Research Topics
| Dirk BrueggerSummaryAffiliation: University of Munich Country: Germany Publications
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Detail Information
Publications
Causes of metabolic acidosis in canine hemorrhagic shock: role of unmeasured ionsDirk Bruegger
Clinic of Anesthesiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Crit Care 11:R130. 2007..Metabolic acidosis during hemorrhagic shock is common and conventionally considered to be due to hyperlactatemia. There is increasing awareness, however, that other nonlactate, unmeasured anions contribute to this type of acidosis...- Exogenous nitric oxide requires an endothelial glycocalyx to prevent postischemic coronary vascular leak in guinea pig heartsDirk Bruegger
Clinic of Anesthesiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Crit Care 12:R73. 2008..The objective of this study was to investigate the effect of exogenous administration of NO during reperfusion on both coronary endothelial glycocalyx and vascular integrity... 
Release of atrial natriuretic peptide precedes shedding of the endothelial glycocalyx equally in patients undergoing on- and off-pump coronary artery bypass surgeryDirk Bruegger
Department of Anesthesiology, LMU Munich, Marchioninistrasse 15, 81377 Munich, Germany
Basic Res Cardiol 106:1111-21. 2011..These data suggest that release of ANP may lead to perturbation of the endothelial glycocalyx in both on- and off-pump coronary artery bypass surgery...- Conservative treatment of a left atrial intramural hematoma after left atrial thrombus resection and concomitant mitral valve replacement--case reportDirk Bruegger
Department of Anesthesiology, Ludwig Maximilians University Munich, Marchioninistrasse 15, 81377 Munich, Germany
J Cardiothorac Surg 6:50. 2011..3 months after surgery, a reassessed transthoracic echocardiography and computed tomography demonstrated an almost complete resolution of the pre-existing hematoma... 
Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyxDaniel Chappell
Clinic of Anesthesiology, Ludwig Maximilians University Munich, Munich, Germany
Anesthesiology 107:776-84. 2007..Healthy vascular endothelium is coated by the endothelial glycocalyx, diminution of which increases capillary permeability, suggesting that the glycocalyx is a target for hydrocortisone action...- Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemiaMarkus Rehm
Clinic of Anesthesiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Circulation 116:1896-906. 2007..As already demonstrated, this structure plays a key role in the regulation of inflammation and vascular permeability... - The endothelial glycocalyx affords compatibility of Starling's principle and high cardiac interstitial albumin levelsMatthias Jacob
Clinic of Anesthesiology, Ludwig Maximilians University Munich, Nussbaumstr 20, D 80336 Munich, Germany
Cardiovasc Res 73:575-86. 2007..To test the role of an oncotic pressure gradient across the endothelial glycocalyx with respect to extravasation of fluid and colloids and development of tissue edema in a whole organ setting... - The endothelial glycocalyx prefers albumin for evoking shear stress-induced, nitric oxide-mediated coronary dilatationMatthias Jacob
Clinic of Anesthesiology, Ludwig Maximilians University Munich, Munich, Germany
J Vasc Res 44:435-43. 2007..This should involve the endothelial glycocalyx (EG). A greater effect was expected of albumin versus hydroxyethyl starch (HES) perfusion, because albumin seals coronary leaks more effectively than HES in an EG-dependent way... - Perspectives in microvascular fluid handling: does the distribution of coagulation factors in human myocardium comply with plasma extravasation in venular coronary segments?Matthias Jacob
Clinic of Anesthesiology, Ludwig Maximilians University, Munich, Germany
J Vasc Res 48:219-26. 2011..The distribution of pro- and anti-coagulatively active factors in human heart tissue has now been determined in relation to the types of microvessels... - Contrasting effects of colloid and crystalloid resuscitation fluids on cardiac vascular permeabilityMatthias Jacob
Clinic of Anesthesiology, Ludwig-Maximilians University Munich, Germany
Anesthesiology 104:1223-31. 2006..This effect was partly independent of colloid osmotic pressure and may be attributable to an interaction of albumin with the endothelial glycocalyx... - Changes in acid-base balance following bolus infusion of 20% albumin solution in humansDirk Bruegger
Clinic of Anesthesiology, Ludwig-Maximilians-University, Marchioninistrasse 15, 81377 Munich, Germany
Intensive Care Med 31:1123-7. 2005..Alternatively, the acidifying effect of the 20% albumin solution may stem from the titratable acid content of the solution... - Ischemia-reperfusion-induced unmeasured anion generation and glycocalyx shedding: sevoflurane versus propofol anesthesiaThorsten Annecke
Department of Anesthesiology, University Hospital, Ludwig Maximilians University Munich, Munich, Germany
J Invest Surg 25:162-8. 2012..In vitro, sevoflurane attenuates these changes. Therefore, we compared sevoflurane with propofol with regard to the protection of the glycocalyx and the release of negatively charged substances in vivo... - Heparin-induced thrombosis without thrombocytopenia causing fulminant pulmonary embolism after off-pump coronary artery bypass graftingAmir K Bigdeli
Department of Cardiac Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, D 81377 Munchen, Germany
Heart Surg Forum 12:E368-70. 2009..We report the case of a 57-year-old male patient who developed fulminant pulmonary embolism following heparin-induced thrombosis without thrombocytopenia after off-pump coronary artery bypass surgery... - Extracorporeal support in a patient with cardiogenic shock due to Aerococcus urinae endocarditisDirk Bruegger
Department of Anesthesiology, Ludwig Maximilians University, Munich, Germany
J Heart Valve Dis 18:418-20. 2009..urinae double valve endocarditis. Following aortic and mitral valve replacement, the patient suffered from refractory cardiogenic shock; extracorporeal membrane oxygenation was used successfully as a rescue mechanical support... - Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potentialBernhard F Becker
Department of Physiology, Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University, Schillerstrasse 44, Munich, Germany
Cardiovasc Res 87:300-10. 2010..Infusion of human plasma albumin (to maintain mechanical and chemical stability of the endothelial surface layer) seems the easiest treatment to implement... - Use of methylene blue in the treatment of refractory vasodilatory shock after cardiac assist device implantation: report of four consecutive casesSebastian Michel
Department of Cardiac Surgery, Ludwig Maximilians University, Munich, Germany
J Clin Med Res 4:212-5. 2012..However, controlled clinical trials are necessary to substantiate safety and efficacy... - Effect of hypertonic saline dextran on acid-base balance in patients undergoing surgery of abdominal aortic aneurysmDirk Bruegger
Clinic of Anesthesiology, Ludwig-Maximilians-University Munich, Germany
Crit Care Med 33:556-63. 2005..This suggests dilution of plasma buffers or a decrease in strong ion difference to be the primary cause of metabolic acidosis... - Delayed intracardial shunting and hypoxemia after massive pulmonary embolism in a patient with a biventricular assist deviceThomas Weig
Department of Anaesthesiology, Ludwig Maximilians University, Munich, Germany
J Cardiothorac Surg 6:133. 2011..Percutaneous placement of a PFO occluder device is an appropriate strategy to stop intracardiac shunting through PFO in fixed elevation of pulmonary vascular resistance... - Development and validation of a mathematical algorithm for quantifying preoperative blood volume by means of the decrease in hematocrit resulting from acute normovolemic hemodilutionMatthias Jacob
Anesthesiology Clinic, Ludwig Maximilians University, Munich, Germany
Transfusion 45:562-71. 2005..The interindividual variability of blood volume (BV) is high. The aim of this work was to use the decrease in large-vessel hematocrit (HK(LV)) during acute normovolemic hemodilution (ANH) as an instrument for estimating preoperative BV... - Huge intracardiac thrombosis in a patient on veno-arterial extracorporeal membrane oxygenation supportFlorian Weis
Department of Anesthesiology, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
Interact Cardiovasc Thorac Surg 8:247-9. 2009..Following this the patient developed a nearly complete thrombosis of the left-sided cardiac chambers, despite successful laboratory anticoagulation... - Effect of high altitude and exercise on microvascular parameters in acclimatized subjectsAndreas Bauer
Clinic for Anaesthesiology, Ludwig Maximilians University Munich, Marchioninistr 15, 81377 Munich, Germany
Clin Sci (Lond) 110:207-15. 2006..We hypothesize that this inverse relationship reflects the haemodynamic changes at the microvascular interface, possibly attributable to the flow-induced increases in endothelial surface shear forces... - Severe metabolic acidosis resulting from a dislocated gastric bandDirk Bruegger
Clinic for Anesthesiology, Ludwig-Maximilians-University Munich, Munich, Germany
Obes Surg 14:555-8. 2004..This type of acidosis was treated successfully with intravenous administration of glucose and insulin as well as sodium bicarbonate, with urgent removal of the band... - Atrial natriuretic peptide induces shedding of endothelial glycocalyx in coronary vascular bed of guinea pig heartsDirk Bruegger
Clinic for Anesthesiology, Ludwig-Maximilians-Univ, Marchioninistr. 15, D-81377 Munich, Germany
Am J Physiol Heart Circ Physiol 289:H1993-9. 2005..Thus the permeability-increasing effect of ANP may be at least partially related to changes in the integrity of the endothelial glycocalyx...