M Brand

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain
    M Brand
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:179-90. 1996
  2. ncbi Mutations affecting development of the midline and general body shape during zebrafish embryogenesis
    M Brand
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:129-42. 1996
  3. ncbi dino and mercedes, two genes regulating dorsal development in the zebrafish embryo
    M Hammerschmidt
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:95-102. 1996
  4. ncbi Genes involved in forebrain development in the zebrafish, Danio rerio
    C P Heisenberg
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:191-203. 1996
  5. ncbi Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes
    M C Mullins
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:81-93. 1996
  6. ncbi Mutations affecting the formation of the notochord in the zebrafish, Danio rerio
    J Odenthal
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:103-15. 1996
  7. ncbi Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva
    M Granato
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:399-413. 1996
  8. ncbi The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio
    P Haffter
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:1-36. 1996
  9. ncbi Zebrafish mutations affecting retinotectal axon pathfinding
    R O Karlstrom
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:427-38. 1996
  10. ncbi Mutations affecting somite formation and patterning in the zebrafish, Danio rerio
    F J van Eeden
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:153-64. 1996

Collaborators

Detail Information

Publications40

  1. ncbi Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain
    M Brand
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:179-90. 1996
    ..Our results confirm and extend a previous report, and show that at least one member of this conserved signalling pathway is required for formation of the boundary between midbrain and hindbrain in the zebrafish...
  2. ncbi Mutations affecting development of the midline and general body shape during zebrafish embryogenesis
    M Brand
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:129-42. 1996
    ..As a working hypothesis, we propose that midline-group genes may act to maintain proper structure and inductive function of zebrafish midline tissues...
  3. ncbi dino and mercedes, two genes regulating dorsal development in the zebrafish embryo
    M Hammerschmidt
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:95-102. 1996
    ..Their function in the patterning of the ventrolateral mesoderm and the induction of the neuroectoderm is similar to the function of the Spemann organizer in the amphibian embryo...
  4. ncbi Genes involved in forebrain development in the zebrafish, Danio rerio
    C P Heisenberg
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:191-203. 1996
    ..In an appendix to this study we list mutants showing alterations in the size of the eyes and abnormal differentiation of the lenses...
  5. ncbi Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes
    M C Mullins
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:81-93. 1996
    ..This pathway provides ventral positional information, counteracting the dorsalizing instructions of the organizer, which is localized in the dorsal shield...
  6. ncbi Mutations affecting the formation of the notochord in the zebrafish, Danio rerio
    J Odenthal
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:103-15. 1996
    ..In addition to the four mutants with defects in early notochord formation, we have isolated 84 mutants, defining at least 15 genes, with defects in later stages of notochord development. These are listed in an appendix to this study...
  7. ncbi Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva
    M Granato
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:399-413. 1996
    ..Mutations in two genes, nevermind (nev) and macho (mao), affect axonal projection in the optic tectum, whereas axon formation and elongation of motorneurons are disrupted by mutations in the diwanka (diw) and the unplugged (unp) genes...
  8. ncbi The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio
    P Haffter
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:1-36. 1996
    ..Here we give an overview of the spectrum of mutant phenotypes obtained, and discuss the limits and the potentials of a genetic saturation screen in the zebrafish...
  9. ncbi Zebrafish mutations affecting retinotectal axon pathfinding
    R O Karlstrom
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:427-38. 1996
    ..The retinotectal pathfinding mutants reveal important choice points encountered by neuronal growth cones as they navigate between eye and tectum...
  10. ncbi Mutations affecting somite formation and patterning in the zebrafish, Danio rerio
    F J van Eeden
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:153-64. 1996
    ....
  11. ncbi Mutations affecting the cardiovascular system and other internal organs in zebrafish
    J N Chen
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:293-302. 1996
    ..The mutations presented here could serve as an entry point to the establishment of a genetic hierarchy underlying organogenesis...
  12. ncbi Zebrafish pigmentation mutations and the processes of neural crest development
    R N Kelsh
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:369-89. 1996
    ..In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development...
  13. ncbi Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio
    M Hammerschmidt
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:143-51. 1996
    ..Mutants in kugelig (kgg) do not form the yolk tube at the posterior side of the yolk sac...
  14. ncbi Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio
    Y J Jiang
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, FRG
    Development 123:205-16. 1996
    ..atlantis (atl), big head (bid), wicked brain (win), scabland (sbd) and eisspalte (ele) mutants have different malformation of the brain folds. Some of them have transient phenotypes, and mutant individuals may grow up to adults...
  15. ncbi The zebrafish early arrest mutants
    D A Kane
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:57-66. 1996
    ....
  16. ncbi Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio
    J Odenthal
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:391-8. 1996
    ..These mutations may affect xanthophore pigment distribution within the cells or xanthophore cell shape. Mutations in seven genes affecting xanthophore pigmentation remain unclassified...
  17. ncbi Genetic analysis of fin formation in the zebrafish, Danio rerio
    F J van Eeden
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:255-62. 1996
    ..Stein und bein (sub) has reduced dorsal and pelvic fins, whereas finless (fls) and wanda (wan) mutants affect all adult fins. Finally, mutations in four genes causing defects in embryonic skin formation will be briefly reported...
  18. ncbi Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation
    T Piotrowski
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:345-56. 1996
    ..The mutants presented here may be valuable tools for elucidating the genetic mechanisms that underlie the development of the mandibular and the hyoid arches, as well as the process of cartilage differentiation...
  19. ncbi Neural degeneration mutants in the zebrafish, Danio rerio
    M Furutani-Seiki
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:229-39. 1996
    ..These results suggest that focal cell death may be a useful clue for the detection of early patterning defects of the vertebrate nervous system in regions devoid of visible landmarks...
  20. ncbi The zebrafish epiboly mutants
    D A Kane
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:47-55. 1996
    ..Furthermore, the dominant zygotic-maternal effect phenotypes illustrate the maternal and zygotic interplay of genes that orchestrate the early cell movements of the zebrafish...
  21. ncbi Characterization of zebrafish mutants with defects in embryonic hematopoiesis
    D G Ransom
    Max Planck Institut für Entwickslungbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:311-9. 1996
    ..The analysis of these mutants provides a powerful approach towards defining the molecular mechanisms involved in vertebrate hematopoietic development...
  22. ncbi A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary
    K Lun
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    Development 125:3049-62. 1998
    ..We propose that noi/pax2.1 participates in sequential signaling processes as a key integrator of midbrain-hindbrain boundary development...
  23. ncbi Asymmetric division and polarity of neuroepithelial cells
    W B Huttner
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Curr Opin Neurobiol 7:29-39. 1997
    ....
  24. ncbi Zebrafish no isthmus reveals a role for pax2.1 in tubule differentiation and patterning events in the pronephric primordia
    A Majumdar
    Renal Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Development 127:2089-98. 2000
    ....
  25. ncbi Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection
    A Picker
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    Development 126:2967-78. 1999
    ..The MHB organizer, possibly via Fgf8 itself, is thus required for midbrain polarisation and for restricting axonal growth, but other cell populations may also influence midbrain polarity...
  26. ncbi Overlapping and distinct functions provided by fgf17, a new zebrafish member of the Fgf8/17/18 subgroup of Fgfs
    F Reifers
    Max Planck Institute for Cell Biology and Genetics, Dresden, c o Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D 69120, Heidelberg, Germany
    Mech Dev 99:39-49. 2000
    ..Taken together, our results argue that Fgf8 and Fgf17 act as hierarchically organized signaling molecules during development of the MHB organizer and possibly other organizers in the developing nervous system...
  27. ncbi Jaw and branchial arch mutants in zebrafish I: branchial arches
    T F Schilling
    Imperial Cancer Research Fund, London, UK
    Development 123:329-44. 1996
    ....
  28. pmc The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger
    Y G Gangloff
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch Cedex, C U de Strasbourg, France
    Mol Cell Biol 21:5109-21. 2001
    ..These conserved domains are critical for yTAF(II)65 function in vivo. Our results therefore identify metazoan homologues of yTAF(II)47 and yTAF(II)65...
  29. ncbi Mutations affecting development of the zebrafish inner ear and lateral line
    T T Whitfield
    ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK
    Development 123:241-54. 1996
    ..At least one mutant, dog-eared, shows defects in both the ear and another placodally derived sensory system, the lateral line, while hypersensitive mutants have additional trunk lateral line organs...
  30. ncbi asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation
    M Brand
    Howard Huges Medical Institute, University of California, San Francisco, CA 94143 0724, USA
    Development 119:1-17. 1993
    ..Our studies therefore serve as a cautionary note for the inference of normal gene function based on the gain-of-function phenotype after ectopic expression...
  31. ncbi Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development
    F Raible
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Mech Dev 107:105-17. 2001
    ....
  32. ncbi Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon
    S Shanmugalingam
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 127:2549-61. 2000
    ..However, as ace mutant neural plate cells still retain at least some inductive activity, then other signals must also be produced by the anterior margin of the neural plate...
  33. ncbi sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish
    M Fürthauer
    Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS INSERM ULP, BP 163, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 128:2175-86. 2001
    ....
  34. ncbi Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace
    M Adamska
    Department of Molecular and Cellular Biology, Technical University, Braunschweig, Spielmannstrasse 7, D 38106, Braunschweig, Germany
    Mech Dev 97:161-5. 2000
    ..In the FGF8 zebrafish mutant ace, expression of Nkx5-1 in the otic structures is diminished. The most significant reduction of zfNkx5-1 expression was observed in cells of the vestibulo-acoustic ganglion...
  35. ncbi Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis
    U Leimer
    Department of Molecular Biology, Central Institute of Mental Health, Mannheim, Germany
    Biochemistry 38:13602-9. 1999
    ..These data provide further evidence that PS proteins are directly involved in the proteolytic cleavage of betaAPP and demonstrate that this function is evolutionarily conserved...
  36. ncbi Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function
    P L Pfeffer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Development 125:3063-74. 1998
    ..Consequently, the noi mutation of zebrafish is equivalent to combined inactivation of the mouse Pax2 and Pax5 genes with regard to the loss of midbrain-hindbrain boundary development...
  37. ncbi daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex
    M Caudy
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143
    Cell 55:1061-7. 1988
    ..The role of da as a gene controlling cell determination in multiple developmental pathways is discussed...
  38. ncbi The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors
    A P Jarman
    Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0724, USA
    Development 119:19-29. 1993
    ..asense differs from the other AS-C members in its expression pattern, regulation, mutant phenotype and some DNA-binding properities...
  39. ncbi daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143, USA
    Development 120:935-45. 1994
    ..da is not required for the initial appearance of nascent neuronal precursors but is required for these cells to express multiple neuronal precursor genes and to produce the normal number of neurons...
  40. doi Neuropsychological and neural correlates of autobiographical deficits in a mother who killed her children
    E Kalbe
    Department of Neurology, University Clinic Cologne, Cologne, Germany
    Neurocase 14:15-28. 2008
    ..Furthermore, they indicate that beliefs or prejudices may have a major impact on the brain's processing of the personal past...