Holger Cario

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. ncbi request reprint Childhood polycythemias/erythrocytoses: classification, diagnosis, clinical presentation, and treatment
    H Cario
    Department of Pediatrics, University Hospital Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany
    Ann Hematol 84:137-45. 2005
  2. ncbi request reprint A microdeletion syndrome due to a 3-Mb deletion on 19q13.2--Diamond-Blackfan anemia associated with macrocephaly, hypotonia, and psychomotor retardation
    H Cario
    Department of Pediatrics, University Children s Hospital Ulm, Germany
    Clin Genet 55:487-92. 1999
  3. ncbi request reprint Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis
    Holger Cario
    Dept of Pediatrics, University Hospital Ulm, Prittwitzstrasse 43 D 89075 Ulm, Germany
    Haematologica 90:19-24. 2005
  4. ncbi request reprint Congenital erythrocytosis and polycythemia vera in childhood and adolescence
    H Cario
    Department of Paediatrics, University Hospital Ulm, Germany
    Klin Padiatr 216:157-62. 2004
  5. ncbi request reprint Familial polycythemia vera with Budd-Chiari syndrome in childhood
    Holger Cario
    Department of Paediatrics, University Hospital Ulm, Germany
    Br J Haematol 123:346-52. 2003
  6. ncbi request reprint Insulin sensitivity and beta-cell secretion in thalassaemia major with secondary haemochromatosis: assessment by oral glucose tolerance test
    Holger Cario
    Department of Paediatrics, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany
    Eur J Pediatr 162:139-46. 2003
  7. ncbi request reprint Disproportionately elevated fasting proinsulin levels in normoglycemic patients with thalassemia major are correlated to the degree of iron overload
    Holger Cario
    Department of Pediatrics, University of Ulm, Germany
    Horm Res 59:73-8. 2003
  8. ncbi request reprint Treatment with hydroxyurea in thalassemia intermedia with paravertebral pseudotumors of extramedullary hematopoiesis
    H Cario
    Department of Pediatrics, University of Ulm, University Children s Hospital, Prittwitzstr 43, 89070 Ulm, Germany
    Ann Hematol 81:478-82. 2002
  9. ncbi request reprint Epidemiological situation and treatment of patients with thalassemia major in Germany: results of the German multicenter beta-thalassemia study
    H Cario
    Department of Pediatrics, University Children s Hospital, Prittwitzstrasse 43, D 89070 Ulm, Germany
    Ann Hematol 79:7-12. 2000
  10. ncbi request reprint Postinflammatorial stenoses of the pharynx in a child with Barth-syndrome
    Ulla Folger
    Department of Otorhinolaryngology, University of Ulm, Prittwitzstrasse 73, 89075 Ulm, Germany
    Int J Pediatr Otorhinolaryngol 67:117-20. 2003

Detail Information

Publications15

  1. ncbi request reprint Childhood polycythemias/erythrocytoses: classification, diagnosis, clinical presentation, and treatment
    H Cario
    Department of Pediatrics, University Hospital Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany
    Ann Hematol 84:137-45. 2005
    ..g., by hemoglobin variants with increased oxygen affinity, by 2,3-bisphosphoglycerate deficiency, or by mutations in the von Hippel-Lindau gene associated with a disturbed oxygen-dependent regulation of Epo synthesis...
  2. ncbi request reprint A microdeletion syndrome due to a 3-Mb deletion on 19q13.2--Diamond-Blackfan anemia associated with macrocephaly, hypotonia, and psychomotor retardation
    H Cario
    Department of Pediatrics, University Children s Hospital Ulm, Germany
    Clin Genet 55:487-92. 1999
    ..This deletion coincides with the deletion reported here. We suggest that the complex phenotype of our patient, including both DBA and the associated features, represent a microdeletion syndrome...
  3. ncbi request reprint Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis
    Holger Cario
    Dept of Pediatrics, University Hospital Ulm, Prittwitzstrasse 43 D 89075 Ulm, Germany
    Haematologica 90:19-24. 2005
    ..Subsequently this and other mutations in the VHL gene were also detected in several patients of different ethnic origin. Haplotype analyses of the VHL gene suggested a common origin for the Chuvash-type mutation...
  4. ncbi request reprint Congenital erythrocytosis and polycythemia vera in childhood and adolescence
    H Cario
    Department of Paediatrics, University Hospital Ulm, Germany
    Klin Padiatr 216:157-62. 2004
    ....
  5. ncbi request reprint Familial polycythemia vera with Budd-Chiari syndrome in childhood
    Holger Cario
    Department of Paediatrics, University Hospital Ulm, Germany
    Br J Haematol 123:346-52. 2003
    ..The patient underwent orthotopic liver transplantation and is being treated with hydroxyurea. The available literature on familial polycythemia vera and polycythemia vera in childhood with and without Budd-Chiari syndrome is reviewed...
  6. ncbi request reprint Insulin sensitivity and beta-cell secretion in thalassaemia major with secondary haemochromatosis: assessment by oral glucose tolerance test
    Holger Cario
    Department of Paediatrics, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany
    Eur J Pediatr 162:139-46. 2003
    ..Insulin secretion capacity according to the homeostasis assessment model was significantly reduced in patient groups compared to controls (Kruskal-Wallis-test, P<0.004)...
  7. ncbi request reprint Disproportionately elevated fasting proinsulin levels in normoglycemic patients with thalassemia major are correlated to the degree of iron overload
    Holger Cario
    Department of Pediatrics, University of Ulm, Germany
    Horm Res 59:73-8. 2003
    ..To analyze the secretion of the insulin precursor proinsulin in patients with beta-thalassemia and its possible relation to iron overload...
  8. ncbi request reprint Treatment with hydroxyurea in thalassemia intermedia with paravertebral pseudotumors of extramedullary hematopoiesis
    H Cario
    Department of Pediatrics, University of Ulm, University Children s Hospital, Prittwitzstr 43, 89070 Ulm, Germany
    Ann Hematol 81:478-82. 2002
    ..In thalassemia intermedia patients with extramedullary hematopoiesis, hydroxyurea may lead to independence from regular transfusion therapy without further expansion of ectopic hematopoietic tissue...
  9. ncbi request reprint Epidemiological situation and treatment of patients with thalassemia major in Germany: results of the German multicenter beta-thalassemia study
    H Cario
    Department of Pediatrics, University Children s Hospital, Prittwitzstrasse 43, D 89070 Ulm, Germany
    Ann Hematol 79:7-12. 2000
    ..Since the situation concerning siderosis and the lack of compliance proved to be particularly difficult with adolescent patients, further efforts should concentrate on this age-group...
  10. ncbi request reprint Postinflammatorial stenoses of the pharynx in a child with Barth-syndrome
    Ulla Folger
    Department of Otorhinolaryngology, University of Ulm, Prittwitzstrasse 73, 89075 Ulm, Germany
    Int J Pediatr Otorhinolaryngol 67:117-20. 2003
    ..The tracheostomy was closed and the gastrostomy tube was removed. Throughout a 40 month period of observation the child had no more complaints relating to the minor residual pharyngeal stenoses...
  11. doi request reprint Clinical and molecular characterisation of a prospectively collected cohort of children and adolescents with polycythemia vera
    Holger Cario
    Department of Paediatrics, University Hospital Ulm, Ulm, Germany
    Br J Haematol 142:622-6. 2008
    ..The JAK2(V617F) mutation was found in six patients; two patients displayed JAK2 exon 12 mutations, including one novel mutation (JAK2(H538-K539delinsI)). CD177 (PRV-1) mRNA expression was increased in three of five patients tested...
  12. ncbi request reprint The JAK2V617F mutation is acquired secondary to the predisposing alteration in familial polycythaemia vera
    Holger Cario
    Br J Haematol 130:800-1. 2005
  13. ncbi request reprint Molecular genetic analyses in familial and sporadic congenital primary erythrocytosis
    Susana Rives
    Department of Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona, Spain
    Haematologica 92:674-7. 2007
    ..All familial cases, varied in phenotype, presented the EPOR 1414C->G (Tyr426Stop) mutation. JAK2 mutations are not involved in the pathogenesis of primary congenital erythrocytosis...
  14. ncbi request reprint Prospective evaluation of patient-reported outcomes during treatment with deferasirox or deferoxamine for iron overload in patients with beta-thalassemia
    Maria Domenica Cappellini
    Fondazione Policlinico IRCCS, Universitd di Milano, Milan, Italy
    Clin Ther 29:909-17. 2007
    ..Deferasirox is an orally administered iron chelator that has been approved for use in the United States, Switzerland, and other countries...
  15. pmc Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study
    John Porter
    University College London, London, UK
    Eur J Haematol 80:168-76. 2008
    ..Dosage was determined by baseline liver iron concentration (LIC)...