Walburgis Brenner

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. doi request reprint Migration of renal tumor cells depends on dephosphorylation of Shc by PTEN
    Elke Schneider
    Department of Urology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr 1, Mainz, Germany
    Int J Oncol 38:823-31. 2011
  2. ncbi request reprint Differential inhibition of renal cancer cell invasion mediated by fibronectin, collagen IV and laminin
    W Brenner
    Urological Clinic and Policlinic, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131, Mainz, Germany
    Cancer Lett 155:199-205. 2000
  3. ncbi request reprint Regulation of beta1 integrin expression by PKCepsilon in renal cancer cells
    Walburgis Brenner
    Department of Urology, University of Mainz, D 55131 Mainz, Germany
    Int J Oncol 25:1157-63. 2004
  4. ncbi request reprint Protein kinase C eta is associated with progression of renal cell carcinoma (RCC)
    Walburgis Brenner
    Department of Urology, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Anticancer Res 23:4001-6. 2003
  5. ncbi request reprint Loss of tumor suppressor protein PTEN during renal carcinogenesis
    Walburgis Brenner
    Department of Urology, University of Mainz, Mainz, Germany
    Int J Cancer 99:53-7. 2002
  6. ncbi request reprint Identification of fatty acid binding proteins as markers associated with the initiation and/or progression of renal cell carcinoma
    Barbara Seliger
    Johannes Gutenberg University Mainz, 3rd Department of Internal Medicine, Mainz, Germany
    Proteomics 5:2631-40. 2005
  7. pmc Adhesion of renal carcinoma cells to endothelial cells depends on PKCmu
    Walburgis Brenner
    Department of Urology, University Medical Center Mainz, Mainz, Germany
    BMC Cancer 10:183. 2010
  8. doi request reprint Intraoperative peripheral frozen sections do not significantly affect prognosis after nerve-sparing radical prostatectomy for prostate cancer
    Rolf Gillitzer
    Department of Urology, University Medical Center Department of Pathology, University Medical Centre, Johannes Gutenberg University, Mainz, Germany
    BJU Int 107:755-9. 2011
  9. doi request reprint Treatment efficacy and outcomes using a third generation shockwave lithotripter
    Andreas Neisius
    Department of Urology, University Medical Center Mainz, Mainz, Germany Division of Urologic Surgery, Duke University Medical Center, Durham, NC, USA
    BJU Int 112:972-81. 2013
  10. ncbi request reprint Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses
    Rudolf Lichtenfels
    IIIrd Department of Internal Medicine, Johannes Gutenberg University, Langenbeckstr 1, D 55101 Mainz, Germany
    Biochim Biophys Acta 1646:21-31. 2003

Collaborators

Detail Information

Publications32

  1. doi request reprint Migration of renal tumor cells depends on dephosphorylation of Shc by PTEN
    Elke Schneider
    Department of Urology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr 1, Mainz, Germany
    Int J Oncol 38:823-31. 2011
    ..This new insight opens an alley of additional approaches complementing current cancer therapy and metastasis prediction in RCC...
  2. ncbi request reprint Differential inhibition of renal cancer cell invasion mediated by fibronectin, collagen IV and laminin
    W Brenner
    Urological Clinic and Policlinic, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131, Mainz, Germany
    Cancer Lett 155:199-205. 2000
    ..The molecular interactions in this process are strongly dependent on beta(1)-integrins and the corresponding amino acid sequence RGD...
  3. ncbi request reprint Regulation of beta1 integrin expression by PKCepsilon in renal cancer cells
    Walburgis Brenner
    Department of Urology, University of Mainz, D 55131 Mainz, Germany
    Int J Oncol 25:1157-63. 2004
    ..These findings provide a conceptual basis for treatment of renal cell carcinoma by interfering with tumor cell proliferation...
  4. ncbi request reprint Protein kinase C eta is associated with progression of renal cell carcinoma (RCC)
    Walburgis Brenner
    Department of Urology, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Anticancer Res 23:4001-6. 2003
    ..The expression of all eleven PKC-isoforms in clear cell RCCs (ccRCC) and in the corresponding normal renal tissue was quantified. A possible association of PKC-isoforms with histopathological parameters was examined...
  5. ncbi request reprint Loss of tumor suppressor protein PTEN during renal carcinogenesis
    Walburgis Brenner
    Department of Urology, University of Mainz, Mainz, Germany
    Int J Cancer 99:53-7. 2002
    ..We conclude that PTEN expression and PTEN membrane localization are lost during early renal cell carcinogenesis and may therefore be a valuable RCC tumor marker...
  6. ncbi request reprint Identification of fatty acid binding proteins as markers associated with the initiation and/or progression of renal cell carcinoma
    Barbara Seliger
    Johannes Gutenberg University Mainz, 3rd Department of Internal Medicine, Mainz, Germany
    Proteomics 5:2631-40. 2005
    ..These include members of the fatty acid binding protein family, which have the potential to serve as diagnostic or prognostic markers for the screening of RCC patients...
  7. pmc Adhesion of renal carcinoma cells to endothelial cells depends on PKCmu
    Walburgis Brenner
    Department of Urology, University Medical Center Mainz, Mainz, Germany
    BMC Cancer 10:183. 2010
    ..To identify a relation between PKC isoforms and tumor progression in renal cell carcinoma (RCC), the influence of PKC isoforms on cell adhesion and proliferation, and possible influences of integrins were analyzed in RCC cells...
  8. doi request reprint Intraoperative peripheral frozen sections do not significantly affect prognosis after nerve-sparing radical prostatectomy for prostate cancer
    Rolf Gillitzer
    Department of Urology, University Medical Center Department of Pathology, University Medical Centre, Johannes Gutenberg University, Mainz, Germany
    BJU Int 107:755-9. 2011
    ....
  9. doi request reprint Treatment efficacy and outcomes using a third generation shockwave lithotripter
    Andreas Neisius
    Department of Urology, University Medical Center Mainz, Mainz, Germany Division of Urologic Surgery, Duke University Medical Center, Durham, NC, USA
    BJU Int 112:972-81. 2013
    ..To compare the results of the Lithoskop with other currently available systems and the reference standard lithotripter, the HM-3 (Dornier MedTech Europe GmbH, Wessling, Germany)...
  10. ncbi request reprint Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses
    Rudolf Lichtenfels
    IIIrd Department of Internal Medicine, Johannes Gutenberg University, Langenbeckstr 1, D 55101 Mainz, Germany
    Biochim Biophys Acta 1646:21-31. 2003
    ..Thus, PROTEOMEX represents a valuable approach for the identification of metabolic enzymes which might be used as markers for the diagnosis of RCC...
  11. doi request reprint Functional analysis of elective nephron-sparing surgery vs radical nephrectomy for renal tumors larger than 4 cm
    Frederik C Roos
    Department of Urology, Medical Center, Johannes Gutenberg University, Mainz, Germany
    Urology 79:607-13. 2012
    ..Little is known about perioperative morbidity and long-term functional outcome of patients after elective NSS compared with radical nephrectomy (RN) in renal tumors >4 cm...
  12. ncbi request reprint Superior antitumor in vitro responses of allogeneic matched sibling compared with autologous patient CD8+ T cells
    Sandra Kausche
    Department of Medicine III, Hematology and Oncology, University of Mainz, Mainz, Germany
    Cancer Res 66:11447-54. 2006
    ..These data encourage the generation of antitumor T-cell products from HLA-identical siblings and their potential use in adoptive immunotherapy of metastatic RCC patients...
  13. ncbi request reprint Identification of markers for the selection of patients undergoing renal cell carcinoma-specific immunotherapy
    Barbara Seliger
    The Johannes Gutenberg University, IIIrd Department of Internal Medicine, Mainz, Germany
    Proteomics 3:979-90. 2003
    ..In conclusion, conventional proteome analysis as well as PROTEOMEX could be successfully employed for the identification of markers which may allow the selection of patients prior to specific immunotherapy...
  14. ncbi request reprint Migration of renal carcinoma cells is dependent on protein kinase Cdelta via beta1 integrin and focal adhesion kinase
    Walburgis Brenner
    Department of Urology, University of Mainz, D 55131 Mainz, Germany
    Int J Oncol 32:1125-31. 2008
    ..These results can provide a basis for new strategies in preventing metastases of renal cell carcinoma...
  15. doi request reprint Oncologic long-term outcome of elective nephron-sparing surgery versus radical nephrectomy in patients with renal cell carcinoma stage pT1b or greater in a matched-pair cohort
    Frederik C Roos
    Department of Urology, Medical Center, Johannes Gutenberg University, Mainz, Germany
    Urology 77:803-8. 2011
    ..To analyze the oncologic outcome and overall survival (OS) for patients with renal cell carcinoma (RCC) >4 cm undergoing radical nephrectomy (RN) or elective nephron-sparing surgery (NSS) in a matched-pair cohort...
  16. doi request reprint Short-term functional and oncologic outcomes of nephron-sparing surgery for renal tumours ≥ 7 cm
    Frank Becker
    Department of Urology, University of Saarland, Kirrbergerstrasse, Homburg Saar, Germany
    Eur Urol 59:931-7. 2011
    ..Little is known about perioperative and oncologic outcomes of patients following NSS in renal tumours ≥ 7 cm in the presence of a healthy contralateral kidney...
  17. ncbi request reprint Interferon-beta: a therapeutic for autoimmune lupus in MRL-Faslpr mice
    Andreas Schwarting
    First Department of Medicine, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz 55131, Germany
    J Am Soc Nephrol 16:3264-72. 2005
    ..In conclusion, IFN-beta treatment of lupus nephritis in MRL-Fas(lpr) mice is remarkably beneficial and suggests that IFN-beta may be an appealing therapeutic candidate for subtypes of human lupus...
  18. ncbi request reprint ERCC1 and XPF expression in human testicular germ cell tumors
    Beate Köberle
    Institute of Toxicology, University Medical Center Mainz, Mainz, Germany
    Oncol Rep 23:223-7. 2010
    ..The data indicate a possible up-regulation of ERCC1 and XPF during TGCT progression...
  19. doi request reprint Perioperative morbidity and renal function in young and elderly patients undergoing elective nephron-sparing surgery or radical nephrectomy for renal tumours larger than 4 cm
    Frederik C Roos
    Department of Urology, Medical Center, Johannes Gutenberg University, Mainz, Germany
    BJU Int 107:554-61. 2011
    ....
  20. pmc High calcium concentration in bones promotes bone metastasis in renal cell carcinomas expressing calcium-sensing receptor
    Elke Joeckel
    Department of Urology, Johannes Gutenberg University Medical Center, Langenbeckstr 1, Mainz 55131, Germany
    Mol Cancer 13:42. 2014
    ..In this study, we show a promoting effect of an enhanced extracellular calcium concentration on mechanisms of bone metastasis via the calcium-sensing receptor (CaSR) and its downstream signaling molecules...
  21. doi request reprint Impact of several histopathological prognosticators and local tumour extension on oncological outcome in pT3b/c N0M0 renal cell carcinoma
    Frederik C Roos
    Department of Urology, Johannes Gutenberg University, Mainz, Germany
    BJU Int 104:461-9. 2009
    ....
  22. doi request reprint Single center comparison of anastomotic strictures after radical perineal and radical retropubic prostatectomy
    Rolf Gillitzer
    Department of Urology, Johannes Gutenberg University Medical School, Mainz, Germany
    Urology 76:417-22. 2010
    ..To analyze the incidence and management of anastomotic strictures (ASs) after radical perineal prostatectomy (RPP) and retropubic prostatectomy (RRP) and to identify possible predisposing factors...
  23. ncbi request reprint Analysis of the structural integrity of the TAP2 gene in renal cell carcinoma
    Isabelle Hodson
    Third Department of Internal Medicine, Johannes Gutenberg University, Mainz, Germany
    Int J Oncol 23:991-9. 2003
    ..3% heterozygosity independent of a particular allele. Thus, TAP2 gene polymorphism is not linked to renal cell carcinoma since no association between a particular amino acid residue and the disease was found...
  24. pmc Strong expression of chemokine receptor CXCR4 by renal cell carcinoma correlates with advanced disease
    Thomas C Wehler
    Third Department of Internal Medicine, Johannes Gutenberg University of Mainz, 55131 Mainz, Germany
    J Oncol 2008:626340. 2008
    ..039), tumor dedifferentiation (P = .0005), and low hemoglobin (P = .039). In summary, strong CXCR4 expression was significantly associated with advanced dedifferentiated renal cell carcinoma...
  25. ncbi request reprint Heat shock protein expression and anti-heat shock protein reactivity in renal cell carcinoma
    Rudolf Lichtenfels
    IIIrd Department of Internal Medicine, Johannes Gutenberg University, Mainz, Germany
    Proteomics 2:561-70. 2002
    ..These data suggest that HSP play a role in the immunogenicity of RCC and thus might be used for the design of immunization strategies to induce a potent antitumor response in this disease...
  26. ncbi request reprint Proteinase 3/myeloblastin as a growth factor in human kidney cells
    Manfred Relle
    Department of Medicine, University of Mainz, Mainz, Germany
    J Nephrol 16:831-40. 2003
    ..However, whether PR3 is expressed in non-myeloid cells remains a matter of debate even though recent studies clearly demonstrated its expression in endothelium, kidney epithelial cells and epithelial tumor cell lines...
  27. ncbi request reprint ERBB2-mediated transcriptional up-regulation of the alpha5beta1 integrin fibronectin receptor promotes tumor cell survival under adverse conditions
    Christian Spangenberg
    Children s Hospital, University of Mainz, Obere Zahlbacher Strasse 63, 55131 Mainz, Germany
    Cancer Res 66:3715-25. 2006
    ..This new insight could be the basis for additional approaches complementing current cancer therapy...
  28. ncbi request reprint Switching off HER-2/neu in a tetracycline-controlled mouse tumor model leads to apoptosis and tumor-size-dependent remission
    Ilka B Schiffer
    Institute of Toxicology, Johannes Gutenberg University of Mainz, Obere Zahlbacherstrasse 67, 55131 Mainz, Germany
    Cancer Res 63:7221-31. 2003
    ..Tumor remission was dependent on the volume of the tumors before down-regulation of HER-2/neu...
  29. ncbi request reprint DNA repair protein O6-methylguanine-DNA methyltransferase in testis and testicular tumors as determined by a novel nonradioactive assay
    Georg Nagel
    Division of Applied Toxicology, Institute of Toxicology, University of Mainz, D 55131 Mainz, Germany
    Anal Biochem 321:38-43. 2003
    ..In various tumor samples MGMT was lower than MGMT in the normal tissue from the same patient or was even not detectable. The MGMT-ELISA might become a useful tool for MGMT determination in clinical routine and health control...
  30. doi request reprint Low-frequency extracorporeal shock wave lithotripsy improves renal pelvic stone disintegration in a pig model
    Rolf Gillitzer
    Department of Urology, Johannes Gutenberg University, Mainz, Germany
    BJU Int 103:1284-8. 2009
    ..To compare disintegration rates for renal stones treated by 60 vs 120 shock waves (SW)/min at the same energy settings, using standardized validated artificial stones in a pig model...
  31. ncbi request reprint Ubiquitin COOH-terminal hydrolase 1: a biomarker of renal cell carcinoma associated with enhanced tumor cell proliferation and migration
    Barbara Seliger
    Institute of Medical Immunology, Martin Luther University Halle Wittenberg, Halle, Germany
    Clin Cancer Res 13:27-37. 2007
    ..Due to the currently inefficient therapies and the low 5-year survival rates of RCC patients, novel diagnostic, prognostic, and therapeutic markers are urgently needed for this disease...
  32. ncbi request reprint Targeting of tumor associated antigens in renal cell carcinoma using proteome-based analysis and their clinical significance
    Roland Kellner
    Merck, Darmstadt, Germany
    Proteomics 2:1743-51. 2002
    ..In conclusion, PROTEOMEX could be employed for the identification of tumor-associated antigens of the cytoskeleton which are differentially expressed in RCC of distinct subtypes as well as in normal renal epithelium...