Hermann Brenner

..The objective of this prospective cohort study was to investigate the prognostic value of the physicians' assessment of patient compliance and other factors with respect to all-cause mortality during a one year follow-up period...

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..In this study, we applied a new method for up-to-date analysis of long-term survival to evaluate if and to what extent these patients still have any excess mortality compared to the general population...

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..Application of period analysis may be particularly useful in the field of childhood cancer as it may help to prevent patients, their families and clinicians from being burdened by outdated, often too pessimistic survival expectations...

..I aimed to assess achievements in cancer patients' survival by an alternative method of survival analysis,known as period analysis, which provides more up-to-date estimates of long-term survival rates than do conventional methods...

..Age adjusted estimates were less biased in most scenarios, which may be an additional argument for application of age adjustment in the analysis and reporting of population-based cancer survival rates...

..The authors conclude that period analysis should be routinely used to advance detection of progress in long-term cancer patient survival...

..We show that stage adjustment may often further enhance the benefits of period analysis for deriving up-to-date cancer survival estimates...

..We assessed clustering of H pylori infections in a large community-based study from Germany that included both high-prevalence and low-prevalence population subgroups...

..We find that both methods provide almost identical results for absolute survival but the new method generally provides more meaningful estimates of relative survival with often a smaller standard error...

..We show ways to overcome this inconsistency in the derivation and interpretation of crude and age-adjusted relative survival rates...

..Repeated offers of screening examinations could provide substantial additional benefit with the levels of compliance to be expected in practice, but they would have to be weighed against the increased risks and costs...

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..We outline the computational realisation of this approach, and we give an empirical illustration of its application using data from the nationwide Finnish Cancer Registry...

..We conclude that long-term survival expectations of cancer patients have increased in all age groups in the 1990s. However, for most common forms of cancer, the age gradient in survival has either persisted or widened...

..We outline strategies on how to minimise or overcome potential biases...

..Finally, epidemiologic methods should be more widely used for studies of medical and nursing care, and results of epidemiologic research need to be more effectively transferred into the practice of prevention...

..The authors conclude that conventional derivation may substantially overestimate standard errors for relative survival...

..More widespread use by cancer registries should help to increase the use of cancer survival statistics for patients, clinicians, and public health authorities...

..The H. pylori-gastric cancer relation may be much stronger than previously thought, and H. pylori infection may even be a (close to) necessary condition for development of noncardia gastric cancer...

..Over the last decades, long-term survival rates have substantially increased for many forms of cancer. However, these improvements have often been detected with substantial delay by traditional methods of survival analyses...

..The aim of this paper is to provide a comprehensive empirical evaluation of the use of this method...

..Andreas Kruse), and the Department of Epidemiology (established in 2000, chair: Prof. Hermann Brenner)...

..We conclude that period analysis should be more widely used for deriving more up-to-date long-term survival estimates...

..Much of this progress remains unaccounted for in traditional estimates of long-term survival rates, which essentially reflect the survival experience of patients who were diagnosed many years ago...

..Using data of the Finnish Cancer Registry, we provide an empirical assessment of the use of a new method of survival analysis, denoted period analysis, for deriving more up-to-date survival curves...

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..We illustrate application of the program with examples from the nationwide Finnish Cancer Registry...

..However, the CCND1 G870A polymorphism may modify the protective effect of postmenopausal hormone use on the development of CRC...

..There is increasing evidence of frequent clearance of the infection during progression of CAG. We aimed to assess the association between host inflammatory polymorphisms and H. pylori seropositivity among CAG patients from Germany...

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..In diagnostic studies promising results were shown for myeloid related protein-14 in serum and urine. However, confirmation in longitudinal population based studies is needed...

..coli) can lead to life-threatening situations. Epidemiological data on the prevalence and major determinants of carriage of antibiotic resistant E. coli among children in the community setting are sparse...

..There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with time since negative colonoscopies...

..12, P(males) = 0.0017). CONCLUSION: Our results support the notion of a detrimental interaction between cigarette smoking and alcohol consumption as determinants of elevated serum gamma-GT, especially in men...

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..We investigated the prevalence and potential determinants of mutant K-ras in stool in a large sample of unselected older adults and assessed the association with colonoscopic findings...

..Among these, differences between patients with breast and prostate cancer are probably due to more intensive screening activities...

..The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy...

..The aim of the study was the gender specific analysis of cross-sectional and longitudinal associations between body mass index class (BMI-class) and symptoms of depression in a representative sample of elderly German people...

..This study presents analyses of the prognostic value of baseline PTH for subsequent cardiovascular events and all-cause mortality in a high-risk population with stable coronary heart disease...

..To determine prevalences and stages of chronic kidney disease (CKD), and evaluate association of CKD with related covariables in a large population of older adults...

..pylori infection in a large population-based study...

..pylori. However, the observed patterns suggest that other mechanisms are likely to contribute to the association as well...

..We aimed to assess the association of sibship size with H. pylori infection and chronic atrophic gastritis (CAG) in a population-based study from Germany...

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..The aim of this study was to provide up-to-date survival estimates and trends for patients with stomach and esophagus cancer in Germany...

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..There is debate whether infection with Helicobacter (H.) pylori, the main inducer of chronic atrophic gastritis (CAG), is a risk factor for cardiovascular disease and premature mortality...

..g. awareness of hypertension, number of types of antihypertensive drugs, comorbidity), and health-related quality of life (HRQOL) in a large cohort of patients with hypertension, over a follow-up period of 5 years...

..The aim of the study was to determine predictors that influence health-related quality of life (HRQOL) in a large cohort of elderly diabetes patients from primary care over a follow-up period of five years...

..The prevalence and main determinants of exocrine pancreatic insufficiency were investigated in a large population-based sample of older adults by measuring pancreatic elastase-1 in stool...

..03-12.15) and for women exposed to >23 pack-years of spousal smoking (OR: 3.02; 95% CI: 0.99-9.28). Our findings do not indicate a major impact of ETS on CRC risk but suggest that risk may be increased following spousal exposure...

..Additionally, a pro-inflammatory genotype did not increase the colorectal cancer risk associated with H. pylori infection. H. pylori positive subjects carrying the pro-inflammatory genotypes even had a lower risk...

..The association of age and H. pylori infection with CAG may be strongly underestimated in studies in which CAG is defined by pepsinogen I only...

..To derive age and sex specific estimates of transition rates from advanced adenomas to colorectal cancer by combining data of a nationwide screening colonoscopy registry and national data on colorectal cancer (CRC) incidence...

..We aimed to review prevalence estimates of history of colonoscopy or sigmoidoscopy in the general population and to analyze recent trends...

..Projections from model-based analysis may contribute to improved timeliness of monitoring of concurrent trends in population-based cancer survival in cancer registries operating in different populations and socioeconomic environments...

..Our results forecast a major rapid reduction of the CRC burden in Germany by screening colonoscopy...

..However, our results provide evidence that CRC subsets may be affected. If confirmed, this knowledge may be used to assess individual susceptibility and to target potential measures of cancer prevention...

..We aimed to assess their impact on the risk of chronic atrophic gastritis (CAG) in a population-based study...

..The number of older siblings was not a risk factor for H. pylori infection of the child. CONCLUSIONS: This longitudinal study suggests that infected mothers are the main source of H. pylori infection of their children...

..We aimed to compare ovarian cancer survival in Philippine residents, Filipino-Americans and Caucasians living in the US, using a high resolution approach, taking potential differences in prognostic factors into account...

..Screening recommendations for colorectal cancer (CRC) commonly take family history but no other risk factors into account. We compared and assessed risk factors of colorectal polyps in a large population undergoing screening colonoscopy...

..Therefore we compared QOL in women with breast cancer undergoing BCT versus women undergoing mastectomy over a 5-year period following primary surgery...

..pylori infection and CAG in this study population from Germany. Further studies with larger sample size are needed to clarify a potential modest effect of Gab1 genetic polymorphisms...

..001). In conclusion, GroEL was identified as a new independent risk marker that may contribute to enhanced quantification of H. pylori-related GC risk...

..58), and reasonable for year of examination (kappa = 0.70). Self-reports of previous colorectal endoscopies agreed well with medical records, but validation appears to be essential with respect to details of the examination...

..This study supports the hypothesis that smoking for a long duration at a high cumulative dose increases the risk for colorectal cancer, particularly among women, and suggests that there is risk reduction after longterm smoking cessation...

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..8 to 5.3) when the father was saliva-positive. CONCLUSION: This study strengthens previous evidence that in the population studied infected parents, in particular mothers may play a key role in transmission of H. pylori to the child...

..Cross-sectional analyses estimated that men reach an equivalent prevalence at a much younger age than women. However, cross-sectional estimates may be confounded by birth cohort effects...

..Therefore it seems unlikely that HP and HAV sero-prevalence strongly influence CVD progression in patients with diabetes...

..We performed a case-control study to investigate whether tHcy levels and MTHFR genotype (677 C-->T mutation and 1298 A-->C mutation) are associated with CHD under special consideration of the possibility for confounding...

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..pylori infection. At higher levels of alcohol consumption, the antimicrobial effects of alcoholic beverages may be opposed by adverse systemic effects of drinking, such as adverse effects on the immune defense...

..pylori strains provokes major systemic inflammation. The mechanisms underlying the inverse association between H. pylori infection and serum albumin and the clinical relevance of this finding require further research...

..The aim of this study was to assess long-term survival in a large population-based sample of patients diagnosed with breast cancer before age 50 years...

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..Even higher cost-effectiveness is to be expected if screening intervals can be extended to 20 or more years, as suggested by recent epidemiological evidence...

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..In preventing overweight in children, there is the need to identify and deal with high risk environments rather than high risk ethnic groups...

..The aim of this study was to investigate the association of body mass index (BMI) with work disability among construction workers...

..While our analysis confirms advantages of period analysis over traditional methods in terms of up-to-dateness of cancer survival data, further improvements are possible by flexible use of model-based approaches...

..We assessed the association of H. pylori infection with chronic atrophic gastritis according to severity of disease...

..Furthermore, relative survival was also better in female than in male patients and decreased with age for most cancer sites...

..We aimed to elucidate the association of concurrent alcohol consumption with the probability of smoking cessation in non-clinical populations...

..To disclose most recent trends in long-term cancer patient survival...

..The 'period' method has been shown particularly useful for that purpose...

..65; 95% confidence interval, 0.42-1.00). CONCLUSION: Our analysis supports the hypothesis that alcohol consumption may facilitate elimination of H. pylori infection among adults...

..To review and summarize evidence from longitudinal studies on the association between serum 25-hydroxyvitamin D (25(OH)D) and the risk of prostate cancer (PC)...

..To evaluate new strategies to enhance the promotion of smoking cessation in general practice...

..The ageing of populations makes outcome monitoring among elderly cancer patients particularly important...

..To evaluate the management of cardiovascular risk factors in a population-based cohort of adults with diabetes mellitus in Germany...

..pylori infected subjects. After adjustment for covariates the OR was 0.67 (95% CI: 0.47-0.95). These results support the hypothesis that colonization with H. pylori may protect from gastrointestinal infections that cause diarrhoea...

..19, 95% CI: 0.06-0.64). We conclude that risk reduction by screening endoscopy is long lasting, in particular with respect to advanced CRC...

..We examined the associations between serum adiponectin and several biomarkers related to cardiovascular disease and heart failure in a large high-risk population comprising patients with prevalent CHD...