Sven Cichon

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint A summary statistic approach to sequence variation in noncoding regions of six schizophrenia-associated gene loci
    Jane Winantea
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Eur J Hum Genet 14:1037-43. 2006
  2. pmc Copy number variants in German patients with schizophrenia
    Lutz Priebe
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    PLoS ONE 8:e64035. 2013
  3. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
  4. pmc Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder
    Sven Cichon
    Institute of Neuroscience and Medicine INM 1, Structural and Functional Organization of the Brain, Genomic Imaging, Research Center Juelich, Juelich, Germany
    Am J Hum Genet 88:372-81. 2011
  5. pmc Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III
    Sven Cichon
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Am J Hum Genet 79:1098-104. 2006
  6. ncbi request reprint Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder
    Sven Cichon
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Hum Mol Genet 17:87-97. 2008
  7. doi request reprint Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia
    Manuel Mattheisen
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Schizophr Res 141:262-5. 2012
  8. doi request reprint Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder
    Thomas W Mühleisen
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Schizophr Res 138:69-73. 2012
  9. ncbi request reprint Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 141:663-5. 2006
  10. ncbi request reprint No evidence for an association between variants at the gamma-amino-n-butyric acid type A receptor beta2 locus and schizophrenia
    Rami Abou Jamra
    Institute of Human Genetics, Department of Psychiatry, Life and Brain Center, University of Bonn, Bonn, Germany
    Psychiatr Genet 17:43-5. 2007

Detail Information

Publications80

  1. ncbi request reprint A summary statistic approach to sequence variation in noncoding regions of six schizophrenia-associated gene loci
    Jane Winantea
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Eur J Hum Genet 14:1037-43. 2006
    ..This showed a more prominent role of variants from the loci AKT1, BDNF and RGS4. Taken together, our approach provides promising strategy to investigate the genetics of schizophrenia and related phenotypes...
  2. pmc Copy number variants in German patients with schizophrenia
    Lutz Priebe
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    PLoS ONE 8:e64035. 2013
    ..The dataset could be useful for the identification of new disease-relevant CNVs that are currently overlooked due to their very low frequency and lack of power for their detection in individual studies. ..
  3. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
    ..With the integrated replication effort, we present a specific hypothesis for further studies...
  4. pmc Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder
    Sven Cichon
    Institute of Neuroscience and Medicine INM 1, Structural and Functional Organization of the Brain, Genomic Imaging, Research Center Juelich, Juelich, Germany
    Am J Hum Genet 88:372-81. 2011
    ..These areas are involved in cognition and emotion regulation and have previously been implicated in BD by neuropsychological, neuroimaging, and postmortem studies...
  5. pmc Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III
    Sven Cichon
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Am J Hum Genet 79:1098-104. 2006
    ..The results of our study represent an important step toward an understanding of the molecular processes involved in HAE type III and provide diagnostic and possibly new therapeutic opportunities...
  6. ncbi request reprint Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder
    Sven Cichon
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Hum Mol Genet 17:87-97. 2008
    ..Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD...
  7. doi request reprint Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia
    Manuel Mattheisen
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Schizophr Res 141:262-5. 2012
    ..0042, OR=0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia...
  8. doi request reprint Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder
    Thomas W Mühleisen
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Schizophr Res 138:69-73. 2012
    ..0239, odds ratio=1.07). Our data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia...
  9. ncbi request reprint Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 141:663-5. 2006
    ..Therefore, our data does not support an involvement of the PIP5K2A locus in the etiology of either schizophrenia or BPAD in the German population...
  10. ncbi request reprint No evidence for an association between variants at the gamma-amino-n-butyric acid type A receptor beta2 locus and schizophrenia
    Rami Abou Jamra
    Institute of Human Genetics, Department of Psychiatry, Life and Brain Center, University of Bonn, Bonn, Germany
    Psychiatr Genet 17:43-5. 2007
    ....
  11. doi request reprint Studies in humans and mice implicate neurocan in the etiology of mania
    Xavier Miro
    Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany
    Am J Psychiatry 169:982-90. 2012
    ..The aims of this study were to characterize the clinical symptomatology most strongly influenced by NCAN and to explore the behavioral phenotype of Ncan knockout (Ncan(-/-)) mice...
  12. doi request reprint Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
    Elisabeth Mangold
    Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany
    Nat Genet 42:24-6. 2010
    ..07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56)...
  13. doi request reprint Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Psychiatr Genet 18:199-203. 2008
    ..Based on the functional evidence and on the hypothesis that further genes, which are involved in the regulation of D-serine, could be involved in the disease aetiology, we considered VAMP2 and VAMP3 as candidate genes for BPAD...
  14. ncbi request reprint Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Bonn
    Biol Psychiatry 58:307-14. 2005
    ....
  15. doi request reprint Resequencing and follow-up of neurexin 1 (NRXN1) in schizophrenia patients
    Thomas W Mühleisen
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany Institute of Human Genetics, University of Bonn, Bonn, Germany
    Schizophr Res 127:35-40. 2011
    ..Overall, however, the results do not suggest the existence of rare, highly penetrant NRXN1 mutations in patients with schizophrenia...
  16. doi request reprint Genome-wide association data provide further support for an association between 5-HTTLPR and major depressive disorder
    Britta Haenisch
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    J Affect Disord 146:438-40. 2013
    ..A length polymorphism repeat in the 5-HTT promoter region, termed 5-HTTLPR, has been commonly investigated for an association with psychiatric disorders...
  17. doi request reprint Susceptibility variants for male-pattern baldness on chromosome 20p11
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, D 53127 Bonn, Germany
    Nat Genet 40:1279-81. 2008
    ..7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway...
  18. pmc Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Hum Genet 78:52-62. 2006
    ....
  19. pmc The G72/G30 gene locus in psychiatric disorders: a challenge to diagnostic boundaries?
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, D 53111 Bonn, Germany
    Schizophr Bull 32:599-608. 2006
    ....
  20. ncbi request reprint Systematic screening for mutations in the human N-methyl-D-aspartate receptor 1 gene in schizophrenic patients from the German population
    Sebastian Paus
    Department of Neurology, Institute of Human Genetics, University of Bonn, Bonn, Germany
    Psychiatr Genet 14:233-4. 2004
    ..Our results suggest that the NMDAR1 subunit is not frequently involved in the development of schizophrenia in the German population...
  21. pmc Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci
    Kerstin U Ludwig
    Institute of Human Genetics, University of Bonn, Germany
    Nat Genet 44:968-71. 2012
    ..51 × 10(-11); homozygote relative risk = 2.41, 95% confidence interval (CI) 1.84-3.16)...
  22. doi request reprint A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:878-84. 2010
    ..25 and 1.46. Our findings may indicate that MCHR2 is a putative risk factor for BPAD. These findings should be interpreted with caution and replicated in independent BPAD samples...
  23. doi request reprint Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample
    Franziska Degenhardt
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 159:263-73. 2012
    ..The association finding for common SNPs provides further support for the hypothesis that this region is involved in the development of MDD. © 2012 Wiley Periodicals, Inc...
  24. pmc The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Hum Genet 81:974-86. 2007
    ..Our results provide systematic insights in the framework of BPAD epistasis and locus heterogeneity, which should facilitate gene identification by the use of more-comprehensive cloning strategies...
  25. doi request reprint Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24
    Stefanie Birnbaum
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Nat Genet 41:473-7. 2009
    ..05 (95% CI = 3.88-9.43) for the homozygous genotype. The calculated population attributable risk for this marker is 0.41, suggesting that this study has identified a major susceptibility locus for NSCL/P...
  26. doi request reprint Brain function in carriers of a genome-wide supported bipolar disorder variant
    Susanne Erk
    Division of Medical Psychology, University of Bonn, Bonn, Germany
    Arch Gen Psychiatry 67:803-11. 2010
    ..2...
  27. ncbi request reprint Association study between two variants in the DOPA decarboxylase gene in bipolar and unipolar affective disorder
    Esther Jahnes
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet 114:519-22. 2002
    ..For both BPAD and UPAD we could not detect a genetic association with either variant. Thus, our results do not support an involvement of the 1-bp or 4-bp deletion within the DDC gene in the etiology of affective disorders...
  28. doi request reprint Genome-wide association study reveals two new risk loci for bipolar disorder
    Thomas W Mühleisen
    1 Institute of Human Genetics, University of Bonn, D 53127 Bonn, Germany 2 Department of Genomics, Life and Brain Center, University of Bonn, D 53127 Bonn, Germany 3 Institute of Neuroscience and Medicine INM 1, Research Centre Julich, D 52425 Julich, Germany 4
    Nat Commun 5:3339. 2014
    ..31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD. ..
  29. doi request reprint TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue
    Katharina Pernhorst
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Seizure 22:675-8. 2013
    ..Furthermore, we characterized the cell types expressing the respective proteins in epileptic hippocampi...
  30. ncbi request reprint No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, D 53111 Bonn, Germany
    Psychiatr Genet 15:195-8. 2005
    ..Neither single marker nor haplotype analysis revealed an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder...
  31. doi request reprint VEGF gene haplotypes are associated with sarcoidosis
    Stefan Pabst
    Department of Internal Medicine II, Division of Pneumology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Chest 137:156-63. 2010
    ..In this study, we examined whether haplotypes of vascular endothelial growth factor (VEGF) and its receptors VEGFR-1 and VEGFR-2 are associated with the onset or the course of sarcoidosis...
  32. pmc Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24
    Johannes Schumacher
    Institute of Human Genetics, Life and Brain Center, University of Bonn, D 53105 Bonn, Germany
    Am J Hum Genet 77:1102-11. 2005
    ....
  33. ncbi request reprint Family-based association studies of alpha-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 126:79-81. 2004
    ..Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes...
  34. pmc Single nucleotide variation analysis in 65 candidate genes for CNS disorders in a representative sample of the European population
    Yun Freudenberg-Hua
    Institute of Human Genetics, University of Bonn, D 53111 Bonn, Germany
    Genome Res 13:2271-6. 2003
    ..Therefore, radical variants obtain distinctively lower database coverage. However, those variants appear to be under weak purifying selection and thus could play a role in the etiology of genetically complex diseases...
  35. ncbi request reprint No association between genetic variants at the GLYT2 gene and bipolar affective disorder and schizophrenia
    Rami Abou Jamra
    Institute of Human Genetics bInstitute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
    Psychiatr Genet 16:91. 2006
  36. doi request reprint Marie Unna hereditary hypotrichosis: identification of a U2HR mutation in the family from the original 1925 report
    Silke Redler
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    J Am Acad Dermatol 64:e45-50. 2011
    ..Causal mutations in U2HR, an inhibitory upstream open reading frame in the 5'-untranslated region of the human hairless (HR) gene, were recently identified in several unrelated MUHH families from various ethnic backgrounds...
  37. ncbi request reprint No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis
    Roland Ivo
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Psychiatr Genet 16:197-203. 2006
    ..In our present study, we have examined NOTCH4 markers in large samples of German and Palestinian-Arab origin...
  38. pmc The opioid peptides enkephalin and beta-endorphin in alcohol dependence
    Ildiko Racz
    Institute of Molecular Psychiatry, Life and Brain Center, University of Bonn, Bonn, Germany
    Biol Psychiatry 64:989-97. 2008
    ..Because stress is an important factor contributing to drug dependence and relapse, we have now studied ethanol preference in enkephalin- and beta-endorphin-deficient mice under baseline conditions and after stress exposure...
  39. doi request reprint Epigenetic alteration of the dopamine transporter gene in alcohol-dependent patients is associated with age
    Vanessa Nieratschker
    Departments of Genetic Epidemiology in Psychiatry Addictive Behavior and Addiction Medicine Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Germany, Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Germany Institute of Neuroscience and Medicine, Research Centre Julich, Germany Department of Genomics, Life and Brain Center Institute of Human Genetics University of Bonn, Germany and German Center for Neurodegenerative Disorders DZNE, Germany
    Addict Biol 19:305-11. 2014
    ....
  40. pmc New findings in the genetics of major psychoses
    Markus M Nothen
    Department of Genomics, Life and Brain Centre, University of Bonn, Bonn, Germany
    Dialogues Clin Neurosci 12:85-93. 2010
    ..This review summarizes recent developments in genetic research into schizophrenia and bipolar disorder, and discusses possible future directions in this field...
  41. ncbi request reprint Haplotype interaction analysis of unlinked regions
    Tim Becker
    Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
    Genet Epidemiol 29:313-22. 2005
    ..The method described here has been implemented in FAMHAP...
  42. ncbi request reprint Identification of mutations in the human hairless gene in two new families with congenital atrichia
    Regina C Betz
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, Bonn, Germany
    Arch Dermatol Res 299:157-61. 2007
    ..Our study emphasizes the importance of sequencing the complete coding sequence and exon/intron junctions in the molecular diagnostics of AUC and APL...
  43. doi request reprint Promoter variants determine γ-aminobutyric acid homeostasis-related gene transcription in human epileptic hippocampi
    Katharina Pernhorst
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    J Neuropathol Exp Neurol 70:1080-8. 2011
    ..This might contribute to the episodic onset of symptoms and point to new targets for pharmacotherapies...
  44. doi request reprint Feasible and successful: genome-wide interaction analysis involving all 1.9 x 10(11) pair-wise interaction tests
    Michael Steffens
    Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
    Hum Hered 69:268-84. 2010
    ..Results from GWAS are beginning to reveal a 'missing heritability' in complex traits and diseases. Systematic, hypothesis-free analysis of epistatic interaction (GWIA) may help to close this increasingly recognized gap in heritability...
  45. ncbi request reprint No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approach
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
    Hum Genet 114:115-7. 2003
    ..0). Thus, our study does not support the hypothesis of an involvement of DUP25 in panic disorder...
  46. doi request reprint Volition diminishes genetically mediated amygdala hyperreactivity
    Dina M Schardt
    Department of Psychiatry, Division of Medical Psychology, University of Bonn, Germany
    Neuroimage 53:943-51. 2010
    ....
  47. ncbi request reprint Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder
    Daniel J Muller
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 114:74-8. 2002
    ..We observed a significantly increased frequency of genotypes homozygous for the C allele in females with BPAD in comparison with controls (P=0.017). Thus, our data strengthen the role of the SYBL1 gene as a candidate gene for BPAD...
  48. pmc Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Am J Hum Genet 77:140-8. 2005
    ..The X-chromosomal location of AR stresses the importance of the maternal line in the inheritance of AGA...
  49. ncbi request reprint Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population
    Sylvia Bort Martí
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet 114:46-50. 2002
    ..It is therefore unlikely that this variant plays a major role in predisposing to schizophrenia and/or bipolar affective disorder at least in the German population...
  50. ncbi request reprint Human metabotropic glutamate receptor 2 gene (GRM2): chromosomal sublocalization (3p21.1-p21.2) and genomic organization
    Sylvia Bort Martí
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet 114:12-4. 2002
    ..1-p21.2. The genomic organization of the GRM2 gene was established using a premade library of adaptor-ligated, human-specific genomic DNA fragments. The gene consists of 5 exons, with sizes ranging from 74 to 1,076 bp...
  51. doi request reprint Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population
    Maria Grigoroiu-Serbanescu
    Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania
    Psychiatr Genet 18:240-7. 2008
    ..The second objective was to investigate the influence of the phenotypic traits 'age-of-onset' , 'family history', and 'parent-of-origin', defined according to clinical criteria, on the degree of association between TPH2 and BPI...
  52. pmc Large recurrent microdeletions associated with schizophrenia
    Hreinn Stefansson
    CNS Division, deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nature 455:232-6. 2008
    ..CNV analysis may also point the way to the identification of additional and more prevalent risk variants in genes and pathways involved in schizophrenia...
  53. doi request reprint Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior
    Gunter Schumann
    Interdisciplinary Research Group Addiction, MRC SGDP Center, Institute of Psychiatry at King s College, POB 080, London SE5 8AF, England
    Arch Gen Psychiatry 65:826-38. 2008
    ..Glutamatergic neurotransmission is implicated in alcohol-drinking behavior in animal models...
  54. doi request reprint G72 and its association with major depression and neuroticism in large population-based groups from Germany
    Marcella Rietschel
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Am J Psychiatry 165:753-62. 2008
    ..The authors tested whether the previously observed risk haplotypes are also associated with major depression and neuroticism...
  55. ncbi request reprint Linking single nucleotide polymorphisms
    Markus M Nothen
    Department of Medical Genetics, University of Antwerp, Belgium
    Pharmacogenetics 12:89-90. 2002
  56. ncbi request reprint Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin
    Sven Cichon
    Nat Genet 36:783-4; author reply 784-5. 2004
  57. pmc Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers
    Erik G Jonsson
    Department of Clinical Neuroscience, Psychiatry Section, HUBIN project, Karolinska Institutet, Stockholm, Sweden
    BMC Psychiatry 4:4. 2004
    ..CSF monoamine metabolite concentrations are partly determined by genetic influences...
  58. ncbi request reprint Genetic association between the phospholipase A2 gene and unipolar affective disorder: a multicentre case-control study
    George N Papadimitriou
    Athens University Medical School, Department of Psychiatry, Eginition Hospital, Athens, Greece
    Psychiatr Genet 13:211-20. 2003
    ..02). These findings suggest that structural variations at the PLA2 gene or the chromosomal region around it may confer susceptibility for unipolar affective disorder...
  59. pmc The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease
    Ann Van Den Bogaert
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Am J Hum Genet 73:1438-43. 2003
    ..This would also explain the difficulty of replicating this association in consecutively ascertained case-control samples, which usually comprise only a small proportion of subjects with a family history of disease...
  60. ncbi request reprint No association between a putative functional promoter variant in the dopamine beta-hydroxylase gene and schizophrenia
    Erik G Jonsson
    Department of Clinical Neuroscience, Psychiatry Section, HUBIN project, Karolinska Institute, SE 171 76 Stockholm, Sweden
    Psychiatr Genet 13:175-8. 2003
    ..We attempted to investigate a putative functional promoter polymorphism in the dopamine beta-hydroxylase gene (DBH) for association with schizophrenia...
  61. ncbi request reprint Dopamine D4 receptor gene (DRD4) variants and schizophrenia: meta-analyses
    Erik G Jonsson
    Schizophr Res 61:111-9. 2003
  62. ncbi request reprint Is there a phenotypic difference between probands in case-control versus family-based association studies?
    Thomas G Schulze
    Am J Med Genet B Neuropsychiatr Genet 118:25-6; author reply 27-8. 2003
  63. ncbi request reprint Can long-range microsatellite data be used to predict short-range linkage disequilibrium?
    Thomas G Schulze
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 11:1363-72. 2002
    ....
  64. ncbi request reprint No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 58:78-80. 2005
    ..It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ()...
  65. ncbi request reprint No association between the serine racemase gene (SRR) and schizophrenia in a German case-control sample
    Jana Strohmaier
    Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
    Psychiatr Genet 17:125. 2007
  66. ncbi request reprint Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample
    Alexander Georgi
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, D 68159 Mannheim, Germany
    Psychiatr Genet 17:308-10. 2007
    ..Although significances did not withstand correction for multiple testing, the results of our exploratory analysis warrant further studies on GRIN1 and schizophrenia...
  67. ncbi request reprint No association between genetic variants at the ASCT1 gene and schizophrenia or bipolar disorder in a German sample
    Markus H Skowronek
    Psychiatr Genet 16:233-4. 2006
    ..Allele and haplotype frequencies did not differ between cases and controls. Our results do not support an association of the ASCT1 gene with BD or SCZ in the German population...
  68. ncbi request reprint No association between genetic variants at the GRIN1 gene and bipolar disorder in a German sample
    Alexander Georgi
    Central Institute of Mental Health, Mannheim, Germany
    Psychiatr Genet 16:183-4. 2006
    ..This stratified analysis did not yield any significant association either. Our results do not support an association of the GRIN1 gene with bipolar disorder in the German population...
  69. ncbi request reprint Hereditary angioedema with normal C1 inhibitor gene in a family with affected women and men is associated with the p.Thr328Lys mutation in the F12 gene
    Ludovic Martin
    J Allergy Clin Immunol 120:975-7. 2007
  70. ncbi request reprint Lack of genetic association between the phospholipase A2 gene and bipolar mood disorder in a European multicentre case-control study
    Dimitris G Dikeos
    Department of Psychiatry, Athens University Medical School and University Mental Health Research Institute, Greece, and Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Psychiatr Genet 16:169-71. 2006
    ..On the basis of these results, mutations of the phospholipase A2 gene, at least in the region close to the polymorphism examined between exons 1 and 2, are not involved in the pathogenesis of bipolar mood disorder...
  71. ncbi request reprint Brain-derived neurotrophic factor gene (BDNF) variants and schizophrenia: an association study
    Erik G Jonsson
    Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, R5 00, SE 171 76 Stockholm, Sweden
    Prog Neuropsychopharmacol Biol Psychiatry 30:924-33. 2006
    ..Thus, the BDNF gene may confer susceptibility to schizophrenia. Additional studies are warranted to shed further light on this possibility...
  72. ncbi request reprint Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia
    Erik G Jonsson
    Department of Clinical Neuroscience, Psychiatry Section, R5 00, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Am J Med Genet B Neuropsychiatr Genet 141:71-5. 2006
    ..It cannot be excluded, however, that the XBP1 polymorphism is involved in schizophrenia in other populations or adds minor susceptibility to the disorder...
  73. ncbi request reprint Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health J5, 68159 Mannheim, Germany
    Am J Psychiatry 162:2101-8. 2005
    ....
  74. ncbi request reprint No association between the serine racemase gene (SRR) and bipolar disorder in a German case-control sample
    Frederike Schirmbeck
    Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
    Psychiatr Genet 17:127. 2007
  75. ncbi request reprint Further evidence for age of onset being an indicator for severity in bipolar disorder
    Thomas G Schulze
    J Affect Disord 68:343-5. 2002
  76. ncbi request reprint Association between a promoter dopamine D2 receptor gene variant and the personality trait detachment
    Erik G Jonsson
    Department of Clinical Neuroscience, Psychiatry Section, HUBIN project, Karolinska Institute, Stockholm, Sweden
    Biol Psychiatry 53:577-84. 2003
    ..A putative functional promoter polymorphism in the dopamine D(2) receptor gene (DRD2), -141C ins/del, has been associated with dopamine D(2) receptor density...
  77. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...
  78. pmc Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
    Matthew B McQueen
    Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
    Am J Hum Genet 77:582-95. 2005
    ..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches...
  79. ncbi request reprint Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin
    Etgar Levy-Nissenbaum
    Danek Gartner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel and Tel Aviv University, Tel Aviv, Israel
    Nat Genet 34:151-3. 2003
    ..Truncated CDSN aggregates were detected in the superficial dermis and at the periphery of hair follicles. Our findings suggest that CDSN is important in normal scalp hair physiology...
  80. ncbi request reprint DRD4 exon 3 variants are not associated with symptomatology of major psychoses in a German population
    Alessandro Serretti
    Department of Psychiatry, San Raffaele Institute, Vita Salute University, Milan, Italy
    Neurosci Lett 368:269-73. 2004
    ..However it should be considered that the original sample included a much higher rate of mood disorders and this could partially explain the discrepancy...