Research Topics
| R BrehmSummaryAffiliation: University of Giessen Country: Germany Publications
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Detail Information
Publications
Altered expression of connexins 26 and 43 in Sertoli cells in seminiferous tubules infiltrated with carcinoma-in-situ or seminomaRalph Brehm
Institute of Veterinary Anatomy, University of Giessen, Germany
J Pathol 197:647-53. 2002....
A sertoli cell-specific knockout of connexin43 prevents initiation of spermatogenesisRalph Brehm
Justus Liebig Universitaet, Institut fuer Veterinaer Anatomie, Histologie, und Embryologie, Frankfurter Strasse 98, Giessen, Germany
Am J Pathol 171:19-31. 2007..Our data demonstrate for the first time that cx43 expression in SCs is an absolute requirement for normal testicular development and spermatogenesis...- Transition from preinvasive carcinoma in situ to seminoma is accompanied by a reduction of connexin 43 expression in Sertoli cells and germ cellsRalph Brehm
Institute of Veterinary Anatomy, Histology and Embryology, University of Giessen, Giessen, Germany
Neoplasia 8:499-509. 2006.... - Mitotic activity of Sertoli cells in adult human testis: an immunohistochemical study to characterize Sertoli cells in testicular cords from patients showing testicular dysgenesis syndromeRalph Brehm
Institute of Veterinary Anatomy, Histology and Embryology, University of Giessen, Giessen, Germany
Anat Embryol (Berl) 211:223-36. 2006.... - Regulation of Sertoli cell and germ cell differentationR Brehm
Institut für Veterinär Anatomie, Histologie und Embryologie, Justus Liebig Universtät, Giessen, Germany
Adv Anat Embryol Cell Biol 181:1-93. 2005.... - Connexin 43 expression of foreign body giant cells after implantation of nanoparticulate hydroxyapatiteKatja Herde
Institute of Veterinary Anatomy, University of Giessen, Frankfurter Str 98, 35392, Giessen, Germany
Biomaterials 28:4912-21. 2007.... 
Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in menCornelia Fink
Institute of Veterinary Anatomy, Histology and Embryology, University of Giessen, Frankfurter Str 98, 35392 Giessen, Germany
Histochem Cell Biol 131:755-64. 2009..In TIN tubules, claudin-11 is up-regulated and dislocated from the BTB. Therefore, the disruption of the BTB is related to a dysfunction of claudin-11 and not to a failure of its expression...- Specific localisation of gap junction protein connexin 32 in the gastric mucosa of horsesCornelia Fink
Department of Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, Frankfurter Strasse 98, Giessen, Germany
Histochem Cell Biol 125:307-13. 2006..These results suggest that gap junctions develop during the maturation of surface cells. Whether the lack of Cx32 at pars nonglandularis contributes to its susceptibility for developing ulcers, has to be further elucidated... - Connexin 33: a rodent-specific member of the gap junction protein family?Petra Fischer
Department of Veterinary Anatomy, Histology, and Embryology, University of Giessen, Germany
J Androl 26:75-84. 2005..These data indicate that cx33 seems to be the first rodent-specific testicular cx... - Cellular localization of estrogen receptor-alpha (ERalpha) and -beta (ERbeta) mRNA in the boar testisO Lekhkota
Institute of Veterinary Anatomy, Histology, and Embryology, Justus Liebig University Giessen, Frankfurterstrasse 98, 35392 Giessen, Germany
Histochem Cell Biol 125:259-64. 2006..Interstitial Leydig cells revealed neither ERalpha nor ERbeta mRNA. The data suggest a direct impact of estrogen in the boar on Sertoli cell function via ERbeta and germ cell formation via ERalpha... - Expression of connexin 43 in normal canine testes and canine testicular tumorsChristina Rüttinger
Institute of Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, Frankfurter Str 98, 35392 Giessen, Germany
Histochem Cell Biol 130:537-48. 2008..This study represents the first morphological work on the spatiotemporal expression pattern of Cx43 in normal and neoplastic canine testis... - DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancerOlufunmilade A Omisanjo
Department of Urology and Pediatric Urology, Giessen, Germany
Histochem Cell Biol 127:175-81. 2007..This holds true also in testicular tumors, where HDAC1 has been demonstrated in embryonal carcinoma, seminoma and teratoma. Interestingly, DNMT1 was not expressed in seminoma, but upregulated in embryonal carcinoma... - From carcinoma in situ to testicular germ cell tumourJudith Donner
Institute of Veterinary Anatomy, University of Giessen, Germany
APMIS 112:79-88. 2004..e. that the switch from pre-invasive CIS to invasive tumour takes place in situ by tubular enlargement due to tumour cell proliferation followed by Sertoli cell degeneration and conversion of the tubular wall into connective tissue... - Role of connexin 43 in Sertoli cells of testisSanthi Sridharan
Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
Ann N Y Acad Sci 1120:131-43. 2007..These model systems show that CX43 is important in Sertoli cell development, and will be useful in further studies of its role in Sertoli cell and testis biology... - Spatial expression of germ cell markers during maturation of human fetal male gonads: an immunohistochemical studyKatharina Pauls
Institute of Pathology and Department of Developmental Pathology, University of Bonn, Germany
Hum Reprod 21:397-404. 2006..The aim of the present study was to examine fetal male germ cells for expression of proteins associated with differentiation and maturation and to compare them with morphologically defined subpopulations... - Novel germ cell markers characterize testicular seminoma and fetal testisIsabella Gashaw
Institute of Anatomy, University of Duisburg Essen, Essen, Germany
Mol Hum Reprod 13:721-7. 2007.... - Gene expression profiling identifies new biological markers of neoplastic germ cellsKatharina Biermann
Institute of Pathology, University Hospital Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
Anticancer Res 27:3091-100. 2007..There is only limited knowledge about gene expression in human testicular germ cell tumors of adolescents and adults (TGCTs), and, in particular in its preinvasive stage intratubular germ cell neoplasia unclassified (IGCNU)... - Genome-wide expression profiling reveals new insights into pathogenesis and progression of testicular germ cell tumorsKatharina Biermann
Department of Pathology, University of Bonn, Bonn, Germany
Cancer Genomics Proteomics 4:359-67. 2007..In summary, our data identified tumor type-specific gene signatures of GCT and provided new insights into genetic pathways driving the transition to seminomas and embryonal carcinomas from their respective precursor lesions...