R Brehm

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. ncbi request reprint Altered expression of connexins 26 and 43 in Sertoli cells in seminiferous tubules infiltrated with carcinoma-in-situ or seminoma
    Ralph Brehm
    Institute of Veterinary Anatomy, University of Giessen, Germany
    J Pathol 197:647-53. 2002
  2. pmc A sertoli cell-specific knockout of connexin43 prevents initiation of spermatogenesis
    Ralph Brehm
    Justus Liebig Universitaet, Institut fuer Veterinaer Anatomie, Histologie, und Embryologie, Frankfurter Strasse 98, Giessen, Germany
    Am J Pathol 171:19-31. 2007
  3. pmc Transition from preinvasive carcinoma in situ to seminoma is accompanied by a reduction of connexin 43 expression in Sertoli cells and germ cells
    Ralph Brehm
    Institute of Veterinary Anatomy, Histology and Embryology, University of Giessen, Giessen, Germany
    Neoplasia 8:499-509. 2006
  4. ncbi request reprint Mitotic activity of Sertoli cells in adult human testis: an immunohistochemical study to characterize Sertoli cells in testicular cords from patients showing testicular dysgenesis syndrome
    Ralph Brehm
    Institute of Veterinary Anatomy, Histology and Embryology, University of Giessen, Giessen, Germany
    Anat Embryol (Berl) 211:223-36. 2006
  5. ncbi request reprint Regulation of Sertoli cell and germ cell differentation
    R Brehm
    Institut für Veterinär Anatomie, Histologie und Embryologie, Justus Liebig Universtät, Giessen, Germany
    Adv Anat Embryol Cell Biol 181:1-93. 2005
  6. ncbi request reprint Connexin 43 expression of foreign body giant cells after implantation of nanoparticulate hydroxyapatite
    Katja Herde
    Institute of Veterinary Anatomy, University of Giessen, Frankfurter Str 98, 35392, Giessen, Germany
    Biomaterials 28:4912-21. 2007
  7. doi request reprint Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men
    Cornelia Fink
    Institute of Veterinary Anatomy, Histology and Embryology, University of Giessen, Frankfurter Str 98, 35392 Giessen, Germany
    Histochem Cell Biol 131:755-64. 2009
  8. ncbi request reprint Specific localisation of gap junction protein connexin 32 in the gastric mucosa of horses
    Cornelia Fink
    Department of Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, Frankfurter Strasse 98, Giessen, Germany
    Histochem Cell Biol 125:307-13. 2006
  9. ncbi request reprint Connexin 33: a rodent-specific member of the gap junction protein family?
    Petra Fischer
    Department of Veterinary Anatomy, Histology, and Embryology, University of Giessen, Germany
    J Androl 26:75-84. 2005
  10. ncbi request reprint Cellular localization of estrogen receptor-alpha (ERalpha) and -beta (ERbeta) mRNA in the boar testis
    O Lekhkota
    Institute of Veterinary Anatomy, Histology, and Embryology, Justus Liebig University Giessen, Frankfurterstrasse 98, 35392 Giessen, Germany
    Histochem Cell Biol 125:259-64. 2006

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Altered expression of connexins 26 and 43 in Sertoli cells in seminiferous tubules infiltrated with carcinoma-in-situ or seminoma
    Ralph Brehm
    Institute of Veterinary Anatomy, University of Giessen, Germany
    J Pathol 197:647-53. 2002
    ....
  2. pmc A sertoli cell-specific knockout of connexin43 prevents initiation of spermatogenesis
    Ralph Brehm
    Justus Liebig Universitaet, Institut fuer Veterinaer Anatomie, Histologie, und Embryologie, Frankfurter Strasse 98, Giessen, Germany
    Am J Pathol 171:19-31. 2007
    ..Our data demonstrate for the first time that cx43 expression in SCs is an absolute requirement for normal testicular development and spermatogenesis...
  3. pmc Transition from preinvasive carcinoma in situ to seminoma is accompanied by a reduction of connexin 43 expression in Sertoli cells and germ cells
    Ralph Brehm
    Institute of Veterinary Anatomy, Histology and Embryology, University of Giessen, Giessen, Germany
    Neoplasia 8:499-509. 2006
    ....
  4. ncbi request reprint Mitotic activity of Sertoli cells in adult human testis: an immunohistochemical study to characterize Sertoli cells in testicular cords from patients showing testicular dysgenesis syndrome
    Ralph Brehm
    Institute of Veterinary Anatomy, Histology and Embryology, University of Giessen, Giessen, Germany
    Anat Embryol (Berl) 211:223-36. 2006
    ....
  5. ncbi request reprint Regulation of Sertoli cell and germ cell differentation
    R Brehm
    Institut für Veterinär Anatomie, Histologie und Embryologie, Justus Liebig Universtät, Giessen, Germany
    Adv Anat Embryol Cell Biol 181:1-93. 2005
    ....
  6. ncbi request reprint Connexin 43 expression of foreign body giant cells after implantation of nanoparticulate hydroxyapatite
    Katja Herde
    Institute of Veterinary Anatomy, University of Giessen, Frankfurter Str 98, 35392, Giessen, Germany
    Biomaterials 28:4912-21. 2007
    ....
  7. doi request reprint Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men
    Cornelia Fink
    Institute of Veterinary Anatomy, Histology and Embryology, University of Giessen, Frankfurter Str 98, 35392 Giessen, Germany
    Histochem Cell Biol 131:755-64. 2009
    ..In TIN tubules, claudin-11 is up-regulated and dislocated from the BTB. Therefore, the disruption of the BTB is related to a dysfunction of claudin-11 and not to a failure of its expression...
  8. ncbi request reprint Specific localisation of gap junction protein connexin 32 in the gastric mucosa of horses
    Cornelia Fink
    Department of Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, Frankfurter Strasse 98, Giessen, Germany
    Histochem Cell Biol 125:307-13. 2006
    ..These results suggest that gap junctions develop during the maturation of surface cells. Whether the lack of Cx32 at pars nonglandularis contributes to its susceptibility for developing ulcers, has to be further elucidated...
  9. ncbi request reprint Connexin 33: a rodent-specific member of the gap junction protein family?
    Petra Fischer
    Department of Veterinary Anatomy, Histology, and Embryology, University of Giessen, Germany
    J Androl 26:75-84. 2005
    ..These data indicate that cx33 seems to be the first rodent-specific testicular cx...
  10. ncbi request reprint Cellular localization of estrogen receptor-alpha (ERalpha) and -beta (ERbeta) mRNA in the boar testis
    O Lekhkota
    Institute of Veterinary Anatomy, Histology, and Embryology, Justus Liebig University Giessen, Frankfurterstrasse 98, 35392 Giessen, Germany
    Histochem Cell Biol 125:259-64. 2006
    ..Interstitial Leydig cells revealed neither ERalpha nor ERbeta mRNA. The data suggest a direct impact of estrogen in the boar on Sertoli cell function via ERbeta and germ cell formation via ERalpha...
  11. doi request reprint Expression of connexin 43 in normal canine testes and canine testicular tumors
    Christina Rüttinger
    Institute of Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, Frankfurter Str 98, 35392 Giessen, Germany
    Histochem Cell Biol 130:537-48. 2008
    ..This study represents the first morphological work on the spatiotemporal expression pattern of Cx43 in normal and neoplastic canine testis...
  12. ncbi request reprint DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer
    Olufunmilade A Omisanjo
    Department of Urology and Pediatric Urology, Giessen, Germany
    Histochem Cell Biol 127:175-81. 2007
    ..This holds true also in testicular tumors, where HDAC1 has been demonstrated in embryonal carcinoma, seminoma and teratoma. Interestingly, DNMT1 was not expressed in seminoma, but upregulated in embryonal carcinoma...
  13. ncbi request reprint From carcinoma in situ to testicular germ cell tumour
    Judith Donner
    Institute of Veterinary Anatomy, University of Giessen, Germany
    APMIS 112:79-88. 2004
    ..e. that the switch from pre-invasive CIS to invasive tumour takes place in situ by tubular enlargement due to tumour cell proliferation followed by Sertoli cell degeneration and conversion of the tubular wall into connective tissue...
  14. ncbi request reprint Role of connexin 43 in Sertoli cells of testis
    Santhi Sridharan
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
    Ann N Y Acad Sci 1120:131-43. 2007
    ..These model systems show that CX43 is important in Sertoli cell development, and will be useful in further studies of its role in Sertoli cell and testis biology...
  15. ncbi request reprint Spatial expression of germ cell markers during maturation of human fetal male gonads: an immunohistochemical study
    Katharina Pauls
    Institute of Pathology and Department of Developmental Pathology, University of Bonn, Germany
    Hum Reprod 21:397-404. 2006
    ..The aim of the present study was to examine fetal male germ cells for expression of proteins associated with differentiation and maturation and to compare them with morphologically defined subpopulations...
  16. ncbi request reprint Novel germ cell markers characterize testicular seminoma and fetal testis
    Isabella Gashaw
    Institute of Anatomy, University of Duisburg Essen, Essen, Germany
    Mol Hum Reprod 13:721-7. 2007
    ....
  17. ncbi request reprint Gene expression profiling identifies new biological markers of neoplastic germ cells
    Katharina Biermann
    Institute of Pathology, University Hospital Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Anticancer Res 27:3091-100. 2007
    ..There is only limited knowledge about gene expression in human testicular germ cell tumors of adolescents and adults (TGCTs), and, in particular in its preinvasive stage intratubular germ cell neoplasia unclassified (IGCNU)...
  18. ncbi request reprint Genome-wide expression profiling reveals new insights into pathogenesis and progression of testicular germ cell tumors
    Katharina Biermann
    Department of Pathology, University of Bonn, Bonn, Germany
    Cancer Genomics Proteomics 4:359-67. 2007
    ..In summary, our data identified tumor type-specific gene signatures of GCT and provided new insights into genetic pathways driving the transition to seminomas and embryonal carcinomas from their respective precursor lesions...