Research Topics
Genomes and Genes
| Sven CichonSummaryAffiliation: University of Bonn Country: Germany Publications
| Collaborators
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Detail Information
Publications
A summary statistic approach to sequence variation in noncoding regions of six schizophrenia-associated gene lociJane Winantea
Institute of Human Genetics, University of Bonn, Bonn, Germany
Eur J Hum Genet 14:1037-43. 2006..This showed a more prominent role of variants from the loci AKT1, BDNF and RGS4. Taken together, our approach provides promising strategy to investigate the genetics of schizophrenia and related phenotypes...
Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorderSven Cichon
Institute of Neuroscience and Medicine INM 1, Structural and Functional Organization of the Brain, Genomic Imaging, Research Center Juelich, Juelich, Germany
Am J Hum Genet 88:372-81. 2011..These areas are involved in cognition and emotion regulation and have previously been implicated in BD by neuropsychological, neuroimaging, and postmortem studies...- Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorderSven Cichon
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Hum Mol Genet 17:87-97. 2008..Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD... - Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type IIISven Cichon
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Am J Hum Genet 79:1098-104. 2006..The results of our study represent an important step toward an understanding of the molecular processes involved in HAE type III and provide diagnostic and possibly new therapeutic opportunities... 
Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorderThomas W Mühleisen
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Schizophr Res 138:69-73. 2012..0239, odds ratio=1.07). Our data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia...- No evidence for an association between variants at the gamma-amino-n-butyric acid type A receptor beta2 locus and schizophreniaRami Abou Jamra
Institute of Human Genetics, Department of Psychiatry, Life and Brain Center, University of Bonn, Bonn, Germany
Psychiatr Genet 17:43-5. 2007.... - Studies in humans and mice implicate neurocan in the etiology of maniaXavier Miro
Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany
Am J Psychiatry 169:982-90. 2012..The aims of this study were to characterize the clinical symptomatology most strongly influenced by NCAN and to explore the behavioral phenotype of Ncan knockout (Ncan(-/-)) mice... - Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, Bonn, Germany
Psychiatr Genet 18:199-203. 2008..Based on the functional evidence and on the hypothesis that further genes, which are involved in the regulation of D-serine, could be involved in the disease aetiology, we considered VAMP2 and VAMP3 as candidate genes for BPAD... - Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palateElisabeth Mangold
Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany
Nat Genet 42:24-6. 2010..07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56)... - Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexiaJohannes Schumacher
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Hum Genet 78:52-62. 2006.... - The G72/G30 gene locus in psychiatric disorders: a challenge to diagnostic boundaries?Rami Abou Jamra
Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, D 53111 Bonn, Germany
Schizophr Bull 32:599-608. 2006.... - Susceptibility variants for male-pattern baldness on chromosome 20p11Axel M Hillmer
Department of Genomics, Life and Brain Center, University of Bonn, D 53127 Bonn, Germany
Nat Genet 40:1279-81. 2008..7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway... - Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Med Genet B Neuropsychiatr Genet 141:663-5. 2006..Therefore, our data does not support an involvement of the PIP5K2A locus in the etiology of either schizophrenia or BPAD in the German population... - No association between genetic variants at the GLYT2 gene and bipolar affective disorder and schizophreniaRami Abou Jamra
Institute of Human Genetics bInstitute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
Psychiatr Genet 16:91. 2006 - A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Med Genet B Neuropsychiatr Genet 153:878-84. 2010..25 and 1.46. Our findings may indicate that MCHR2 is a putative risk factor for BPAD. These findings should be interpreted with caution and replicated in independent BPAD samples... - Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depressionJohannes Schumacher
Institute of Human Genetics, University of Bonn, Bonn
Biol Psychiatry 58:307-14. 2005.... - Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk lociKerstin U Ludwig
Institute of Human Genetics, University of Bonn, Germany
Nat Genet 44:968-71. 2012..51 × 10(-11); homozygote relative risk = 2.41, 95% confidence interval (CI) 1.84-3.16)... - Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24Stefanie Birnbaum
Institute of Human Genetics, University of Bonn, Bonn, Germany
Nat Genet 41:473-7. 2009..05 (95% CI = 3.88-9.43) for the homozygous genotype. The calculated population attributable risk for this marker is 0.41, suggesting that this study has identified a major susceptibility locus for NSCL/P... - Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sampleFranziska Degenhardt
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Med Genet B Neuropsychiatr Genet 159:263-73. 2012..The association finding for common SNPs provides further support for the hypothesis that this region is involved in the development of MDD. © 2012 Wiley Periodicals, Inc... - Genetic variation at the synaptic vesicle gene SV2A is associated with schizophreniaManuel Mattheisen
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Schizophr Res 141:262-5. 2012..0042, OR=0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia... - VEGF gene haplotypes are associated with sarcoidosisStefan Pabst
Department of Internal Medicine II, Division of Pneumology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
Chest 137:156-63. 2010..In this study, we examined whether haplotypes of vascular endothelial growth factor (VEGF) and its receptors VEGFR-1 and VEGFR-2 are associated with the onset or the course of sarcoidosis... - No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, D 53111 Bonn, Germany
Psychiatr Genet 15:195-8. 2005..Neither single marker nor haplotype analysis revealed an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder... - Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24Johannes Schumacher
Institute of Human Genetics, Life and Brain Center, University of Bonn, D-53105 Bonn, Germany
Am J Hum Genet 77:1102-11. 2005.... - Resequencing and follow-up of neurexin 1 (NRXN1) in schizophrenia patientsThomas W Mühleisen
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany Institute of Human Genetics, University of Bonn, Bonn, Germany
Schizophr Res 127:35-40. 2011..Overall, however, the results do not suggest the existence of rare, highly penetrant NRXN1 mutations in patients with schizophrenia... - Marie Unna hereditary hypotrichosis: identification of a U2HR mutation in the family from the original 1925 reportSilke Redler
Institute of Human Genetics, University of Bonn, Bonn, Germany
J Am Acad Dermatol 64:e45-50. 2011..Causal mutations in U2HR, an inhibitory upstream open reading frame in the 5'-untranslated region of the human hairless (HR) gene, were recently identified in several unrelated MUHH families from various ethnic backgrounds... - Brain function in carriers of a genome-wide supported bipolar disorder variantSusanne Erk
Division of Medical Psychology, University of Bonn, Bonn, Germany
Arch Gen Psychiatry 67:803-11. 2010..2... - Systematic screening for mutations in the human N-methyl-D-aspartate receptor 1 gene in schizophrenic patients from the German populationSebastian Paus
Department of Neurology, Institute of Human Genetics, University of Bonn, Bonn, Germany
Psychiatr Genet 14:233-4. 2004..Our results suggest that the NMDAR1 subunit is not frequently involved in the development of schizophrenia in the German population... - The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6qRami Abou Jamra
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Hum Genet 81:974-86. 2007..Our results provide systematic insights in the framework of BPAD epistasis and locus heterogeneity, which should facilitate gene identification by the use of more-comprehensive cloning strategies... - The opioid peptides enkephalin and beta-endorphin in alcohol dependenceIldiko Racz
Institute of Molecular Psychiatry, Life and Brain Center, University of Bonn, Bonn, Germany
Biol Psychiatry 64:989-97. 2008..Because stress is an important factor contributing to drug dependence and relapse, we have now studied ethanol preference in enkephalin- and beta-endorphin-deficient mice under baseline conditions and after stress exposure... - Haplotype interaction analysis of unlinked regionsTim Becker
Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Genet Epidemiol 29:313-22. 2005..The method described here has been implemented in FAMHAP... - New findings in the genetics of major psychosesMarkus M Nothen
Department of Genomics, Life and Brain Centre, University of Bonn, Bonn, Germany
Dialogues Clin Neurosci 12:85-93. 2010..This review summarizes recent developments in genetic research into schizophrenia and bipolar disorder, and discusses possible future directions in this field... - Identification of mutations in the human hairless gene in two new families with congenital atrichiaRegina C Betz
Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, Bonn, Germany
Arch Dermatol Res 299:157-61. 2007..Our study emphasizes the importance of sequencing the complete coding sequence and exon/intron junctions in the molecular diagnostics of AUC and APL... - Feasible and successful: genome-wide interaction analysis involving all 1.9 x 10(11) pair-wise interaction testsMichael Steffens
Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Hum Hered 69:268-84. 2010..Results from GWAS are beginning to reveal a 'missing heritability' in complex traits and diseases. Systematic, hypothesis-free analysis of epistatic interaction (GWIA) may help to close this increasingly recognized gap in heritability... - No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysisRoland Ivo
Institute of Human Genetics, University of Bonn, Bonn, Germany
Psychiatr Genet 16:197-203. 2006..In our present study, we have examined NOTCH4 markers in large samples of German and Palestinian-Arab origin... - No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approachJohannes Schumacher
Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
Hum Genet 114:115-7. 2003..0). Thus, our study does not support the hypothesis of an involvement of DUP25 in panic disorder... - Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorderDaniel J Muller
Department of Psychiatry, University of Bonn, Bonn, Germany
Am J Med Genet 114:74-8. 2002..We observed a significantly increased frequency of genotypes homozygous for the C allele in females with BPAD in comparison with controls (P=0.017). Thus, our data strengthen the role of the SYBL1 gene as a candidate gene for BPAD... - Promoter variants determine γ-aminobutyric acid homeostasis-related gene transcription in human epileptic hippocampiKatharina Pernhorst
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
J Neuropathol Exp Neurol 70:1080-8. 2011..This might contribute to the episodic onset of symptoms and point to new targets for pharmacotherapies... - Volition diminishes genetically mediated amygdala hyperreactivityDina M Schardt
Department of Psychiatry, Division of Medical Psychology, University of Bonn, Germany
Neuroimage 53:943-51. 2010.... - Family-based association studies of alpha-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
Am J Med Genet B Neuropsychiatr Genet 126:79-81. 2004..Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes... - Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German populationSylvia Bort Martí
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Med Genet 114:46-50. 2002..It is therefore unlikely that this variant plays a major role in predisposing to schizophrenia and/or bipolar affective disorder at least in the German population... - Single nucleotide variation analysis in 65 candidate genes for CNS disorders in a representative sample of the European populationYun Freudenberg-Hua
Institute of Human Genetics, University of Bonn, D-53111 Bonn, Germany
Genome Res 13:2271-6. 2003..Therefore, radical variants obtain distinctively lower database coverage. However, those variants appear to be under weak purifying selection and thus could play a role in the etiology of genetically complex diseases... - Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopeciaAxel M Hillmer
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Am J Hum Genet 77:140-8. 2005..The X-chromosomal location of AR stresses the importance of the maternal line in the inheritance of AGA... - Association study between two variants in the DOPA decarboxylase gene in bipolar and unipolar affective disorderEsther Jahnes
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Med Genet 114:519-22. 2002..For both BPAD and UPAD we could not detect a genetic association with either variant. Thus, our results do not support an involvement of the 1-bp or 4-bp deletion within the DDC gene in the etiology of affective disorders... - Human metabotropic glutamate receptor 2 gene (GRM2): chromosomal sublocalization (3p21.1-p21.2) and genomic organizationSylvia Bort Martí
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Med Genet 114:12-4. 2002..1-p21.2. The genomic organization of the GRM2 gene was established using a premade library of adaptor-ligated, human-specific genomic DNA fragments. The gene consists of 5 exons, with sizes ranging from 74 to 1,076 bp... - G72 and its association with major depression and neuroticism in large population-based groups from GermanyMarcella Rietschel
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Am J Psychiatry 165:753-62. 2008..The authors tested whether the previously observed risk haplotypes are also associated with major depression and neuroticism... - Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteersErik G Jonsson
Department of Clinical Neuroscience, Psychiatry Section, HUBIN project, Karolinska Institutet, Stockholm, Sweden
BMC Psychiatry 4:4. 2004..CSF monoamine metabolite concentrations are partly determined by genetic influences... - Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behaviorGunter Schumann
Interdisciplinary Research Group Addiction, MRC SGDP Center, Institute of Psychiatry at King s College, POB 080, London SE5 8AF, England
Arch Gen Psychiatry 65:826-38. 2008..Glutamatergic neurotransmission is implicated in alcohol-drinking behavior in animal models... - Large recurrent microdeletions associated with schizophreniaHreinn Stefansson
CNS Division, deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
Nature 455:232-6. 2008..CNV analysis may also point the way to the identification of additional and more prevalent risk variants in genes and pathways involved in schizophrenia... - Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian populationMaria Grigoroiu-Serbanescu
Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania
Psychiatr Genet 18:240-7. 2008..The second objective was to investigate the influence of the phenotypic traits 'age-of-onset' , 'family history', and 'parent-of-origin', defined according to clinical criteria, on the degree of association between TPH2 and BPI... - Hereditary angioedema with normal C1 inhibitor gene in a family with affected women and men is associated with the p.Thr328Lys mutation in the F12 geneLudovic Martin
J Allergy Clin Immunol 120:975-7. 2007 - Linking single nucleotide polymorphismsMarkus M Nothen
Department of Medical Genetics, University of Antwerp, Belgium
Pharmacogenetics 12:89-90. 2002 - Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European originSven Cichon
Nat Genet 36:783-4; author reply 784-5. 2004 - Genetic association between the phospholipase A2 gene and unipolar affective disorder: a multicentre case-control studyGeorge N Papadimitriou
Athens University Medical School, Department of Psychiatry, Eginition Hospital, Athens, Greece
Psychiatr Genet 13:211-20. 2003..02). These findings suggest that structural variations at the PLA2 gene or the chromosomal region around it may confer susceptibility for unipolar affective disorder... - The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the diseaseAnn Van Den Bogaert
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Am J Hum Genet 73:1438-43. 2003..This would also explain the difficulty of replicating this association in consecutively ascertained case-control samples, which usually comprise only a small proportion of subjects with a family history of disease... - No association between a putative functional promoter variant in the dopamine beta-hydroxylase gene and schizophreniaErik G Jonsson
Department of Clinical Neuroscience, Psychiatry Section, HUBIN project, Karolinska Institute, SE 171 76 Stockholm, Sweden
Psychiatr Genet 13:175-8. 2003..We attempted to investigate a putative functional promoter polymorphism in the dopamine beta-hydroxylase gene (DBH) for association with schizophrenia... - Dopamine D4 receptor gene (DRD4) variants and schizophrenia: meta-analysesErik G Jonsson
Schizophr Res 61:111-9. 2003 - Is there a phenotypic difference between probands in case-control versus family-based association studies?Thomas G Schulze
Am J Med Genet B Neuropsychiatr Genet 118:25-6; author reply 27-8. 2003 - Can long-range microsatellite data be used to predict short-range linkage disequilibrium?Thomas G Schulze
Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
Hum Mol Genet 11:1363-72. 2002.... - No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samplesBeate Glaser
Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom
Biol Psychiatry 58:78-80. 2005..It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ()... - No association between genetic variants at the ASCT1 gene and schizophrenia or bipolar disorder in a German sampleMarkus H Skowronek
Psychiatr Genet 16:233-4. 2006..Allele and haplotype frequencies did not differ between cases and controls. Our results do not support an association of the ASCT1 gene with BD or SCZ in the German population... - No association between the serine racemase gene (SRR) and bipolar disorder in a German case-control sampleFrederike Schirmbeck
Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
Psychiatr Genet 17:127. 2007 - No association between genetic variants at the GRIN1 gene and bipolar disorder in a German sampleAlexander Georgi
Central Institute of Mental Health, Mannheim, Germany
Psychiatr Genet 16:183-4. 2006..This stratified analysis did not yield any significant association either. Our results do not support an association of the GRIN1 gene with bipolar disorder in the German population... - Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypesThomas G Schulze
Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health J5, 68159 Mannheim, Germany
Am J Psychiatry 162:2101-8. 2005.... - Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sampleAlexander Georgi
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, D 68159 Mannheim, Germany
Psychiatr Genet 17:308-10. 2007..Although significances did not withstand correction for multiple testing, the results of our exploratory analysis warrant further studies on GRIN1 and schizophrenia... - Lack of genetic association between the phospholipase A2 gene and bipolar mood disorder in a European multicentre case-control studyDimitris G Dikeos
Department of Psychiatry, Athens University Medical School and University Mental Health Research Institute, Greece, and Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
Psychiatr Genet 16:169-71. 2006..On the basis of these results, mutations of the phospholipase A2 gene, at least in the region close to the polymorphism examined between exons 1 and 2, are not involved in the pathogenesis of bipolar mood disorder... - Brain-derived neurotrophic factor gene (BDNF) variants and schizophrenia: an association studyErik G Jonsson
Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, R5 00, SE 171 76 Stockholm, Sweden
Prog Neuropsychopharmacol Biol Psychiatry 30:924-33. 2006..Thus, the BDNF gene may confer susceptibility to schizophrenia. Additional studies are warranted to shed further light on this possibility... - Association study of a functional promoter polymorphism in the XBP1 gene and schizophreniaErik G Jonsson
Department of Clinical Neuroscience, Psychiatry Section, R5 00, Karolinska Institutet, SE 171 76 Stockholm, Sweden
Am J Med Genet B Neuropsychiatr Genet 141:71-5. 2006..It cannot be excluded, however, that the XBP1 polymorphism is involved in schizophrenia in other populations or adds minor susceptibility to the disorder... - No association between the serine racemase gene (SRR) and schizophrenia in a German case-control sampleJana Strohmaier
Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
Psychiatr Genet 17:125. 2007 - Further evidence for age of onset being an indicator for severity in bipolar disorderThomas G Schulze
J Affect Disord 68:343-5. 2002 - Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosinEtgar Levy-Nissenbaum
Danek Gartner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel and Tel Aviv University, Tel Aviv, Israel
Nat Genet 34:151-3. 2003..Truncated CDSN aggregates were detected in the superficial dermis and at the periphery of hair follicles. Our findings suggest that CDSN is important in normal scalp hair physiology... - Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorderRicardo Segurado
Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
Am J Hum Genet 73:49-62. 2003..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region... - Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8qMatthew B McQueen
Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
Am J Hum Genet 77:582-95. 2005..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches... - Association between a promoter dopamine D2 receptor gene variant and the personality trait detachmentErik G Jonsson
Department of Clinical Neuroscience, Psychiatry Section, HUBIN project, Karolinska Institute, Stockholm, Sweden
Biol Psychiatry 53:577-84. 2003..A putative functional promoter polymorphism in the dopamine D(2) receptor gene (DRD2), -141C ins/del, has been associated with dopamine D(2) receptor density... - DRD4 exon 3 variants are not associated with symptomatology of major psychoses in a German populationAlessandro Serretti
Department of Psychiatry, San Raffaele Institute, Vita Salute University, Milan, Italy
Neurosci Lett 368:269-73. 2004..However it should be considered that the original sample included a much higher rate of mood disorders and this could partially explain the discrepancy...