Matthias Choschzick

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. doi request reprint Estrogen receptor gene amplification occurs rarely in ovarian cancer
    Rana M Issa
    Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Mod Pathol 22:191-6. 2009
  2. doi request reprint Role of cyclin D1 amplification and expression in vulvar carcinomas
    Matthias Choschzick
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg 20246, Germany
    Hum Pathol 43:1386-93. 2012
  3. doi request reprint BIRC2 amplification in squamous cell carcinomas of the uterine cervix
    M Choschzick
    Department of Pathology, University Medical Centre Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Virchows Arch 461:123-8. 2012
  4. doi request reprint Overexpression of carbonic anhydrase IX (CAIX) is an independent unfavorable prognostic marker in endometrioid ovarian cancer
    Matthias Choschzick
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Virchows Arch 459:193-200. 2011
  5. doi request reprint Role of TP53 mutations in vulvar carcinomas
    Matthias Choschzick
    Institute of Pathology, Department of Gynaecology, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Int J Gynecol Pathol 30:497-504. 2011
  6. doi request reprint Immunohistochemistry and molecular analyses in myeloid sarcoma of the breast in a patient with relapse of NPM1-mutated and FLT3-mutated AML after allogeneic stem cell transplantation
    Matthias Choschzick
    Department of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Clin Pathol 63:558-61. 2010
  7. doi request reprint Overexpression of carbonic anhydrase IX (CAIX) in vulvar cancer is associated with tumor progression and development of locoregional lymph node metastases
    Matthias Choschzick
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Virchows Arch 456:483-90. 2010
  8. doi request reprint Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcome
    Matthias Choschzick
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Mod Pathol 23:603-10. 2010
  9. doi request reprint Overexpression of cell division cycle 7 homolog is associated with gene amplification frequency in breast cancer
    Matthias Choschzick
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany
    Hum Pathol 41:358-65. 2010
  10. doi request reprint MDM2 amplification is an independent prognostic feature of node-negative, estrogen receptor-positive early-stage breast cancer
    Matthias Choschzick
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Germany
    Cancer Biomark 8:53-60. 2010

Collaborators

Detail Information

Publications26

  1. doi request reprint Estrogen receptor gene amplification occurs rarely in ovarian cancer
    Rana M Issa
    Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Mod Pathol 22:191-6. 2009
    ..The data demonstrate that estrogen receptor-alpha amplification occurs only rarely in ovarian cancer...
  2. doi request reprint Role of cyclin D1 amplification and expression in vulvar carcinomas
    Matthias Choschzick
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg 20246, Germany
    Hum Pathol 43:1386-93. 2012
    ..57 each). In conclusion, CCND1 is amplified and overexpressed in a substantial proportion of vulvar carcinomas and associated with the occurrence of locoregional lymph node metastases, especially in human papillomavirus-negative tumors...
  3. doi request reprint BIRC2 amplification in squamous cell carcinomas of the uterine cervix
    M Choschzick
    Department of Pathology, University Medical Centre Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Virchows Arch 461:123-8. 2012
    ..In conclusion, BIRC2 is amplified in a subset of squamous cell carcinoma of the uterine cervix. Further studies are necessary to evaluate possible prognostic effects of BIRC2 copy number gains in cervical carcinomas...
  4. doi request reprint Overexpression of carbonic anhydrase IX (CAIX) is an independent unfavorable prognostic marker in endometrioid ovarian cancer
    Matthias Choschzick
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Virchows Arch 459:193-200. 2011
    ..Our data support the potential therapeutic benefit of newly developed targeting antibodies in advanced ovarian cancer...
  5. doi request reprint Role of TP53 mutations in vulvar carcinomas
    Matthias Choschzick
    Institute of Pathology, Department of Gynaecology, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Int J Gynecol Pathol 30:497-504. 2011
    ..These data support the potential utility of restoring TP53 function as a therapeutic alternative in vulvar cancer. Further studies are necessary to clarify the prognostic implications of TP53 mutations in vulvar carcinomas...
  6. doi request reprint Immunohistochemistry and molecular analyses in myeloid sarcoma of the breast in a patient with relapse of NPM1-mutated and FLT3-mutated AML after allogeneic stem cell transplantation
    Matthias Choschzick
    Department of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Clin Pathol 63:558-61. 2010
    ..In summary, combined molecular and immunohistochemical examination of NPM1 and FLT3 is helpful in the diagnosis of extramedullary manifestations of AML in core needle biopsies...
  7. doi request reprint Overexpression of carbonic anhydrase IX (CAIX) in vulvar cancer is associated with tumor progression and development of locoregional lymph node metastases
    Matthias Choschzick
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Virchows Arch 456:483-90. 2010
    ..Our data support the potential therapeutic benefit of newly developed targeting antibodies in advanced vulvar cancer...
  8. doi request reprint Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcome
    Matthias Choschzick
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Mod Pathol 23:603-10. 2010
    ..The position of our FISH probe and data of a previously performed high-resolution CGH study in the breast cancer cell line SK-BR-3 involve TCEB1 and TMEM70 as new possible candidate oncogenes at 8q21 in breast cancer...
  9. doi request reprint Overexpression of cell division cycle 7 homolog is associated with gene amplification frequency in breast cancer
    Matthias Choschzick
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany
    Hum Pathol 41:358-65. 2010
    ..These data support the potential utility of newly developed small molecule cell division cycle 7 inhibitors as a therapeutic alternative in at least a subset of breast carcinomas...
  10. doi request reprint MDM2 amplification is an independent prognostic feature of node-negative, estrogen receptor-positive early-stage breast cancer
    Matthias Choschzick
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Germany
    Cancer Biomark 8:53-60. 2010
    ..Only little is known about the role of MDM2 amplifications in early-stage breast carcinomas with positive estrogen receptor status...
  11. doi request reprint PPFIA1 and CCND1 are frequently coamplified in breast cancer
    Ana Maria Dancau
    Department of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Genes Chromosomes Cancer 49:1-8. 2010
    ....
  12. doi request reprint Heterogenous high-level HER-2 amplification in a small subset of colorectal cancers
    Andreas H Marx
    Institute for Pathology, Hubertus Wald Tumorzentrum University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Hum Pathol 41:1577-85. 2010
    ..Heterogeneity of amplification may limit the utility of anti- HER-2 therapy in some of these tumors and therefore, adequate clinical trials are needed to further evaluate this approach...
  13. doi request reprint Prognostic role of lymph node metastases in vulvar cancer and implications for adjuvant treatment
    Linn Woelber
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Gynecol Cancer 22:503-8. 2012
    ..However, information regarding the impact of the number of positive nodes in vulvar cancer is inconsistent, and so are recommendations when to apply adjuvant radiotherapy...
  14. doi request reprint Prognostic value of pathological resection margin distance in squamous cell cancer of the vulva
    Linn Woelber
    Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Ann Surg Oncol 18:3811-8. 2011
    ..A tumor-free resection margin of at least 8 mm is considered state of the art in vulvar cancer. This standard is based on small and heterogeneous patient cohorts, and its implementation can result in mutilation...
  15. pmc Relevance of activated leukocyte cell adhesion molecule (ALCAM) in tumor tissue and sera of cervical cancer patients
    Maike Ihnen
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    BMC Cancer 12:140. 2012
    ..In some cancers ALCAM has a prognostic value or is predictive for the benefit of therapeutic interventions. To date there are no data on the role of ALCAM in cervical cancer available...
  16. pmc Carbonic anhydrase IX in tumor tissue and sera of patients with primary cervical cancer
    Linn Woelber
    Department of Gynecology and Gynecologic Oncology, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    BMC Cancer 11:12. 2011
    ..The protein is overexpressed in a variety of tumors and potentially associated with negative outcome. This study was designed to investigate the prognostic role of CAIX in serum and tumor tissue of patients with primary cervical cancer...
  17. doi request reprint Serum carbonic anhydrase IX and its prognostic relevance in vulvar cancer
    Lilli Kock
    Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Gynecol Cancer 21:141-8. 2011
    ..We therefore determined CAIX serum concentration and its prognostic relevance in correlation to intratumoral CAIX expression in patients with primary vulvar cancer...
  18. doi request reprint Relevance of cellular and serum carbonic anhydrase IX in primary breast cancer
    Dina Schütze
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    J Cancer Res Clin Oncol 139:747-54. 2013
    ..The aim of this study was to examine the relationships of CAIX mRNA expression and s-CAIX levels with clinicopathological parameters and survival of patients with primary breast cancer...
  19. pmc Management of patients with vulvar cancer: a perspective review according to tumour stage
    Linn Woelber
    Department of Gynaecology and Gynaecologic Oncology, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Ther Adv Med Oncol 5:183-92. 2013
    ..This review therefore puts different recommendations of clinical management in context and highlights the need for future trials...
  20. doi request reprint Rare oncogenic mutations of predictive markers for targeted therapy in triple-negative breast cancer
    Tobias J Grob
    Department of Pathology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Breast Cancer Res Treat 134:561-7. 2012
    ..5 %). TP53 gene mutation was found in 36/63 (57.1 %) tumors. We conclude that targetable genetic aberrations in the receptor tyrosine kinase/RAS/MAPK pathway occur rarely in TNBC...
  21. doi request reprint Prognostic and predictive relevance of CA-125 at primary surgery of ovarian cancer
    Dina Mury
    Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    J Cancer Res Clin Oncol 137:1131-7. 2011
    ..To stratify patients for optimal therapy, prognostic and predictive factors are needed. We examined the role of pre- and postoperative CA-125 in this context...
  22. doi request reprint Assessment of cervical intraepithelial neoplasia (CIN) with colposcopic biopsy and efficacy of loop electrosurgical excision procedure (LEEP)
    Nina Duesing
    Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Arch Gynecol Obstet 286:1549-54. 2012
    ..The present study analyses the accuracy of preoperative assessment of CIN with cytology plus colposcopic biopsy and assesses the efficacy of LEEP for the treatment of CIN...
  23. ncbi request reprint Clinicopathological prognostic factors and patterns of recurrence in vulvar cancer
    Linn Woelber
    Department of Gynaecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Anticancer Res 29:545-52. 2009
    ..The aim of this study was to determine prognostic variables for recurrence and survival and to identify patterns of recurrence in patients with vulvar cancer...
  24. doi request reprint Clinical management of primary vulvar cancer
    Linn Woelber
    Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Eur J Cancer 47:2315-21. 2011
    ..This article discusses the current literature to elaborate recommendations for the management of primary vulvar cancer in clinical routine...
  25. doi request reprint Secondary sentinel node biopsy after previous excision of the primary tumor in squamous cell carcinoma of the vulva
    Linn Woelber
    Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Ann Surg Oncol 20:1701-6. 2013
    ..It has been proven to be a safe alternative in early-stage disease. Feasibility and safety of the procedure after previous vulvar surgery remain unclear...
  26. doi request reprint Homogeneous EGFR amplification defines a subset of aggressive Barrett's adenocarcinomas with poor prognosis
    Andreas H Marx
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Histopathology 57:418-26. 2010
    ..The aim of this study was performed to determine the potential impact of tumour heterogeneity on anti-EGFR therapy in Barrett's adenocarcinoma (BAC)...