Roland Buhl

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint Newly diagnosed chronic obstructive pulmonary disease. Clinical features and distribution of the novel stages of the Global Initiative for Obstructive Lung Disease
    O Kornmann
    Pulmonary Department, Internal Medicine, University HospitalMainz, Mainz, Germany
    Respiration 70:67-75. 2003
  2. doi request reprint [Early treatment of COPD with tiotropium]
    R Buhl
    Universitätsmedizin der Johannes Gutenberg Universität, III Med Klinik, Schwerpunkt Pneumologie, Mainz
    Pneumologie 66:589-95. 2012
  3. pmc Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trial
    Jurgen Behr
    Medizinische Klinik I, Klinikum Grosshadern der Ludwig Maximilians Universität, Munchen, Germany
    Respir Res 10:101. 2009
  4. ncbi request reprint Omalizumab provides long-term control in patients with moderate-to-severe allergic asthma
    R Buhl
    Pulmonary Division, University Hospital, Mainz, Germany
    Eur Respir J 20:73-8. 2002
  5. ncbi request reprint Current and future pharmacologic therapy of exacerbations in chronic obstructive pulmonary disease and asthma
    Roland Buhl
    Pulmonary Department, Mainz University Hospital, Langenbeckstrasse 1, D 55131 Mainz, Germany
    Proc Am Thorac Soc 1:136-42. 2004
  6. ncbi request reprint The anti-IgE antibody omalizumab improves asthma-related quality of life in patients with allergic asthma
    R Buhl
    Pulmonary Division, University Hospital, Mainz, Germany
    Eur Respir J 20:1088-94. 2002
  7. ncbi request reprint Omalizumab (Xolair) improves quality of life in adult patients with allergic asthma: a review
    R Buhl
    Pulmonary Department, University Hospital, Mainz, Germany
    Respir Med 97:123-9. 2003
  8. ncbi request reprint Budesonide/formoterol maintenance and reliever therapy: a new treatment approach for adult patients with asthma
    R Buhl
    Pulmonary Department, Mainz University Hospital, Mainz, Germany
    Curr Med Res Opin 23:1867-78. 2007
  9. ncbi request reprint Budesonide/formoterol for the treatment of asthma
    Roland Buhl
    Pulmonary Division, Mainz University Hospital, Langenbeckstrasse 1, D 55131 Mainz, Germany
    Expert Opin Pharmacother 4:1393-406. 2003
  10. ncbi request reprint Once-daily budesonide/formoterol in a single inhaler in adults with moderate persistent asthma
    R Buhl
    Pulmonary Division, University Hospital, Mainz Germany
    Respir Med 97:323-30. 2003

Collaborators

Detail Information

Publications99

  1. ncbi request reprint Newly diagnosed chronic obstructive pulmonary disease. Clinical features and distribution of the novel stages of the Global Initiative for Obstructive Lung Disease
    O Kornmann
    Pulmonary Department, Internal Medicine, University HospitalMainz, Mainz, Germany
    Respiration 70:67-75. 2003
    ..This study describes the frequency distribution of GOLD stages in newly diagnosed COPD patients in a large city pulmonary practice...
  2. doi request reprint [Early treatment of COPD with tiotropium]
    R Buhl
    Universitätsmedizin der Johannes Gutenberg Universität, III Med Klinik, Schwerpunkt Pneumologie, Mainz
    Pneumologie 66:589-95. 2012
    ....
  3. pmc Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trial
    Jurgen Behr
    Medizinische Klinik I, Klinikum Grosshadern der Ludwig Maximilians Universität, Munchen, Germany
    Respir Res 10:101. 2009
    ..To better understand the clinical implications of these findings we performed additional, explorative analyses of the IFGENIA data set...
  4. ncbi request reprint Omalizumab provides long-term control in patients with moderate-to-severe allergic asthma
    R Buhl
    Pulmonary Division, University Hospital, Mainz, Germany
    Eur Respir J 20:73-8. 2002
    ..Treatment with omalizumab was well tolerated and the incidence of adverse events was similar between groups. In conclusion, these results suggest that omalizumab is a promising new agent for the long-term control of allergic asthma...
  5. ncbi request reprint Current and future pharmacologic therapy of exacerbations in chronic obstructive pulmonary disease and asthma
    Roland Buhl
    Pulmonary Department, Mainz University Hospital, Langenbeckstrasse 1, D 55131 Mainz, Germany
    Proc Am Thorac Soc 1:136-42. 2004
    ....
  6. ncbi request reprint The anti-IgE antibody omalizumab improves asthma-related quality of life in patients with allergic asthma
    R Buhl
    Pulmonary Division, University Hospital, Mainz, Germany
    Eur Respir J 20:1088-94. 2002
    ..The results of the present study show that these changes are paralleled by improvements in asthma-related quality of life that are meaningful to such patients...
  7. ncbi request reprint Omalizumab (Xolair) improves quality of life in adult patients with allergic asthma: a review
    R Buhl
    Pulmonary Department, University Hospital, Mainz, Germany
    Respir Med 97:123-9. 2003
    ..Through effective disease control, omalizumab therefore leads to significant improvements in health-related QoL that are meaningful to patients with allergic asthma...
  8. ncbi request reprint Budesonide/formoterol maintenance and reliever therapy: a new treatment approach for adult patients with asthma
    R Buhl
    Pulmonary Department, Mainz University Hospital, Mainz, Germany
    Curr Med Res Opin 23:1867-78. 2007
    ..This option is well tolerated and offers greater reductions in asthma exacerbations together with similar improvements in daily symptom control, at a lower overall steroid load, compared with fixed-dose ICS/LABA plus SABA...
  9. ncbi request reprint Budesonide/formoterol for the treatment of asthma
    Roland Buhl
    Pulmonary Division, Mainz University Hospital, Langenbeckstrasse 1, D 55131 Mainz, Germany
    Expert Opin Pharmacother 4:1393-406. 2003
    ..The future for treatment with budesonide/formoterol may include as-needed administration in addition to maintenance therapy...
  10. ncbi request reprint Once-daily budesonide/formoterol in a single inhaler in adults with moderate persistent asthma
    R Buhl
    Pulmonary Division, University Hospital, Mainz Germany
    Respir Med 97:323-30. 2003
    ..In the majority of patients with moderate persistent asthma requiring ICS and long-acting beta-agonists, once-daily formoterol/budesonide provided sustained efficacy over 24 h, similar to twice-daily dosing...
  11. ncbi request reprint Comparable efficacy of ciclesonide once daily versus fluticasone propionate twice daily in asthma
    Roland Buhl
    Universitätsklinikum Mainz, Mainz, Germany
    Pulm Pharmacol Ther 19:404-12. 2006
    ..Ciclesonide is an inhaled corticosteroid with on-site lung activation that provides potent anti-inflammatory activity and has been shown to have a good safety profile, even at high doses...
  12. ncbi request reprint The effect of adjustable dosing with budesonide/formoterol on health-related quality of life and asthma control compared with fixed dosing
    R Buhl
    Mainz University Hospital, Germany
    Curr Med Res Opin 20:1209-20. 2004
    ..Budesonide/formoterol in a single inhaler is an effective therapy for asthma. We investigated whether adjustable maintenance dosing with budesonide/formoterol could maintain health-related quality of life (HRQL) and asthma control...
  13. ncbi request reprint [Guidelines for diagnosis and treatment of asthma patients]
    R Buhl
    Schwerpunkt Pneumologie, III Medizinische Klinik, Mainz
    Pneumologie 60:139-77. 2006
  14. ncbi request reprint Future directions in the pharmacologic therapy of chronic obstructive pulmonary disease
    Roland Buhl
    Mainz University Hospital, Langenbeckstrasse 1, Mainz, D 55131, Germany
    Proc Am Thorac Soc 2:83-93. 2005
    ....
  15. ncbi request reprint Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: a randomized, double-blind, placebo-controlled clinical cross-over-trial
    Kai M Beeh
    Pulmonary Department, Internal Medicine, University Hospital, Mainz, Germany
    Pulm Pharmacol Ther 19:233-41. 2006
    ..We evaluated the effect of inhaled bimosiamose (TBC1269), a synthetic pan-selectin antagonist, on allergen-induced late asthmatic reactions (LAR) in mild asthmatics...
  16. doi request reprint TA-MUC1 epitope in non-small cell lung cancer
    Andreas Kuemmel
    Pulmonary Division, Department of Medicine III, Johannes Gutenberg University Medical Center, 55101 Mainz, Germany
    Lung Cancer 63:98-105. 2009
    ..As this is the first report on a well-defined MUC1 epitope associated with improved survival in NSCLC, a more differentiated view on MUC1 may be mandatory...
  17. doi request reprint Regulatory T cells more effectively suppress Th1-induced airway inflammation compared with Th2
    Nina Dehzad
    III Medical Department, Johannes Gutenberg University, Mainz, Germany
    J Immunol 186:2238-44. 2011
    ....
  18. doi request reprint [Budesonide/formoterol maintenance and reliever therapy. A new treatment approach for adult patients with asthma]
    Stephanie Korn
    Schwerpunkt Pneumologie, III Medizinische Klinik, Universitätsklinikum Mainz, Mainz
    Med Klin (Munich) 103:299-310. 2008
    ..This option is well tolerated and offers greater reductions in asthma exacerbations together with similar improvements in daily symptom control, at a lower overall steroid load, compared with fixed-dose ICS/LABA plus SABA...
  19. doi request reprint Efficacy of a fixed combination of ciclesonide and formoterol: the EXCITED-study
    Stephanie Korn
    Pulmonary Department, Mainz University Hospital, Langenbeckstr 1, D 55131 Mainz, Germany
    Respir Med 106:57-67. 2012
    ..The studied fixed combination of ciclesonide/formoterol is not inferior to the marketed fixed combination of fluticasone/salmeterol in terms of efficacy and tolerability...
  20. ncbi request reprint Induced sputum methodology: Validity and reproducibility of total glutathione measurement in supernatant of healthy and asthmatic individuals
    Jutta Beier
    Pulmonary Department, Division of Internal Medicine, University Hospital Mainz, Mainz, Germany
    J Lab Clin Med 144:38-44. 2004
    ..78, P <.001; and R(i) =.51, P =.003, respectively). With the use of standardized protocols for duration of induction and sample processing, sputum GSH measurement in healthy subjects and asthmatic individuals is valid and reproducible...
  21. ncbi request reprint An open-label, prospective phase I/II study evaluating the immunogenicity and safety of a ras peptide vaccine plus GM-CSF in patients with non-small cell lung cancer
    Ralf G Meyer
    III Medical Department, Mainz University Hospital, Langenbeckstrasse 1, 55101 Mainz, Germany
    Lung Cancer 58:88-94. 2007
    ..Vaccination with mutated ras peptides is feasible and well tolerated. One patient revealed a positive DTH test. An ex vivo detectable T cell response was not induced in any of the patients...
  22. doi request reprint TLR3 but not TLR7/8 ligand induces allergic sensitization to inhaled allergen
    Sebastian Reuter
    III Department of Medicine, University Hospital Mainz, Mainz, Germany
    J Immunol 188:5123-31. 2012
    ..These findings give further insight into the effects of stimulation of different TLRs on the development of asthma...
  23. ncbi request reprint Sputum levels of reduced glutathione increase 24 hours after allergen challenge in isolated early, but not dual asthmatic responders
    Jutta Beier
    Pulmonary Department, Internal Medicine, University Hospital Mainz, Mainz, Germany
    Int Arch Allergy Immunol 135:30-5. 2004
    ..We compared reduced (GSH) and oxidized glutathione (GSSG) and nitrosothiols in induced sputum following allergen challenge in mild asthmatics with isolated early (EAR) and dual early and late (LAR) asthmatic responses...
  24. pmc The effect of budesonide/formoterol maintenance and reliever therapy on the risk of severe asthma exacerbations following episodes of high reliever use: an exploratory analysis of two randomised, controlled studies with comparisons to standard therapy
    Roland Buhl
    Mainz University Hospital, Langenbeckstrasse 1, Mainz, D 55131, Germany
    Respir Res 13:59. 2012
    ..Exacerbations may be reduced by the use of budesonide/formoterol as reliever medication during periods of unstable asthma. We examined the risk of a severe exacerbation in the period after a single day with high reliever use...
  25. doi request reprint CD4-mediated regulatory T-cell activation inhibits the development of disease in a humanized mouse model of allergic airway disease
    Helen Martin
    III Medical Department, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    J Allergy Clin Immunol 129:521-8, 528.e1-7. 2012
    ..We have previously demonstrated that stimulation of the CD4 molecule on human Treg cells activates their suppressive activity in vitro and in vivo...
  26. ncbi request reprint Effect of histamine and adenosine 5'-monophosphate provocation on sputum neutrophils and related mediators in atopic patients
    Daniel Pohl
    Pulmonary Department, Internal Medicine, University Hospital, Mainz, Germany
    Ann Allergy Asthma Immunol 95:197-203. 2005
    ..Airway hyperresponsiveness and inflammation can be noninvasively studied by bronchial provocation using direct (histamine) or indirect (adenosine 5'-monophosphate [AMP]) stimuli and induced sputum...
  27. ncbi request reprint Sputum matrix metalloproteinase-9, tissue inhibitor of metalloprotinease-1, and their molar ratio in patients with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and healthy subjects
    K M Beeh
    Pulmonary Department, Internal Medicine University Hospital Mainz, Lagen beckstr 1, Main 2 55131, Germany
    Respir Med 97:634-9. 2003
    ..We have compared sputum concentrations of MMP-9, TIMP-1 and the controlling cytokine tumor necrosis factor (TNF)-alpha in patients with COPD, IPF and healthy subjects...
  28. ncbi request reprint The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics
    M Soler
    Pulmonary Division, University Hospital, Basel, Switzerland
    Eur Respir J 18:254-61. 2001
    ..These results indicate that omalizumab therapy safely improves asthma control in allergic asthmatics who remain symptomatic despite regular use of inhaled corticosteroids and simultaneous reduction in corticosteroid requirement...
  29. doi request reprint Prospective evaluation of current asthma control using ACQ and ACT compared with GINA criteria
    Stephanie Korn
    Pulmonary Department, Mainz University Hospital, Langenbeckstr 1, 55131 Mainz, Germany
    Ann Allergy Asthma Immunol 107:474-9. 2011
    ..The goal of asthma treatment is to achieve and maintain current best control and reduce future risk of exacerbations and long-term morbidity...
  30. doi request reprint Mast cells induce migration of dendritic cells in a murine model of acute allergic airway disease
    Sebastian Reuter
    Department of Pulmonary Medicine, Third Medical Clinic, Johannes Gutenberg University Mainz, Mainz, Germany
    Int Arch Allergy Immunol 151:214-22. 2010
    ..However, the function of mast cells can be bypassed in models utilizing activated allergen-exposed DCs to initiate the development of allergic airway disease...
  31. pmc IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease
    Christian Taube
    III Medical Clinic, Johannes Gutenberg University, Mainz, Germany
    PLoS ONE 6:e21799. 2011
    ..We conclude that innate IL-22 limits airway inflammation, tissue damage and clinical decline in allergic lung disease...
  32. doi request reprint Use of a portable device to record maximum inspiratory flow in relation to dyspnoea in patients with COPD
    Christian Taube
    Pulmonary Department, Johannes Gutenberg University, Mainz, Germany
    Respir Med 105:316-21. 2011
    ..The results suggest that a simple, portable device for recording forced inspiration could be useful in monitoring COPD, as a functional correlate of acute changes in dyspnoea...
  33. ncbi request reprint Increased concentrations of glutathione in induced sputum of patients with mild or moderate allergic asthma
    Jutta Beier
    Pulmonary Department, Internal Medicine, University Hospital, Mainz, Germany
    Ann Allergy Asthma Immunol 92:459-63. 2004
    ..Glutathione is a vital intracellular and extracellular protective pulmonary antioxidant. It plays a key role in regulating oxidant-induced lung epithelial cell function and also in the control of proinflammatory processes...
  34. ncbi request reprint Neutrophilic inflammation in induced sputum of patients with idiopathic pulmonary fibrosis
    Kai Michael Beeh
    Pulmonary Department, Internal Medicine, University Hospital Mainz, Germany
    Sarcoidosis Vasc Diffuse Lung Dis 20:138-43. 2003
    ..This paper adresses the issue of whether the safe and non-invasive method of sputum induction is a suitable tool to study respiratory tract inflammation in IPF...
  35. ncbi request reprint The prognostic impact of blood group-related antigen Lewis Y and the ABH blood groups in resected non-small cell lung cancer
    Andreas Kuemmel
    Pulmonary Division, Department of Medicine III, Johannes Gutenberg University Medical Center, Mainz, Germany
    Tumour Biol 28:340-9. 2007
    ..We hypothesize that related blood group antigens both on tumor cells and in peripheral blood may have an underestimated function for progression in resected NSCLC...
  36. doi request reprint [Lung cancer]
    Berthold Fischer
    III Medizinische Klinik und Poliklinik, Schwerpunkt Pneumologie, Klinikum der Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131 Mainz
    Med Klin (Munich) 103:311-20. 2008
    ..Patient selection for therapeutic use of bevacizumab is crucial to optimize safety. Ongoing trials explore multitargeted agents such as sorafenib, sunitinib, and vandetanib...
  37. ncbi request reprint Clinical application of a simple questionnaire for the differentiation of asthma and chronic obstructive pulmonary disease
    Kai Michael Beeh
    Pulmonary Department, Internal Medicine, University Hospital Mainz, Lagenbeckstr 1, Mainz 55131, Germany
    Respir Med 98:591-7. 2004
    ..Due to some common characteristic traits, asthma and COPD are often lumped together in clinical practice. We sought to develop a simple questionnaire for the distinction of asthma and COPD...
  38. doi request reprint Effectiveness of omalizumab in patients 50 years and older with severe persistent allergic asthma
    Stephanie Korn
    Pulmonary Department, Mainz University Hospital, Mainz, Germany
    Ann Allergy Asthma Immunol 105:313-9. 2010
    ..Omalizumab is approved for the treatment of severe allergic asthma...
  39. ncbi request reprint Characterization of c-kit expression in small cell lung cancer: prognostic and therapeutic implications
    Patrick Micke
    III Medical Department, Pulmonary Division, University Hospital, D 55101 Mainz, Germany
    Clin Cancer Res 9:188-94. 2003
    ..To further evaluate the frequency and pathogenic relevance of c-kit expression, tumor tissue together with the corresponding clinical data of SCLC patients was analyzed...
  40. pmc Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPD
    Roland Buhl
    Pulmonary Department, Mainz University Hospital, Mainz, Germany
    Int J Chron Obstruct Pulmon Dis 7:729-41. 2012
    ..Phase III studies are currently ongoing to assess the long-term efficacy and safety of this combination...
  41. doi request reprint Monitoring free serum IgE in severe asthma patients treated with omalizumab
    Stephanie Korn
    Pulmonary Department, Mainz University Hospital, Langenbeckstrasse 1, D 55131 Mainz, Germany
    Respir Med 106:1494-500. 2012
    ..It is unclear if monitoring free serum IgE is clinically meaningful once omalizumab treatment is initiated...
  42. ncbi request reprint Dissimilarity between seasonal changes in airway responsiveness to adenosine-5'-monophosphate and methacholine in patients with grass pollen allergic rhinitis: relation to induced sputum
    Jutta Beier
    Pulmonary Department, Internal Medicine, University Hospital, Mainz, Germany
    Int Arch Allergy Immunol 132:76-81. 2003
    ..Seasonal allergic rhinitis offers a dynamic model to study changes in BHR and airway inflammation during natural allergen exposure...
  43. doi request reprint Measurement of exhaled nitric oxide: comparison of different analysers
    Stephanie Korn
    Pulmonary Department, Mainz University Hospital, Germany
    Respirology 15:1203-8. 2010
    ..The aim of this study was to compare five NO analysers: Medisoft (M), Aerocrine Niox (N), Aerocrine Niox flex (NF), Aerocrino Niox mino (NM) and EcoMedics (E)...
  44. ncbi request reprint Increased glutathione disulfide and nitrosothiols in sputum supernatant of patients with stable COPD
    Kai Michael Beeh
    Pulmonary Department, Internal Medicine, University Hospital, Langenbeckstrasse 1, 55131 Mainz, Germany
    Chest 126:1116-22. 2004
    ..We studied the concentrations of total and reduced GSH, glutathione disulfide (GSSG), and nitrosothiols in sputum supernatant of patients with COPD...
  45. doi request reprint Omalizumab in patients with severe persistent allergic asthma in a real-life setting in Germany
    S Korn
    Pulmonary Dept, Mainz University Hospital, Germany
    Respir Med 103:1725-31. 2009
    ....
  46. ncbi request reprint Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: results of a multicenter phase II study
    M Schuler
    Department of Medicine III, Johannes Gutenberg University, Mainz, Germany
    J Clin Oncol 19:1750-8. 2001
    ..CONCLUSION: Intratumoral adenoviral p53 gene therapy appears to provide no additional benefit in patients receiving an effective first-line chemotherapy for advanced NSCLC...
  47. ncbi request reprint The Wnt/β-Catenin Pathway Attenuates Experimental Allergic Airway Disease
    Sebastian Reuter
    Pulmonary Department, III Medical Clinic, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, Germany
    J Immunol 193:485-95. 2014
    ..These results demonstrate an important role for the canonical Wnt/β-catenin pathway in the DC-mediated regulation of allergic responses in the lung. ..
  48. pmc Outcome measures in chronic obstructive pulmonary disease (COPD): strengths and limitations
    Thomas Glaab
    Pulmonary Department, University Hospital, Johannes Gutenberg University, Mainz, Germany
    Respir Res 11:79. 2010
    ....
  49. doi request reprint Inhibition of cAMP degradation improves regulatory T cell-mediated suppression
    Tobias Bopp
    Institute for Immunology, Johannes Gutenberg University, Mainz, Germany
    J Immunol 182:4017-24. 2009
    ....
  50. ncbi request reprint Anti-IgE antibodies for the treatment of asthma
    Roland Buhl
    Pulmonary Department, Mainz University Hospital, Germany
    Curr Opin Pulm Med 11:27-34. 2005
    ..Attenuating allergic disease by specifically inhibiting IgE and the development of the monoclonal anti-IgE antibody, omalizumab, were major breakthroughs in asthma management...
  51. ncbi request reprint Dysfunctional inhibitory muscarinic receptors mediate enhanced histamine release in isolated human bronchi
    Ignaz Wessler
    Institute of Pathology, University Hospital Mainz, Langenbeckstr 1, D 55101 Mainz, Germany
    Life Sci 80:2294-7. 2007
    ..In conclusion, the present experiments show an enhanced histamine release in advanced COPD, which can be explained by a dysfunction of inhibitory muscarinic receptors...
  52. ncbi request reprint Treatment of non-small cell lung cancer patients with the trifunctional monoclonal antibody catumaxomab (anti-EpCAM x anti-CD3): a phase I study
    Martin Sebastian
    III Medical Clinic, Department of Pulmonary Medicine, University of Mainz, and Pulmoary Research Institute, Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Germany
    Cancer Immunol Immunother 56:1637-44. 2007
    ..As EpCAM is also overexpressed in NSCLC, the present study was conducted in order to evaluate safety and tolerability of intravenous treatment with catumaxomab...
  53. pmc Soluble triggering receptor expressed on myeloid cells 1 is released in patients with stable chronic obstructive pulmonary disease
    Markus P Radsak
    Institute of Immunology, University of Mainz, Obere Zahlbacher Street 67, 55131 Mainz, Germany
    Clin Dev Immunol 2007:52040. 2007
    ..In summary, serum concentrations of sTREM-1 are increased in patients with COPD. Prospective studies are warranted to evaluate the relevance of sTREM-1 as a potential marker of the disease in patients with COPD...
  54. ncbi request reprint Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients
    P Micke
    Pulmonary Division III, Medical Department, Mainz University Hospital, Germany
    Eur J Nutr 41:12-8. 2002
    ..The semi-essential amino acid cysteine is the main source of the free sulfhydryl group of GSH and limits its synthesis. Whey proteins are rich in cysteine as well as in GSH precursor peptides...
  55. doi request reprint [Immunomodulation therapy for allergic asthma. What is already possible, what is to come?]
    C Taube
    III Medizinische Klinik, Schwerpunkt Pneumologie, Johannes Gutenberg Universitat, Mainz
    Dtsch Med Wochenschr 133:727-32. 2008
    ..Further approaches, like inhibition or modulation of T cell responses, inhibition of effector cytokines or inhibition of cell migration are very interesting but still in development and so far not established for treatment of patients...
  56. doi request reprint [Hemorrhagic pericardial effusion and multiple pulmonary nodules in a 37 year old male who has "never smoked"]
    M Sebastian
    III Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55101 Mainz
    Internist (Berl) 50:91-4. 2009
    ..In this case report we describe a 37 year old non-smoker who developed a non-small cell lung cancer. Following therapy with Erlotinib a partial response could be achieved...
  57. ncbi request reprint [Therapy of lung cancer]
    B Fischer
    III Medizinische Klinik und Poliklinik, Schwerpunkt Pneumologie, Universitätskliniken Mainz
    Pneumologie 59:783-97; quiz 798-803. 2005
  58. doi request reprint [Does phenotyping asthma help to improve differential treatment?]
    C Taube
    III Medizinische Klinik, Schwerpunkt Pneumologie, Universitatsmedizin, Mainz
    Dtsch Med Wochenschr 135:468-73. 2010
    ..Also for some of these phenotypes specifical treatpeuthic options are available. Therefore a good definition and classification of asthma phenotypes is important in regard of diagnosis, prognosis and therapy of these patients...
  59. ncbi request reprint [efficacy and safety of salmeterol in long-term therapy in patients with chronic obstructive airway diseases]
    K M Beeh
    Schwerpunkt Pneumologie, III Medizinische Klinik und Poliklinik, Klinikum der Johannes Gutenberg Universitat, Mainz
    Pneumologie 54:225-31. 2000
    ..Salmeterol is a long-acting inhaled beta 2-agonist with a bronchodilating effect lasting over 10 to 12 hours...
  60. ncbi request reprint [Tiotropium (Spiriva) - a long-acting inhaled anticholinergic for the treatment of chronic obstructive pulmonary disease (COPD)]
    K M Beeh
    Schwerpunkt Pneumologie, III Medizinische Klinik und Poliklinik, Klinikum der Johannes Gutenberg Universitat, Mainz, Germany
    Pneumologie 57:519-25. 2003
    ..Besides a higher incidence of dry mouth, the side effect profile was comparable to ipratropium bromide. In conclusion, present clinical data suggest that tiotropium has the potential of a first-line treatment for patients with COPD...
  61. ncbi request reprint Sputum induction leads to a decrease of exhaled nitric oxide unrelated to airflow
    J Beier
    Pulmonary Dept, Internal Medicine, University Hospital, Mainz, Germany
    Eur Respir J 22:354-7. 2003
    ..This methodological interference should be taken into account when sputum induction and exhaled nitric oxide measurements are performed in the same subject...
  62. ncbi request reprint Platinum-based, leukocyte-depleting chemotherapy does not alter induced sputum markers of neutrophilic inflammation in COPD patients with unresectable non-small cell lung cancer
    K M Beeh
    Department of Internal Medicine, University Hospital of Mainz, Mainz, Germany
    Respiration 70:166-71. 2003
    ..Systemic chemotherapy has broad side effects, including neutrophil toxicity...
  63. ncbi request reprint A single nasal allergen challenge increases induced sputum inflammatory markers in non-asthmatic subjects with seasonal allergic rhinitis: correlation with plasma interleukin-5
    K M Beeh
    Pulmonary Department, Internal Medicine, University Hospital Mainz, Mainz, Germany
    Clin Exp Allergy 33:475-82. 2003
    ..Nasal allergic inflammation enhances bone-marrow eosinophil production, mainly via IL-5, and rhinitis patients have increased airway inflammation during the pollen season...
  64. ncbi request reprint [Onset of action of formoterol in patients with moderate to severe, partially reversible airflow obstruction assessed by bodyplethysmography]
    J Beier
    Schwerpunkt Pneumologie, III Medizinische Klinik und Poliklinik, Klinikum der Johannes Gutenberg Universitat, Mainz
    Pneumologie 56:535-41. 2002
    ..Compared with Salmeterol, Formoterol has a rapid onset of bronchodilation. There are only scant data regarding the comparative onset of action using bodyplethysmography in moderate to severely obstructive patients...
  65. ncbi request reprint Glutathione deficiency of the lower respiratory tract in patients with idiopathic pulmonary fibrosis
    K M Beeh
    Pulmonary Dept, University Hospital Mainz, Germany
    Eur Respir J 19:1119-23. 2002
    ....
  66. ncbi request reprint [Efficacy and safety of salmeterol (50 microgram) and fluticasone (250 microgram) in a single inhaler device (diskus) in patients with mild to moderate asthma]
    K M Beeh
    Schwerpunkt Pneumologie, III Medizinische Klinik und Poliklinik, Klinikum der Johannes Gutenberg Universitat, Mainz
    Pneumologie 56:91-7. 2002
    ..Several lines of evidence have shown, that inhaled corticosteroids and long-acting beta-agonist have multiple synergisms both in vivo and in vitro, leading to improved clinical asthma control...
  67. ncbi request reprint Sputum levels of metalloproteinase-9 and tissue inhibitor of metalloproteinase-1, and their ratio correlate with airway obstruction in lung transplant recipients: relation to tumor necrosis factor-alpha and interleukin-10
    K M Beeh
    Pulmonary Department, Internal Medicine, University Hospital, Mainz, Germany
    J Heart Lung Transplant 20:1144-51. 2001
    ..Matrix-metalloproteinases (MMPs) and their inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), are involved in the turnover of extracellular matrix...
  68. pmc Induced sputum cell profiles in lung transplant recipients with or without chronic rejection: correlation with lung function
    K M Beeh
    Pulmonary Department, Internal Medicine, University Hospital, 55131 Mainz, Germany
    Thorax 56:557-60. 2001
    ..The aim of this study was to establish sputum cell counts and differentials in patients after lung transplantation (LTx), with or without chronic transplant rejection...
  69. ncbi request reprint c-erbB-2 expression in small-cell lung cancer is associated with poor prognosis
    P Micke
    III Medical Department, Pulmonary Division, Mainz University Hospital, Mainz, Germany
    Int J Cancer 92:474-9. 2001
    ..Since c-erbB-2 is a therapeutical target in other types of cancer, further studies to identify the role of c-erbB-2 in SCLC are clearly warranted...
  70. ncbi request reprint [Pathogenesis of bronchial asthma--unveiling new therapeutic prospects]
    K M Beeh
    Schwerpunkt Pneumologie, III Medizinische Klinik, Universitätsklinikum Mainz
    Med Klin (Munich) 96:15-25. 2001
    ..An improved understanding of underlying pathological features and mechanisms of asthmatic inflammation is essential to achieve an enhanced asthma symptom control and may lead to prevention in the future...
  71. ncbi request reprint [Correlation of plasma glutathione and total IgE level: evidence for a regulatory role of antipxodants in vivo]
    K M Beeh
    Schwerpunkt Pneumologie, III Medizinische Klinik, Universitatsklinik Mainz
    Pneumologie 54:569-71. 2000
    ..However, in vivo data consistent with these findings have not been reported...
  72. ncbi request reprint Oral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patients
    P Micke
    Pulmonary Division, III Medical Department, Mainz University Hospital, D 455101 Mainz, Germany
    Eur J Clin Invest 31:171-8. 2001
    ..A long-term clinical trial is clearly warranted to see if this "biochemical efficacy" of whey proteins translates into a more favourable course of the disease...
  73. ncbi request reprint [Anticholinergic drugs in therapy of chronic obstructive lung disease (COPD)]
    K M Beeh
    III Medizinische Klinik, Klinikum der Johannes Gutenberg Universitat, Mainz
    Med Klin (Munich) 95:552-8. 2000
    ..Novel, long-acting anticholinergics may hold a future potential for further improvement of therapy in COPD, particularly in terms of user friendliness and compliance...
  74. ncbi request reprint Stability of glutathione in induced sputum: impact of freezing
    J Beier
    Pulmonary Department, Internal Medicine, University Hospital Mainz, Mainz, Germany
    Respiration 70:523-7. 2003
    ..Measuring glutathione (GSH) in induced sputum (IS) offers a noninvasive tool to study oxidative stress in airway diseases...
  75. ncbi request reprint [Seasonal variations of serum-IgE and potential impact on dose-calculation of omalizumab (rhuMab-E25, anti-IgE)]
    K M Beeh
    Schwerpunkt Pneumologie III Medizinische Klinik, Universitätsklinikum Mainz
    Pneumologie 58:546-51. 2004
    ..g. pollen, and seasonal exposure may increase total and specific IgE levels ("boost"), thus leading to an imbalance between IgE levels and omalizumab with possible impact on therapeutic outcome...
  76. ncbi request reprint [Paraneoplastic limbic encephalitis in small cell lung carcinoma]
    B Fischer
    III Medizinische Klinik und Poliklinik, Hämatologie Onkologie Pneumologie, Klinikum der Johannes Gutenberg Universitat, Mainz
    Pneumologie 58:316-9. 2004
    ..The primary tumour responded to therapy but improvement of cerebral symptoms was unsatisfactory. Severe memory loss and personality changes remained unchanged while there was a slight improvement in confusion and hallucinations...
  77. ncbi request reprint Demonstration of pulmonary beta2-adrenergic receptor binding in vivo with [18F]fluoroethyl-fenoterol in a guinea pig model
    A Helisch
    Department of Nuclear Medicine, University Hospital, Langenbeckstrasse 1, 55101 Mainz, Germany
    Eur J Nucl Med Mol Imaging 32:1324-8. 2005
    ....
  78. ncbi request reprint Cigarette smoking, but not sensitization to Alternaria, is associated with severe asthma in urban patients
    K M Beeh
    Pulmonary Department, University Hospital, Mainz, Germany
    J Asthma 38:41-9. 2001
    ..Cigarette smoking is an independent risk factor associated with severe asthma in urban patients, whereas sensitization to Alternaria is of less importance in these patients...
  79. pmc Guideline-based survey of outpatient COPD management by pulmonary specialists in Germany
    Thomas Glaab
    Department of Respiratory Diseases III, Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Int J Chron Obstruct Pulmon Dis 7:101-8. 2012
    ..The aim of this study was to assess their outpatient management in relation to current guideline recommendations for COPD...
  80. doi request reprint MDCT assessment of airway wall thickness in COPD patients using a new method: correlations with pulmonary function tests
    Tobias Achenbach
    Department of Diagnostic and Interventional Radiology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101, Mainz, Germany
    Eur Radiol 18:2731-8. 2008
    ..In COPD patients, the wall thickness measured as a mean for a given patient correlated with the values of FEV1 and FEV1% predicted. Correlation with FEV1 was higher when only small airways were considered...
  81. ncbi request reprint Long-term repeatability of induced sputum cells and inflammatory markers in stable, moderately severe COPD
    Kai M Beeh
    Pulmonary Department, Internal Medicine, University Hospital, Mainz, Germany
    Chest 123:778-83. 2003
    ..Although short-term repeatability of selected sputum markers has been extensively studied in several populations, data on the long-term repeatability of induced sputum markers in stable COPD are scant...
  82. ncbi request reprint Mast cell-derived tumour necrosis factor is essential for allergic airway disease
    S Reuter
    III Medical Clinic, Dept of Pulmonary Medicine, University of Mainz, Mainz, Germany
    Eur Respir J 31:773-82. 2008
    ..The present results demonstrate the significance of mast cells in the development of airway disease and highlight the importance of mast cell-derived tumour necrosis factor in these responses...
  83. ncbi request reprint SeroGRID: an improved method for the rapid selection of antigens with disease related immunogenicity
    Patricia Krause
    III Department of Internal Medicine, Johannes Gutenberg University Mainz, Obere Zahlbacherstr 63, D 55131 Mainz, Germany
    J Immunol Methods 283:261-7. 2003
    ..Here, we show that seroreactivity of multiple SEREX-derived antigens can be simultaneously evaluated using a rapid and versatile high throughput procedure, which we call SeroGRID...
  84. ncbi request reprint Anticholinergics in the treatment of chronic obstructive pulmonary disease
    Kai Michael Beeh
    Pulmonary Division, 3rd Medical Department, University Hospital Mainz, Germany
    Respiration 69:372-9. 2002
    ..The introduction of new, long-acting anticholinergics is a promising addition to the treatment of COPD and is expected to lead to improved treatment outcomes and improved patient compliance...
  85. ncbi request reprint Characterization of the interstitial lung and peripheral blood T cell receptor repertoire in cigarette smokers
    Stephanie Korn
    Pulmonary Department, Mainz University Hospital, Langenbeckstrasse 1, D 55131 Mainz, Germany
    Am J Respir Cell Mol Biol 32:142-8. 2005
    ..039). Thus, TCR oligoclonality is preferentially found in the CD8(+) T cell subset, most distinctive in the lung. These findings indicate a specific interstitial T cell differentiation in response to local stimuli...
  86. ncbi request reprint Synthesis and preliminary evaluation of (R,R)(S,S) 5-(2-(2-[4-(2-[(18)F]fluoroethoxy)phenyl]-1-methylethylamino)-1-hydroxyethyl)-benzene-1,3-diol ([(18)F]FEFE) for the in vivo visualisation and quantification of the beta2-adrenergic receptor status in lun
    Esther Schirrmacher
    Institute of Nuclear Chemistry, University of Mainz, Fritz Strassmann Weg 2, D 55128, Mainz, Germany
    Bioorg Med Chem Lett 13:2687-92. 2003
    ....
  87. ncbi request reprint Staging small cell lung cancer: Veterans Administration Lung Study Group versus International Association for the Study of Lung Cancer--what limits limited disease?
    Patrick Micke
    III Medical Department, Pulmonary Division, Mainz University Hospital, D 55101 Mainz, Germany
    Lung Cancer 37:271-6. 2002
    ..In conclusion, the IASLC staging criteria for SCLC patients have a higher prognostic impact and are therefore preferable in clinical practice and future therapeutic trials...
  88. ncbi request reprint Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma
    R Buhl
    Mainz University Hospital, Mainz, Germany
    Allergy 61:518-26. 2006
    ..The goal in developing a new ICS is to include key pharmacologic characteristics that reduce oropharyngeal exposure to active drug while maintaining efficacy comparable with currently available ICS...
  89. ncbi request reprint Discrepant nasal and bronchial nitric oxide kinetics during early and late phase allergic reactions
    Stephanie Korn
    Pulmonary Department, Internal Medicine, University Hospital Mainz
    Respir Med 99:1595-9. 2005
    ..039). Despite similar functional responses in nose and bronchi, nasal NO kinetics following allergen challenge differ from bronchial NO. The concise mechanisms accounting for this discrepancy warrant further investigations...
  90. ncbi request reprint [Guidelines for diagnosis and therapy of patients with asthma 2005. The most important aspects for adults]
    Gerhard Schultze-Werninghaus
    BG Kliniken Bergmannsheil Ruhr Universität Bochum, Medizinische Klinik III Pneumologie, Allergologie, Schlaf und Beatmungsmedizin, Burkle de la Camp Platz 1, 44789 Bochum
    Med Klin (Munich) 101:60-4. 2006
  91. ncbi request reprint [Bronchodilators in chronic obstructive pulmonary disease (COPD)]
    Adrian Gillissen
    Robert Koch Klinik, Klinikum St Georg, Leipzig
    Med Klin (Munich) 100:246-54. 2005
    ..The addition of inhaled corticosteroids is only recommended in stages III and IV. Besides, pharmacotherapy of COPD should always be flanked by smoking prevention programs, and supportive therapy, if indicated in severe disease stages...
  92. ncbi request reprint [National Disease Management Guideline for Asthma: recommendations and evidence for "asthma prevention" issues]
    Dietrich Berdel
    Gesellschaft für pädiatrische Pneumologie e V
    Z Arztl Fortbild Qualitatssich 100:425-30. 2006
    ..Regarding tertiary prevention, position statements on vaccination and specific immunotherapy are developed. The present paper presents both the original texts of the recommendations and the evidence underlying them...
  93. ncbi request reprint High-dose acetylcysteine in idiopathic pulmonary fibrosis
    Maurits Demedts
    University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium
    N Engl J Med 353:2229-42. 2005
    ..Idiopathic pulmonary fibrosis is a chronic progressive disorder with a poor prognosis...
  94. ncbi request reprint Improvement in quality of life with omalizumab in patients with severe allergic asthma
    Bradley Chipps
    Capital Allergy and Respiratory Disease Center, Sacramento, California 95819, USA
    Curr Med Res Opin 22:2201-8. 2006
    ..Patients with severe persistent asthma experience daily symptoms and frequent serious exacerbations that contribute to a significant impairment of health-related quality of life (QoL)...
  95. ncbi request reprint Economic assessment of adjustable maintenance treatment with budesonide/formoterol in a single inhaler versus fixed treatment in asthma
    Bernd Brüggenjürgen
    Institute for Social Medicine, Epidemiology and Health Economics, Charite University Medical Center, Berlin, Germany
    Pharmacoeconomics 23:723-31. 2005
    ..To compare the costs and effectiveness of adjustable maintenance dosing with budesonide/formoterol in a single inhaler versus fixed dosing in adults with asthma...
  96. ncbi request reprint Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4
    Kai M Beeh
    Thoracic Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Chest 123:1240-7. 2003
    ..The present study was designed to assess the contribution of interleukin (IL)-8 and leukotriene B(4) (LTB(4)) to neutrophil chemotaxis evoked by sputum obtained from patients with established COPD...
  97. ncbi request reprint Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients
    Kai M Beeh
    insaf Respiratory Research Institute, Biebricher Allee 34, 65187 Wiesbaden, Germany
    Lung 182:369-77. 2004
    ..These data underline the potential of PDE-4 inhibition as a novel therapeutic approach to inflammatory airway diseases like asthma or COPD...
  98. ncbi request reprint c-kit expression in adenocarcinomas of the lung
    Patrick Micke
    Institute of Legal Medicine and Rudolf Boehm Institute of Pharmacology and Toxicology, Leipzig, Germany
    Tumour Biol 25:235-42. 2004
    ..The results of this study support clinical trials targeting the c-kit receptor with specific c-kit inhibitors (e.g. imatinib)...
  99. ncbi request reprint [COPD, a systemic disease--nutritional approaches]
    Joachim Bargon
    St Elisabethen Krankenhaus, Frankfurt Main
    Med Klin (Munich) 99:719-26. 2004
    ..Patients with COPD are often undernourished and have a low muscle mass even if the body mass is normal...