Research Topics
Genomes and GenesSpecies | J M BrandnerSummaryAffiliation: University of Hamburg Country: Germany Publications
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Publications
Tight junction proteins in the skinJ M Brandner
Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Germany
Skin Pharmacol Physiol 19:71-7. 2006..Their involvement in the barrier function of mammalian skin has been shown. This review summarizes our current knowledge about TJ and TJ proteins in mammalian skin...- Organization and formation of the tight junction system in human epidermis and cultured keratinocytesJohanna M Brandner
Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Germany
Eur J Cell Biol 81:253-63. 2002..The pattern of formation and possible functions of epidermal TJ and related structures are discussed... - Tight junctions and tight junction proteins in mammalian epidermisJohanna M Brandner
Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Eur J Pharm Biopharm 72:289-94. 2009..g. psoriasis. Meanwhile several TJ modulators are known from simple epithelia. We discuss their putative usability for drug delivery into and through the skin... - Connexins 26, 30, and 43: differences among spontaneous, chronic, and accelerated human wound healingJohanna M Brandner
Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Hamburg, Germany
J Invest Dermatol 122:1310-20. 2004..We discuss the assumption that direct cell-cell communication via GJ contribute to the acceleration of wound healing after the transplantation of keratinocytes... - Evidence for distinct populations of human Merkel cellsA C Eispert
Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Histochem Cell Biol 132:83-93. 2009..We conclude that there are distinct populations of MCs, but all populations contain markers for epithelial as well as neural cells. Putative functions of the distinct populations are discussed... - Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokinesNina Kirschner
Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
Am J Pathol 175:1095-106. 2009..Our data indicate that cytokines are involved in alterations of TJ proteins observed in psoriasis... - In vitro isolation and cell culture of vestibular inner ear melanocytesMarcos Sanchez Hanke
Department of Otorhinolaryngology, Medical School, Hamburg University, DE 20246 Hamburg, Germany
Audiol Neurootol 10:191-200. 2005.... - Human Merkel cells--aspects of cell biology, distribution and functionsIngrid Moll
Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf Martinistr 52, D 20246 Hamburg, Germany
Eur J Cell Biol 84:259-71. 2005..We summarize and discuss data on the distribution, function and heterogeneity of human Merkel cells in normal and diseased skin... - An ex-vivo oral mucosa infection model for the evaluation of the topical activity of antifungal agentsU Ohnemus
Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
Mycoses 51:21-9. 2008..Additionally, it seems to be a valuable tool for further investigations of the pathogenesis of C. albicans infections... - Expression and localization of tight junction-associated proteins in human hair folliclesJohanna M Brandner
Department of Dermatology and Venerology, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Arch Dermatol Res 295:211-21. 2003..The morphological and biological importance of these findings and the possible roles of TJ in hair follicles, e.g. in follicular penetration, are discussed... - Regulation of epidermal tight-junctions (TJ) during infection with exfoliative toxin-negative Staphylococcus strainsUlrich Ohnemus
Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Hamburg, Germany
J Invest Dermatol 128:906-16. 2008..aureus. As we did not find a change in actin, and as changes of TJ preceded alterations of AJs and desmosomes, we suggest that S. aureus targets TJ... - Melanoma progression exhibits a significant impact on connexin expression patterns in the epidermal tumor microenvironmentNikolas K Haass
Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Histochem Cell Biol 133:113-24. 2010..In summary, here we show for the first time a significant association between the progression of melanoma and alterations in its epithelial tumor microenvironment... - Biphasic regulation of AP-1 subunits during human epidermal wound healingAngela Neub
Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Hamburg, Germany
J Invest Dermatol 127:2453-62. 2007.... - Expression of matrix metalloproteinases, cytokines, and connexins in diabetic and nondiabetic human keratinocytes before and after transplantation into an ex vivo wound-healing modelJohanna M Brandner
Department of Dermatology and Venerology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Diabetes Care 31:114-20. 2008..Therefore, we intended to characterize transplanted keratinocytes from diabetic and nondiabetic origin before and after transplantation... - Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctionsChong Wee Liew
Institut fur Zellbiochemie und klinische Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
FEBS Lett 583:49-54. 2009..Interaction with MUPP1 enables the receptor to regulate transepithelial permeability in a pertussis toxin sensitive manner, suggesting that hSSTR3 can activate G-proteins locally at tight junctions... - Differential induction of connexins 26 and 30 in skin tumors and their adjacent epidermisNikolas K Haass
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
J Histochem Cytochem 54:171-82. 2006..We further discuss the putative roles of these gap junctional proteins in tumor progression... - Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefromLutz Langbein
Division of Cell Biology, German Cancer Research Center, Heidelberg
Eur J Cell Biol 81:419-35. 2002..The significance of these structures and their possible biological importance are discussed... - Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesionKeiran S M Smalley
Wistar Institute, 3601 Spruce St, Philadelphia, Pennsylvania 19104, USA
Am J Pathol 166:1541-54. 2005.... - Selection for deafness?Christian G Meyer
Nat Med 8:1332-3. 2002 - Hash4, a novel human achaete-scute homologue found in fetal skinMarianne Jonsson
Research Center for Endocrinology and Metabolism, Department of Clinical Chemistry and Transfusion Medicine, The Sahlgrenska Academy at Gothenburg University, S 413 45 Gothenburg, Sweden
Genomics 84:859-66. 2004..Quantification of the Hash4 expression by real-time PCR revealed a 7-fold higher expression in fetal skin compared to adult skin. Our results suggest HASH4 to be involved in skin development...