Dirk Bruegger

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc Causes of metabolic acidosis in canine hemorrhagic shock: role of unmeasured ions
    Dirk Bruegger
    Clinic of Anesthesiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Crit Care 11:R130. 2007
  2. pmc Exogenous nitric oxide requires an endothelial glycocalyx to prevent postischemic coronary vascular leak in guinea pig hearts
    Dirk Bruegger
    Clinic of Anesthesiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Crit Care 12:R73. 2008
  3. doi request reprint Release of atrial natriuretic peptide precedes shedding of the endothelial glycocalyx equally in patients undergoing on- and off-pump coronary artery bypass surgery
    Dirk Bruegger
    Department of Anesthesiology, LMU Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Basic Res Cardiol 106:1111-21. 2011
  4. pmc Conservative treatment of a left atrial intramural hematoma after left atrial thrombus resection and concomitant mitral valve replacement--case report
    Dirk Bruegger
    Department of Anesthesiology, Ludwig Maximilians University Munich, Marchioninistrasse 15, 81377 Munich, Germany
    J Cardiothorac Surg 6:50. 2011
  5. ncbi request reprint Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx
    Daniel Chappell
    Clinic of Anesthesiology, Ludwig Maximilians University Munich, Munich, Germany
    Anesthesiology 107:776-84. 2007
  6. ncbi request reprint Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia
    Markus Rehm
    Clinic of Anesthesiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Circulation 116:1896-906. 2007
  7. ncbi request reprint The endothelial glycocalyx affords compatibility of Starling's principle and high cardiac interstitial albumin levels
    Matthias Jacob
    Clinic of Anesthesiology, Ludwig Maximilians University Munich, Nussbaumstr 20, D 80336 Munich, Germany
    Cardiovasc Res 73:575-86. 2007
  8. ncbi request reprint The endothelial glycocalyx prefers albumin for evoking shear stress-induced, nitric oxide-mediated coronary dilatation
    Matthias Jacob
    Clinic of Anesthesiology, Ludwig Maximilians University Munich, Munich, Germany
    J Vasc Res 44:435-43. 2007
  9. doi request reprint Perspectives in microvascular fluid handling: does the distribution of coagulation factors in human myocardium comply with plasma extravasation in venular coronary segments?
    Matthias Jacob
    Clinic of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    J Vasc Res 48:219-26. 2011
  10. ncbi request reprint Contrasting effects of colloid and crystalloid resuscitation fluids on cardiac vascular permeability
    Matthias Jacob
    Clinic of Anesthesiology, Ludwig Maximilians University Munich, Germany
    Anesthesiology 104:1223-31. 2006

Detail Information

Publications23

  1. pmc Causes of metabolic acidosis in canine hemorrhagic shock: role of unmeasured ions
    Dirk Bruegger
    Clinic of Anesthesiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Crit Care 11:R130. 2007
    ..Metabolic acidosis during hemorrhagic shock is common and conventionally considered to be due to hyperlactatemia. There is increasing awareness, however, that other nonlactate, unmeasured anions contribute to this type of acidosis...
  2. pmc Exogenous nitric oxide requires an endothelial glycocalyx to prevent postischemic coronary vascular leak in guinea pig hearts
    Dirk Bruegger
    Clinic of Anesthesiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Crit Care 12:R73. 2008
    ..The objective of this study was to investigate the effect of exogenous administration of NO during reperfusion on both coronary endothelial glycocalyx and vascular integrity...
  3. doi request reprint Release of atrial natriuretic peptide precedes shedding of the endothelial glycocalyx equally in patients undergoing on- and off-pump coronary artery bypass surgery
    Dirk Bruegger
    Department of Anesthesiology, LMU Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Basic Res Cardiol 106:1111-21. 2011
    ..These data suggest that release of ANP may lead to perturbation of the endothelial glycocalyx in both on- and off-pump coronary artery bypass surgery...
  4. pmc Conservative treatment of a left atrial intramural hematoma after left atrial thrombus resection and concomitant mitral valve replacement--case report
    Dirk Bruegger
    Department of Anesthesiology, Ludwig Maximilians University Munich, Marchioninistrasse 15, 81377 Munich, Germany
    J Cardiothorac Surg 6:50. 2011
    ..3 months after surgery, a reassessed transthoracic echocardiography and computed tomography demonstrated an almost complete resolution of the pre-existing hematoma...
  5. ncbi request reprint Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx
    Daniel Chappell
    Clinic of Anesthesiology, Ludwig Maximilians University Munich, Munich, Germany
    Anesthesiology 107:776-84. 2007
    ..Healthy vascular endothelium is coated by the endothelial glycocalyx, diminution of which increases capillary permeability, suggesting that the glycocalyx is a target for hydrocortisone action...
  6. ncbi request reprint Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia
    Markus Rehm
    Clinic of Anesthesiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Circulation 116:1896-906. 2007
    ..As already demonstrated, this structure plays a key role in the regulation of inflammation and vascular permeability...
  7. ncbi request reprint The endothelial glycocalyx affords compatibility of Starling's principle and high cardiac interstitial albumin levels
    Matthias Jacob
    Clinic of Anesthesiology, Ludwig Maximilians University Munich, Nussbaumstr 20, D 80336 Munich, Germany
    Cardiovasc Res 73:575-86. 2007
    ..To test the role of an oncotic pressure gradient across the endothelial glycocalyx with respect to extravasation of fluid and colloids and development of tissue edema in a whole organ setting...
  8. ncbi request reprint The endothelial glycocalyx prefers albumin for evoking shear stress-induced, nitric oxide-mediated coronary dilatation
    Matthias Jacob
    Clinic of Anesthesiology, Ludwig Maximilians University Munich, Munich, Germany
    J Vasc Res 44:435-43. 2007
    ..This should involve the endothelial glycocalyx (EG). A greater effect was expected of albumin versus hydroxyethyl starch (HES) perfusion, because albumin seals coronary leaks more effectively than HES in an EG-dependent way...
  9. doi request reprint Perspectives in microvascular fluid handling: does the distribution of coagulation factors in human myocardium comply with plasma extravasation in venular coronary segments?
    Matthias Jacob
    Clinic of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    J Vasc Res 48:219-26. 2011
    ..The distribution of pro- and anti-coagulatively active factors in human heart tissue has now been determined in relation to the types of microvessels...
  10. ncbi request reprint Contrasting effects of colloid and crystalloid resuscitation fluids on cardiac vascular permeability
    Matthias Jacob
    Clinic of Anesthesiology, Ludwig Maximilians University Munich, Germany
    Anesthesiology 104:1223-31. 2006
    ..Albumin is presumed to interact with the endothelial glycocalyx. The authors' objective was to compare the impact of different resuscitation fluids (human albumin, hydroxyethyl starch, saline) on vascular integrity...
  11. ncbi request reprint Changes in acid-base balance following bolus infusion of 20% albumin solution in humans
    Dirk Bruegger
    Clinic of Anesthesiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 31:1123-7. 2005
    ..To evaluate changes in acid-base balance following bolus infusions of a 20% albumin solution...
  12. doi request reprint Ischemia-reperfusion-induced unmeasured anion generation and glycocalyx shedding: sevoflurane versus propofol anesthesia
    Thorsten Annecke
    Department of Anesthesiology, University Hospital, Ludwig Maximilians University Munich, Munich, Germany
    J Invest Surg 25:162-8. 2012
    ..In vitro, sevoflurane attenuates these changes. Therefore, we compared sevoflurane with propofol with regard to the protection of the glycocalyx and the release of negatively charged substances in vivo...
  13. doi request reprint Heparin-induced thrombosis without thrombocytopenia causing fulminant pulmonary embolism after off-pump coronary artery bypass grafting
    Amir K Bigdeli
    Department of Cardiac Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, D 81377 Munchen, Germany
    Heart Surg Forum 12:E368-70. 2009
    ..We report the case of a 57-year-old male patient who developed fulminant pulmonary embolism following heparin-induced thrombosis without thrombocytopenia after off-pump coronary artery bypass surgery...
  14. ncbi request reprint Extracorporeal support in a patient with cardiogenic shock due to Aerococcus urinae endocarditis
    Dirk Bruegger
    Department of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    J Heart Valve Dis 18:418-20. 2009
    ..urinae double valve endocarditis. Following aortic and mitral valve replacement, the patient suffered from refractory cardiogenic shock; extracorporeal membrane oxygenation was used successfully as a rescue mechanical support...
  15. ncbi request reprint Effect of hypertonic saline dextran on acid-base balance in patients undergoing surgery of abdominal aortic aneurysm
    Dirk Bruegger
    Clinic of Anesthesiology, Ludwig Maximilians University Munich, Germany
    Crit Care Med 33:556-63. 2005
    ..To evaluate the magnitude and cause of metabolic acidosis after infusion of 7.5% sodium chloride 6% dextran 70...
  16. doi request reprint Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potential
    Bernhard F Becker
    Department of Physiology, Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University, Schillerstrasse 44, Munich, Germany
    Cardiovasc Res 87:300-10. 2010
    ..Infusion of human plasma albumin (to maintain mechanical and chemical stability of the endothelial surface layer) seems the easiest treatment to implement...
  17. pmc Use of methylene blue in the treatment of refractory vasodilatory shock after cardiac assist device implantation: report of four consecutive cases
    Sebastian Michel
    Department of Cardiac Surgery, Ludwig Maximilians University, Munich, Germany
    J Clin Med Res 4:212-5. 2012
    ..However, controlled clinical trials are necessary to substantiate safety and efficacy...
  18. ncbi request reprint Development and validation of a mathematical algorithm for quantifying preoperative blood volume by means of the decrease in hematocrit resulting from acute normovolemic hemodilution
    Matthias Jacob
    Anesthesiology Clinic, Ludwig Maximilians University, Munich, Germany
    Transfusion 45:562-71. 2005
    ..The interindividual variability of blood volume (BV) is high. The aim of this work was to use the decrease in large-vessel hematocrit (HK(LV)) during acute normovolemic hemodilution (ANH) as an instrument for estimating preoperative BV...
  19. pmc Delayed intracardial shunting and hypoxemia after massive pulmonary embolism in a patient with a biventricular assist device
    Thomas Weig
    Department of Anaesthesiology, Ludwig Maximilians University, Munich, Germany
    J Cardiothorac Surg 6:133. 2011
    ..Percutaneous placement of a PFO occluder device is an appropriate strategy to stop intracardiac shunting through PFO in fixed elevation of pulmonary vascular resistance...
  20. doi request reprint Huge intracardiac thrombosis in a patient on veno-arterial extracorporeal membrane oxygenation support
    Florian Weis
    Department of Anesthesiology, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    Interact Cardiovasc Thorac Surg 8:247-9. 2009
    ..Following this the patient developed a nearly complete thrombosis of the left-sided cardiac chambers, despite successful laboratory anticoagulation...
  21. ncbi request reprint Effect of high altitude and exercise on microvascular parameters in acclimatized subjects
    Andreas Bauer
    Clinic for Anaesthesiology, Ludwig Maximilians University Munich, Marchioninistr 15, 81377 Munich, Germany
    Clin Sci (Lond) 110:207-15. 2006
    ..We hypothesize that this inverse relationship reflects the haemodynamic changes at the microvascular interface, possibly attributable to the flow-induced increases in endothelial surface shear forces...
  22. ncbi request reprint Severe metabolic acidosis resulting from a dislocated gastric band
    Dirk Bruegger
    Clinic for Anesthesiology, Ludwig Maximilians University Munich, Munich, Germany
    Obes Surg 14:555-8. 2004
    ..This type of acidosis was treated successfully with intravenous administration of glucose and insulin as well as sodium bicarbonate, with urgent removal of the band...
  23. ncbi request reprint Atrial natriuretic peptide induces shedding of endothelial glycocalyx in coronary vascular bed of guinea pig hearts
    Dirk Bruegger
    Clinic for Anesthesiology, Ludwig Maximilians Univ, Marchioninistr 15, D 81377 Munich, Germany
    Am J Physiol Heart Circ Physiol 289:H1993-9. 2005
    ..Thus the permeability-increasing effect of ANP may be at least partially related to changes in the integrity of the endothelial glycocalyx...