Research Topics
| R BuchertSummaryAffiliation: University of Hamburg Country: Germany Publications
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Detail Information
Publications
Low-cost, small-animal shelf for simultaneously assessing several small animals with a whole-body PET scannerR Buchert
Department of Nuclear Medicine, University Hospital Eppendorf, Hamburg, Germany
J Nucl Med Technol 28:171-2. 2000..The purpose of this work was to establish a low-cost device for simple positioning of several small animals within a whole-body PET scanner...- Improved statistical power of the multilinear reference tissue approach to the quantification of neuroreceptor ligand binding by regularizationRalph Buchert
Department of Nuclear Medicine, University Hospital Eppendorf, Hamburg, Germany
J Cereb Blood Flow Metab 23:612-20. 2003..Correct distribution volume ratios can be obtained by imposing physiologic constraints on the rate constants... - Accurate determination of metabolic rates from dynamic positron emission tomography data with very-low temporal resolutionRalph Buchert
Clinic of Nuclear Medicine, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
J Comput Assist Tomogr 27:597-605. 2003..Cardiac gating and three-dimensional (3D) acquisition of dynamic studies is hardly possible with this approach. Therefore, a new variant of the graphical method is proposed which can be used with a very low number of rather long frames... - Long-term effects of "ecstasy" use on serotonin transporters of the brain investigated by PETRalph Buchert
Department of Nuclear Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
J Nucl Med 44:375-84. 2003.... - Limitations of bi-linear regression analysis for the determination of receptor occupancy with positron emission tomographyRalph Buchert
Department of Nuclear Medicine, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
Nucl Med Commun 25:451-9. 2004..In addition, improvement of the bi-linear reference tissue method by regularization using physiological constraints was evaluated... - Is correction for age necessary in SPECT or PET of the central serotonin transporter in young, healthy adults?Ralph Buchert
Department of Nuclear Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Nucl Med 47:38-42. 2006..The aim of the present study was to verify these findings in young subjects... - A voxel-based PET investigation of the long-term effects of "Ecstasy" consumption on brain serotonin transportersRalph Buchert
Department of Nuclear Medicine, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
Am J Psychiatry 161:1181-9. 2004..quot; However, these studies have often been limited by small sample size, lack of tracer selectivity, unreliable assessment of MDMA doses, insufficiently matched comparison groups, or region-of-interest analysis... - Long-term effects of 'ecstasy' abuse on the human brain studied by FDG PETR Buchert
Department of Nuclear Medicine, University Hospital Eppendorf, Hamburg, Germany
Nucl Med Commun 22:889-97. 2001..However, several questions still remain to be answered, i.e. the correlation of the neuronal alterations and the history of ecstasy use (cumulative dose, and time since the last dose) and its reversibility... - Value of FDG PET in patients with fever of unknown originJ Lorenzen
Department of Radiology, University Hospital Eppendorf, Hamburg, Germany
Nucl Med Commun 22:779-83. 2001..In conclusion, FDG whole-body PET appears to be a promising diagnostic tool in patients with FUO, in whom conventional diagnostics had been unsuccessful... - Reversibility of ecstasy-induced reduction in serotonin transporter availability in polydrug ecstasy usersRalph Buchert
Department of Nuclear Medicine, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Eur J Nucl Med Mol Imaging 33:188-99. 2006.... - Adjusted scaling of FDG positron emission tomography images for statistical evaluation in patients with suspected Alzheimer's diseaseRalph Buchert
Department of Nuclear Medicine, University Medical School Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
J Neuroimaging 15:348-55. 2005..However, in cases of extensive hypometabolic areas, proportional scaling overestimates scaled uptake. This may cause significant underestimation of the extent of hypometabolic areas by the statistical test... - Computer simulations suggest that acute correction of hyperglycaemia with an insulin bolus protocol might be useful in brain FDG PETR Buchert
Department of Nuclear Medicine, Center of Gynaecology, Obstetrics and Paediatrics, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
Nuklearmedizin 48:44-54. 2009..Compute insulin dose with the updated blood glucose level. (iii) Wait further 20 min before injection of FDG. (iv) Continuous supervision of the patient during the whole scanning procedure... - Reduced thalamic 18F-flurodeoxyglucose retention in adults with neurofibromatosis type 1Ralph Buchert
Department of Nuclear Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Nucl Med Commun 29:17-26. 2008..18F-Flurodeoxyglucose positron emission tomography (FDG PET) might be used to investigate putative functional correlates in the brain... - IBZM tool: a fully automated expert system for the evaluation of IBZM SPECT studiesRalph Buchert
Department of Nuclear Medicine, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Eur J Nucl Med Mol Imaging 33:1073-83. 2006..Therefore, the present paper proposes a new software tool ("IBZM tool") for fully automated and standardised processing, evaluation and documentation of [(123)I]IBZM SPECT scans... - Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) usersR Thomasius
Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
Psychopharmacology (Berl) 167:85-96. 2003..Chronic recreational ecstasy (MDMA) use has often been reported to be associated with psychopathology, memory impairments and serotonergic alterations. However, the findings have not been consistent... - Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users: the longitudinal perspectiveR Thomasius
Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Germany
J Psychopharmacol 20:211-25. 2006..5 years of abstinence and thus may represent persistent functional consequences of MDMA neurotoxicity. However, alternative causes such as pre-existing group differences cannot be completely ruled out in spite of the longitudinal design... - Radioprotection of salivary glands by amifostine in high-dose radioiodine treatment. Results of a double-blinded, placebo-controlled study in patients with differentiated thyroid cancerK H Bohuslavizki
Department of Nuclear Medicine, University Hospital Eppendorf, Hamburg, Germany
Strahlenther Onkol 175:6-12. 1999..Therefore, the radioprotective effect of the radical scavenger amifostine was evaluated prospectively in patients receiving high-dose radioiodine treatment... - Impact of FDG PET on patients with differentiated thyroid cancer who present with elevated thyroglobulin and negative 131I scanB Schluter
Department of Nuclear Medicine, University Hospital Eppendorf Hamburg, Germany
J Nucl Med 42:71-6. 2001..The aim of this study was to evaluate the impact of FDG PET on treatment in these patients... - 18FDG-PET following treatment as valid predictor for disease-free survival in Hodgkin's lymphomaM de Wit
Department of Oncology and Hematology, University Hospital Eppendorf, Hamburg, Germany
Ann Oncol 12:29-37. 2001..The value of 18FDG-PET to predict the outcome after therapy in Hodgkin's lymphoma was compared to morphologic staging and ESR... - Salivary gland protection by S-2-(3-aminopropylamino)-ethylphosphorothioic acid (amifostine) in high-dose radioiodine treatment: results obtained in a rabbit animal model and in a double-blind multi-arm trialK H Bohuslavizki
Department of Nuclear Medicine, University Hospital Eppendorf, Hamburg, Germany
Cancer Biother Radiopharm 14:337-47. 1999..Thus, parenchymal damage in salivary glands induced by high-dose radioiodine therapy can be reduced significantly by amifostine. This may improve quality of life of patients with differentiated thyroid cancer... 
FDG PET/CT in cancer therapy monitoring: computer-assisted analysis of baseline together with up to two follow-upsI Apostolova
Department of Nuclear Medicine, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
Nuklearmedizin 50:83-92. 2011..The tool also supports visual analysis by local spatial registration which allows display of tumor lesions with the same orientation in all scans. The tool's stability and accuracy was tested at typical everyday image quality...- Specific neurotoxicity of chronic use of ecstasyJ Obrocki
Department of Psychiatry and Psychotherapy, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Toxicol Lett 127:285-97. 2002..The uptake rates tended to be negatively correlated with the cumulative ecstasy doses. The results indicate that younger ecstasy users may be more vulnerable with regard to neurotoxicity... - In vitro and in vivo tracer characteristics of an established multidrug-resistant human colon cancer cell lineD E Lorke
Departments of Neuroanatomy and Nuclear Medicine, University Hospital Eppendorf, Hamburg, Germany
J Nucl Med 42:646-54. 2001..Negative 99mTc-MIBI scintigrams are not necessarily associated with MDR expression. In some tumors, FDG may be an in vivo marker for MDR as suggested by PET... - FDG PET in the diagnosis of hilar cholangiocarcinomaA Fritscher-Ravens
Department of Interdisciplinary Endoscopy, University Hospital Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany
Nucl Med Commun 22:1277-85. 2001..However, FDG PET may have significant influence on the treatment strategy in as much as 20% of the patients, since it may detect distant metastases... - The simplified reference tissue model for SPECT/PET brain receptor studies. Interpretation of its parametersR Buchert
Department of Nuclear Medicine, University Medical Center Hamburg Eppendorf, Martinistrase 52, Hamburg, Germany
Nuklearmedizin 47:167-74. 2008..Empirically, the SRTM might well describe also tracers which do not fulfil this constraint, such as [(11)C]raclopride, for example. However, this has not been justified rigorously... - Time benefit in the assessment of recurrences following fractionated radiotherapy in an experimental tumour system using positron-emission tomography with 18F-fluorodeoxyglucoseM de Wit
Department of Medicine, University Hospital Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
Int J Radiat Biol 80:529-39. 2004..In addition, the time benefit of FDG-PET concerning early recognition of recurrences after fractionated radiotherapy was assessed... - Myocardial viability assessed by positron emission tomography in infants and children after the arterial switch operation and suspected infarctionC Rickers
Department of Pediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany
J Am Coll Cardiol 36:1676-83. 2000.... - IBZM SPECT and FDG PET in the differential diagnosis of Parkinsonian syndromes: comparison with respect to inter-rater agreementT Derlin
Department of Nuclear Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Nuklearmedizin 49:139-47. 2010..The present study compared both modalities with respect to inter-rater agreement in 30 patients with neurodegenerative parkinsonian syndromes (PS) confirmed by FP-CIT SPECT... - [Image quality of thickened slabs in multislice CT chest examinations: postprocessing vs. direct reconstruction]U Wedegärtner
Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg
Rofo 179:373-9. 2007..The purpose of this study was to compare the image quality of thickened slabs from MSCT chest examinations that have either been directly reconstructed from the raw data or have been retrospectively generated via postprocessing... 
Reduction of striatal glucose metabolism in McLeod choreoacanthocytosisM Oechsner
Neurologische Klinik, Universitaetsklinikum Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
J Neurol Neurosurg Psychiatry 70:517-20. 2001..Frontal lobe metabolism was not affected. Basal ganglia dysfunction with early impairment of striatal glucose metabolism thus seems obligatory for McLeod syndrome, as found in other forms of chorea with or without acanthocytosis...- Prediction of left ventricular functional recovery by dobutamine echocardiography, F-18 deoxyglucose or 99mTc sestamibi nuclear imaging in patients with chronic myocardial infarctionG K Lund
Department of Internal Medicine, Division of Cardiology, University Hospital Eppendorf, Hamburg, Germany
Cardiology 98:202-9. 2002.... - MR Imaging of Prostate Cancer: Diffusion Weighted Imaging and (3D) Hydrogen 1 (H) MR Spectroscopy in Comparison with HistologyJ Yamamura
Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
Radiol Res Pract 2011:616852. 2011..9% and 98.3%, respectively. Conclusion. The results of our study showed that both DWI and MRS should be considered as an additional and complementary tool to the T2-weighted MRI for detecting prostate cancer... - Screening for atherosclerotic plaques in the abdominal aorta in high-risk patients with multicontrast-weighted MRI: a prospective study at 3.0 and 1.5 teslaJ H Buhk
Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Br J Radiol 84:883-9. 2011..Weighted κ statistics were calculated to assess interobserver agreement... - Evaluation of a new expert system for fully automated detection of the Alzheimer's dementia pattern in FDG PETDaniel von Borczyskowski
Department of Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Germany
Nucl Med Commun 27:739-43. 2006..The PALZ tool is fully automated, easy to use, and insensitive to the spatial resolution of the PET scanner used. Therefore, it has the potential for widespread clinical use... - On the effect of sample size of the normal database on statistical power of single subject analysisRalph Buchert
Nucl Med Commun 29:837. 2008 - Gene expression patterns and tumor uptake of 18F-FDG, 18F-FLT, and 18F-FEC in PET/MRI of an orthotopic mouse xenotransplantation model of pancreatic cancerCorinna Von Forstner
Department of Nuclear Medicine, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
J Nucl Med 49:1362-70. 2008.... - Evaluation of non-uniform weighting in non-linear regression for pharmacokinetic neuroreceptor modellingFrank Thiele
Philips Research Europe, Aachen, Germany
Nucl Med Commun 29:179-88. 2008..The objective of this study was to evaluate the impact of commonly used weights on neuroreceptor quantification with the simplified reference tissue model (SRTM)... - Prognostic relevance of FDG PET in patients with neurofibromatosis type-1 and malignant peripheral nerve sheath tumoursWinfried Brenner
Department of Nuclear Medicine, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
Eur J Nucl Med Mol Imaging 33:428-32. 2006..Since histopathology and tumour grading are not well correlated with prognosis, we aimed to evaluate the potential of (18)F-fluorodeoxyglucose positron emission tomography (FDG PET) for prediction of patient outcome in MPNST... - Inhibition of serotonin transport by (+)McN5652 is noncompetitiveRené Hummerich
Biochemical Laboratory, Central Institute of Mental Health, 68159 Mannheim, Germany
Nucl Med Biol 33:317-23. 2006..The aim of the present study therefore was to pharmacologically characterize the interaction of [11C] (+)McN5652 and serotonin at the SERT... - Occurrence of an artifact in brain 18F-FDG PET with calculated attenuation correctionDaniel von Borczyskowski
Department of Nuclear Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Nucl Med Technol 34:232-4. 2006..The result was a significant overestimation and overcorrection of attenuation, particularly in the region of skin near the fist... - Visualisation of neuroblastoma growth in a Scid mouse model using [18F]FDG and [18F]FLT-PETNina Krieger-Hinck
Department of Anatomy II: Experimental Morphology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
Anticancer Res 26:3467-72. 2006..CONCLUSION: [18F]FLT showed a higher uptake than [18F]FDG and, therefore, might be more suitable for monitoring anticancer therapy, at least in this tumor model... - Ecstasy-induced reduction of the availability of the brain serotonin transporter as revealed by [11C](+)McN5652-PET and the multi-linear reference tissue model: loss of transporters or artifact of tracer kinetic modelling?Ralph Buchert
Department of Nuclear Medicine, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
J Psychopharmacol 21:628-34. 2007..SRTM analysis did not confirm previous findings in neocortical brain areas... - Potential time benefit in the assessment of recurrent rat rhabdomyosarcoma using positron emission tomography (PET) with (18)fluorodeoxyglucose depends on therapy-specific growth delayAnnette Raabe
Department of Radiotherapy and Radiooncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Strahlenther Onkol 182:610-5. 2006.... - Feasibility of central cannabinoid CB1 receptor imaging with [124I]AM281 PET demonstrated in a schizophrenic patientGeorg Berding
Department of Nuclear Medicine, University School of Medicine, Carl Neuberg Str 1, D 30625 Hannover, Germany
Psychiatry Res 147:249-56. 2006..Nevertheless, limited image contrast and relatively high radiation exposure (physical half-life of 124I: 4 days) have to be taken into account. Asymmetric receptor binding may possibly reflect pathologic changes in schizophrenia... - Dementia and leukoencephalopathy due to lymphomatosis cerebriJan Lewerenz
J Neurol Neurosurg Psychiatry 78:777-8. 2007 - Iomazenil-single-photon emission computed tomography reveals selective neuronal loss in magnetic resonance-defined mismatch areasDorothee Saur
Department of Neurology, University Medical Center Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
Stroke 37:2713-9. 2006.... - [123I]AM281 single-photon emission computed tomography imaging of central cannabinoid CB1 receptors before and after Delta9-tetrahydrocannabinol therapy and whole-body scanning for assessment of radiation dose in tourette patientsGeorg Berding
Nuclear Medicine, University School of Medicine, Hannover, Germany
Biol Psychiatry 55:904-15. 2004..Radiation exposure with [123I]AM281 is low; that with [124I]AM281 is higher but acceptable for single investigations...