E Cario

Summary

Affiliation: University of Essen
Country: Germany

Publications

  1. ncbi Intestinal epithelial TOLLerance versus inTOLLerance of commensals
    Elke Cario
    Divison of Gastroenterology and Hepatology, University Hospital of Essen, Institutsgruppe I, Virchowstr 171, D 45147 Essen, Germany
    Mol Immunol 42:887-93. 2005
  2. ncbi Trypsin-sensitive modulation of intestinal epithelial MD-2 as mechanism of lipopolysaccharide tolerance
    Elke Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen, Germany
    J Immunol 176:4258-66. 2006
  3. ncbi "For whom the bell tolls!" -- innate defense mechanisms and survival strategies of the intestinal epithelium against lumenal pathogens
    E Cario
    Division of Gastroenterology and Hepatology, University of Essen, Essen, Germany
    Z Gastroenterol 40:983-90. 2002
  4. ncbi Toll-like receptors and intestinal defence: molecular basis and therapeutic implications
    Elke Cario
    Division of Gastroenterology and Hepatology, University of Essen, Institutsgruppe I C 8, Virchowstr 171, D 45147 Essen, Germany
    Expert Rev Mol Med 5:1-15. 2003
  5. ncbi Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2
    E Cario
    University Hospital of Essen, Division of Gastroenterology and Hepatology, Institutsgruppe I, Virchowstr 171 D 45147 Essen, Germany
    Gut 54:1182-93. 2005
  6. ncbi Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C
    Elke Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen, Germany
    Gastroenterology 127:224-38. 2004
  7. ncbi Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
    E Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen and Medical School University of Duisburg Essen, Essen, Germany
    Gastroenterology 132:1359-74. 2007
  8. ncbi Barrier-protective function of intestinal epithelial Toll-like receptor 2
    E Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen and Medical School, University of Duisburg Essen, Essen, Germany
    Mucosal Immunol 1:S62-6. 2008
  9. ncbi Therapeutic impact of toll-like receptors on inflammatory bowel diseases: a multiple-edged sword
    Elke Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen, University of Duisburg Essen, Institutsgruppe I, Virchowstrasse 171, Essen, Germany
    Inflamm Bowel Dis 14:411-21. 2008
  10. ncbi TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury
    Birgit Ey
    Division of Gastroenterology and Hepatology, University Hospital of Essen, and Medical School, University of Duisburg Essen, 45147 Essen, Germany
    J Biol Chem 284:22332-43. 2009

Detail Information

Publications16

  1. ncbi Intestinal epithelial TOLLerance versus inTOLLerance of commensals
    Elke Cario
    Divison of Gastroenterology and Hepatology, University Hospital of Essen, Institutsgruppe I, Virchowstr 171, D 45147 Essen, Germany
    Mol Immunol 42:887-93. 2005
    ....
  2. ncbi Trypsin-sensitive modulation of intestinal epithelial MD-2 as mechanism of lipopolysaccharide tolerance
    Elke Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen, Germany
    J Immunol 176:4258-66. 2006
    ....
  3. ncbi "For whom the bell tolls!" -- innate defense mechanisms and survival strategies of the intestinal epithelium against lumenal pathogens
    E Cario
    Division of Gastroenterology and Hepatology, University of Essen, Essen, Germany
    Z Gastroenterol 40:983-90. 2002
    ....
  4. ncbi Toll-like receptors and intestinal defence: molecular basis and therapeutic implications
    Elke Cario
    Division of Gastroenterology and Hepatology, University of Essen, Institutsgruppe I C 8, Virchowstr 171, D 45147 Essen, Germany
    Expert Rev Mol Med 5:1-15. 2003
    ..Intestinal disease might result from inappropriate activation of the mucosal immune system driven by TLRs in response to normal luminal flora...
  5. ncbi Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2
    E Cario
    University Hospital of Essen, Division of Gastroenterology and Hepatology, Institutsgruppe I, Virchowstr 171 D 45147 Essen, Germany
    Gut 54:1182-93. 2005
    ..In disease, aberrant TLRx and/or NOD2 signalling may stimulate diverse inflammatory responses leading to acute and chronic intestinal inflammation with many different clinical phenotypes...
  6. ncbi Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C
    Elke Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen, Germany
    Gastroenterology 127:224-38. 2004
    ..The aim of this study was to determine whether TLR2 may activate PKC in response to specific ligands, thus potentially modulating barrier function in IECs...
  7. ncbi Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
    E Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen and Medical School University of Duisburg Essen, Essen, Germany
    Gastroenterology 132:1359-74. 2007
    ..The aim of this study was to determine the functional relevance of TLR2 to control tight junction (TJ)-associated intestinal epithelial barrier integrity to balance mucosal homeostasis against inflammatory stress-induced damage...
  8. ncbi Barrier-protective function of intestinal epithelial Toll-like receptor 2
    E Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen and Medical School, University of Duisburg Essen, Essen, Germany
    Mucosal Immunol 1:S62-6. 2008
    ..Thus, cell-specific TLR2 targeting may offer a novel therapeutic approach to human IBD therapy by protecting IEC barrier function...
  9. ncbi Therapeutic impact of toll-like receptors on inflammatory bowel diseases: a multiple-edged sword
    Elke Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen, University of Duisburg Essen, Institutsgruppe I, Virchowstrasse 171, Essen, Germany
    Inflamm Bowel Dis 14:411-21. 2008
    ..This review evaluates potential strategies as well as their rationale and future prospects...
  10. ncbi TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury
    Birgit Ey
    Division of Gastroenterology and Hepatology, University Hospital of Essen, and Medical School, University of Duisburg Essen, 45147 Essen, Germany
    J Biol Chem 284:22332-43. 2009
    ..In conclusion, Cx43 plays an important role in innate immune control of commensal-mediated intestinal epithelial wound repair...
  11. ncbi Innate immune signalling at intestinal mucosal surfaces: a fine line between host protection and destruction
    Elke Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen, and Medical School, University of Duisburg Essen, Essen, Germany
    Curr Opin Gastroenterol 24:725-32. 2008
    ..The present review focuses on defining the recently described mechanistic functions through which the innate immune signalling apparatus shapes mucosal homeostasis of the intestine in health and disease...
  12. ncbi Toll-like receptor signaling and its relevance to intestinal inflammation
    Elke Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen, Institutsgruppe I, Virchowstrasse 171, D 45147 Essen, Germany
    Ann N Y Acad Sci 1072:332-8. 2006
    ....
  13. ncbi Functional and biochemical characterization of epithelial bactericidal/permeability-increasing protein
    Geraldine Canny
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Gastrointest Liver Physiol 290:G557-67. 2006
    ..Taken together, these data confirm the transcriptional regulation of BPI in intestinal epithelia and provide insight into the relevance of BPI as an anti-infective molecule at intestinal surfaces...
  14. ncbi Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells
    Jan-Michel Otte
    Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, USA
    Gastroenterology 126:1054-70. 2004
    ..Down-regulation of TLR surface expression and up-regulation of inhibitory Tollip with decreased phosphorylation of IRAK might all contribute to this hyporesponsiveness...
  15. ncbi Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium
    Elke Cario
    Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Pathol 160:165-73. 2002
    ..The results of this dynamic epithelial surveillance can then be conveyed to the underlying cell populations of the lamina propria via these innate immune pattern recognition receptors...
  16. ncbi Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice
    Emiko Mizoguchi
    Center for the Study of Inflammatory Bowel Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 122:134-44. 2002
    ..Tumor necrosis factor (TNF) induces multiple effects including cell proliferation and death by ligation with TNF receptor type II (TNFR2). We studied the role of TNFR2 in chronic inflammation-induced colonic epithelial alteration...