Mark Coburn

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi request reprint Influence of a 30-min break on divided attention and working memory in resident anaesthetists on daily routine
    M Coburn
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen Pauwelsstreet 30, D 52072 Aachen, Germany
    Br J Anaesth 97:315-9. 2006
  2. pmc The Hip Fracture Surgery in Elderly Patients (HIPELD) study: protocol for a randomized, multicenter controlled trial evaluating the effect of xenon on postoperative delirium in older patients undergoing hip fracture surgery
    Mark Coburn
    Department of Anaesthesiology, University Hospital Aachen, RWTH, Aachen, Germany
    Trials 13:180. 2012
  3. pmc Solulin reduces infarct volume and regulates gene-expression in transient middle cerebral artery occlusion in rats
    Yu Mi Ryang
    Department of Neurosurgery, Klinikum rechts der Isar, Hospital of the Technical University Munich, Ismaningerstr, 22, 81675 Munich, Germany
    BMC Neurosci 12:113. 2011
  4. ncbi request reprint Emergence and early cognitive function in the elderly after xenon or desflurane anaesthesia: a double-blinded randomized controlled trial
    M Coburn
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D 52074 Aachen, Germany
    Br J Anaesth 98:756-62. 2007
  5. pmc Early cognitive function, recovery and well-being after sevoflurane and xenon anaesthesia in the elderly: a double-blinded randomized controlled trial
    Jan Cremer
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstrase 30, D 52074 Aachen, Germany
    Med Gas Res 1:9. 2011
  6. doi request reprint Postoperative cognitive dysfunction: Incidence and prophylaxis
    M Coburn
    Klinik fur Anasthesiologie, Universitatsklinikum Aachen, Deutschland
    Anaesthesist 59:177-84; quiz 185. 2010
  7. ncbi request reprint A comparison of waste gas concentrations during xenon or nitrous oxide anaesthesia
    M Coburn
    University Hospital Aachen, RWTH Aachen, Department of Anaesthesiology, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Eur J Anaesthesiol 25:748-51. 2008
  8. doi request reprint Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia
    M Coburn
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D 52072 Aachen, Germany
    Br J Anaesth 100:787-91. 2008
  9. doi request reprint The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury
    Mark Coburn
    Biophysics Section, Blackett Laboratory, Imperial College, South Kensington, London SW7 2AZ, UK
    Crit Care Med 36:588-95. 2008
  10. ncbi request reprint Patients' self-evaluation after 4-12 weeks following xenon or propofol anaesthesia: a comparison
    M Coburn
    University Hospital of the RWTH Aachen, Department of Anaesthesiology, Aachen, Germany
    Eur J Anaesthesiol 22:870-4. 2005

Detail Information

Publications41

  1. ncbi request reprint Influence of a 30-min break on divided attention and working memory in resident anaesthetists on daily routine
    M Coburn
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen Pauwelsstreet 30, D 52072 Aachen, Germany
    Br J Anaesth 97:315-9. 2006
    ..The aim of this study is to test the hypothesis that a standard 30-min break in a routine 7.5 h period of work makes a difference in cognitive function...
  2. pmc The Hip Fracture Surgery in Elderly Patients (HIPELD) study: protocol for a randomized, multicenter controlled trial evaluating the effect of xenon on postoperative delirium in older patients undergoing hip fracture surgery
    Mark Coburn
    Department of Anaesthesiology, University Hospital Aachen, RWTH, Aachen, Germany
    Trials 13:180. 2012
    ....
  3. pmc Solulin reduces infarct volume and regulates gene-expression in transient middle cerebral artery occlusion in rats
    Yu Mi Ryang
    Department of Neurosurgery, Klinikum rechts der Isar, Hospital of the Technical University Munich, Ismaningerstr, 22, 81675 Munich, Germany
    BMC Neurosci 12:113. 2011
    ..Thrombolysis after acute ischemic stroke has only proven to be beneficial in a subset of patients. The soluble recombinant analogue of human thrombomodulin, Solulin, was studied in an in vivo rat model of acute ischemic stroke...
  4. ncbi request reprint Emergence and early cognitive function in the elderly after xenon or desflurane anaesthesia: a double-blinded randomized controlled trial
    M Coburn
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D 52074 Aachen, Germany
    Br J Anaesth 98:756-62. 2007
    ..Xenon, known to be an N-methyl-d-aspartate antagonist, may be advantageous. In this study, the early cognitive function in the elderly after general anaesthesia with xenon was compared with that after desflurane...
  5. pmc Early cognitive function, recovery and well-being after sevoflurane and xenon anaesthesia in the elderly: a double-blinded randomized controlled trial
    Jan Cremer
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstrase 30, D 52074 Aachen, Germany
    Med Gas Res 1:9. 2011
    ..abstract:..
  6. doi request reprint Postoperative cognitive dysfunction: Incidence and prophylaxis
    M Coburn
    Klinik fur Anasthesiologie, Universitatsklinikum Aachen, Deutschland
    Anaesthesist 59:177-84; quiz 185. 2010
    ..The age of the patient is one of the main risk factors for the development of POCD. Data on how to avoid POCD are limited. However, the maintenance of homoeostasis is an important cornerstone of prophylaxis...
  7. ncbi request reprint A comparison of waste gas concentrations during xenon or nitrous oxide anaesthesia
    M Coburn
    University Hospital Aachen, RWTH Aachen, Department of Anaesthesiology, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Eur J Anaesthesiol 25:748-51. 2008
    ..The aim of this study was to compare waste gas concentrations during xenon or nitrous oxide anaesthesia...
  8. doi request reprint Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia
    M Coburn
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D 52072 Aachen, Germany
    Br J Anaesth 100:787-91. 2008
    ..v. technique, we tested the hypothesis that general anaesthesia with xenon would result in a reduced incidence of PONV similar to that observed with propofol-based anaesthesia...
  9. doi request reprint The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury
    Mark Coburn
    Biophysics Section, Blackett Laboratory, Imperial College, South Kensington, London SW7 2AZ, UK
    Crit Care Med 36:588-95. 2008
    ..The "inert" gas xenon has been shown to be an effective neuroprotectant in a variety of in vitro and in vivo models of neuronal injury. We examined its neuroprotective properties in an in vitro model of traumatic brain injury...
  10. ncbi request reprint Patients' self-evaluation after 4-12 weeks following xenon or propofol anaesthesia: a comparison
    M Coburn
    University Hospital of the RWTH Aachen, Department of Anaesthesiology, Aachen, Germany
    Eur J Anaesthesiol 22:870-4. 2005
    ..The aim of this study was to assess postoperative patients' self-evaluation after xenon anaesthesia compared to total intravenous anaesthesia with propofol...
  11. ncbi request reprint Randomized controlled trial of the haemodynamic and recovery effects of xenon or propofol anaesthesia
    M Coburn
    Department of Anaesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Br J Anaesth 94:198-202. 2005
    ..There is limited clinical experience with xenon in a large number of patients. We present intra- and postoperative haemodynamic and recovery data comparing xenon and total intravenous anaesthesia with propofol...
  12. ncbi request reprint Xenon does not modify mivacurium induced neuromuscular block
    Oliver Kunitz
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Can J Anaesth 52:940-3. 2005
    ..The interaction between mivacurium and inhaled anesthetics is known, with the exception of xenon. We compared the pharmacodynamics of mivacurium during xenon anesthesia vs total iv anesthesia with propofol...
  13. doi request reprint Early administration of xenon or isoflurane may not improve functional outcome and cerebral alterations in a porcine model of cardiac arrest
    Michael Fries
    Department of Anaesthesiology, University Hospital RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Resuscitation 80:584-90. 2009
    ..Xenon (Xe) is neuroprotective when given 1h after cardiopulmonary resuscitation (CPR). Here, we investigated if an earlier administration of Xe or isoflurane (Iso) would also reduce neurological dysfunction...
  14. pmc Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury
    Marc Schoeler
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrase 30, 52074 Aachen, Germany
    BMC Neurol 12:20. 2012
    ..The α2-adrenoreceptor agonist dexmedetomidine is known to provide neuroprotection under ischemic conditions. In this study we investigated whether dexmedetomidine has a protective effect in an in vitro model for traumatic brain injury...
  15. doi request reprint Combining xenon and mild therapeutic hypothermia preserves neurological function after prolonged cardiac arrest in pigs
    Michael Fries
    Department of Surgical Intensive Care, University Hospital RWTH Aachen, Aachen, Germany
    Crit Care Med 40:1297-303. 2012
    ..Administering xenon may confer an additional neuroprotective effect after successful cardiopulmonary resuscitation due to its ability to stabilize cellular calcium homeostasis via N-methyl-D-aspartate-receptor antagonism...
  16. doi request reprint The noble gas argon modifies extracellular signal-regulated kinase 1/2 signaling in neurons and glial cells
    Astrid V Fahlenkamp
    Institute for Neuroanatomy, Medical Faculty, RWTH Aachen, Wendlingweg 2, D 52074 Aachen, Germany
    Eur J Pharmacol 674:104-11. 2012
    ..Whether ERK 1/2 activation by argon affects cellular functions like differentiation and survival in the brain in vivo will have to be determined in future experiments...
  17. ncbi request reprint Bispectral index monitoring during balanced xenon or sevoflurane anaesthesia in elderly patients
    Astrid V Fahlenkamp
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Germany
    Eur J Anaesthesiol 27:906-11. 2010
    ..We evaluated the bispectral index (BIS) for monitoring depth of anaesthesia during clinically guided balanced xenon or sevoflurane anaesthesia in aged patients...
  18. pmc Does a 4 diagram manual enable laypersons to operate the Laryngeal Mask Supreme®? A pilot study in the manikin
    Gereon Schälte
    Department of Anesthesiology, University Hospital Aachen, Aachen, Germany
    Scand J Trauma Resusc Emerg Med 20:21. 2012
    ..The aim of this pilot study was to determine whether an instruction manual consisting of four diagrams enables laypersons to operate a Laryngeal Mask Supreme® (LMAS) in the manikin...
  19. pmc High postoperative blood levels of macrophage migration inhibitory factor are associated with less organ dysfunction in patients after cardiac surgery
    Christian Stoppe
    Department of Anesthesiology, University Hospital, RWTH Aachen, Germany
    Mol Med 18:843-50. 2012
    ..Moreover, MIF values on postoperative d 1 were related to the calculated cardiac power index (r = 0.420, p < 0.05). Elevated postoperative MIF levels are inversely correlated with organ dysfunction in patients after cardiac surgery...
  20. pmc Argon: neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury
    Philip D Loetscher
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany
    Crit Care 13:R206. 2009
    ..Since traumatic brain injury and stroke are widespread and generate an enormous economic and social burden, we investigated the possible neuroprotective effect in in vitro models of traumatic brain injury and cerebral ischemia...
  21. ncbi request reprint Xenon does not prolong neuromuscular block of rocuronium
    Oliver Kunitz
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Anesth Analg 99:1398-401; table of contents. 2004
    ..4 +/- 5.3 min), and clinical recovery (xenon group 18.0 +/- 10.2 and propofol group 17.1 +/- 8.5 min). We conclude that the neuromuscular blocking effects of rocuronium are not different when given during propofol versus xenon anesthesia...
  22. pmc Propofol: neuroprotection in an in vitro model of traumatic brain injury
    Jan Rossaint
    Department of Anesthesiology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 13:R61. 2009
    ..We examined its neuroprotective properties in an in vitro model of traumatic brain injury...
  23. ncbi request reprint Xenon reduces neurohistopathological damage and improves the early neurological deficit after cardiac arrest in pigs
    Michael Fries
    Department of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany
    Crit Care Med 36:2420-6. 2008
    ..Treatment options to ameliorate brain damage following cardiopulmonary resuscitation from cardiac arrest are limited...
  24. doi request reprint Selenium blood concentrations in patients undergoing elective cardiac surgery and receiving perioperative sodium selenite
    Christian Stoppe
    Department of Anesthesiology, University Hospital, RWTH Aachen, Germany
    Nutrition 29:158-65. 2013
    ..The aim of this study was to assess the effects of perioperative high-dose sodium-selenite administration on selenium blood concentrations in cardiac surgical patients...
  25. ncbi request reprint Hydrogen sulfide does not increase resuscitability in a porcine model of prolonged cardiac arrest
    Matthias Derwall
    Department of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany
    Shock 34:190-5. 2010
    ..Although animals receiving Na2S developed higher troponin T serum levels, these differences remained insignificant. In this investigation, Na2S did not improve resuscitability but significantly compromised postresuscitation hemodynamics...
  26. pmc Blood levels of macrophage migration inhibitory factor after successful resuscitation from cardiac arrest
    Christian Stoppe
    Department of Anaesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany
    PLoS ONE 7:e33512. 2012
    ....
  27. doi request reprint Xenon enhances LPS-induced IL-1β expression in microglia via the extracellular signal-regulated kinase 1/2 pathway
    Astrid V Fahlenkamp
    Department of Anaesthesiology, University Hospital Aachen, RWTH Aachen, Germany
    J Mol Neurosci 45:48-59. 2011
    ..In conclusion, xenon enhanced LPS-induced IL-1β expression in microglia by activation of ERK 1/2 signalling. Xenon's interference with phosphatases may be a key feature to affect multiple intracellular signalling pathways...
  28. pmc Neuroprotective properties of levosimendan in an in vitro model of traumatic brain injury
    Anna B Roehl
    Department of Anaesthesiology, RWTH Aachen University Hospital, Pauwelsstrase 30, 52074 Aachen, Germany
    BMC Neurol 10:97. 2010
    ..We investigated the neuroprotective properties of levosimendan, a novel inodilator, in an in vitro model of traumatic brain injury...
  29. ncbi request reprint Comparison of early cognitive function and recovery after desflurane or sevoflurane anaesthesia in the elderly: a double-blinded randomized controlled trial
    D Rörtgen
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D 52072 Aachen, Germany
    Br J Anaesth 104:167-74. 2010
    ..We hypothesized that the use of the shorter-acting volatile anaesthetic desflurane would be associated with less incidence of POCD when compared with sevoflurane...
  30. doi request reprint The intraoperative decrease of selenium is associated with the postoperative development of multiorgan dysfunction in cardiac surgical patients
    Christian Stoppe
    Department of Anaesthesiology, University Hospital, RWTH Aachen, Germany
    Crit Care Med 39:1879-85. 2011
    ..Cardiac surgery using cardiopulmonary bypass provokes ischemia-reperfusion-mediated oxidative stress. We hypothesized that an intraoperative decrease of circulating trace elements may be involved in this response...
  31. doi request reprint Expression analysis of the early chemokine response 4 h after in vitro traumatic brain injury
    Astrid V Fahlenkamp
    Department of Anesthesiology, University Hospital Aachen, RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Inflamm Res 60:379-87. 2011
    ..We investigated the early local cytokine and chemokine expression and the development of tissue injury after moderate mechanical hippocampus trauma...
  32. pmc What is the significance of perioperative release of macrophage migration inhibitory factor in cardiac surgery?
    Christian Stoppe
    Department of Anesthesiology, University Hospital of the RWTH Aachen, 52074 Aachen, Germany
    Antioxid Redox Signal 19:231-9. 2013
    ..Based on current observations, we hypothesize that intraoperative MIF secretion is due to I/R and enhances the antioxidant capacity in patients during cardiac surgery...
  33. pmc Laypersons can successfully place supraglottic airways with 3 minutes of training. A comparison of four different devices in the manikin
    Gereon Schälte
    Department of Anesthesiology, University Hospital Aachen, Aachen, Germany
    Scand J Trauma Resusc Emerg Med 19:60. 2011
    ..Limited data exists concerning laypersons without any medical or paramedical background. We hypothesized that even laymen would be able to operate supraglottic airway devices after a brief training session...
  34. doi request reprint Myocardial blood flow during general anesthesia with xenon in humans: a positron emission tomography study
    Wolfgang Schaefer
    Department of Nuclear Medicine, University Hospital of the RWTH, Aachen, Germany
    Anesthesiology 114:1373-9. 2011
    ..However, little is known about the effects of xenon anesthesia on myocardial blood flow (MBF) and coronary vascular resistance in humans...
  35. doi request reprint Xenon alters right ventricular function
    M Hein
    Department of Anesthesiology, University Hospital of Aken, Aachen, Germany
    Acta Anaesthesiol Scand 52:1056-63. 2008
    ..Therefore, we used an animal model to study the effects of xenon as a supplemental anesthetic on right ventricular function, especially right ventricular afterload...
  36. doi request reprint Evaluation of bispectral index and auditory evoked potentials for hypnotic depth monitoring during balanced xenon anaesthesia compared with sevoflurane
    A V Fahlenkamp
    Department of Anaesthesiology, University Hospital Aachen, RWTH Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Br J Anaesth 105:334-41. 2010
    ..We investigated the performance of the bispectral index (BIS) and the composite A-line autoregressive index (cAAI) while comparing balanced xenon with sevoflurane anaesthesia...
  37. ncbi request reprint Recombinant factor VIIa reduces bleeding after blunt liver injury in coagulopathic, hypofibrinogenaemic pigs
    O Grottke
    Department of Anaesthesiology, RWTH Aachen University Hospital, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Br J Anaesth 105:789-97. 2010
    ..We therefore investigated the efficacy of rFVIIa treatment under conditions of hypofibrinogenaemia in a pig model of blunt liver injury...
  38. ncbi request reprint Xenon: recent developments and future perspectives
    M Derwall
    Department of Anesthesiology, University Hospital Aachen, RWTH Aachen, Germany
    Minerva Anestesiol 75:37-45. 2009
    ..Future studies will have to prove whether the high costs of xenon administration might be outweighed by its ability to substantially reduce the sequelae of myocardial and cerebral ischemia...
  39. doi request reprint [Current developments in xenon research. Importance for anesthesia and intensive care medicine]
    A Brücken
    Klinik fur Anasthesiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstr 30, 52074 Aachen
    Anaesthesist 59:883-95. 2010
    ..As the high cost of xenon will probably preclude its wider use as a routine anesthetic, data from extensive tests in large numbers of high risk patients is needed to confirm its possible superiority in this setting...
  40. pmc Effects of different fibrinogen concentrations on blood loss and coagulation parameters in a pig model of coagulopathy with blunt liver injury
    Oliver Grottke
    Department of Anaesthesiology, RWTH Aachen University Hospital Pauwelsstrasse 30, Aachen, Germany
    Crit Care 14:R62. 2010
    ..We postulated that fibrinogen concentration is correlated with blood loss in a pig model of coagulopathy with blunt liver injury...
  41. ncbi request reprint Neurocognitive performance after cardiopulmonary resuscitation in pigs
    Michael Fries
    Department of Anesthesiology and Institute of Neuropathology, University Hospital RWTH Aachen, Aachen, Germany
    Crit Care Med 36:842-7. 2008
    ..Furthermore, to characterize the influence of different durations of cardiac arrest on cognitive performance and the accompanying neurohistopathological changes...