L O Brandenburg


Affiliation: University Hospital
Country: Germany


  1. Aust V, Kress E, Abraham S, Schröder N, Kipp M, Stope M, et al. Lack of chemokine (C-C motif) ligand 3 leads to decreased survival and reduced immune response after bacterial meningitis. Cytokine. 2018;111:246-254 pubmed publisher
    ..Pharmacological modulation of the CCL3 pathways might, therefore, represent a future therapeutic option to manage Streptococcus pneumoniae meningitis. ..
  2. Tohidnezhad M, Wruck C, Slowik A, Kweider N, Beckmann R, Bayer A, et al. Role of platelet-released growth factors in detoxification of reactive oxygen species in osteoblasts. Bone. 2014;65:9-17 pubmed publisher
    ..Nrf2 activation via PRGF may have great potential as an effective therapeutic drug target in fracture healing. ..
  3. Beckmann R, Houben A, Tohidnezhad M, Kweider N, Fragoulis A, Wruck C, et al. Mechanical forces induce changes in VEGF and VEGFR-1/sFlt-1 expression in human chondrocytes. Int J Mol Sci. 2014;15:15456-74 pubmed publisher
    ..More importantly, it induces disturbed VEGF signaling, providing a molecular mechanism for a stress-induced increase in angiogenesis in cartilage pathologies. ..
  4. Dörr A, Kress E, Podschun R, Pufe T, Tauber S, Brandenburg L. Intrathecal application of the antimicrobial peptide CRAMP reduced mortality and neuroinflammation in an experimental model of pneumococcal meningitis. J Infect. 2015;71:188-99 pubmed publisher
    ..The APs may be a promising approach for the development of an adjuvant therapy for bacterial meningitis. ..
  5. Brandenburg L, Jansen S, Wruck C, Lucius R, Pufe T. Antimicrobial peptide rCRAMP induced glial cell activation through P2Y receptor signalling pathways. Mol Immunol. 2010;47:1905-13 pubmed publisher
    ..This study provides evidence that rCRAMP participates in brain immunity by stimulating cytokine production and glial cell activation, and aid in the protection of brain cells by inducing neurotrophic factors. ..
  6. Brandenburg L, Jansen S, Albrecht L, Merres J, Gerber J, Pufe T, et al. CpG oligodeoxynucleotides induce the expression of the antimicrobial peptide cathelicidin in glial cells. J Neuroimmunol. 2013;255:18-31 pubmed publisher
    ..Additional findings suggest also that CpG-DNA-induced effects are not only mediated by TLR9, but also mediated by other pattern recognition receptors. ..
  7. Schumacher A, Denecke B, Braunschweig T, Stahlschmidt J, Ziegler S, Brandenburg L, et al. Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy. J Hematol Oncol. 2015;8:64 pubmed publisher
  8. Böhland M, Kress E, Stope M, Pufe T, Tauber S, Brandenburg L. Lack of Toll-like receptor 2 results in higher mortality of bacterial meningitis by impaired host resistance. J Neuroimmunol. 2016;299:90-97 pubmed publisher
  9. Esser S, Göpfrich L, Bihler K, Kress E, Nyamoya S, Tauber S, et al. Toll-Like Receptor 2-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination. Mol Neurobiol. 2018;55:6237-6249 pubmed publisher
    ..Future studies now have to address the underlying mechanisms of the region-specific TLR2-mediated glia activation. ..

More Information


  1. Brandenburg L, Kipp M, Lucius R, Pufe T, Wruck C. Sulforaphane suppresses LPS-induced inflammation in primary rat microglia. Inflamm Res. 2010;59:443-50 pubmed publisher
    ..We showed that SF, and also LPS by itself, are able to activate the cell's defence against oxidative and electrophilic stress. We conclude that SF could be a candidate agent for anti-inflammatory treatment of the central nervous system. ..
  2. Bihler K, Kress E, Esser S, Nyamoya S, Tauber S, Clarner T, et al. Formyl Peptide Receptor 1-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination. J Mol Neurosci. 2017;62:232-243 pubmed publisher
    ..Combined together, these results suggest that the FPR1 is an important part of the innate immune response in the course of cuprizone-induced demyelination. ..
  3. Brandenburg L, Konrad M, Wruck C, Koch T, Lucius R, Pufe T. Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells. J Neurochem. 2010;113:749-60 pubmed publisher
    ..These results suggest that FPRL1 plays a pivotal role for Abeta1-42-induced signal transduction in glial cells and the interaction with MARCO could explain the broad ligand spectrum of formyl peptide receptors. ..
  4. Brandenburg L, Konrad M, Wruck C, Koch T, Pufe T, Lucius R. Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization and signal transduction of amyloid beta 1-42 in glial cells. Neuroscience. 2008;156:266-76 pubmed publisher
    ..Together, these data suggest that PLD plays an important role in the regulation of Abeta1-42-induced endocytosis and FPRL1 receptor signaling. ..
  5. Brandenburg L, Varoga D, Nicolaeva N, Leib S, Podschun R, Wruck C, et al. Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cells. J Neuroimmunol. 2009;217:55-64 pubmed publisher
    ..These results suggest that cathelicidins produced by meningeal cells play an important part in the innate immune response against pathogens in CNS bacterial infections. ..
  6. Fragoulis A, Siegl S, Fendt M, Jansen S, Soppa U, Brandenburg L, et al. Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease. Redox Biol. 2017;12:843-853 pubmed publisher
    ..Therefore, kavalactones might be suitable candidates to serve as lead compounds for the development of a new class of neuroprotective drugs. ..
  7. Kress E, Merres J, Albrecht L, Hammerschmidt S, Pufe T, Tauber S, et al. CRAMP deficiency leads to a pro-inflammatory phenotype and impaired phagocytosis after exposure to bacterial meningitis pathogens. Cell Commun Signal. 2017;15:32 pubmed publisher
    ..The results indicate the importance of CRAMP to maintain and regulate the delicate balance between beneficial and harmful immune response in the brain. ..
  8. Brandenburg L, Seyferth S, Wruck C, Koch T, Rosenstiel P, Lucius R, et al. Involvement of Phospholipase D 1 and 2 in the subcellular localization and activity of formyl-peptide-receptors in the human colonic cell line HT29. Mol Membr Biol. 2009;26:371-83 pubmed publisher
    ..The constitutive internalization rate was unaffected. Our results support the importance of PLD1 and 2 in formyl peptide receptor function and the role of endocytosis, receptor recycling and reactivation for receptor activity. ..