brain, skull base and sacral region
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Radiother Oncol 98:63-7. 2011
    ..To asses carbon ion radiation therapy (RT) performed as re-irradiation in 28 patients with recurrent tumors...
  42. doi [Radiotherapy of hepatic metastases]
    S E Combs
    Abteilung Radioonkologie und Strahlentherapie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany
    Chirurg 81:526-32. 2010
    ..Modern devices which combine radiation therapy with imaging techniques (image-guided radiotherapy) in particular allow precise dose application, especially for hypofractionated treatment concepts requiring daily repositioning...
  43. pmc Radiotherapeutic alternatives for previously irradiated recurrent gliomas
    Stephanie E Combs
    University Hospital of Heidelberg, Department of Radiation Oncology, Im Neuenheimer Feld 400, 69120 Heidelberg, German
    BMC Cancer 7:167. 2007
    ....
  44. ncbi In vitro responsiveness of glioma cell lines to multimodality treatment with radiotherapy, temozolomide, and epidermal growth factor receptor inhibition with cetuximab
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 68:873-82. 2007
    ..The majority of glioblastoma multiforme (GBM) cells express the epidermal growth factor receptor (EGFR). The present study evaluates the combination of temozolomide (TMZ), EGFR inhibition, and radiotherapy (RT) in GBM cell lines...
  45. pmc Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocol
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 6:133. 2006
    ..Therefore, addition of EGFR-inhibition with cetuximab to the current standard treatment approach with radiotherapy and TMZ seems promising...
  46. ncbi Local high-dose radiotherapy and sparing of normal tissue using intensity-modulated radiotherapy (IMRT) for mucosal melanoma of the nasal cavity and paranasal sinuses
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Strahlenther Onkol 183:63-8. 2007
    ..To evaluate the clinical outcome of intensity-modulated radiotherapy (IMRT) in patients with mucosal melanoma (MM) of the nasal cavity and paranasal sinuses...
  47. ncbi Fractionated stereotactic radiotherapy of optic pathway gliomas: tolerance and long-term outcome
    Stephanie E Combs
    Department of Radiation Oncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 62:814-9. 2005
    ..To evaluate the effectiveness and toxicity of fractionated stereotactically guided radiotherapy (FSRT) in the management of optic glioma...
  48. ncbi Temozolomide combined with irradiation as postoperative treatment of primary glioblastoma multiforme. Phase I/II study
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Strahlenther Onkol 181:372-7. 2005
    ..To evaluate the feasibility and toxicity of irradiation and concomitant administration of 50 mg/m(2) temozolomide in patients with primary malignant glioma, this phase I/II study was conducted...
  49. ncbi Stereotactically guided fractionated re-irradiation in recurrent glioblastoma multiforme
    S E Combs
    Department of Radiation Oncology, German Cancer Research Center DKFZ, INF 280, and University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neurooncol 74:167-71. 2005
    ..To assess the feasibility, efficacy and toxicity of fractionated stereotactic radiotherapy in the treatment of recurrent glioblastoma multiforme...
  50. ncbi [Advances in radio-oncology. From precision radiotherapy with photons to ion therapy with protons and carbon ions]
    S E Combs
    Klinik fur Radioonkologie und Strahlentherapie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Deutschland
    Chirurg 77:1126-32. 2006
    ..Carbon ions also offer the advantage of increased relative biological effectiveness. For certain tumor types, a significant increase in local control and survival rates could be obtained with carbon ions...
  51. ncbi Stereotactic radiosurgery (SRS): treatment option for recurrent glioblastoma multiforme (GBM)
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Cancer 104:2168-73. 2005
    ..This article describes the results of a study of stereotactic radiosurgery (SRS) in the treatment of patients with recurrent malignant glioma...
  52. pmc Local radiotherapeutic management of ependymomas with fractionated stereotactic radiotherapy (FSRT)
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    BMC Cancer 6:222. 2006
    ..To assess the role of Fractionated Stereotactic Radiotherapy (FSRT) in the management of ependymomas...
  53. pmc Intensity modulated radiotherapy (IMRT) in patients with carcinomas of the paranasal sinuses: clinical benefit for complex shaped target volumes
    Stephanie E Combs
    University of Heidelberg, Department of Radiation Oncology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 1:23. 2006
    ..The aim of the study was to evaluate the clinical outcome of intensity modulated radiotherapy (IMRT) in 46 patients with paranasal sinus tumors with special respect to treatment-related toxicity...
  54. ncbi Precision radiotherapy for hemangiopericytomas of the central nervous system
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Cancer 104:2457-65. 2005
    ..The present analysis evaluates the role of precision RT in the management of HAP of the central nervous system (CNS) and represents one of the largest series of HAP treated with RT that can be found in the literature...
  55. ncbi Reirradiation of recurrent WHO grade III astrocytomas using fractionated stereotactic radiotherapy (FSRT)
    Stephanie E Combs
    Department of Radiation Oncology German Cancer Research Center DKFZ, INF 280, Heidelberg, Germany
    Strahlenther Onkol 181:768-73. 2005
    ..To assess the effect of reirradiation in recurrent WHO grade III astrocytomas...
  56. pmc Intensity Modulated Radiotherapy (IMRT) and Fractionated Stereotactic Radiotherapy (FSRT) for children with head-and-neck-rhabdomyosarcoma
    Stephanie E Combs
    University of Heidelberg, Department of Radiation Oncology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 7:177. 2007
    ....
  57. ncbi Postoperative treatment of primary glioblastoma multiforme with radiation and concomitant temozolomide in elderly patients
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 70:987-92. 2008
    ..To evaluate efficacy and toxicity in elderly patients with glioblastoma multiforme (GBM) treated with postoperative radiochemotherapy with temozolomide (TMZ)...
  58. doi Particle therapy at the Heidelberg Ion Therapy Center (HIT) - Integrated research-driven university-hospital-based radiation oncology service in Heidelberg, Germany
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, 69120 Heidelberg, Germany
    Radiother Oncol 95:41-4. 2010
    ..In November 2009, patient treatment has begun. The aim of the center is to provide high-end radiotherapy, and to define the role of particle therapy through clinical trials...
  59. doi Carbon ion radiation therapy for high-risk meningiomas
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, 69120 Heidelberg, Germany
    Radiother Oncol 95:54-9. 2010
    ..We analyzed outcome after a carbon ion boost in combination with precision photon radiation therapy in patients with meningiomas...
  60. ncbi Efficacy of fractionated stereotactic reirradiation in recurrent gliomas: long-term results in 172 patients treated in a single institution
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    J Clin Oncol 23:8863-9. 2005
    ..To evaluate the efficacy of fractionated stereotactic radiotherapy (FSRT) performed as reirradiation in 172 patients with recurrent low- and high-grade gliomas...
  61. ncbi Radiochemotherapy with temozolomide as re-irradiation using high precision fractionated stereotactic radiotherapy (FSRT) in patients with recurrent gliomas
    Stephanie E Combs
    Neuro Radiation Oncology Research Group, Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    J Neurooncol 89:205-10. 2008
    ..To evaluate outcome after fractionated stereotactic radiotherapy (FSRT) and concomitant daily temozolomide (TMZ) in patients with recurrent gliomas...
  62. doi Differences in clinical results after LINAC-based single-dose radiosurgery versus fractionated stereotactic radiotherapy for patients with vestibular schwannomas
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 76:193-200. 2010
    ..To evaluate the outcomes of patients with vestibular schwannoma (VS) treated with fractionated stereotactic radiotherapy (FSRT) vs. those treated with stereotactic radiosurgery (SRS)...
  63. doi Radiation therapy
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, Heidelberg 69120, Germany
    Recent Results Cancer Res 171:125-40. 2009
    ..These new radiation qualities now offer promising treatment alternatives that will be evaluated within clinical studies in the near future and have the potential to further improve outcome in patients with gliomas...
  64. doi Radiobiological evaluation and correlation with the local effect model (LEM) of carbon ion radiation therapy and temozolomide in glioblastoma cell lines
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg
    Int J Radiat Biol 85:126-37. 2009
    ..To investigate the cytotoxic effect of high linear-energy transfer (LET) carbon irradiation on glioblastoma cells lines in combination with temozolomide (TMZ)...
  65. ncbi Carbon ion radiotherapy for pediatric patients and young adults treated for tumors of the skull base
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Cancer 115:1348-55. 2009
    ..The current study was conducted to evaluate the outcome of carbon ion radiotherapy (RT) in children and young adults with skull base chordomas and chondrosarcomas...
  66. ncbi Comparative evaluation of radiochemotherapy with temozolomide versus standard-of-care postoperative radiation alone in patients with WHO grade III astrocytic tumors
    Stephanie E Combs
    University Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, Germany
    Radiother Oncol 88:177-82. 2008
    ..No significant difference in overall survival or progression-free survival between both groups was calculated. RCHT seems not to result in an improved outcome. Further randomized studies are needed to support these results...
  67. ncbi Influence of radiotherapy treatment concept on the outcome of patients with localized ependymomas
    Stephanie E Combs
    Neuro Radiation Oncology Research Group, Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 71:972-8. 2008
    ..To assess the outcome of 57 patients with localized ependymomas treated with radiotherapy (RT)...
  68. ncbi Radiochemotherapy in patients with primary glioblastoma comparing two temozolomide dose regimens
    Stephanie E Combs
    Neuro Radiation Oncology Research Group, Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 71:999-1005. 2008
    ..To evaluate toxicity and outcomes in patients with primary glioblastoma (GB) treated with postoperative radiochemotherapy (RCHT) with temozolomide (TMZ) comparing two dose regimens...
  69. ncbi Long-term outcome of stereotactic radiosurgery (SRS) in patients with acoustic neuromas
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 64:1341-7. 2006
    ..To evaluate the effectiveness and long-term outcome of stereotactic radiosurgery (SRS) for acoustic neuromas (AN)...
  70. ncbi Recurrent low-grade gliomas: the role of fractionated stereotactic re-irradiation
    S E Combs
    Department of Radiation Oncology, German Cancer Research Center DKFZ, INF 280, Germany
    J Neurooncol 71:319-23. 2005
    ..To assess the effectiveness of re-irradiation in recurrent low-grade gliomas (LGG)...
  71. doi Outcome after neoadjuvant chemoradiation and correlation with nutritional status in patients with locally advanced pancreatic cancer
    P Naumann
    Department of Radiation Oncology, University Clinic Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Strahlenther Onkol 189:745-52. 2013
    ..In the present article, we quantify this frequently observed weight loss and assess its impact on outcome and survival...
  72. doi Survival and prognostic factors in non-small cell lung cancer patients with spinal bone metastases: a retrospective analysis of 303 patients
    H Rief
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Strahlenther Onkol 190:59-63. 2014
    ..We report on stability-dependent fracture and survival rates in over 300 non-small cell lung cancer (NSCLC) patients...
  73. ncbi Time evaluation of image-guided radiotherapy in patients with spinal bone metastases. A single-center study
    H Rief
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Strahlenther Onkol 190:287-92. 2014
    ..This prospective analysis aimed to evaluate time management during RT of patients with spine metastases, focusing particularly on the impact of image-guided RT (IGRT)...
  74. doi [Database supported electronic retrospective analyses in radiation oncology: establishing a workflow using the example of pancreatic cancer]
    K A Kessel
    Abteilung für Radioonkolgie und Strahlentherapie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland
    Strahlenther Onkol 188:1119-24. 2012
    ..With the example of patients with pancreatic cancer treated with radio-chemotherapy, we performed a therapy evaluation by using an analysis system connected with a documentation system...
  75. ncbi Chemoradiation in patients with unresectable extrahepatic and hilar cholangiocarcinoma or at high risk for disease recurrence after resection : Analysis of treatment efficacy and failure in patients receiving postoperative or primary chemoradiation
    D Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, Germany
    Strahlenther Onkol 188:795-801. 2012
    ....
  76. ncbi Influence of intra-fractional breathing movement in step-and-shoot IMRT
    M Schaefer
    Clinical Cooperation Unit Radiotherapy, German Cancer Research Center DKFZ, Im Neuenheimer Feld 290, 69120 Heidelberg, Germany
    Phys Med Biol 49:N175-9. 2004
    ....
  77. ncbi Long-term outcome of postoperative irradiation in patients with newly diagnosed WHO grade III anaplastic gliomas
    Monika Nagy
    Department of Radiation Oncology University Hospital of Heidelberg, Heidelberg, Germany
    Tumori 95:317-24. 2009
    ..In most analyses, WHO grade III and 1V tumors are not analyzed separately. The present analysis reports outcome after postoperative radiotherapy in patients with WHO grade III gliomas...
  78. ncbi Treatment of cerebral metastases from breast cancer with stereotactic radiosurgery
    Stephanie E Combs
    Department of Radiation Oncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Strahlenther Onkol 180:590-6. 2004
    ..To elucidate the role of SRS in this context, a retrospective study evaluating the benefit of SRS and prognostic factors for survival was performed...
  79. ncbi Radiotherapy in the treatment of primary osteosarcoma--a single center experience
    Susanne Oertel
    Department of Radiooncology, University Clinic Heidelberg, Germany
    Tumori 96:582-8. 2010
    ..To analyze our experiences concerning radiation treatment in patients with osteosarcoma...
  80. ncbi Achievement of long-term local control in patients with craniopharyngiomas using high precision stereotactic radiotherapy
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Cancer 109:2308-14. 2007
    ..The long-term outcome in patients with craniopharyngiomas treated with fractionated stereotactic radiotherapy (FSRT) was evaluated...
  81. ncbi Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas
    Daniela Schulz-Ertner
    Department of Radiation Oncology, University of Heidelberg, Heidelberg
    Int J Radiat Oncol Biol Phys 68:449-57. 2007
    ..The aim of this study was to evaluate the effectiveness and toxicity of carbon ion radiotherapy in chordomas of the skull base...
  82. ncbi Fractionated stereotactic radiation therapy in the management of primary oligodendroglioma and oligoastrocytoma
    Stephanie E Combs
    Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 62:797-802. 2005
    ....
  83. ncbi Carbon ion radiotherapy of skull base chondrosarcomas
    Daniela Schulz-Ertner
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 67:171-7. 2007
    ..To evaluate the effectiveness and toxicity of carbon ion radiotherapy in chondrosarcomas of the skull base...
  84. ncbi Management of acoustic neuromas with fractionated stereotactic radiotherapy (FSRT): long-term results in 106 patients treated in a single institution
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 63:75-81. 2005
    ..To assess the long-term outcome and toxicity of fractionated stereotactic radiotherapy for acoustic neuromas in 106 patients treated in a single institution...
  85. ncbi Differentiation therapy exerts antitumor effects on stem-like glioma cells
    Benito Campos
    Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 16:2715-28. 2010
    ..In glioma, knowledge about the efficacy of retinoic acid-induced differentiation to target the stem-like tumor cell pool could have therapeutic implications...
  86. ncbi Light ion facility projects in Europe: methodological aspects for the calculation of the treatment cost per protocol
    Pascal Pommier
    Dept of Radiation Oncology, Centre Leon Berard, 28 rue Laennec, 69373 Lyon, France
    Radiother Oncol 73:S183-5. 2004
    ..The resulting cost model will take into account the specificities of each therapeutic protocol as well as the particularities of each of the European projects...
  87. ncbi Suppression of proinvasive RGS4 by mTOR inhibition optimizes glioma treatment
    M Weiler
    Clinical Cooperation Unit Neurooncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Oncogene 32:1099-109. 2013
    ..We conclude that combined RT and mTOR inhibition is a promising therapeutic option that warrants further clinical investigation in upfront glioblastoma therapy...
  88. ncbi 3D radial projection technique with ultrashort echo times for sodium MRI: clinical applications in human brain and skeletal muscle
    Sonia Nielles-Vallespin
    Medical Physics in Radiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Magn Reson Med 57:74-81. 2007
    ....