Lars Ove Brandenburg

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi request reprint Role of glial cells in the functional expression of LL-37/rat cathelin-related antimicrobial peptide in meningitis
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    J Neuropathol Exp Neurol 67:1041-54. 2008
  2. doi request reprint Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroimmunol 217:55-64. 2009
  3. doi request reprint Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    J Neurochem 113:749-60. 2010
  4. doi request reprint Sulforaphane suppresses LPS-induced inflammation in primary rat microglia
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Inflamm Res 59:443-50. 2010
  5. pmc The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis
    Benedikt J Braun
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroinflammation 8:11. 2011
  6. pmc Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE)--and amyloid beta 1-42-induced signal transduction in glial cells
    Alexander Slowik
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Mol Neurodegener 7:55. 2012
  7. doi request reprint ADAM12 is expressed by astrocytes during experimental demyelination
    Fabian Baertling
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
    Brain Res 1326:1-14. 2010
  8. pmc Expression and function of psoriasin (S100A7) and koebnerisin (S100A15) in the brain
    Sandra Jansen
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    Infect Immun 81:1788-97. 2013
  9. doi request reprint Nrf2 expression by neurons, astroglia, and microglia in the cerebral cortical penumbra of ischemic rats
    Jon Dang
    Institute of Neuroanatomy, Medical Faculty, RWTH Aachen University, Aachen, Germany
    J Mol Neurosci 46:578-84. 2012
  10. pmc Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter
    Christoph Jan Wruck
    Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
    J Biol Chem 286:4493-9. 2011

Collaborators

Detail Information

Publications22

  1. doi request reprint Role of glial cells in the functional expression of LL-37/rat cathelin-related antimicrobial peptide in meningitis
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    J Neuropathol Exp Neurol 67:1041-54. 2008
    ..Together, these results suggest that cathelicidins produced by glia and other cells play an important part in the innate immune response against pathogens in central nervous system bacterial infections...
  2. doi request reprint Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroimmunol 217:55-64. 2009
    ..These results suggest that cathelicidins produced by meningeal cells play an important part in the innate immune response against pathogens in CNS bacterial infections...
  3. doi request reprint Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    J Neurochem 113:749-60. 2010
    ..These results suggest that FPRL1 plays a pivotal role for Abeta1-42-induced signal transduction in glial cells and the interaction with MARCO could explain the broad ligand spectrum of formyl peptide receptors...
  4. doi request reprint Sulforaphane suppresses LPS-induced inflammation in primary rat microglia
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Inflamm Res 59:443-50. 2010
    ..Additionally, we investigated the effects of SF and LPS on the activity of Nrf2...
  5. pmc The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis
    Benedikt J Braun
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroinflammation 8:11. 2011
    ..Expression of the antimicrobial peptide cathelicidin CRAMP/LL-37 is up-regulated in bacterial meningitis, but the mechanisms underlying CRAMP expression are far from clear...
  6. pmc Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE)--and amyloid beta 1-42-induced signal transduction in glial cells
    Alexander Slowik
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Mol Neurodegener 7:55. 2012
    ..Formyl peptide receptors and RAGE were inhibited by a small synthetic antagonist WRW4 and an inactive receptor variant delta-RAGE, lacking the intracytoplasmatic domains...
  7. doi request reprint ADAM12 is expressed by astrocytes during experimental demyelination
    Fabian Baertling
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
    Brain Res 1326:1-14. 2010
    ..In summary, we demonstrated that ADAM12 is not a suitable marker for oligodendrocytes. Our results further suggest that ADAM12 might be implicated in the course of distinct CNS diseases such as demyelinating disorders...
  8. pmc Expression and function of psoriasin (S100A7) and koebnerisin (S100A15) in the brain
    Sandra Jansen
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    Infect Immun 81:1788-97. 2013
    ..In conclusion, our results indicate an occurrence of psoriasin in the brain. An involvement of psoriasin as an antimicrobial protein that modulates the innate immune system after bacterial or viral stimulation is possible...
  9. doi request reprint Nrf2 expression by neurons, astroglia, and microglia in the cerebral cortical penumbra of ischemic rats
    Jon Dang
    Institute of Neuroanatomy, Medical Faculty, RWTH Aachen University, Aachen, Germany
    J Mol Neurosci 46:578-84. 2012
    ..These results provide strong evidence that Nrf2 is involved in acute stroke-dependent neurodegeneration in the penumbra but not core region and indicate the presence of a systemic Nrf2 activator independent from oxidative stress...
  10. pmc Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter
    Christoph Jan Wruck
    Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
    J Biol Chem 286:4493-9. 2011
    ..Our findings suggest a possible role of IL-6 in oxidative stress defense and also give indication about an important function for Nrf2 in the regulation of hematopoietic and inflammatory processes...
  11. doi request reprint Antimicrobial peptide rCRAMP induced glial cell activation through P2Y receptor signalling pathways
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, University Hospital Aachen, Aachen, Germany
    Mol Immunol 47:1905-13. 2010
    ..This study provides evidence that rCRAMP participates in brain immunity by stimulating cytokine production and glial cell activation, and aid in the protection of brain cells by inducing neurotrophic factors...
  12. doi request reprint Involvement of Phospholipase D 1 and 2 in the subcellular localization and activity of formyl-peptide-receptors in the human colonic cell line HT29
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, Aachen, Germany
    Mol Membr Biol 26:371-83. 2009
    ..The constitutive internalization rate was unaffected. Our results support the importance of PLD1 and 2 in formyl peptide receptor function and the role of endocytosis, receptor recycling and reactivation for receptor activity...
  13. doi request reprint Thrombocytes are effectors of the innate immune system releasing human beta defensin-3
    Mersedeh Tohidnezhad
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    Injury 42:682-6. 2011
    ..In this study we investigated the antimicrobial effect of PRP against gram-negative microbes which frequently cause severe complications in orthopaedic trauma surgery...
  14. doi request reprint CpG oligodeoxynucleotides induce the expression of the antimicrobial peptide cathelicidin in glial cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroimmunol 255:18-31. 2013
    ..Additional findings suggest also that CpG-DNA-induced effects are not only mediated by TLR9, but also mediated by other pattern recognition receptors...
  15. doi request reprint Platelets display potent antimicrobial activity and release human beta-defensin 2
    Mersedeh Tohidnezhad
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2 D 52074, Aachen, Germany
    Platelets 23:217-23. 2012
    ..coli and P. mirabilis for this effect by the detection of an antimicrobial peptide (hBD-2). This study may advocate the clinical use of PRP by highlighting a new aspect of platelet action...
  16. doi request reprint Effects of controlled released BMP-7 on markers of inflammation and degradation during the cultivation of human osteoarthritic chondrocytes
    Karsten Gavenis
    Department of Orthopaedic and Trauma Surgery, Aachen University Hospital, and Department of Anatomy and Cell Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany
    J Biomater Appl 26:419-33. 2011
    ..In summary, controlled release of low concentrated BMP-7 from polylactide microspheres leads to a decrease in gene expression of the investigated inflammation and matrix degradation markers whereas matrix synthesis is induced...
  17. doi request reprint Impact of Nrf2 on esophagus epithelium cornification
    Christoph J Wruck
    Department of Anatomy and Cell Biology, Medical Faculty, Rheinisch Westfälische Technische Hochschule Aachen University, Aachen, Germany
    Int J Dermatol 50:1362-5. 2011
    ..Nrf2 is a transcription factor that is known to maintain cellular defense against the toxicity of electrophiles and reactive oxygen species (ROS)...
  18. doi request reprint Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation
    Christoph J Wruck
    Department of Anatomy and Cell Biology, RWTH Aachen, Wendlingweg 2, 52074 Aachen, Germany
    Mol Pharmacol 73:1785-95. 2008
    ..These findings indicate that the use of purified kavalactones might be considered as an adjunct therapeutic strategy to combat neural demise in Alzheimer disease and other oxidative stress-related diseases...
  19. doi request reprint Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice
    Christoph Jan Wruck
    Correspondence to Christoph J Wruck, Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Ann Rheum Dis 70:844-50. 2011
    ..The aim of this study was to elucidate the role of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that maintains the cellular defence against oxidative stress, in RA...
  20. doi request reprint Lack of hepatic c-Met and gp130 expression is associated with an impaired antibacterial response and higher lethality after bile duct ligation
    Arne Giebeler
    Department of Medicine III, University Hospital, Aachen, Germany
    Lab Invest 92:1726-37. 2012
    ..In conclusion, Gp130 and c-Met are involved in the hepatic antibacterial and innate immune response, control the APR and thus prevent sepsis and liver injury during cholestatic conditions...
  21. doi request reprint Internalization and signal transduction of PrP(106-126) in neuronal cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany Department of Anatomy, University of Kiel, Germany
    Ann Anat 191:459-68. 2009
    ....
  22. doi request reprint Role of a fetal defence mechanism against oxidative stress in the aetiology of preeclampsia
    Christoph Jan Wruck
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    Histopathology 55:102-6. 2009
    ..The aim of this study was to elucidate the placental defence mechanisms employed against oxidative stress and, in particular, the specific role of nuclear factor erythroid 2-related factor 2 (Nrf2)...