O Brüstle

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Pluripotent stem cell-derived somatic stem cells as tool to study the role of microRNAs in early human neural development
    B Roese-Koerner
    Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, Sigmund Freud Strasse 25, D 53127 Bonn, Germany
    Curr Mol Med 13:707-22. 2013
  2. ncbi request reprint Disease-specific iPS cell models in neuroscience
    M Peitz
    Institute of Reconstructive Neurobiology, University of Bonn LIFE and BRAIN Center, and LIFE and BRAIN GmbH, Sigmund Freud Strasse 25, D 53127 Bonn, Germany
    Curr Mol Med 13:832-41. 2013
  3. pmc Human embryonic stem cell-derived neurons establish region-specific, long-range projections in the adult brain
    Julius A Steinbeck
    Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, 53127 Bonn, Germany
    Cell Mol Life Sci 69:461-70. 2012
  4. pmc Transcription factor-based modulation of neural stem cell differentiation using direct protein transduction
    Kristin Stock
    Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn, Bonn, Germany
    Cell Mol Life Sci 67:2439-49. 2010
  5. ncbi request reprint Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats
    O Brüstle
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4092, USA
    Nat Biotechnol 16:1040-4. 1998
  6. ncbi request reprint Building brains: neural chimeras in the study of nervous system development and repair
    O Brüstle
    Department of Neuropathology, University of Bonn Medical Center, Germany
    Brain Pathol 9:527-45. 1999
  7. ncbi request reprint Embryonic stem cell-derived glial precursors: a source of myelinating transplants
    O Brüstle
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Science 285:754-6. 1999
  8. ncbi request reprint Neuronal progenitors as tools for cell replacement in the nervous system
    O Brüstle
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4092, USA
    Curr Opin Neurobiol 6:688-95. 1996
  9. ncbi request reprint Increase of nestin-immunoreactive neural precursor cells in the dentate gyrus of pediatric patients with early-onset temporal lobe epilepsy
    I Blumcke
    Department of Neuropathology, University of Bonn Medical Center, Germany
    Hippocampus 11:311-21. 2001
  10. ncbi request reprint Long-term survival, migration, and differentiation of neural cells without functional NMDA receptors in vivo
    U Maskos
    Laboratory of Molecular Biology, NINDS NIH, Bethesda, Maryland 20892 4092, USA
    Dev Biol 231:103-12. 2001

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Pluripotent stem cell-derived somatic stem cells as tool to study the role of microRNAs in early human neural development
    B Roese-Koerner
    Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, Sigmund Freud Strasse 25, D 53127 Bonn, Germany
    Curr Mol Med 13:707-22. 2013
    ..This work provides insights into the regulation of early human neuroepithelial cells by microRNAs and highlights the potential of controlling differentiation of human stem cells by modulating the expression of selected microRNAs...
  2. ncbi request reprint Disease-specific iPS cell models in neuroscience
    M Peitz
    Institute of Reconstructive Neurobiology, University of Bonn LIFE and BRAIN Center, and LIFE and BRAIN GmbH, Sigmund Freud Strasse 25, D 53127 Bonn, Germany
    Curr Mol Med 13:832-41. 2013
    ..In this review, we focus on the current progress made in hiPS cell-based modeling of neurodegenerative diseases and discuss recent advances in the quality assessment of hiPS cell lines...
  3. pmc Human embryonic stem cell-derived neurons establish region-specific, long-range projections in the adult brain
    Julius A Steinbeck
    Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, 53127 Bonn, Germany
    Cell Mol Life Sci 69:461-70. 2012
    ..Together, these data indicate that neurons derived from human pluripotent stem cells are endowed with a remarkable potential to establish orthotopic long-range projections in the adult mammalian brain...
  4. pmc Transcription factor-based modulation of neural stem cell differentiation using direct protein transduction
    Kristin Stock
    Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn, Bonn, Germany
    Cell Mol Life Sci 67:2439-49. 2010
    ..The results of this proof-of-concept study depict direct intracellular delivery of transcription factors as alternative modality to control lineage differentiation in NSC cultures without genetic modification...
  5. ncbi request reprint Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats
    O Brüstle
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4092, USA
    Nat Biotechnol 16:1040-4. 1998
    ..These chimeras provide a unique model to study human neural cell migration and differentiation in a functional nervous system...
  6. ncbi request reprint Building brains: neural chimeras in the study of nervous system development and repair
    O Brüstle
    Department of Neuropathology, University of Bonn Medical Center, Germany
    Brain Pathol 9:527-45. 1999
    ..Generation of interspecies neural chimeras composed of human and rodent cells facilitates the translation of these advances into clinical strategies for human nervous system repair...
  7. ncbi request reprint Embryonic stem cell-derived glial precursors: a source of myelinating transplants
    O Brüstle
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Science 285:754-6. 1999
    ..Thus, ES cells can serve as a valuable source of cell type-specific somatic precursors for neural transplantation...
  8. ncbi request reprint Neuronal progenitors as tools for cell replacement in the nervous system
    O Brüstle
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4092, USA
    Curr Opin Neurobiol 6:688-95. 1996
    ..These findings, together with recent evidence for the persistence of neural stem cells in the adult mammalian brain, have made precursor cell recruitment a new focus in CNS reconstruction...
  9. ncbi request reprint Increase of nestin-immunoreactive neural precursor cells in the dentate gyrus of pediatric patients with early-onset temporal lobe epilepsy
    I Blumcke
    Department of Neuropathology, University of Bonn Medical Center, Germany
    Hippocampus 11:311-21. 2001
    ..These findings provide evidence for increased neurogenesis in pediatric patients with early onset of temporal lobe epilepsy and/or point towards a delay in hippocampal maturation in a subgroup of patients with TLE...
  10. ncbi request reprint Long-term survival, migration, and differentiation of neural cells without functional NMDA receptors in vivo
    U Maskos
    Laboratory of Molecular Biology, NINDS NIH, Bethesda, Maryland 20892 4092, USA
    Dev Biol 231:103-12. 2001
    ....