T Burmester

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint A vertebrate globin expressed in the brain
    T Burmester
    Institute of Zoology, Johannes Gutenberg University Mainz, Germany
    Nature 407:520-3. 2000
  2. ncbi request reprint Molecular evolution of the arthropod hemocyanin superfamily
    T Burmester
    Institute of Zoology, University of Mainz, D 55099 Mainz, Germany
    Mol Biol Evol 18:184-95. 2001
  3. ncbi request reprint Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues
    Thorsten Burmester
    Institute of Zoology, Biosafety Research and Consulting, Johannes Gutenberg University Mainz, Becherweg 32, D 55099 Mainz, Germany
    Mol Biol Evol 19:416-21. 2002
  4. ncbi request reprint Zebrafish reveals different and conserved features of vertebrate neuroglobin gene structure, expression pattern, and ligand binding
    Christine Fuchs
    Institute of Molecular Genetics, Johannes Gutenberg University of Mainz, D 55099 Mainz, Germany
    J Biol Chem 279:24116-22. 2004
  5. ncbi request reprint The amphibian globin gene repertoire as revealed by the Xenopus genome
    C Fuchs
    Institute of Molecular Genetics, Johannes Gutenberg University Mainz, Mainz, Germany
    Cytogenet Genome Res 112:296-306. 2006
  6. doi request reprint A putative hexamerin from a Campodea sp. suggests an independent origin of haemocyanin-related storage proteins in Hexapoda
    C Pick
    Institute of Zoology, University of Hamburg, Hamburg, Germany
    Insect Mol Biol 18:673-9. 2009
  7. ncbi request reprint Diplopod hemocyanin sequence and the phylogenetic position of the Myriapoda
    K Kusche
    Institute of Zoology, University of Mainz, Mainz, Germany
    Mol Biol Evol 18:1566-73. 2001
  8. ncbi request reprint Interspecies comparison of neuroglobin, cytoglobin and myoglobin: sequence evolution and candidate regulatory elements
    S Wystub
    Institute of Molecular Genetics and Institute of Zoology, Johannes Gutenberg University Mainz, Mainz, Germany
    Cytogenet Genome Res 105:65-78. 2004
  9. ncbi request reprint Molecular cloning and evolution of lobster hemocyanin
    K Kusche
    Institute of Zoology, University of Mainz, , Mainz, D-55099, Germany
    Biochem Biophys Res Commun 282:887-92. 2001
  10. ncbi request reprint Neuroglobins from the zebrafish Danio rerio and the pufferfish Tetraodon nigroviridis
    C Awenius
    Institute of Zoology, Biosafety Research and Consulting, Johannes Gutenberg University of Mainz, Müllerweg 6, D 55099 Mainz, Germany
    Biochem Biophys Res Commun 287:418-21. 2001

Collaborators

Detail Information

Publications73

  1. ncbi request reprint A vertebrate globin expressed in the brain
    T Burmester
    Institute of Zoology, Johannes Gutenberg University Mainz, Germany
    Nature 407:520-3. 2000
    ..Neuroglobin represents a distinct protein family that diverged early in metazoan evolution, probably before the Protostomia/Deuterostomia split...
  2. ncbi request reprint Molecular evolution of the arthropod hemocyanin superfamily
    T Burmester
    Institute of Zoology, University of Mainz, D 55099 Mainz, Germany
    Mol Biol Evol 18:184-95. 2001
    ..The time of divergence of the insect proteins from the malacostracan hemocyanins was estimated to be about 430-440 MYA, providing support for the notion that the Hexapoda evolved from the same crustacean lineage as the Malacostraca...
  3. ncbi request reprint Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues
    Thorsten Burmester
    Institute of Zoology, Biosafety Research and Consulting, Johannes Gutenberg University Mainz, Becherweg 32, D 55099 Mainz, Germany
    Mol Biol Evol 19:416-21. 2002
    ..This indicates that the vertebrate myoglobins are in fact a specialized intracellular globin that evolved in adaptation to the special needs of muscle cells...
  4. ncbi request reprint Zebrafish reveals different and conserved features of vertebrate neuroglobin gene structure, expression pattern, and ligand binding
    Christine Fuchs
    Institute of Molecular Genetics, Johannes Gutenberg University of Mainz, D 55099 Mainz, Germany
    J Biol Chem 279:24116-22. 2004
    ..Neuroglobin appears to be associated with mitochondria-rich cell types and thus oxygen consumption rates, suggesting a myoglobin-like function of this protein in facilitated oxygen diffusion...
  5. ncbi request reprint The amphibian globin gene repertoire as revealed by the Xenopus genome
    C Fuchs
    Institute of Molecular Genetics, Johannes Gutenberg University Mainz, Mainz, Germany
    Cytogenet Genome Res 112:296-306. 2006
    ..Database and gene synteny analyses confirm the absence of a myoglobin gene in X. tropicalis...
  6. doi request reprint A putative hexamerin from a Campodea sp. suggests an independent origin of haemocyanin-related storage proteins in Hexapoda
    C Pick
    Institute of Zoology, University of Hamburg, Hamburg, Germany
    Insect Mol Biol 18:673-9. 2009
    ..Hence, haemocyanin-related storage proteins emerged at least two times independently in Hexapoda...
  7. ncbi request reprint Diplopod hemocyanin sequence and the phylogenetic position of the Myriapoda
    K Kusche
    Institute of Zoology, University of Mainz, Mainz, Germany
    Mol Biol Evol 18:1566-73. 2001
    ..The latter topology is also supported by a unique shared deletion of an alpha-helix. A common ancestry of Myriapoda and Chelicerata should be seriously considered...
  8. ncbi request reprint Interspecies comparison of neuroglobin, cytoglobin and myoglobin: sequence evolution and candidate regulatory elements
    S Wystub
    Institute of Molecular Genetics and Institute of Zoology, Johannes Gutenberg University Mainz, Mainz, Germany
    Cytogenet Genome Res 105:65-78. 2004
    ..The cytoglobin gene, in contrast, harbors both conserved HREs and mRNA stabilization sites, strongly suggestive of an oxygen-dependent regulation...
  9. ncbi request reprint Molecular cloning and evolution of lobster hemocyanin
    K Kusche
    Institute of Zoology, University of Mainz, , Mainz, D-55099, Germany
    Biochem Biophys Res Commun 282:887-92. 2001
    ..Under the assumption of a molecular clock we calculated that alpha- and gamma-subunits split about 214 +/- 14 million years ago, suggesting their divergence only in the decapod Crustacea...
  10. ncbi request reprint Neuroglobins from the zebrafish Danio rerio and the pufferfish Tetraodon nigroviridis
    C Awenius
    Institute of Zoology, Biosafety Research and Consulting, Johannes Gutenberg University of Mainz, Müllerweg 6, D 55099 Mainz, Germany
    Biochem Biophys Res Commun 287:418-21. 2001
    ..93 x 10(-9) amino acid substitutions per site and year) compared with their mammalian proteins ( approximately 0.39 x 10(-9) replacements per site and year)...
  11. ncbi request reprint Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia
    Marc Schmidt
    Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
    J Biol Chem 279:8063-9. 2004
    ..Surprisingly, cytoglobin is localized in both the cytoplasm and nucleus of neurons, indicating a possible additional role of this protein in neuronal tissues...
  12. doi request reprint Molecular characterization of hemocyanin and hexamerin from the firebrat Thermobia domestica (Zygentoma)
    Christian Pick
    Institute of Zoology, University of Hamburg, D 20146 Hamburg, Germany
    Insect Biochem Mol Biol 38:977-83. 2008
    ..Molecular clock calculations using hexamerins suggest that the divergence of Zygentoma and Pterygota occurred around 387 million years ago, which is in excellent agreement with the available fossil record...
  13. ncbi request reprint Putative phenoloxidases in the tunicate Ciona intestinalis and the origin of the arthropod hemocyanin superfamily
    A Immesberger
    Institute of Zoology, University of Mainz, 55099, Mainz, Germany
    J Comp Physiol B 174:169-80. 2004
    ..The hemocyanins evolved in agreement with the expected phylogeny of the Arthropoda, with the Onychophora diverged first, followed by the Chelicerata and Pancrustacea. The position of the myriapod hemocyanins is not resolved...
  14. doi request reprint Globins and hypoxia adaptation in the goldfish, Carassius auratus
    Anja Roesner
    Institute of Zoology, University of Mainz, Germany
    FEBS J 275:3633-43. 2008
    ....
  15. ncbi request reprint Limulus polyphemus hemocyanin: 10 A cryo-EM structure, sequence analysis, molecular modelling and rigid-body fitting reveal the interfaces between the eight hexamers
    Andreas G Martin
    Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
    J Mol Biol 366:1332-50. 2007
    ..The molecular model shows the amino acid residues involved, and reveals that several of the interfaces are intriguingly histidine-rich and likely to transfer allosteric signals between the different levels of the nested hierarchy...
  16. ncbi request reprint Neuroglobin, cytoglobin, and a novel, eye-specific globin from chicken
    Dominik Kugelstadt
    Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
    Biochem Biophys Res Commun 325:719-25. 2004
    ..0. Phylogenetic analyses suggest that this globin is most closely related to the cytoglobin lineage. Although the function of this eye-globin remains presently uncertain, it adds an additional diversity to the vertebrate globin family...
  17. ncbi request reprint Divergent distribution in vascular and avascular mammalian retinae links neuroglobin to cellular respiration
    Anke Bentmann
    Department of Molecular Animal Physiology, Institute of Zoology, Johannes Gutenberg University of Mainz, D 55099 Mainz, Germany
    J Biol Chem 280:20660-5. 2005
    ..Our results clearly demonstrate an association of neuroglobin and mitochondria, thus supporting the hypothesis that neuroglobin is a respiratory protein that supplies oxygen to the respiratory chain...
  18. ncbi request reprint Complete subunit sequences, structure and evolution of the 6 x 6-mer hemocyanin from the common house centipede, Scutigera coleoptrata
    Kristina Kusche
    Institute of Zoology, Molecular Animal Physiology, University of Mainz, Germany
    Eur J Biochem 270:2860-8. 2003
    ..Phylogenetic analyses do not support a common clade of Myriapoda and Hexapoda, whereas there is evidence in favor of monophyletic Mandibulata...
  19. ncbi request reprint Molecular characterisation and evolution of the hemocyanin from the European spiny lobster, Palinurus elephas
    K Kusche
    Institute of Zoology, University of Mainz, Müllerweg 6, 55099 Mainz, Germany
    J Comp Physiol B 173:319-25. 2003
    ....
  20. ncbi request reprint Duplicated cytoglobin genes in teleost fishes
    Christine Fuchs
    Institute of Molecular Genetics, Johannes Gutenberg University Mainz, D 55099 Mainz, Germany
    Biochem Biophys Res Commun 337:216-23. 2005
    ..However, Cygb-2 is more than 250-fold stronger expressed in neuronal tissues, suggesting a subfunctionalization of the two cytoglobin paralogs after gene duplication...
  21. ncbi request reprint A globin gene of ancient evolutionary origin in lower vertebrates: evidence for two distinct globin families in animals
    Anja Roesner
    Institute of Zoology, Johannes Gutenberg University, Mainz, Germany
    Mol Biol Evol 22:12-20. 2005
    ..Phylogenetic analyses confirm an ancient evolutionary relationship of globin X with neuroglobin and suggest the existence of two distinct globin types in the last common ancestor of Protostomia and Deuterostomia...
  22. ncbi request reprint Diversity of stonefly hexamerins and implication for the evolution of insect storage proteins
    Silke Hagner-Holler
    Institute of Zoology, Johannes Gutenberg University of Mainz, D 55099 Mainz, Germany
    Insect Biochem Mol Biol 37:1064-74. 2007
    ....
  23. ncbi request reprint Divergent distribution of cytoglobin and neuroglobin in the murine eye
    Marc Schmidt
    Institute of Zoology, Molecular Animal Physiology, University of Mainz, Müllerweg 6, D 55099 Mainz, Germany
    Neurosci Lett 374:207-11. 2005
    ..While neuroglobin seems to be associated with oxygen consumption, a respiratory function of cytoglobin is unlikely...
  24. ncbi request reprint Ligands and receptors: common theme in insect storage protein transport
    T Burmester
    Institut fur Zoologie, Universitat Mainz, D 55059 Mainz, Germany
    Naturwissenschaften 86:468-74. 1999
    ..Sequence comparison shows that the hexamerins and hexamerin receptors diverged early in insect evolution and derive from a common hemocyanin ancestor...
  25. ncbi request reprint The hemoglobin genes of Drosophila
    Thorsten Burmester
    Institute of Zoology, University of Mainz, Germany
    FEBS J 273:468-80. 2006
    ..glob1 is closely related to the intracellular hemoglobin of the botfly Gasterophilus intestinalis, and the extracellular hemoglobins from the chironomid midges derive from this clade...
  26. ncbi request reprint The cellular and subcellular localization of neuroglobin and cytoglobin -- a clue to their function?
    Thomas Hankeln
    Institute of Molecular Genetics, University of Mainz, D 55099 Mainz, Germany
    IUBMB Life 56:671-9. 2004
    ..Cytoglobin is also expressed in distinct cell types of brain and retina. Its distribution strikingly differs from neuroglobin, suggesting an independent, yet unknown function...
  27. ncbi request reprint Biochemical and molecular characterisation of hemocyanin from the amphipod Gammarus roeseli: complex pattern of hemocyanin subunit evolution in Crustacea
    Silke Hagner-Holler
    Institute of Zoology, University of Mainz, Müllerweg 6, 55099 Mainz, Germany
    J Comp Physiol B 175:445-52. 2005
    ....
  28. ncbi request reprint Characterization of Drosophila hemoglobin. Evidence for hemoglobin-mediated respiration in insects
    Thomas Hankeln
    Institute of Molecular Genetics, Biosafety Research and Consulting, University of Mainz, D 55099 Mainz, Germany
    J Biol Chem 277:29012-7. 2002
    ..This suggests that oxygen supply in insects may be more complex than thought previously and may depend on hemoglobin-mediated oxygen transport and storage in addition to simple diffusion...
  29. doi request reprint News from an ancient world: two novel astacin metalloproteases from the horseshoe crab
    Christoph Becker-Pauly
    Institute of Zoology, Cell and Matrix Biology, Johannes Gutenberg University, Mainz, Germany
    J Mol Biol 385:236-48. 2009
    ..For example, LAST_MAM is the only astacin protease known so far that is active in its zymogen form, indicating that the presence of the N-terminal propeptide does not prevent proteolytic activity...
  30. ncbi request reprint The respiratory proteins of insects
    Thorsten Burmester
    Institute of Zoology, Biozentrum Grindel, University of Hamburg, Martin Luther King Platz 3, D 20146 Hamburg, Germany
    J Insect Physiol 53:285-94. 2007
    ..Nevertheless, the occurrence of respiratory proteins in insects adds further complexity to our view on insect respiration...
  31. ncbi request reprint Subunit sequences of the 4 x 6-mer hemocyanin from the golden orb-web spider, Nephila inaurata
    Anne Averdam
    Institute of Zoology, Johannes Gutenberg University, Mainz, Germany
    Eur J Biochem 270:3432-9. 2003
    ..Assuming a clock-like evolution of the chelicerate hemocyanins, a timescale for the evolution of the Chelicerata was obtained that agrees with the fossil record...
  32. pmc A hemocyanin from the Onychophora and the emergence of respiratory proteins
    Kristina Kusche
    Institute of Zoology, Johannes Gutenberg University Mainz, D 55099 Mainz, Germany
    Proc Natl Acad Sci U S A 99:10545-8. 2002
    ..6 kDa). Phylogenetic analyses of the arthropod hemocyanin sequences show that the Onychophora form a robust sister-group of the Euarthropoda, whereas the monophyly of the Tracheata is not supported...
  33. ncbi request reprint Evolutionary history and diversity of arthropod hemocyanins
    Thorsten Burmester
    Institute of Zoology, University of Mainz, Mainz D 55099, Germany
    Micron 35:121-2. 2004
    ..Hemocyanins also gave rise to non-respiratory proteins (crustacean pseudo-hemocyanins, insect hexamerins, and hexamerin receptors), which most likely have storage functions...
  34. ncbi request reprint Quaternary structure of the European spiny lobster (Palinurus elephas) 1x6-mer hemocyanin from cryoEM and amino acid sequence data
    Ulrich Meissner
    Institute of Zoology, University of Mainz, Muellerweg 6, D 55099 Mainz, Germany
    J Mol Biol 325:99-109. 2003
    ..By molecular modelling, we have found the putative locations for the amino acid sequence (597-605) and the C-terminal end (654-657), which are absent in the available P.interruptus X-ray data...
  35. ncbi request reprint Neuroglobin and cytoglobin: genes, proteins and evolution
    Thorsten Burmester
    Institute of Zoology, University of Mainz, D 55099 Mainz, Germany
    IUBMB Life 56:703-7. 2004
    ..This result suggests either multiple independent functional changes or a yet undefined respiratory role of tissue globins like Ngb and Cygb...
  36. ncbi request reprint Origin and evolution of arthropod hemocyanins and related proteins
    T Burmester
    Institute of Zoology, University of Mainz, Germany
    J Comp Physiol B 172:95-107. 2002
    ..Molecular phylogenetic analyses show a close relationship of the crustacean and insect proteins, providing strong support for a pancrustacean taxon, while structural data suggest a myriapod-chelicerate clade...
  37. ncbi request reprint Neuroglobin and cytoglobin in search of their role in the vertebrate globin family
    Thomas Hankeln
    Institute of Molecular Genetics, Johannes Gutenberg University of Mainz, D 55099 Mainz, Germany
    J Inorg Biochem 99:110-9. 2005
    ..Cytoglobin is predominantly expressed in fibroblasts and related cell types, but also in distinct nerve cell populations. Much less is known about its function, although in fibroblasts it might be involved in collagen synthesis...
  38. doi request reprint Oxygen-induced changes in hemoglobin expression in Drosophila
    Eva Gleixner
    Institute of Molecular Genetics, University of Mainz, Germany
    FEBS J 275:5108-16. 2008
    ..Rather, dmeglob1 may protect the fly from an excess of O2, either by buffering the flux of O2 from the tracheoles to the cells or by degrading noxious reactive oxygen species...
  39. ncbi request reprint Complete hemocyanin subunit sequences of the hunting spider Cupiennius salei: recent hemocyanin remodeling in entelegyne spiders
    Pia Ballweber
    Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
    J Biol Chem 277:14451-7. 2002
    ....
  40. ncbi request reprint How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina
    Marc Schmidt
    Department of Molecular Animal Physiology, Institute of Zoology, Johannes Gutenberg University of Mainz, D 55099 Mainz, Germany
    J Biol Chem 278:1932-5. 2003
    ..These findings suggest that neuroglobin supplies oxygen to the retina, similar to myoglobin in the myocardium and the skeletal muscle...
  41. ncbi request reprint Neuron-specific expression of neuroglobin in mammals
    Tilmann L Laufs
    Institute of Molecular Genetics, Biosafety Research and Consulting, Johannes Gutenberg University, Mainz, Germany
    Neurosci Lett 362:83-6. 2004
    ..Analysis of the neuroglobin genomic sequence from man and mouse identifies sequence motifs with similarity to the neuron-restrictive silencer element, possibly explaining a neuron-specific expression of neuroglobin...
  42. ncbi request reprint Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio)
    Anja Roesner
    Institute of Zoology, University of Mainz, D 55099 Mainz, Germany
    J Exp Biol 209:2129-37. 2006
    ..There was little change in the expression of the two cytoglobin genes. Globin X mRNA significantly decreased under hypoxia, pointing to a functional linkage to oxygen-dependent metabolism...
  43. ncbi request reprint Molecular characterization of hemoglobin from the honeybee Apis mellifera
    Thomas Hankeln
    Institute of Molecular Genetics, University of Mainz, D 55099 Mainz, Germany
    J Insect Physiol 52:701-10. 2006
    ..Although insect hemoglobins may be in fact involved in oxygen metabolism, it remains uncertain whether they carry out a myoglobin-like function in oxygen storage and delivery...
  44. ncbi request reprint Characterization of two globin genes from the malaria mosquito Anopheles gambiae: divergent origin of nematoceran haemoglobins
    Thorsten Burmester
    Institute of Zoology, University of Hamburg, Hamburg, Germany
    Insect Mol Biol 16:133-42. 2007
    ..0, providing evidence for a recent intron gain event. Both mosquito glob2 genes have lost the B12.2 intron. This pattern must be interpreted in terms of dynamic intron gain and loss events in the globin gene lineage...
  45. ncbi request reprint Localization of neuroglobin protein in the mouse brain
    Sylvia Wystub
    Institute of Molecular Genetics, Biosafety Research and Consulting, Department of Biology, Johannes Gutenberg University, Mainz, Germany
    Neurosci Lett 346:114-6. 2003
    ..Regionally differing intensities of immunostaining suggest different levels of neuroglobin protein expression, in line with the idea that brain regions show variation in their tolerance towards hypoxic conditions...
  46. doi request reprint Genomic response of the rat brain to global ischemia and reperfusion
    Fabian Büttner
    Institute of Zoology, University of Mainz, Müllerweg 6, D 55099 Mainz, Germany
    Brain Res 1252:1-14. 2009
    ..Delayed gene expression response is characterised by inflammation and immune-related genes. These results support the hypothesis that the brain's response to ischemia is an active, specific and coordinated process...
  47. pmc Neuroglobin and other hexacoordinated hemoglobins show a weak temperature dependence of oxygen binding
    Julien Uzan
    INSERM U473, 94276 Le Kremlin Bicetre, France
    Biophys J 87:1196-204. 2004
    ..This effect could be of biological relevance for certain organisms, since it could provide a globin with an oxygen affinity that is nearly independent of temperature...
  48. ncbi request reprint Neuroglobin ligand binding kinetics
    Laurent Kiger
    INSERM U473, 94275 Le Kremlin Bicetre, France
    IUBMB Life 56:709-19. 2004
    ..This effect could be of biological relevance for certain organisms, since it would lead to an oxygen affinity that is nearly independent of temperature...
  49. ncbi request reprint Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity
    Alessandra Pesce
    Department of Physics INFM and Centre for Excellence in Biomedical Research, University of Genova, Via Dodecaneso 33, I 16146 Genova, Italy
    Structure 11:1087-95. 2003
    ....
  50. ncbi request reprint Neuroglobin mRNA expression after transient global brain ischemia and prolonged hypoxia in cell culture
    Rainald Schmidt-Kastner
    Department of Neurology, University of Miami School of Medicine, Miami, FL 33101, USA
    Brain Res 1103:173-80. 2006
    ..Therefore, it is unlikely that neuroglobin is instrumental in the acute response of neurons to hypoxic or ischemic insults, for which the mammalian brain is not adapted...
  51. ncbi request reprint Cyanide binding and heme cavity conformational transitions in Drosophila melanogaster hexacoordinate hemoglobin
    Daniele de Sanctis
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, P O Box 127, 2781 901 Oeiras, Portugal
    Biochemistry 45:10054-61. 2006
    ....
  52. ncbi request reprint Regulation and role of neuroglobin and cytoglobin under hypoxia
    Thorsten Burmester
    Institute of Zoology and Zoological Museum, University of Hamburg, Hamburg, Germany
    Adv Exp Med Biol 618:169-80. 2007
    ..Cell culture data suggest that in fibroblasts Cygb is involved in cell proliferation, possibly in collagen synthesis. In neurons, there is evidence for an additional role of Cygb related to nitric oxide metabolism...
  53. ncbi request reprint EST sequencing of Onychophora and phylogenomic analysis of Metazoa
    Falko Roeding
    Institute of Zoology and Zoological Museum, University of Hamburg, D 20146 Hamburg, Germany
    Mol Phylogenet Evol 45:942-51. 2007
    ..In agreement with previous studies, we have demonstrated that random sequencing of cDNAs results in sequence information suitable for phylogenomic approaches to resolve metazoan relationships...
  54. ncbi request reprint Human neuroglobin: crystals and preliminary X-ray diffraction analysis
    Alessandra Pesce
    Department of Physics INFM and Center of Excellence for Biomedical Research, University of Genova, Via Dodecaneso 33, I 16146 Genova, Italy
    Acta Crystallogr D Biol Crystallogr 58:1848-50. 2002
    ..95 A resolution using synchrotron radiation. The crystals belong to space group P2(1), with unit-cell parameters a = 39.6, b = 94.9, c = 67.5 A, beta = 94.4 degrees, and contain 2-4 protein molecules per asymmetric unit...
  55. ncbi request reprint Oxygen binding properties of non-mammalian nerve globins
    Christian Hundahl
    Zoophysiology, Institute of Biological Sciences, University of Aarhus, Denmark
    FEBS J 273:1323-9. 2006
    ..These results demonstrate a remarkable diversity in oxygenation characteristics of vertebrate and invertebrate nerve haemoglobins that clearly reflect distinct physiological roles...
  56. pmc Neuroglobin and cytoglobin. Fresh blood for the vertebrate globin family
    Alessandra Pesce
    Department of Physics INFM and Center for Excellence in Biomedical Research, University of Genova, Via Dodecaneso 33, I 16146 Genova, Italy
    EMBO Rep 3:1146-51. 2002
    ..Strikingly, the data reveal that O2 metabolism in cells is more complicated than was thought before, requiring unexpected O2-binding proteins with potentially novel functional features...
  57. ncbi request reprint Mapping protein matrix cavities in human cytoglobin through Xe atom binding
    Daniele de Sanctis
    Department of Physics INFM and Centre for Excellence in Biomedical Research, University of Genova, Via Dodecaneso 33, Genoa I 16146, Italy
    Biochem Biophys Res Commun 316:1217-21. 2004
    ..Despite the conserved globin fold, the cavity found in CYGB* is structured differently from those recognized to play a functional role in myoglobin, neuroglobin, truncated hemoglobins, and Cerebratulus lacteus mini-hemoglobin...
  58. ncbi request reprint Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination
    Daniele de Sanctis
    Department of Physics INFM, Centre for Excellence in Biomedical Research, University of Genova, Via Dodecaneso 33, 1 16146 Genova, Italy
    J Mol Biol 336:917-27. 2004
    ..The cavity, which may provide a heme ligand diffusion pathway, is connected to the external space through a narrow tunnel nestled between the globin G and H helices...
  59. ncbi request reprint Neuroglobin: a respiratory protein of the nervous system
    Thorsten Burmester
    Institute of Zoology and Institute of Molecular Genetics, Johannes Gutenberg University of Mainz, D 55099 Mainz, Germany
    News Physiol Sci 19:110-3. 2004
    ..Neuroglobin may promote neuronal survival under hypoxic conditions as they occur, for example, in stroke...
  60. pmc A respiratory hemocyanin from an insect
    Silke Hagner-Holler
    Institutes of Zoology and Molecular Biophysics, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany
    Proc Natl Acad Sci U S A 101:871-4. 2004
    ..However, our results demonstrate that, in contrast to the accepted paradigm, certain basal insects have retained an ancestral blood-based mechanism of gas exchange...
  61. ncbi request reprint The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin
    Djemel Hamdane
    INSERM U473, 94276 Le Kremlin Bicetre Cedex, France
    J Biol Chem 278:51713-21. 2003
    ..Hence the oxygen affinity would be directly linked to the redox state of the cell...
  62. ncbi request reprint Physiology: a welcome shortage of breath
    Thorsten Burmester
    Nature 433:471-2. 2005
  63. ncbi request reprint Reversible hexa- to penta-coordination of the heme Fe atom modulates ligand binding properties of neuroglobin and cytoglobin
    Alessandra Pesce
    Department of Physics INFM and Center for Excellence in Biomedical Research, University of Genova, Via Dodecaneso 33, I 16146 Genova, Italy
    IUBMB Life 56:657-64. 2004
    ....
  64. ncbi request reprint Coupling of the heme and an internal disulfide bond in human neuroglobin
    Djemel Hamdane
    INSERM U473, 84 rue du General Leclerc, 94276 Le Kremlin Bicetre, Cedex France
    Micron 35:59-62. 2004
    ..This suggests a novel mechanism for the oxygen binding; reduction of the disulfide bond would provoke the release of oxygen...
  65. ncbi request reprint Hyperthermal stability of neuroglobin and cytoglobin
    Djemel Hamdane
    INSERM U473, Le Kremlin Bicetre, France
    FEBS J 272:2076-84. 2005
    ....
  66. ncbi request reprint Bishistidyl heme hexacoordination, a key structural property in Drosophila melanogaster hemoglobin
    Daniele de Sanctis
    Department of Physics, National Institute for the Physics of Matter NFM, University of Genova, Genova I 16146, Italy
    J Biol Chem 280:27222-9. 2005
    ..Despite the high resolution achieved, no sequence/structure features specifically supporting the heme hexa- to pentacoordination transition required for diatomic ligand binding could be recognized...
  67. ncbi request reprint New insight into the haemoglobin superfamily: preliminary crystallographic characterization of human cytoglobin
    Daniele de Sanctis
    Department of Physics INFM and Center for Excellence in Biomedical Research, University of Genova, Via Dodecaneso 33, I 16146 Genova, Italy
    Acta Crystallogr D Biol Crystallogr 59:1285-7. 2003
    ..8, b = 73.1, c = 98.9 A and two molecules per asymmetric unit. The anomalous difference Patterson map clearly reveals the position of the haem Fe-atom sites, thus paving the way for SAD structure determination...
  68. ncbi request reprint High pressure enhances hexacoordination in neuroglobin and other globins
    Djemel Hamdane
    INSERM U473, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    J Biol Chem 280:36809-14. 2005
    ....
  69. ncbi request reprint Globin genes are present in Ciona intestinalis
    Bettina Ebner
    Institute of Molecular Genetics, Johannes Gutenberg University, Mainz, Germany
    Mol Biol Evol 20:1521-5. 2003
    ..This finding is in agreement with the ancestral phylogeny of the vertebrate globins. Moreover, it seems likely that the Ciona hemocyanin-like sequences have enzymatic instead of respiratory functions...
  70. ncbi request reprint The nerve hemoglobin of the bivalve mollusc Spisula solidissima: molecular cloning, ligand binding studies, and phylogenetic analysis
    Sylvia Dewilde
    Department of Biomedical Sciences, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B 2610 Antwerp, Belgium
    J Biol Chem 281:5364-72. 2006
    ..They most likely fulfill a myoglobin-like function and enhance oxygen supply to the neurons...
  71. ncbi request reprint The pro-opiomelanocortin gene of the zebrafish (Danio rerio)
    Immo A Hansen
    Endocrinology and Diabetes Unit, University of Wuerzburg, Josef Schneider Strasse 2, Germany
    Biochem Biophys Res Commun 303:1121-8. 2003
    ..These findings will facilitate the use of the zebrafish as a model organism in the study of the physiological role of POMC-derived peptides...
  72. ncbi request reprint The human brain hexacoordinated neuroglobin three-dimensional structure
    Alessandra Pesce
    Department of Physics, INFM and Centre for Excellence in Biomedical Research, University of Genova, Via Dodecaneso 33, Genova I 16146, Italy
    Micron 35:63-5. 2004
    ....
  73. ncbi request reprint Exploiting a list of protein sequences
    Michael C Marden
    Department of Biomedical Sciences, University of Antwerp, B 2610 Antwerp, Belgium
    Gene 398:35-41. 2007
    ..Examples are shown based on globin sequences from various species and on the abnormal human hemoglobins. The software should be of interest to protein engineers who need to know what variants are already known...