L O Brandenburg

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi request reprint CpG oligodeoxynucleotides induce the expression of the antimicrobial peptide cathelicidin in glial cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroimmunol 255:18-31. 2013
  2. pmc Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE)--and amyloid beta 1-42-induced signal transduction in glial cells
    Alexander Slowik
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Mol Neurodegener 7:55. 2012
  3. pmc The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis
    Benedikt J Braun
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroinflammation 8:11. 2011
  4. doi request reprint Antimicrobial peptide rCRAMP induced glial cell activation through P2Y receptor signalling pathways
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, University Hospital Aachen, Aachen, Germany
    Mol Immunol 47:1905-13. 2010
  5. doi request reprint Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    J Neurochem 113:749-60. 2010
  6. doi request reprint Sulforaphane suppresses LPS-induced inflammation in primary rat microglia
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Inflamm Res 59:443-50. 2010
  7. doi request reprint Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroimmunol 217:55-64. 2009
  8. doi request reprint Involvement of Phospholipase D 1 and 2 in the subcellular localization and activity of formyl-peptide-receptors in the human colonic cell line HT29
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, Aachen, Germany
    Mol Membr Biol 26:371-83. 2009
  9. doi request reprint Internalization and signal transduction of PrP(106-126) in neuronal cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany Department of Anatomy, University of Kiel, Germany
    Ann Anat 191:459-68. 2009
  10. doi request reprint Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization and signal transduction of amyloid beta 1-42 in glial cells
    L O Brandenburg
    Department of Anatomy and Cell Biology, University Hospital RWTH Aachen, Wendlingweg 2, 52074 Aachen, Germany
    Neuroscience 156:266-76. 2008

Collaborators

Detail Information

Publications18

  1. doi request reprint CpG oligodeoxynucleotides induce the expression of the antimicrobial peptide cathelicidin in glial cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroimmunol 255:18-31. 2013
    ..Additional findings suggest also that CpG-DNA-induced effects are not only mediated by TLR9, but also mediated by other pattern recognition receptors...
  2. pmc Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE)--and amyloid beta 1-42-induced signal transduction in glial cells
    Alexander Slowik
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Mol Neurodegener 7:55. 2012
    ..Formyl peptide receptors and RAGE were inhibited by a small synthetic antagonist WRW4 and an inactive receptor variant delta-RAGE, lacking the intracytoplasmatic domains...
  3. pmc The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis
    Benedikt J Braun
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroinflammation 8:11. 2011
    ..Expression of the antimicrobial peptide cathelicidin CRAMP/LL-37 is up-regulated in bacterial meningitis, but the mechanisms underlying CRAMP expression are far from clear...
  4. doi request reprint Antimicrobial peptide rCRAMP induced glial cell activation through P2Y receptor signalling pathways
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, University Hospital Aachen, Aachen, Germany
    Mol Immunol 47:1905-13. 2010
    ..This study provides evidence that rCRAMP participates in brain immunity by stimulating cytokine production and glial cell activation, and aid in the protection of brain cells by inducing neurotrophic factors...
  5. doi request reprint Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    J Neurochem 113:749-60. 2010
    ..These results suggest that FPRL1 plays a pivotal role for Abeta1-42-induced signal transduction in glial cells and the interaction with MARCO could explain the broad ligand spectrum of formyl peptide receptors...
  6. doi request reprint Sulforaphane suppresses LPS-induced inflammation in primary rat microglia
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Inflamm Res 59:443-50. 2010
    ..Additionally, we investigated the effects of SF and LPS on the activity of Nrf2...
  7. doi request reprint Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroimmunol 217:55-64. 2009
    ..These results suggest that cathelicidins produced by meningeal cells play an important part in the innate immune response against pathogens in CNS bacterial infections...
  8. doi request reprint Involvement of Phospholipase D 1 and 2 in the subcellular localization and activity of formyl-peptide-receptors in the human colonic cell line HT29
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, Aachen, Germany
    Mol Membr Biol 26:371-83. 2009
    ..The constitutive internalization rate was unaffected. Our results support the importance of PLD1 and 2 in formyl peptide receptor function and the role of endocytosis, receptor recycling and reactivation for receptor activity...
  9. doi request reprint Internalization and signal transduction of PrP(106-126) in neuronal cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany Department of Anatomy, University of Kiel, Germany
    Ann Anat 191:459-68. 2009
    ....
  10. doi request reprint Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization and signal transduction of amyloid beta 1-42 in glial cells
    L O Brandenburg
    Department of Anatomy and Cell Biology, University Hospital RWTH Aachen, Wendlingweg 2, 52074 Aachen, Germany
    Neuroscience 156:266-76. 2008
    ..Together, these data suggest that PLD plays an important role in the regulation of Abeta1-42-induced endocytosis and FPRL1 receptor signaling...
  11. ncbi request reprint Internalization of PrP106-126 by the formyl-peptide-receptor-like-1 in glial cells
    Lars Ove Brandenburg
    Department of Anatomy, University of Kiel, Kiel, Germany
    J Neurochem 101:718-28. 2007
    ....
  12. doi request reprint Complex patterns of ADAM12 mRNA and protein splice variants in the human placenta
    M Kokozidou
    Institute of Anatomy and Cell Biology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
    Ann Anat 193:142-8. 2011
    ..Via differential splicing, the ADAM12 gene produces a short and a long form, being the ADAM12-S and the ADAM12-L respectively...
  13. doi request reprint Role of glial cells in the functional expression of LL-37/rat cathelin-related antimicrobial peptide in meningitis
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    J Neuropathol Exp Neurol 67:1041-54. 2008
    ..Together, these results suggest that cathelicidins produced by glia and other cells play an important part in the innate immune response against pathogens in central nervous system bacterial infections...
  14. doi request reprint ADAM12 is expressed by astrocytes during experimental demyelination
    Fabian Baertling
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
    Brain Res 1326:1-14. 2010
    ..In summary, we demonstrated that ADAM12 is not a suitable marker for oligodendrocytes. Our results further suggest that ADAM12 might be implicated in the course of distinct CNS diseases such as demyelinating disorders...
  15. doi request reprint Role of a fetal defence mechanism against oxidative stress in the aetiology of preeclampsia
    Christoph Jan Wruck
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    Histopathology 55:102-6. 2009
    ..The aim of this study was to elucidate the placental defence mechanisms employed against oxidative stress and, in particular, the specific role of nuclear factor erythroid 2-related factor 2 (Nrf2)...
  16. doi request reprint Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation
    Christoph J Wruck
    Department of Anatomy and Cell Biology, RWTH Aachen, Wendlingweg 2, 52074 Aachen, Germany
    Mol Pharmacol 73:1785-95. 2008
    ..These findings indicate that the use of purified kavalactones might be considered as an adjunct therapeutic strategy to combat neural demise in Alzheimer disease and other oxidative stress-related diseases...
  17. pmc Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter
    Christoph Jan Wruck
    Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
    J Biol Chem 286:4493-9. 2011
    ..Our findings suggest a possible role of IL-6 in oxidative stress defense and also give indication about an important function for Nrf2 in the regulation of hematopoietic and inflammatory processes...
  18. doi request reprint Platelet-released growth factors can accelerate tenocyte proliferation and activate the anti-oxidant response element
    M Tohidnezhad
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany
    Histochem Cell Biol 135:453-60. 2011
    ..Here, we provide evidence of a biological effect of PRGF on tenocytes by the promotion of tenocyte growth and activation of the Nrf2-ARE pathway. This is a novel aspect of the action of platelet concentrates on tendon growth...