Stephan Brand

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, Munich, Germany
    J Cell Biochem 97:709-23. 2006
  2. ncbi IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern and University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 292:G1019-28. 2007
  3. ncbi Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
    S Brand
    Department of Medicine II Grosshadern, Ludwig Maximilians University Munich, D 81377 Munich, Germany
    Gut 58:1152-67. 2009
  4. ncbi CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, Germany
    Exp Cell Res 310:117-30. 2005
  5. ncbi IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, D 81377 Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 289:G960-8. 2005
  6. ncbi The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, Munich, Germany
    Inflamm Bowel Dis 11:645-52. 2005
  7. ncbi Formation of antinuclear and double-strand DNA antibodies and frequency of lupus-like syndrome in anti-TNF-α antibody-treated patients with inflammatory bowel disease
    Florian Beigel
    Department of Medicine II, University Hospital Munich Grosshadern, Ludwig Maximilians University Munich, Germany
    Inflamm Bowel Dis 17:91-8. 2011
  8. ncbi IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 290:G827-38. 2006
  9. ncbi Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease
    Helga P Török
    Department of Internal Medicine II, Campus Grosshadern, University of Munich, Munich, Germany
    Am J Gastroenterol 104:1723-33. 2009
  10. ncbi Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease
    Julia Dambacher
    University Hospital Munich Grosshadern, Department of Medicine II, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Gut 56:1257-65. 2007

Collaborators

Detail Information

Publications59

  1. ncbi Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, Munich, Germany
    J Cell Biochem 97:709-23. 2006
    ..CCR6 mediated signals result in increased IEC migration and proliferation suggesting an important role in intestinal homeostasis and intestinal inflammation by mediating chemotaxis of IEC but also in mediating migration of CRC cells...
  2. ncbi IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern and University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 292:G1019-28. 2007
    ..In conclusion, IL-22 promotes liver cell regeneration by increasing hepatic cell proliferation and hepatocyte migration through the activation of Akt and STAT signaling, which is abrogated by SOCS-1/3 overexpression...
  3. ncbi Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
    S Brand
    Department of Medicine II Grosshadern, Ludwig Maximilians University Munich, D 81377 Munich, Germany
    Gut 58:1152-67. 2009
    ..However, the complex relationship between Th1 and Th17 cells has not been completely analysed. This will be of great importance to delineate the specific contributions of these cells to Crohn's disease and other autoimmune diseases...
  4. ncbi CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, Germany
    Exp Cell Res 310:117-30. 2005
    ..Therefore, the CXCL12/CXCR4 system is an important mediator of invasion and metastasis of CXCR4 expressing CRC cells...
  5. ncbi IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, D 81377 Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 289:G960-8. 2005
    ....
  6. ncbi The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, Munich, Germany
    Inflamm Bowel Dis 11:645-52. 2005
    ..We investigated the influence of 2 common Toll-like receptor 4 (TLR4) polymorphisms on susceptibility and disease characteristics of Crohn's disease (CD)...
  7. ncbi Formation of antinuclear and double-strand DNA antibodies and frequency of lupus-like syndrome in anti-TNF-α antibody-treated patients with inflammatory bowel disease
    Florian Beigel
    Department of Medicine II, University Hospital Munich Grosshadern, Ludwig Maximilians University Munich, Germany
    Inflamm Bowel Dis 17:91-8. 2011
    ..However, the clinical relevance of autoantibody formation and predictive factors are unclear...
  8. ncbi IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 290:G827-38. 2006
    ..IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and IEC migration...
  9. ncbi Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease
    Helga P Török
    Department of Internal Medicine II, Campus Grosshadern, University of Munich, Munich, Germany
    Am J Gastroenterol 104:1723-33. 2009
    ....
  10. ncbi Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease
    Julia Dambacher
    University Hospital Munich Grosshadern, Department of Medicine II, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Gut 56:1257-65. 2007
    ..The aim of this study was to analyse IL31 receptor expression, signal transduction, and specific biological functions of this cytokine system in intestinal inflammation...
  11. ncbi The presence of fistulas and NOD2 homozygosity strongly predict intestinal stenosis in Crohn's disease independent of the IL23R genotype
    Matthias Jürgens
    Department of Medicine II, Grosshadern, Ludwig Maximilians University Munich, Marchioninistr 15, 81377, Munich, Germany
    J Gastroenterol 45:721-31. 2010
    ..We analyzed the prevalence of concomitant intestinal stenosis in patients with fistulizing Crohn's disease (CD), including the NOD2/CARD15 and IL23R genotype status...
  12. ncbi The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population
    Jurgen Glas
    Department of Medicine II Grosshadern, University of Munich, Germany
    Am J Gastroenterol 103:682-91. 2008
    ....
  13. ncbi rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population
    Jurgen Glas
    Department of Medicine II, Grosshadern, University of Munich, Germany
    Am J Gastroenterol 104:665-72. 2009
    ..Therefore we aimed to replicate these novel CD susceptibility variants in a large European cohort with inflammatory bowel disease and analyzed potential gene-gene interactions with variants in the NOD2/CARD15, IL23R, and ATG16L1 genes...
  14. ncbi Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD
    Julia Seiderer
    Department of Medicine II Grosshadern, University of Munich, Germany
    Inflamm Bowel Dis 14:437-45. 2008
    ..His161Arg polymorphism on disease susceptibility and phenotype of Crohn's disease (CD) and ulcerative colitis (UC). In addition, we analyzed the IL17F p.His161Arg polymorphism for potential epistasis with IL23R and NOD2/CARD15 variants...
  15. ncbi The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants
    Jurgen Glas
    Department of Medicine II Grosshadern, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 5:e14466. 2010
    ..The aims were to analyze two novel NOD2 variants (rs2066843 and rs2076756) in a large cohort of patients with inflammatory bowel disease and to elucidate phenotypic consequences...
  16. ncbi rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants
    Jurgen Glas
    Departments of Medicine II Grosshadern, University of Munich, Munich, Germany and Clinic for Preventive Dentistry and Parodontology, University of Munich, Munich, Germany
    PLoS ONE 2:e819. 2007
    ..The aim of our study was to test this association in a large German IBD cohort and to elucidate potential interactions with other IBD genes as well as phenotypic consequences of IL23R variants...
  17. ncbi Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease
    Jurgen Glas
    Department of Medicine II, Grosshadern, Ludwig Maximilians University, Munich, Germany
    Am J Gastroenterol 104:1737-44. 2009
    ..Given the increased prevalence of inflammatory bowel disease (IBD) among celiac disease patients, we investigated the possible involvement of these SNPs in IBD...
  18. ncbi SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and MxA induced by the novel interferon-lambdas IL-28A and IL-29
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, Germany
    Biochem Biophys Res Commun 331:543-8. 2005
    ..In conclusion, we assume that despite antiviral properties of IFN-lambdas, their efficacy as antiviral agents may have similar limitations as IFN-alpha due to inhibition by SOCS proteins...
  19. ncbi Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease
    Fabian Schnitzler
    Department of Clinical Chemistry Grosshadern, Ludwig Maximilians University Munich, Marchioninistr 15, 81377 Munich, Germany
    Immunogenetics 58:99-106. 2006
    ..N825K), and c.2546C>T (p.A849V)] were detected in six CD and two IC patients, and one UC patient. A severe disease phenotype was observed especially in patients who are compound-heterozygous for a common and a novel CARD15 mutation...
  20. ncbi PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background
    Jurgen Glas
    Department of Medicine II Grosshadern, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 7:e33682. 2012
    ..However, the exact role of PTPN2 in Crohn's disease (CD) and ulcerative colitis (UC) and its phenotypic effect are unclear. We therefore performed a detailed genotype-phenotype and epistasis analysis of PTPN2 gene variants...
  21. ncbi Disease activity, ANCA, and IL23R genotype status determine early response to infliximab in patients with ulcerative colitis
    Matthias Jürgens
    Department of Medicine II, Grosshadern, Ludwig Maximilians University Munich, Munich, Germany
    Am J Gastroenterol 105:1811-9. 2010
    ..We analyzed the efficacy and safety of the antitumor necrosis factor-alpha antibody infliximab (IFX) for induction therapy in patients with moderate-to-severe ulcerative colitis (UC) in a large single-center cohort...
  22. ncbi Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus
    Julia Diegelmann
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, Munich, Germany
    PLoS ONE 5:e15200. 2010
    ..This is the first study comparatively investigating the transcriptome and the antiviral properties of the Lambda-interferons IL-28A and IL-29...
  23. ncbi Novel interferon-lambdas induce antiproliferative effects in neuroendocrine tumor cells
    Kathrin Zitzmann
    Department of Internal Medicine II, University-Hospital Munich-Grosshadern, University of Munich, Munich, Germany
    Biochem Biophys Res Commun 344:1334-41. 2006
    ..Thus, IFN-lambdas may hint a promising new approach in the antiproliferative therapy of neuroendocrine tumors...
  24. ncbi SOCS1 silencing enhances antitumor activity of type I IFNs by regulating apoptosis in neuroendocrine tumor cells
    Kathrin Zitzmann
    Department of Internal Medicine II, University Hospital Munich Grosshadern, University of Munich, Munich, Germany
    Cancer Res 67:5025-32. 2007
    ..Knocking down SOCS1 by siRNA is a promising new approach to enhance the therapeutic potency of type I IFNs in neuroendocrine tumors...
  25. ncbi Genotype-phenotype analysis of the CXCL16 p.Ala181Val polymorphism in inflammatory bowel disease
    Julia Seiderer
    Department of Medicine II Grosshadern, University of Munich, Germany
    Clin Immunol 127:49-55. 2008
    ..030, OR 4.04, CI 1.27-12.84) and of stenoses (p=0.014; OR 3.97; CI 1.38-11.40) than patients carrying NOD2 variants only, suggesting that this polymorphism contributes to a severe disease phenotype in CD...
  26. ncbi Analysis of IL12B gene variants in inflammatory bowel disease
    Jurgen Glas
    Department of Medicine II Grosshadern, Ludwig Maximilians University LMU, Munich, Germany
    PLoS ONE 7:e34349. 2012
    ..Recent genome-wide association studies identified IL12B and IL23R as susceptibility genes for inflammatory bowel disease (IBD). However, the phenotypic effects and potential gene-gene interactions of IL12B variants are largely unknown...
  27. ncbi The role of osteopontin (OPN/SPP1) haplotypes in the susceptibility to Crohn's disease
    Jurgen Glas
    Department of Medicine II Grosshadern, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 6:e29309. 2011
    ..Its expression is increased in inflammatory bowel disease (IBD). The aim of our study was to analyze the association of osteopontin (OPN/SPP1) gene variants in a large cohort of IBD patients...
  28. ncbi The role of interleukin-22 in hepatitis C virus infection
    Julia Dambacher
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, Marchioninistr 15, 81377 Munich, Germany
    Cytokine 41:209-16. 2008
    ..Taken together, hepatic IL-22 expression is up-regulated in viral hepatitis but IL-22 does not directly regulate antiviral proteins and has, in contrast to IFN-alpha, no effect on HCV replication...
  29. ncbi Increased expression of the chemokine fractalkine in Crohn's disease and association of the fractalkine receptor T280M polymorphism with a fibrostenosing disease Phenotype
    Stephan Brand
    Department of Medicine II, Grosshadern, University of Munich, Munich, Germany
    Am J Gastroenterol 101:99-106. 2006
    ..CONCLUSIONS: The expression of the chemokine fractalkine is upregulated by proinflammatory cytokines and enhanced in inflamed CD lesions. The CX3CR1 T280M polymorphism appears to influence CD phenotype and localization...
  30. ncbi Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset
    Jurgen Glas
    Department of Medicine II Grosshadern, University of Munich, Munich, Germany
    PLoS ONE 5:e10373. 2010
    ..We therefore investigated the influence of STAT4 variants on the susceptibility and phenotype of inflammatory bowel diseases (IBD) in a large patient and control cohort...
  31. ncbi Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status
    Silke Schmechel
    Department of Medicine II, Grosshadern, University of Munich, Germany
    Inflamm Bowel Dis 14:204-12. 2008
    ..We analyzed the influence of Crohn's disease (CD)-associated IL23R gene variants on IL-22 that is expressed in IL-23R+ Th17 cells...
  32. ncbi Perifosine-mediated Akt inhibition in neuroendocrine tumor cells: role of specific Akt isoforms
    Kathrin Zitzmann
    Department of Internal Medicine II, University Hospital Munich Grosshadern, Munich, Germany
    Endocr Relat Cancer 19:423-34. 2012
    ....
  33. ncbi The novel Raf inhibitor Raf265 decreases Bcl-2 levels and confers TRAIL-sensitivity to neuroendocrine tumour cells
    Kathrin Zitzmann
    Department of Internal Medicine II, University Hospital Munich Grosshadern, University of Munich, Marchioninistr 15, 81377 Munich, Germany
    Endocr Relat Cancer 18:277-85. 2011
    ..Taken together, our findings suggest that combinations of Raf-MEK-Erk pathway inhibitors and TRAIL might offer a novel therapeutic strategy in NET disease...
  34. ncbi CEACAM6 gene variants in inflammatory bowel disease
    Jurgen Glas
    Department of Medicine II Grosshadern, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 6:e19319. 2011
    ..Given its contribution to the pathogenesis of CD, we aimed to investigate the role of genetic variants in the CEACAM6 region in patients with inflammatory bowel diseases (IBD)...
  35. ncbi Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: results of a prospective study
    Julia Seiderer
    Department of Internal Medicine II Grosshadern, University of Munich, D 81377 Munich, Germany
    Inflamm Bowel Dis 12:1114-21. 2006
    ..On the basis of these findings, the potential implications for patient management were investigated...
  36. ncbi Compensatory activation of Akt in response to mTOR and Raf inhibitors - a rationale for dual-targeted therapy approaches in neuroendocrine tumor disease
    Kathrin Zitzmann
    Department of Internal Medicine II, University Hospital Munich Grosshadern, University of Munich, Marchioninistr 15, 81377 Munich, Germany
    Cancer Lett 295:100-9. 2010
    ..Together, our data provide a rationale for dual targeting of PI(3)K-Akt-mTOR- and Ras-Raf-MEK-Erk1/2 signaling in NET disease...
  37. ncbi Expression and regulation of the chemokine CXCL16 in Crohn's disease and models of intestinal inflammation
    Julia Diegelmann
    Department of Internal Medicine II Grosshadern, University of Munich, Munich, Germany
    Inflamm Bowel Dis 16:1871-81. 2010
    ..In this study, we determined the so far unknown expression and signal transduction of the novel CXCL16-CXCR6 chemokine-ligand receptor system in intestinal inflammation in vivo and in vitro...
  38. ncbi Analysis of IL2/IL21 gene variants in cholestatic liver diseases reveals an association with primary sclerosing cholangitis
    Johannes Stallhofer
    Department of Medicine II, Biometry and Epidemiology, University Hospital Munich Grosshadern, Munich, Germany
    Digestion 84:29-35. 2011
    ....
  39. ncbi Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease
    Julia Dambacher
    Department of Medicine II Grosshadern, University of Munich, Munich, Germany
    Inflamm Bowel Dis 13:71-82. 2007
    ..The aim of the study was to analyze the role of the MIF -173G/C single nucleotide polymorphism in Crohn's disease (CD)...
  40. ncbi Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis
    Julia Seiderer
    Department of Internal Medicine II, University of Munich, Germany
    Scand J Gastroenterol 41:1421-32. 2006
    ..The purpose of this study was to carry out a CARD15 sequence analysis in a large single-center IBD cohort and to investigate the impact of different genotypes on disease phenotypes...
  41. ncbi Iron status and analysis of efficacy and safety of ferric carboxymaltose treatment in patients with inflammatory bowel disease
    Florian Beigel
    Department of Medicine II, University Hospital Munich Grosshadern, Munich, Germany
    Digestion 85:47-54. 2012
    ..We analyzed iron deficiency and the therapeutic response following intravenous ferric carboxymaltose in a large single-center inflammatory bowel disease (IBD) cohort...
  42. ncbi Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease
    Sebastian Schroepf
    Department of Pediatric Surgery, Research Laboratories, University of Munich, Munich, Germany
    Inflamm Bowel Dis 16:1882-90. 2010
    ....
  43. ncbi NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes
    Vanessa Beynon
    Department of Surgery, Innenstadt, University of Munich, Germany
    Inflamm Bowel Dis 14:1033-40. 2008
    ..The 1007fs mutation results in loss of NF-kappaB activation in response to muramyl dipeptide (MDP) but has also been linked to an increased IL-1beta processing and IL-12 release...
  44. ncbi Severe Legionella pneumophila pneumonia following infliximab therapy in a patient with Crohn's disease
    Florian Beigel
    Department of Medicine II, University Hospital Munich Grosshadern, Ludwig Maximilians University Munich, Germany
    Inflamm Bowel Dis 15:1240-4. 2009
    ..Immunosuppressive therapy with anti-TNF-alpha antibodies is effective in patients with inflammatory bowel disease (IBD). However, there is an increased risk for infections associated with this therapy...
  45. ncbi IRGM variants and susceptibility to inflammatory bowel disease in the German population
    Jurgen Glas
    Department of Medicine II Grosshadern, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 8:e54338. 2013
    ....
  46. ncbi A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory protei
    Julia Diegelmann
    Department of Medicine II Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Biol Chem 287:286-98. 2012
    ..For the first time, we characterize IL-27 as a mediator of intestinal epithelial barrier protection mediated via transcriptional activation of anti-inflammatory and antibacterial target genes...
  47. ncbi Augmenter of liver regeneration causes different kinetics of ERK1/2 and Akt/PKB phosphorylation than EGF and induces hepatocyte proliferation in an EGF receptor independent and liver specific manner
    Maren Ilowski
    Department of Surgery, Ludwig Maximilians University of Munich Hospital Grosshadern, Munich, Germany
    Biochem Biophys Res Commun 394:915-20. 2010
    ..The aim of this study was to compare proliferation as well as the kinetics of ERK1/2 and Akt/PKB phosphorylation by recombinant human ALR (rhALR) and EGF in human hepatocytes and extrahepatic cells...
  48. ncbi The novel mTOR inhibitor RAD001 (everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells
    Kathrin Zitzmann
    Department of Internal Medicine II, University Hospital Munich Grosshadern, University of Munich, Munich, Germany
    Neuroendocrinology 85:54-60. 2007
    ..In this study, we aimed to evaluate the effects of RAD001 on BON cells, a human pancreatic NET cell line that exhibits constitutively activated PI(3)K/Akt/mTOR signaling...
  49. ncbi PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites
    Jurgen Glas
    Department of Medicine II Grosshadern, University of Munich, Munich, Germany
    PLoS ONE 7:e52873. 2012
    ..1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort of patients with inflammatory bowel disease (IBD) and to elucidate genotypic and phenotypic interactions with other IBD genes...
  50. ncbi Nodular regenerative hyperplasia: a reversible entity associated with azathioprine therapy
    Julia Seiderer
    Department of Internal Medicine II, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    Eur J Gastroenterol Hepatol 18:553-5. 2006
    ..Physicians caring for IBD patients need to be alert to this rare but serious complication...
  51. ncbi Hepatosplenic T-cell lymphoma in a patient with Crohn's disease
    Florian Beigel
    Department of Medicine II, University Hospital, Munich Grosshadern, Munich, Germany
    Nat Rev Gastroenterol Hepatol 6:433-6. 2009
    ..He had been taking azathioprine therapy for approximately 5.5 years and had received high-dose steroids. He had also previously taken metronidazole and antihypertensive medications...
  52. ncbi Infliximab does not affect postoperative complication rates in Crohn's patients undergoing abdominal surgery
    Michael S Kasparek
    Department of Surgery, Grosshadern, Ludwig Maximilians University Munich, Munich, Germany
    Inflamm Bowel Dis 18:1207-13. 2012
    ..We aimed to determine the effects of infliximab on postoperative complication rates in patients undergoing abdominal surgery for CD...
  53. ncbi Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes
    Jurgen Glas
    Chirurgische Klinik und Poliklinik Innenstadt, Munchen, Germany
    Inflamm Bowel Dis 12:606-11. 2006
    ..Furthermore, potential interactions of the -94ins/delATTG polymorphism with the IKBL and the IL-1RN genes should be determined...
  54. ncbi Free fatty acids sensitize hepatocytes to bile acid-induced apoptosis
    Thomas Pusl
    Department of Medicine II Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Biochem Biophys Res Commun 371:441-5. 2008
    ..Thus, low levels of cholestasis normally not considered harmful could advance liver injury in patients with NAFLD...
  55. ncbi Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells
    Stephan Brand
    Gastrointestinal Unit, Department of Medicine, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 122:166-77. 2002
    ..In this study, we determined the signal transduction and functional consequences after ligand-specific activation of the fractalkine receptor CX3CR1 in human intestinal epithelial cells...
  56. ncbi CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
    Jan Hendrik Niess
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Science 307:254-8. 2005
    ..Thus, CX3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation...
  57. ncbi SOCS-1 and SOCS-3 inhibit IFN-alpha-induced expression of the antiviral proteins 2,5-OAS and MxA
    George Vlotides
    Department of Internal Medicine II, Grosshadern, Klinikum der Ludwig, Maximilians Universität, Munich 81377, Germany
    Biochem Biophys Res Commun 320:1007-14. 2004
    ..These data suggest a potential role of SOCS proteins in IFN resistance during antiviral treatment...
  58. ncbi Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors
    Martin A Storr
    Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Mol Med (Berl) 86:925-36. 2008
    ..In conclusion, drugs targeting EC degradation offer therapeutic potential in the treatment of inflammatory bowel diseases. Furthermore, reduction of FAAH mRNA expression is involved in the pathophysiological response to colitis...
  59. ncbi Human beta defensin 2 promotes intestinal wound healing in vitro
    Jan Michel Otte
    Department of Internal Medicine I, St Josef Hospital, Ruhr University, Bochum, Germany
    J Cell Biochem 104:2286-97. 2008
    ..Results of this in vitro study suggest, that hBD-2 expression may play a dual role in vivo, i.e. in impaired intestinal barrier function observed in patients with inflammatory bowel disease...