Bernhard Brüne

Summary

Affiliation: University of Kaiserslautern
Country: Germany

Publications

  1. ncbi Nitric oxide and apoptosis in mesangial cells
    Bernhard Brüne
    Department of Cell Biology, University of Kaiserslautern, Erwin Schrodinger Strasse, 67663 Kaiserslautern, Germany
    Kidney Int 61:786-9. 2002
  2. ncbi The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1alpha (HIF-1alpha)
    Bernhard Brüne
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Kaiserslautern, Germany
    Curr Med Chem 10:845-55. 2003
  3. ncbi Nitric oxide evoked p53-accumulation and apoptosis
    Bernhard Brüne
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Erwin Schroedinger Strasse 13 4, 67663 Kaiserslautern, Germany
    Toxicol Lett 139:119-23. 2003
  4. ncbi Nitric oxide: NO apoptosis or turning it ON?
    Bernhard Brüne
    University of Kaiserslautern, Faculty of Biology, Department of Cell Biology, 67663 Kaiserslautern, Germany
    Cell Death Differ 10:864-9. 2003
  5. ncbi The role of nitric oxide and cyclooxygenase-2 in attenuating apoptosis
    Bernhard Brüne
    University of Kaiserslautern, Faculty of Biology, Department of Cell Biology, Germany
    J Environ Pathol Toxicol Oncol 21:103-12. 2002
  6. ncbi The intimate relation between nitric oxide and superoxide in apoptosis and cell survival
    Bernhard Brüne
    University of Kaiserslautern, Faculty of Biology, Department of Cell Biology, Erwin Schrodinger Strasse, 67663 Kaiserslautern, Germany
    Antioxid Redox Signal 7:497-507. 2005
  7. ncbi Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms
    Vladimir A Shatrov
    Faculty of Biology, Department of Cell Biology, University of Kaiserslautern, Germany
    Blood 101:4847-9. 2003
  8. ncbi Activation of peroxisome proliferator-activated receptor gamma by nitric oxide in monocytes/macrophages down-regulates p47phox and attenuates the respiratory burst
    Andreas von Knethen
    Institute of Cell Biology, University of Kaiserslautern, Germany
    J Immunol 169:2619-26. 2002
  9. ncbi HIF-1alpha and p53 as targets of NO in affecting cell proliferation, death and adaptation
    Jie Zhou
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Kaiserslautern, Germany
    Curr Mol Med 4:741-51. 2004
  10. ncbi NO and TNF-alpha released from activated macrophages stabilize HIF-1alpha in resting tubular LLC-PK1 cells
    Jie Zhou
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, 67663 Kaiserslautern, Germany
    Am J Physiol Cell Physiol 284:C439-46. 2003

Collaborators

Detail Information

Publications27

  1. ncbi Nitric oxide and apoptosis in mesangial cells
    Bernhard Brüne
    Department of Cell Biology, University of Kaiserslautern, Erwin Schrodinger Strasse, 67663 Kaiserslautern, Germany
    Kidney Int 61:786-9. 2002
    ..The crosstalk between cell destructive and protective pathways, and their activation or inhibition under the modulatory influence of NO and/or O(-)(2) are summarized...
  2. ncbi The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1alpha (HIF-1alpha)
    Bernhard Brüne
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Kaiserslautern, Germany
    Curr Med Chem 10:845-55. 2003
    ..These contrasting situations evoked by NO provide insights into basic chemical reactions, biochemical signal transduction pathways with broad implications for medicine...
  3. ncbi Nitric oxide evoked p53-accumulation and apoptosis
    Bernhard Brüne
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Erwin Schroedinger Strasse 13 4, 67663 Kaiserslautern, Germany
    Toxicol Lett 139:119-23. 2003
    ..This was verified by heterokaryon analysis. We conclude that attenuated nuclear export contributes to stabilization and activation of p53 under the influence of NO...
  4. ncbi Nitric oxide: NO apoptosis or turning it ON?
    Bernhard Brüne
    University of Kaiserslautern, Faculty of Biology, Department of Cell Biology, 67663 Kaiserslautern, Germany
    Cell Death Differ 10:864-9. 2003
    ..Summarizing emerging concepts to understand p53 accumulation on the one hand while proposing inhibition of procaspase processing on the other may help to define the pro- versus antiapoptotic roles of NO...
  5. ncbi The role of nitric oxide and cyclooxygenase-2 in attenuating apoptosis
    Bernhard Brüne
    University of Kaiserslautern, Faculty of Biology, Department of Cell Biology, Germany
    J Environ Pathol Toxicol Oncol 21:103-12. 2002
    ..Our experiments underscore the role of COX-2 in attenuating natural occurring cell death (i.e., apoptosis)...
  6. ncbi The intimate relation between nitric oxide and superoxide in apoptosis and cell survival
    Bernhard Brüne
    University of Kaiserslautern, Faculty of Biology, Department of Cell Biology, Erwin Schrodinger Strasse, 67663 Kaiserslautern, Germany
    Antioxid Redox Signal 7:497-507. 2005
    ....
  7. ncbi Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms
    Vladimir A Shatrov
    Faculty of Biology, Department of Cell Biology, University of Kaiserslautern, Germany
    Blood 101:4847-9. 2003
    ..This finding may suggest a role of HIF-1 in atherosclerosis and oxLDL-induced pathogenesis...
  8. ncbi Activation of peroxisome proliferator-activated receptor gamma by nitric oxide in monocytes/macrophages down-regulates p47phox and attenuates the respiratory burst
    Andreas von Knethen
    Institute of Cell Biology, University of Kaiserslautern, Germany
    J Immunol 169:2619-26. 2002
    ..We conclude that NO participates in controlling the pro- vs anti-inflammatory phenotype of macrophages by modulating PPARgamma...
  9. ncbi HIF-1alpha and p53 as targets of NO in affecting cell proliferation, death and adaptation
    Jie Zhou
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Kaiserslautern, Germany
    Curr Mol Med 4:741-51. 2004
    ..Considering HIF-1alpha and p53 as targets of reactive nitrogen intermediates (RNI) may provide insights into basic chemical reactions, biochemical signal transduction pathways with broad implications for medicine...
  10. ncbi NO and TNF-alpha released from activated macrophages stabilize HIF-1alpha in resting tubular LLC-PK1 cells
    Jie Zhou
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, 67663 Kaiserslautern, Germany
    Am J Physiol Cell Physiol 284:C439-46. 2003
    ..We conclude that NO and TNF-alpha, derived from activated macrophages, provoke HIF-1alpha stabilization in LLC-PK(1) cells under normoxic conditions, which underscores HIF-1alpha stabilization due to intercellular regulation...
  11. ncbi Activation-induced depletion of protein kinase C alpha provokes desensitization of monocytes/macrophages in sepsis
    Andreas von Knethen
    Department of Cell Biology, University Kaiserslautern, Kaiserslautern, Germany
    J Immunol 174:4960-5. 2005
    ..We suggest that depletion of PKC alpha in monocytes from septic patients contributes to cellular desensitization, giving rise to clinical symptoms of sepsis...
  12. ncbi HIF-1 and p53: communication of transcription factors under hypoxia
    Tobias Schmid
    University of Kaiserslautern, Faculty of Biology, Department of Cell Biology, Kaiserslautern 67663, Germany
    J Cell Mol Med 8:423-31. 2004
    ..Here we summarize recent information on accumulation of HIF-1alpha and p53 under hypoxia and provide a model to explain the communication between HIF-1 and p53 under (patho)physiological conditions...
  13. pmc p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1)
    Tobias Schmid
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Erwin Schroedinger Strasse 13 4, 67663 Kaiserslautern, Germany
    Biochem J 380:289-95. 2004
    ..Thus once p53 becomes activated under conditions of severe hypoxia/anoxia, it contributes to terminating HIF-1 responses...
  14. ncbi Inhibition of GSK3beta by indirubins restores HIF-1alpha accumulation under prolonged periods of hypoxia/anoxia
    Steffen E Schnitzer
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Erwin Schroedinger Strasse, 67663 Kaiserslautern, Germany
    FEBS Lett 579:529-33. 2005
    ..Ruling stability regulation of HIF-1alpha protein and/or enhanced transcription of HIF-1alpha mRNA via GSK3beta inhibition out is suggestive for translational modulation of HIF-1alpha under the influence of GSK3beta...
  15. ncbi Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis
    Anja Tautenhahn
    University of Kaiserslautern, Institute of Cell Biology, Erwin Schroedinger Strasse, Germany
    J Leukoc Biol 73:665-72. 2003
    ..These data may be relevant for pathophysiological conditions accompanied with lymphopenia of T cells under conditions such as sepsis...
  16. ncbi PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation
    Jie Zhou
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, 67663 Kaiserslautern, Germany
    J Biol Chem 279:13506-13. 2004
    ..We conclude that PI3K/Akt contributes to HIF-1alpha stabilization by provoking expression of heat shock proteins...
  17. ncbi NO and transcriptional regulation: from signaling to death
    Jie Zhou
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Erwin Schroedinger Strasse, 67663 Kaiserslautern, Germany
    Toxicology 208:223-33. 2005
    ..e. apoptosis with important implications for medicine...
  18. pmc Nitric oxide donors inhibit formation of the Apaf-1/caspase-9 apoptosome and activation of caspases
    Birgit Zech
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Kaiserslautern, Germany
    Biochem J 371:1055-64. 2003
    ....
  19. pmc Induced expression of manganese superoxide dismutase by non-toxic concentrations of oxidized low-density lipoprotein (oxLDL) protects against oxLDL-mediated cytotoxicity
    Vladimir A Shatrov
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Erwin Schroedinger Strasse, 67663 Kaiserslautern, Germany
    Biochem J 374:505-11. 2003
    ..Our findings suggest that up-regulation of MnSOD by low concentrations of oxLDL is critical for protection towards oxLDL-mediated cytotoxicity...
  20. ncbi Functional integrity of nuclear factor kappaB, phosphatidylinositol 3'-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor alpha-evoked Bcl-2 expression to provoke internal ribosome entry site-dependent translation of hypox
    Jie Zhou
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Kaiserslautern, Germany
    Cancer Res 64:9041-8. 2004
    ..These observations suggest a link between Bcl-2 and HIF-1alpha expression, a situation with potential relevance to cancer biology...
  21. ncbi Nitric oxide induces phosphorylation of p53 and impairs nuclear export
    Nicole Schneiderhan
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Erwin Schrodinger Strasse, 67663 Kaiserslautern, Germany
    Oncogene 22:2857-68. 2003
    ..This was verified by heterokaryon analysis. We conclude that attenuated nuclear export contributes to stabilization and activation of p53 under the influence of NO...
  22. ncbi PPARgamma--an important regulator of monocyte/macrophage function
    Andreas von Knethen
    Department of Cell Biology, University of Kaiserslautern, Kaiserslautern, Germany
    Arch Immunol Ther Exp (Warsz) 51:219-26. 2003
    ..Summarizing current information, a model is proposed which gives rise to potential new therapeutic possibilities for the treatment of diseases presumably involving PPARgamma-dependent regulatory circuits...
  23. ncbi HIF-1 alpha protein as a target for S-nitrosation
    Vadim V Sumbayev
    University of Kaiserslautern, Faculty of Biology, Department of Cell Biology, Erwin Schrodinger Strasse, 67663 Kaiserslautern, Germany
    FEBS Lett 535:106-12. 2003
    ..In conclusion, HIF-1 alpha is a target for S-nitrosation by exogenously and endogenously produced NO...
  24. ncbi Mesangial cells but not hepatocytes are protected against NO/O(2)(-) cogeneration: mechanistic considerations
    Vadim V Sumbayev
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Erwin Schrodinger Strasse, 67663, Kaiserslautern, Germany
    Eur J Pharmacol 444:1-11. 2002
    ..In conclusion, NO/O(2)(-) sensitivity is cell type specific and is determined by the glutathione redox system...
  25. pmc Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1alpha through a nuclear factor-kappaB-dependent pathway
    Jie Zhou
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, 67663 Kaiserslautern, Germany
    Mol Biol Cell 14:2216-25. 2003
    ..These data indicate that HIF-1alpha accumulation by TNF-alpha demands the NF-kappaB pathway, preserves ubiquitination of HIF-1alpha, and allows the HIF-1alpha-pVHL interaction...
  26. ncbi Dualism of oxidized lipoproteins in provoking and attenuating the oxidative burst in macrophages: role of peroxisome proliferator-activated receptor-gamma
    Barbara Fischer
    Faculty of Biology, Department of Cell Biology, University of Kaiserslautern, Kaiserslautern, Germany
    J Immunol 168:2828-34. 2002
    ..Desensitization of macrophages may have important consequences for the behavior of macrophages/foam cells in atherosclerotic lesions...
  27. pmc Heat-shock protein 70 attenuates nitric oxide-induced apoptosis in RAW macrophages by preventing cytochrome c release
    Sabine D Klein
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Erwin Schrodinger Strasse, 67663 Kaiserslautern, Germany
    Biochem J 362:635-41. 2002
    ..We conclude that, in macrophages, Hsp70 interferes with cytochrome c release from mitochondria and, thereby, prevents nitric oxide-induced apoptosis, but leaves p53 accumulation and interference in the cell cycle intact...