Hermann Brenner

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Genotype combinations of plasminogen activator inhibitor-1 and angiotensin-converting enzyme genes and risk for early onset of coronary heart disease
    Michael Loew
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 13:449-56. 2006
  2. ncbi SULT1A1 genotype and susceptibility to colorectal cancer
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 120:201-6. 2007
  3. pmc Calculating age-adjusted cancer survival estimates when age-specific data are sparse: an empirical evaluation of various methods
    A Gondos
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Str 20, Heidelberg 69115, Germany
    Br J Cancer 94:450-4. 2006
  4. pmc Prognostic value of interleukin-1 receptor antagonist gene polymorphism and cytomegalovirus seroprevalence in patients with coronary artery disease
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, University of Heidelberg, Germany
    BMC Cardiovasc Disord 5:10. 2005
  5. ncbi Period analysis for 'up-to-date' cancer survival data: theory, empirical evaluation, computational realisation and applications
    H Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Str 20, D 69115, Heidelberg, Germany
    Eur J Cancer 40:326-35. 2004
  6. ncbi Period analysis of cancer patient survival in datasets from which the month of diagnosis has been removed
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Eur J Cancer 41:438-44. 2005
  7. pmc Population-based monitoring of cancer patient survival in situations with imperfect completeness of cancer registration
    H Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Br J Cancer 92:576-9. 2005
  8. ncbi Use of period analysis for providing more up-to-date estimates of long-term survival rates: empirical evaluation among 370,000 cancer patients in Finland
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    Int J Epidemiol 31:456-62. 2002
  9. ncbi Long-term survival rates of patients with prostate cancer in the prostate-specific antigen screening era: population-based estimates for the year 2000 by period analysis
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    J Clin Oncol 23:441-7. 2005
  10. ncbi Hybrid analysis for up-to-date long-term survival rates in cancer registries with delayed recording of incident cases
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Eur J Cancer 40:2494-501. 2004

Collaborators

Detail Information

Publications165 found, 100 shown here

  1. ncbi Genotype combinations of plasminogen activator inhibitor-1 and angiotensin-converting enzyme genes and risk for early onset of coronary heart disease
    Michael Loew
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 13:449-56. 2006
    ....
  2. ncbi SULT1A1 genotype and susceptibility to colorectal cancer
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 120:201-6. 2007
    ....
  3. pmc Calculating age-adjusted cancer survival estimates when age-specific data are sparse: an empirical evaluation of various methods
    A Gondos
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Str 20, Heidelberg 69115, Germany
    Br J Cancer 94:450-4. 2006
    ..We have illustrated that a recently proposed alternative method of age adjustment involving the use of balanced age groups or age truncation may be useful for enhancing calculability and reliability of adjusted survival estimates...
  4. pmc Prognostic value of interleukin-1 receptor antagonist gene polymorphism and cytomegalovirus seroprevalence in patients with coronary artery disease
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, University of Heidelberg, Germany
    BMC Cardiovasc Disord 5:10. 2005
    ....
  5. ncbi Period analysis for 'up-to-date' cancer survival data: theory, empirical evaluation, computational realisation and applications
    H Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Str 20, D 69115, Heidelberg, Germany
    Eur J Cancer 40:326-35. 2004
    ..More widespread use by cancer registries should help to increase the use of cancer survival statistics for patients, clinicians, and public health authorities...
  6. ncbi Period analysis of cancer patient survival in datasets from which the month of diagnosis has been removed
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Eur J Cancer 41:438-44. 2005
    ....
  7. pmc Population-based monitoring of cancer patient survival in situations with imperfect completeness of cancer registration
    H Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Br J Cancer 92:576-9. 2005
    ..We outline strategies on how to minimise or overcome potential biases...
  8. ncbi Use of period analysis for providing more up-to-date estimates of long-term survival rates: empirical evaluation among 370,000 cancer patients in Finland
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    Int J Epidemiol 31:456-62. 2002
    ..The aim of this paper is to provide a comprehensive empirical evaluation of the use of this method...
  9. ncbi Long-term survival rates of patients with prostate cancer in the prostate-specific antigen screening era: population-based estimates for the year 2000 by period analysis
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    J Clin Oncol 23:441-7. 2005
    ..In this study, we applied a new method for up-to-date analysis of long-term survival to evaluate if and to what extent these patients still have any excess mortality compared to the general population...
  10. ncbi Hybrid analysis for up-to-date long-term survival rates in cancer registries with delayed recording of incident cases
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Eur J Cancer 40:2494-501. 2004
    ....
  11. ncbi An alternative approach to age adjustment of cancer survival rates
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Eur J Cancer 40:2317-22. 2004
    ..We outline the computational realisation of this approach, and we give an empirical illustration of its application using data from the nationwide Finnish Cancer Registry...
  12. ncbi Epidemiology in aging research
    Hermann Brenner
    Department of Epidemiology, German Center for Research on Aging, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Exp Gerontol 39:679-86. 2004
    ..Finally, epidemiologic methods should be more widely used for studies of medical and nursing care, and results of epidemiologic research need to be more effectively transferred into the practice of prevention...
  13. ncbi Advanced detection of time trends in long-term cancer patient survival: experience from 50 years of cancer registration in Finland
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    Am J Epidemiol 156:566-77. 2002
    ..The authors conclude that period analysis should be routinely used to advance detection of progress in long-term cancer patient survival...
  14. ncbi Recent increase in cancer survival according to age: higher survival in all age groups, but widening age gradient
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, Heidelberg, D 69115, Germany
    Cancer Causes Control 15:903-10. 2004
    ..We conclude that long-term survival expectations of cancer patients have increased in all age groups in the 1990s. However, for most common forms of cancer, the age gradient in survival has either persisted or widened...
  15. ncbi Long-term survival rates of cancer patients achieved by the end of the 20th century: a period analysis
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Str 20, 69115, Heidelberg, Germany
    Lancet 360:1131-5. 2002
    ..I aimed to assess achievements in cancer patients' survival by an alternative method of survival analysis,known as period analysis, which provides more up-to-date estimates of long-term survival rates than do conventional methods...
  16. pmc Up-to-date survival curves of children with cancer by period analysis
    H Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Br J Cancer 88:1693-7. 2003
    ..Application of period analysis may be particularly useful in the field of childhood cancer as it may help to prevent patients, their families and clinicians from being burdened by outdated, often too pessimistic survival expectations...
  17. pmc Combining cohort and period methods for retrospective time trend analyses of long-term cancer patient survival rates
    H Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Br J Cancer 89:1260-5. 2003
    ....
  18. ncbi Is Helicobacter pylori infection a necessary condition for noncardia gastric cancer?
    Hermann Brenner
    Department of Epidemiology, German Center for Research on Aging, Heidelberg, Germany
    Am J Epidemiol 159:252-8. 2004
    ..The H. pylori-gastric cancer relation may be much stronger than previously thought, and H. pylori infection may even be a (close to) necessary condition for development of noncardia gastric cancer...
  19. ncbi On crude and age-adjusted relative survival rates
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115, Heidelberg, Germany
    J Clin Epidemiol 56:1185-91. 2003
    ..We show ways to overcome this inconsistency in the derivation and interpretation of crude and age-adjusted relative survival rates...
  20. ncbi Up-to-date long-term survival curves of patients with cancer by period analysis
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    J Clin Oncol 20:826-32. 2002
    ..Using data of the Finnish Cancer Registry, we provide an empirical assessment of the use of a new method of survival analysis, denoted period analysis, for deriving more up-to-date survival curves...
  21. ncbi Long-term survival of children with leukemia achieved by the end of the second millennium
    H Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Cancer 92:1977-83. 2001
    ..Much of this progress remains unaccounted for in traditional estimates of long-term survival rates, which essentially reflect the survival experience of patients who were diagnosed many years ago...
  22. ncbi Substantial overestimation of standard errors of relative survival rates of cancer patients
    Hermann Brenner
    German Centre for Research on Ageing, Heidelberg, Germany
    Am J Epidemiol 161:781-6. 2005
    ..The authors conclude that conventional derivation may substantially overestimate standard errors for relative survival...
  23. ncbi Clustering of Helicobacter pylori infection in couples: differences between high- and low-prevalence population groups
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    Ann Epidemiol 16:516-20. 2006
    ..We assessed clustering of H pylori infections in a large community-based study from Germany that included both high-prevalence and low-prevalence population subgroups...
  24. ncbi Further enhanced monitoring of cancer patient survival by stage-adjusted period analysis
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 14:1917-21. 2005
    ..We show that stage adjustment may often further enhance the benefits of period analysis for deriving up-to-date cancer survival estimates...
  25. pmc Age adjustment of cancer survival rates: methods, point estimates and standard errors
    H Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Br J Cancer 93:372-5. 2005
    ..We find that both methods provide almost identical results for absolute survival but the new method generally provides more meaningful estimates of relative survival with often a smaller standard error...
  26. ncbi The German Center for Research on Aging at the University of Heidelberg: an interdisciplinary approach
    Hermann Brenner
    Department of Epidemiology, German Center for Research on Aging, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Exp Gerontol 39:3-9. 2004
    ..Andreas Kruse), and the Department of Epidemiology (established in 2000, chair: Prof. Hermann Brenner)...
  27. ncbi A computer program for period analysis of cancer patient survival
    H Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Eur J Cancer 38:690-5. 2002
    ..We illustrate application of the program with examples from the nationwide Finnish Cancer Registry...
  28. ncbi Reduction in selective under-ascertainment bias in population-based estimates of cancer patient survival by age adjustment
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Eur J Cancer 41:1788-93. 2005
    ..Age adjusted estimates were less biased in most scenarios, which may be an additional argument for application of age adjustment in the analysis and reporting of population-based cancer survival rates...
  29. ncbi Long-term survival of cancer patients in Germany achieved by the beginning of the third millenium
    H Brenner
    German Centre for Research on Ageing, Heidelberg
    Ann Oncol 16:981-6. 2005
    ..Over the last decades, long-term survival rates have substantially increased for many forms of cancer. However, these improvements have often been detected with substantial delay by traditional methods of survival analyses...
  30. ncbi More up-to-date monitoring of long-term survival rates by cancer registries: an empirical example
    H Brenner
    Dept of Epidemiology, German Centre for Research on Ageing, Heidelberg
    Methods Inf Med 40:248-52. 2001
    ..We conclude that period analysis should be more widely used for deriving more up-to-date long-term survival estimates...
  31. ncbi Reduction of clinically manifest colorectal cancer by endoscopic screening: empirical evaluation and comparison of screening at various ages
    H Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Eur J Cancer Prev 14:231-7. 2005
    ..Repeated offers of screening examinations could provide substantial additional benefit with the levels of compliance to be expected in practice, but they would have to be weighed against the increased risks and costs...
  32. ncbi Inverse association between a pro-inflammatory genetic profile and Helicobacter pylori seropositivity among patients with chronic atrophic gastritis: enhanced elimination of the infection during disease progression?
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, Heidelberg D 69115, Germany
    Eur J Cancer 45:2860-6. 2009
    ..There is increasing evidence of frequent clearance of the infection during progression of CAG. We aimed to assess the association between host inflammatory polymorphisms and H. pylori seropositivity among CAG patients from Germany...
  33. doi The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis
    Xiang Lin Tan
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 122:2573-80. 2008
    ..However, the CCND1 G870A polymorphism may modify the protective effect of postmenopausal hormone use on the development of CRC...
  34. ncbi Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    J Natl Cancer Inst 102:89-95. 2010
    ....
  35. ncbi Frailty prevalence and 10-year survival in community-dwelling older adults: results from the ESTHER cohort study
    Kai Uwe Saum
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Eur J Epidemiol 29:171-9. 2014
    ..We found sex differences in the FI and its increase with age, along with a consistent strong association of the FI with mortality in both sexes, even for age group 50-64...
  36. doi Serum 25-hydroxyvitamin D levels and incident diabetes mellitus type 2: a competing risk analysis in a large population-based cohort of older adults
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Eur J Epidemiol 28:267-75. 2013
    ..In this large cohort study of older adults, serum 25(OH)D levels were inversely associated with incident diabetes in women but not in men. The association was particularly strong in subjects with renal dysfunction...
  37. doi Kidney graft survival in Europe and the United States: strikingly different long-term outcomes
    Adam Gondos
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Transplantation 95:267-74. 2013
    ..Kidney graft survival has never been systematically compared between Europe and the United States...
  38. doi Evaluation of serum and urinary myeloid related protein-14 as a marker for early detection of prostate cancer
    Heiko Muller
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    J Urol 180:1309-12; discussion 1312-3. 2008
    ..In diagnostic studies promising results were shown for myeloid related protein-14 in serum and urine. However, confirmation in longitudinal population based studies is needed...
  39. ncbi Household contacts were key factor for children's colonization with resistant Escherichia coli in community setting
    Susanne Lietzau
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    J Clin Epidemiol 60:1149-55. 2007
    ..coli) can lead to life-threatening situations. Epidemiological data on the prevalence and major determinants of carriage of antibiotic resistant E. coli among children in the community setting are sparse...
  40. doi Low risk of colorectal cancer and advanced adenomas more than 10 years after negative colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology of Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Gastroenterology 138:870-6. 2010
    ..There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with time since negative colonoscopies...
  41. ncbi Is vitamin D deficiency a cause of increased morbidity and mortality at older age or simply an indicator of poor health?
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Eur J Epidemiol 29:199-210. 2014
    ..In conclusion, vitamin D deficiency may not cause frailty or poor general health but may nevertheless be a prognostic marker for mortality, independent of the individual's morbidity. ..
  42. pmc Sex differences in colorectal cancer survival: population-based analysis of 164,996 colorectal cancer patients in Germany
    Ondrej Majek
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 8:e68077. 2013
    ..The effect of sex hormones, either endogenous or through hormonal replacement therapy, might be the most plausible explanation for the observed patterns. ..
  43. pmc Gender disparities in diabetes and coronary heart disease medication among patients with type 2 diabetes: results from the DIANA study
    Heike U Krämer
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120, Heidelberg, Germany
    Cardiovasc Diabetol 11:88. 2012
    ..Coronary heart disease (CHD) is one of the most common long-term complications in people with type 2 diabetes. We analyzed whether or not gender differences exist in diabetes and CHD medication among people with type 2 diabetes...
  44. ncbi Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adults
    Ulrike Haug
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Chem 53:787-90. 2007
    ..We investigated the prevalence and potential determinants of mutant K-ras in stool in a large sample of unselected older adults and assessed the association with colonoscopic findings...
  45. ncbi Cancer survival in Germany and the United States at the beginning of the 21st century: an up-to-date comparison by period analysis
    Adam Gondos
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 121:395-400. 2007
    ..Among these, differences between patients with breast and prostate cancer are probably due to more intensive screening activities...
  46. ncbi Synergism between smoking and alcohol consumption with respect to serum gamma-glutamyltransferase
    Lutz Philipp Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Hepatology 49:802-8. 2009
    ..9 (1.1-7.6) in women and to 3.8 (2.2-6.6) in men (test for interaction between alcohol consumption and smoking: P(females) = 0.12, P(males) = 0.0017)...
  47. ncbi Changes of cardiovascular risk factors and their implications in subsequent birth cohorts of older adults in Germany: a life course approach
    Elke Raum
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 14:809-14. 2007
    ....
  48. ncbi Socioeconomic deprivation and cancer survival in Germany: an ecological analysis in 200 districts in Germany
    Lina Jansen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 134:2951-60. 2014
    ..Studies on individual-level patient data with access to treatment information should be conducted to examine the reasons for these socioeconomic inequalities in cancer survival in more detail. ..
  49. doi Impact of smoking and quitting on cardiovascular outcomes and risk advancement periods among older adults
    Carolin Gellert
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Eur J Epidemiol 28:649-58. 2013
    ..Smoking is a strong risk factor for cardiovascular events even at older age. Smoking cessation is highly and rapidly beneficial also at advanced age. ..
  50. doi Asymmetric and symmetric dimethylarginine and risk of secondary cardiovascular disease events and mortality in patients with stable coronary heart disease: the KAROLA follow-up study
    Bob Siegerink
    German Cancer Research Center DKFZ, Division of Clinical Epidemiology and Aging Research C070, Heidelberg, Germany
    Clin Res Cardiol 102:193-202. 2013
    ..This study aimed to determine the associations of both ADMA and SDMA levels with secondary cardiovascular disease events and all-cause mortality in patients with stable coronary heart disease (CHD)...
  51. doi Genetic variations in the vitamin D binding protein and season-specific levels of vitamin D among older adults
    Laura Perna
    German Cancer Research Center DKFZ, Division of Clinical Epidemiology and Aging Research, Im Neuenheimer Feld 581, Heidelberg, Germany
    Epidemiology 24:104-9. 2013
    ..The quantification of this association among older women and men and its potential variation by season remain unexplored...
  52. doi Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study
    Ben Schöttker
    Divisions of Clinical Epidemiology and Aging Research and Preventive Oncology, German Cancer Research Center, Heidelberg, Germany
    Am J Clin Nutr 97:782-93. 2013
    ..Serum 25-hydroxyvitamin D [25(OH)D] concentration has been linked to mortality in several studies, but appropriate cutoffs to define risk categories are under debate...
  53. ncbi Interval cancers after negative colonoscopy: population-based case-control study
    Hermann Brenner
    Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
    Gut 61:1576-82. 2012
    ..The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy...
  54. doi Gender specific temporal and cross-sectional associations between BMI-class and symptoms of depression in the elderly
    Beate Wild
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital, Heidelberg, Germany
    J Psychosom Res 72:376-82. 2012
    ..The aim of the study was the gender specific analysis of cross-sectional and longitudinal associations between body mass index class (BMI-class) and symptoms of depression in a representative sample of elderly German people...
  55. ncbi Alcohol consumption and chronic atrophic gastritis: population-based study among 9,444 older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 125:2918-22. 2009
    ..pylori. However, the observed patterns suggest that other mechanisms are likely to contribute to the association as well...
  56. doi Serum parathyroid hormone and risk of adverse outcomes in patients with stable coronary heart disease
    Norma Christine Grandi
    Division of Clinical Epidemiology and Ageing Research C070, German Cancer Research Center, Heidelberg, Germany
    Heart 97:1215-21. 2011
    ..This study presents analyses of the prognostic value of baseline PTH for subsequent cardiovascular events and all-cause mortality in a high-risk population with stable coronary heart disease...
  57. doi Sibship size, Helicobacter pylori infection and chronic atrophic gastritis: a population-based study among 9444 older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Epidemiol 39:129-34. 2010
    ..We aimed to assess the association of sibship size with H. pylori infection and chronic atrophic gastritis (CAG) in a population-based study from Germany...
  58. pmc Inter-country and ethnic variation in colorectal cancer survival: comparisons between a Philippine population, Filipino-Americans and Caucasians
    Maria Theresa Redaniel
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    BMC Cancer 10:100. 2010
    ....
  59. doi Epidemiology of chronic kidney disease: results from a population of older adults in Germany
    Qiu Li Zhang
    German Cancer Research Center, Heidelberg, Germany
    Prev Med 48:122-7. 2009
    ..To determine prevalences and stages of chronic kidney disease (CKD), and evaluate association of CKD with related covariables in a large population of older adults...
  60. doi Alcohol consumption, serum gamma-glutamyltransferase, and helicobacter pylori infection in a population-based study among 9733 older adults
    Lei Gao
    German Cancer Research Center, Heidelberg, Germany
    Ann Epidemiol 20:122-8. 2010
    ..pylori infection in a large population-based study...
  61. ncbi The diagnosis of a smoking-related disease is a prominent trigger for smoking cessation in a retrospective cohort study
    Dorothee Twardella
    German Center for Research on Ageing, Bergheimer Str 20, D 69115 Heidelberg, Germany
    J Clin Epidemiol 59:82-9. 2006
    ....
  62. doi Using rate advancement periods for communicating the benefits of quitting smoking to older smokers
    Carolin Gellert
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Tob Control 22:227-30. 2013
    ..We provide empirical evidence on the impact of smoking, and the benefits of quitting on all-cause mortality and RAPs for people aged 60 years and older in a large cohort of older adults...
  63. ncbi Survival of stomach and esophagus cancer patients in Germany in the early 21st century
    Eva Hiripi
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Acta Oncol 51:906-14. 2012
    ..The aim of this study was to provide up-to-date survival estimates and trends for patients with stomach and esophagus cancer in Germany...
  64. doi Cancer survival in Eastern and Western Germany after the fall of the iron curtain
    Lina Jansen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Eur J Epidemiol 27:689-93. 2012
    ....
  65. ncbi Helicobacter pylori infection, chronic atrophic gastritis and major cardiovascular events: a population-based cohort study
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Atherosclerosis 220:569-74. 2012
    ..There is debate whether infection with Helicobacter (H.) pylori, the main inducer of chronic atrophic gastritis (CAG), is a risk factor for cardiovascular disease and premature mortality...
  66. doi Longitudinal predictors of health-related quality of life in middle-aged and older adults with hypertension: results of a population-based study
    Imad Maatouk
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Heidelberg, Germany
    J Hypertens 30:1364-72. 2012
    ..g. awareness of hypertension, number of types of antihypertensive drugs, comorbidity), and health-related quality of life (HRQOL) in a large cohort of patients with hypertension, over a follow-up period of 5 years...
  67. pmc Temporal predictors of health-related quality of life in elderly people with diabetes: results of a German cohort study
    Imad Maatouk
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Heidelberg, Germany
    PLoS ONE 7:e31088. 2012
    ..The aim of the study was to determine predictors that influence health-related quality of life (HRQOL) in a large cohort of elderly diabetes patients from primary care over a follow-up period of five years...
  68. ncbi Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer
    Bernd Frank
    German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 31:1381-6. 2010
    ..However, our results provide evidence that CRC subsets may be affected. If confirmed, this knowledge may be used to assess individual susceptibility and to target potential measures of cancer prevention...
  69. ncbi Helicobacter pylori infection, interleukin-1 gene polymorphisms and the risk of colorectal cancer: evidence from a case-control study in Germany
    Natalia Zumkeller
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Eur J Cancer 43:1283-9. 2007
    ..Additionally, a pro-inflammatory genotype did not increase the colorectal cancer risk associated with H. pylori infection. H. pylori positive subjects carrying the pro-inflammatory genotypes even had a lower risk...
  70. ncbi Epidemiologic findings on serologically defined chronic atrophic gastritis strongly depend on the choice of the cutoff-value
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 121:2782-6. 2007
    ..The association of age and H. pylori infection with CAG may be strongly underestimated in studies in which CAG is defined by pepsinogen I only...
  71. pmc Risk of progression of advanced adenomas to colorectal cancer by age and sex: estimates based on 840,149 screening colonoscopies
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Gut 56:1585-9. 2007
    ..To derive age and sex specific estimates of transition rates from advanced adenomas to colorectal cancer by combining data of a nationwide screening colonoscopy registry and national data on colorectal cancer (CRC) incidence...
  72. doi Model-based projections for deriving up-to-date cancer survival estimates: an international evaluation
    Adam Gondos
    Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 125:2666-72. 2009
    ..Projections from model-based analysis may contribute to improved timeliness of monitoring of concurrent trends in population-based cancer survival in cancer registries operating in different populations and socioeconomic environments...
  73. doi Population-based prevalence estimates of history of colonoscopy or sigmoidoscopy: review and analysis of recent trends
    Christian Stock
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Gastrointest Endosc 71:366-381.e2. 2010
    ..We aimed to review prevalence estimates of history of colonoscopy or sigmoidoscopy in the general population and to analyze recent trends...
  74. ncbi Expected reduction of colorectal cancer incidence within 8 years after introduction of the German screening colonoscopy programme: estimates based on 1,875,708 screening colonoscopies
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, D 69115 Heidelberg, Germany
    Eur J Cancer 45:2027-33. 2009
    ..Our results forecast a major rapid reduction of the CRC burden in Germany by screening colonoscopy...
  75. doi Exposure to environmental tobacco smoke and the risk of colorectal cancer in a case-control study from Germany
    Emaculate Verla-Tebit
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Eur J Cancer Prev 18:9-12. 2009
    ..03-12.15) and for women exposed to >23 pack-years of spousal smoking (OR: 3.02; 95% CI: 0.99-9.28). Our findings do not indicate a major impact of ETS on CRC risk but suggest that risk may be increased following spousal exposure...
  76. ncbi Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study
    Dietrich Rothenbacher
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Scand J Gastroenterol 40:697-704. 2005
    ..The prevalence and main determinants of exocrine pancreatic insufficiency were investigated in a large population-based sample of older adults by measuring pancreatic elastase-1 in stool...
  77. doi Association between a pro-inflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Eur J Cancer 45:428-34. 2009
    ..We aimed to assess their impact on the risk of chronic atrophic gastritis (CAG) in a population-based study...
  78. ncbi Helicobacter pylori infection and gastric cancer risk: evaluation of 15 H. pylori proteins determined by novel multiplex serology
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 69:6164-70. 2009
    ..001). In conclusion, GroEL was identified as a new independent risk marker that may contribute to enhanced quantification of H. pylori-related GC risk...
  79. doi Grb2-associated binder 1 (Gab1) genetic polymorphism, Helicobacter pylori infection, and chronic atrophic gastritis among older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Mol Carcinog 49:869-73. 2010
    ..pylori infection and CAG in this study population from Germany. Further studies with larger sample size are needed to clarify a potential modest effect of Gab1 genetic polymorphisms...
  80. pmc Ovarian cancer survival population differences: a "high resolution study" comparing Philippine residents, and Filipino-Americans and Caucasians living in the US
    Maria Theresa M Redaniel
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    BMC Cancer 9:340. 2009
    ..We aimed to compare ovarian cancer survival in Philippine residents, Filipino-Americans and Caucasians living in the US, using a high resolution approach, taking potential differences in prognostic factors into account...
  81. ncbi Quality of life over 5 years in women with breast cancer after breast-conserving therapy versus mastectomy: a population-based study
    Volker Arndt
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Bergheimer Strasse 20, 69115 Heidelberg, Germany
    J Cancer Res Clin Oncol 134:1311-8. 2008
    ..Therefore we compared QOL in women with breast cancer undergoing BCT versus women undergoing mastectomy over a 5-year period following primary surgery...
  82. ncbi Validity of self-reported endoscopies of the large bowel and implications for estimates of colorectal cancer risk
    Michael Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Epidemiol 166:130-6. 2007
    ..58), and reasonable for year of examination (kappa = 0.70). Self-reports of previous colorectal endoscopies agreed well with medical records, but validation appears to be essential with respect to details of the examination...
  83. doi Male sex and smoking have a larger impact on the prevalence of colorectal neoplasia than family history of colorectal cancer
    Michael Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Gastroenterol Hepatol 8:870-6. 2010
    ..Screening recommendations for colorectal cancer (CRC) commonly take family history but no other risk factors into account. We compared and assessed risk factors of colorectal polyps in a large population undergoing screening colonoscopy...
  84. ncbi The mother as source of Helicobacter pylori infection
    Maria Weyermann
    Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg, Germany
    Epidemiology 17:332-4. 2006
    ..To further elucidate the intrafamilial transmission of Helicobacter pylori infection, we investigated the occurrence of infection by parental infection status in a large community-based birth cohort of children from Germany...
  85. ncbi Cigarette smoking and colorectal cancer risk in Germany: a population-based case-control study
    Emaculate Verla-Tebit
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 119:630-5. 2006
    ..This study supports the hypothesis that smoking for a long duration at a high cumulative dose increases the risk for colorectal cancer, particularly among women, and suggests that there is risk reduction after longterm smoking cessation...
  86. ncbi Role of infected parents in transmission of helicobacter pylori to their children
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg
    Pediatr Infect Dis J 21:674-9. 2002
    ..The aim of this population-based study was to determine the role of parental infection status in transmission of H. pylori to the child by taking into consideration the infection status of both parents simultaneously...
  87. ncbi Relationship between infectious burden, systemic inflammatory response, and risk of stable coronary artery disease: role of confounding and reference group
    Dietrich Rothenbacher
    Department of Epidemiology, German Centre for Research on Ageing at the University of Heidelberg, Heidelberg, Germany
    Atherosclerosis 170:339-45. 2003
    ..We also investigated whether the choice of a larger reference group might affect the results, and whether or not seropositivity to multiple agents was associated with a systemic inflammatory response...
  88. ncbi Sex, age, and birth cohort effects in colorectal neoplasms: a cohort analysis
    Hermann Brenner
    German Cancer Research Center, Heidelberg, Germany
    Ann Intern Med 152:697-703. 2010
    ..Cross-sectional analyses estimated that men reach an equivalent prevalence at a much younger age than women. However, cross-sectional estimates may be confounded by birth cohort effects...
  89. ncbi Helicobacter pylori and hepatitis A virus infections and the cardiovascular risk profile in patients with diabetes mellitus: results of a population-based study
    Mercy Ongey
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 11:471-6. 2004
    ....
  90. ncbi Homocysteine and methylenetetrahydrofolate reductase genotype: association with risk of coronary heart disease and relation to inflammatory, hemostatic, and lipid parameters
    D Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg, Germany
    Atherosclerosis 162:193-200. 2002
    ..We performed a case-control study to investigate whether tHcy levels and MTHFR genotype (677 C-->T mutation and 1298 A-->C mutation) are associated with CHD under special consideration of the possibility for confounding...
  91. ncbi Chronic infection with Helicobacter pylori does not provoke major systemic inflammation in healthy adults: results from a large population-based study
    H Brenner
    Department of Epidemiology, University of Ulm, Helmholtzstrasse 22, D 89081, Ulm, Germany
    Atherosclerosis 147:399-403. 1999
    ..pylori strains provokes major systemic inflammation. The mechanisms underlying the inverse association between H. pylori infection and serum albumin and the clinical relevance of this finding require further research...
  92. ncbi Elevated liver enzyme activity in construction workers: prevalence and impact on early retirement and all-cause mortality
    V Arndt
    Department of Epidemiology, University of Ulm, Germany
    Int Arch Occup Environ Health 71:405-12. 1998
    ....
  93. ncbi Alcohol as a gastric disinfectant? The complex relationship between alcohol consumption and current Helicobacter pylori infection
    H Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg
    Epidemiology 12:209-14. 2001
    ..pylori infection. At higher levels of alcohol consumption, the antimicrobial effects of alcoholic beverages may be opposed by adverse systemic effects of drinking, such as adverse effects on the immune defense...
  94. doi Improvements in survival of adults diagnosed with acute myeloblastic leukemia in the early 21st century
    Dianne Pulte
    Div of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Haematologica 93:594-600. 2008
    ....
  95. ncbi Are patients diagnosed with breast cancer before age 50 years ever cured?
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Aging, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    J Clin Oncol 22:432-8. 2004
    ..The aim of this study was to assess long-term survival in a large population-based sample of patients diagnosed with breast cancer before age 50 years...
  96. doi Family history and age at initiation of colorectal cancer screening
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Gastroenterol 103:2326-31. 2008
    ....
  97. pmc Long-term cancer patient survival achieved by the end of the 20th century: most up-to-date estimates from the nationwide Finnish cancer registry
    H Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Str 20, Heidelberg, D 69115, Germany
    Br J Cancer 85:367-71. 2001
    ....
  98. pmc Major differences in prevalence of overweight according to nationality in preschool children living in Germany: determinants and public health implications
    J Kuepper-Nybelen
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    Arch Dis Child 90:359-63. 2005
    ..To investigate the prevalence of overweight according to nationality in preschool children living in Germany, and to establish the determinants responsible for differences in body mass index...
  99. doi Efficacy, effectiveness and cost-effectiveness of endoscopic screening methods
    H Brenner
    Div of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Z Gastroenterol 46:S20-2. 2008
    ..Even higher cost-effectiveness is to be expected if screening intervals can be extended to 20 or more years, as suggested by recent epidemiological evidence...
  100. doi Overweight, obesity and risk of work disability: a cohort study of construction workers in Germany
    H Claessen
    German Cancer Research Center DKFZ, Division of Clinical Epidemiology and Aging Research, Bergheimer Strasse 20, 69115 Heidelberg, Germany
    Occup Environ Med 66:402-9. 2009
    ..The aim of this study was to investigate the association of body mass index (BMI) with work disability among construction workers...
  101. ncbi Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk
    Lu Yin
    German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol 33:435-45. 2009
    ..To review and summarize evidence from longitudinal studies on the association between serum 25-hydroxyvitamin D (25(OH)D) and the risk of prostate cancer (PC)...