Axel A Brakhage

Summary

Affiliation: University of Hannover
Country: Germany

Publications

  1. ncbi request reprint Menacing mold: the molecular biology of Aspergillus fumigatus
    Axel A Brakhage
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, Germany
    Annu Rev Microbiol 56:433-55. 2002
  2. ncbi request reprint Regulation of penicillin biosynthesis in filamentous fungi
    Axel A Brakhage
    University of Hannover, Institute of Microbiology, Schneiderberg 50, 30167 Hannover, Germany
    Adv Biochem Eng Biotechnol 88:45-90. 2004
  3. ncbi request reprint A basic-region helix-loop-helix protein-encoding gene (devR) involved in the development of Aspergillus nidulans
    André Tüncher
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, D 30167 Hannover, Germany
    Mol Microbiol 52:227-41. 2004
  4. pmc The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus
    Burghard Liebmann
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, D 30167 Hannover, Germany
    Infect Immun 72:5193-203. 2004
  5. ncbi request reprint A single subunit of a heterotrimeric CCAAT-binding complex carries a nuclear localization signal: piggy back transport of the pre-assembled complex to the nucleus
    Stefan Steidl
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, D 30167 Hannover, Germany
    J Mol Biol 342:515-24. 2004
  6. ncbi request reprint Deletion of the Aspergillus fumigatus lysine biosynthesis gene lysF encoding homoaconitase leads to attenuated virulence in a low-dose mouse infection model of invasive aspergillosis
    Burghard Liebmann
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, 30167, Hannover, Germany
    Arch Microbiol 181:378-83. 2004
  7. ncbi request reprint Novel basic-region helix-loop-helix transcription factor (AnBH1) of Aspergillus nidulans counteracts the CCAAT-binding complex AnCF in the promoter of a penicillin biosynthesis gene
    Maria Louise Caruso
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, 30167 Hannover, Germany
    J Mol Biol 323:425-39. 2002
  8. ncbi request reprint Methylcitrate synthase from Aspergillus fumigatus. Propionyl-CoA affects polyketide synthesis, growth and morphology of conidia
    Claudia Maerker
    Institute of Microbiology, University of Hannover, Germany
    FEBS J 272:3615-30. 2005
  9. ncbi request reprint A novel method used to delete a new Aspergillus fumigatus ABC transporter-encoding gene
    Kim Langfelder
    Institut fur Mikrobiologie, Universitat Hannover, Am Schneiderberg 50, 30167 Hannover, Germany
    Curr Genet 41:268-74. 2002
  10. ncbi request reprint Biosynthesis of fungal melanins and their importance for human pathogenic fungi
    Kim Langfelder
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, 30167, Hannover, Germany
    Fungal Genet Biol 38:143-58. 2003

Collaborators

  • Matthias Brock
  • Armin Braun
  • Tetsuo Kobayashi
  • Masashi Kato
  • Hans Reinke
  • Bernhard Jahn
  • Juergen Loeffler
  • Jean Paul Latge
  • WILLIAM CHARLES NIERMAN
  • Steven D Harris
  • Hubertus Haas
  • Gerhard H Braus
  • H Hof
  • G H Goldman
  • Thorsten Heinekamp
  • Márcia Eliana da Silva Ferreira
  • André Tüncher
  • Olaf Kniemeyer
  • Albert Härtl
  • Burghard Liebmann
  • Judith Behnsen
  • Petra Spröte
  • Oumaima Ibrahim-Granet
  • Marcel Thön
  • Peter Hortschansky
  • Sebastian Bergmann
  • Alexander Gehrke
  • Kim Langfelder
  • Franziska Lessing
  • Marcela Savoldi
  • Frank Ebel
  • Manfred Rohde
  • André D Schmidt
  • Hideya Goda
  • Stefan Steidl
  • Maria Louise Caruso
  • Vito Valiante
  • Markus Schrettl
  • Christina Grosse
  • Patrick Ave
  • Martin Eisendle
  • Ernst R Werner
  • Felicitas Schöbel
  • Qusai Al-Abdallah
  • H Stanley Kim
  • Kathrin Luther
  • Katrin Volling
  • Christian Hertweck
  • Jurgen Heesemann
  • Maria Helena S Goldman
  • Venelina Sugareva
  • Claudio Kupfahl
  • Martina Herrmann
  • Claudia Maerker
  • Norihiro Tsukagoshi
  • Meike Muller
  • Goran Martic
  • Silke Busch
  • Michel Huerre
  • Claudia Kragl
  • Marc Dubourdeau
  • Hyojeong Yi
  • Andrea Hartmann
  • Ilse Jacobsen
  • Jeannette Schmaler
  • Paul Illmer
  • Peter F Zipfel
  • Radhika Jain
  • Nina Klippel
  • Beate Abt
  • Kirstin Scherlach
  • Maria Helena de Souza Goldman
  • Hans Peter Saluz
  • Frank Gunzer
  • Antonella Torosantucci
  • Paula Fagundes De Gouvêa
  • Julia Schumann
  • Corinna Lange
  • Iwona Wozniok
  • Birgit Seeber
  • Matthias Gunzer
  • Ursula Bilitewski
  • Camile P Semighini
  • Oliver Kurzai
  • Mike Hasenberg
  • Priyanka Narang
  • Albert Haertl
  • Thomas Ruppert
  • Iran Malavazi
  • Gernot Geginat

Detail Information

Publications39

  1. ncbi request reprint Menacing mold: the molecular biology of Aspergillus fumigatus
    Axel A Brakhage
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, Germany
    Annu Rev Microbiol 56:433-55. 2002
    ..This review summarizes the current knowledge on the biology, molecular genetics, and genomics of A. fumigatus...
  2. ncbi request reprint Regulation of penicillin biosynthesis in filamentous fungi
    Axel A Brakhage
    University of Hannover, Institute of Microbiology, Schneiderberg 50, 30167 Hannover, Germany
    Adv Biochem Eng Biotechnol 88:45-90. 2004
    ..Furthermore, such investigations have contributed to the elucidation of signals leading to the production of penicillin and can be expected to have a major impact on rational strain improvement programs...
  3. ncbi request reprint A basic-region helix-loop-helix protein-encoding gene (devR) involved in the development of Aspergillus nidulans
    André Tüncher
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, D 30167 Hannover, Germany
    Mol Microbiol 52:227-41. 2004
    ..Taken together, devR encodes a bHLH regulatory protein that is part of the tcsA signal transduction network and required for development under standard growth conditions...
  4. pmc The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus
    Burghard Liebmann
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, D 30167 Hannover, Germany
    Infect Immun 72:5193-203. 2004
    ..Taken together, these findings indicate that the cAMP-PKA signal transduction pathway is required for A. fumigatus pathogenicity...
  5. ncbi request reprint A single subunit of a heterotrimeric CCAAT-binding complex carries a nuclear localization signal: piggy back transport of the pre-assembled complex to the nucleus
    Stefan Steidl
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, D 30167 Hannover, Germany
    J Mol Biol 342:515-24. 2004
    ..This enables the cell to provide equimolar concentrations of all subunits to the nucleus...
  6. ncbi request reprint Deletion of the Aspergillus fumigatus lysine biosynthesis gene lysF encoding homoaconitase leads to attenuated virulence in a low-dose mouse infection model of invasive aspergillosis
    Burghard Liebmann
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, 30167, Hannover, Germany
    Arch Microbiol 181:378-83. 2004
    ..In this murine model, the Delta lysF mutant was avirulent, suggesting that lysine biosynthesis, or at least a functional homoaconitase, is important for survival of A. fumigatus in vivo and a potential target for antifungal drugs...
  7. ncbi request reprint Novel basic-region helix-loop-helix transcription factor (AnBH1) of Aspergillus nidulans counteracts the CCAAT-binding complex AnCF in the promoter of a penicillin biosynthesis gene
    Maria Louise Caruso
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, 30167 Hannover, Germany
    J Mol Biol 323:425-39. 2002
    ..The analysis of aatAp-lacZ expression in such a strain indicated that AnBH1 acts as a repressor of aatA gene expression and therefore counteracts the positive action of AnCF...
  8. ncbi request reprint Methylcitrate synthase from Aspergillus fumigatus. Propionyl-CoA affects polyketide synthesis, growth and morphology of conidia
    Claudia Maerker
    Institute of Microbiology, University of Hannover, Germany
    FEBS J 272:3615-30. 2005
    ..Therefore, an impact of methylcitrate synthase in the infection process is discussed...
  9. ncbi request reprint A novel method used to delete a new Aspergillus fumigatus ABC transporter-encoding gene
    Kim Langfelder
    Institut fur Mikrobiologie, Universitat Hannover, Am Schneiderberg 50, 30167 Hannover, Germany
    Curr Genet 41:268-74. 2002
    ..fumigatus knock-out mutant was generated, providing evidence that this method of generating gene deletions can also be used in A. fumigatus and significantly broadens our repertoire of molecular techniques to study A. fumigatus...
  10. ncbi request reprint Biosynthesis of fungal melanins and their importance for human pathogenic fungi
    Kim Langfelder
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, 30167, Hannover, Germany
    Fungal Genet Biol 38:143-58. 2003
    ..In addition, in several fungi the production of fungal virulence factors, such as melanin, has been linked to a cAMP-dependent signaling pathway. Many of the components involved in the signaling pathway have been identified...
  11. ncbi request reprint The CCAAT-binding complex of eukaryotes: evolution of a second NLS in the HapB subunit of the filamentous fungus Aspergillus nidulans despite functional conservation at the molecular level between yeast, A.nidulans and human
    André Tüncher
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, Beutenbergstrasse 11a, D 07745 Jena, Germany
    J Mol Biol 352:517-33. 2005
    ..nidulans hapB mutant was complemented, at least in part, by both the human NF-YA and S.cerevisiae Hap2p this finding suggests that the piggy-back mechanism of nuclear transport found for A.nidulans is conserved in yeast and human...
  12. ncbi request reprint The light-dependent regulator velvet A of Aspergillus nidulans acts as a repressor of the penicillin biosynthesis
    Petra Spröte
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
    Arch Microbiol 188:69-79. 2007
    ..These findings were confirmed by the analysis of a regulatable niiAp-veA gene fusion. Under niiAp-inducing conditions, penicillin titres and acvAp-uidA expression were much lower than in untransformed wild-type strains...
  13. pmc Protein kinase C (PkcA) of Aspergillus nidulans is involved in penicillin production
    Martina Herrmann
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstrasse 11a, D 07745 Jena, Germany
    Appl Environ Microbiol 72:2957-70. 2006
    ..The involvement of Pkc in penicillin biosynthesis is also interesting in light of the fact that in the yeast Saccharomyces cerevisiae, Pkc plays a major role in maintaining cell integrity...
  14. pmc Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron
    Peter Hortschansky
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, and Friedrich Schiller University Jena, Jena, Germany
    EMBO J 26:3157-68. 2007
    ..Remarkably, CBC-mediated regulation has an inverse impact on the expression of the same gene set in A. nidulans, compared with Saccharomyces cerevisae...
  15. pmc Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans
    Judith Behnsen
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    PLoS Pathog 3:e13. 2007
    ..This could explain why "delocalized" Aspergillus infections such as hematogeneous spread are almost uncontrollable diseases, even in immunocompetent individuals...
  16. ncbi request reprint The thioredoxin system of the filamentous fungus Aspergillus nidulans: impact on development and oxidative stress response
    Marcel Thön
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI and Friedrich Schiller University, Beutenbergstrasse 11a, Jena D 07745, Germany
    J Biol Chem 282:27259-69. 2007
    ..Furthermore, by applying the principle of thioredoxin-affinity chromatography we identified several novel putative targets of thioredoxin A, including a hypothetical protein with peroxidase activity and an aldehyde dehydrogenase...
  17. ncbi request reprint Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans
    Sebastian Bergmann
    Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Beutenbergstr 11a, 07745 Jena, Germany
    Nat Chem Biol 3:213-7. 2007
    ..Here we report a new strategy for the successful induction of a silent metabolic pathway in the important model organism Aspergillus nidulans, which led to the discovery of novel PKS-NRPS hybrid metabolites...
  18. ncbi request reprint Apoptosis inhibition of alveolar macrophages upon interaction with conidia of Aspergillus fumigatus
    Katrin Volling
    Department of Cell and Molecular Biology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute HKI, and Friedrich Schiller University Jena, Jena, Germany
    FEMS Microbiol Lett 275:250-4. 2007
    ..This unexpected result was due to inhibition of caspase 3 by a yet unknown mechanism...
  19. pmc The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model
    Franziska Lessing
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, Jena, Germany
    Eukaryot Cell 6:2290-302. 2007
    ..fumigatus wild-type and DeltaAfyap1 mutant germlings by human neutrophilic granulocytes worked equally well irrespective of whether the ROI scavenger glutathione or an NADPH-oxidase inhibitor was added to the cells...
  20. ncbi request reprint Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis
    Oumaima Ibrahim-Granet
    Aspergillus Unit, Institute Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Cell Microbiol 10:134-48. 2008
    ..fumigatus. Thus, blocking of methylcitrate synthase activity abrogates fungal growth and provides a suitable target for new antifungals...
  21. ncbi request reprint The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response
    Vito Valiante
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
    Fungal Genet Biol 45:618-27. 2008
    ..The expression of mpkA was induced by cell wall damaging conditions. Despite its involvement in cell wall signaling no influence on virulence of the deletion of mpkA was observed in a murine infection model...
  22. pmc The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement system
    Judith Behnsen
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany
    Infect Immun 76:820-7. 2008
    ..These data show that A. fumigatus conidia bind to complement regulators, and these bound host regulators may contribute to evasion of a host complement attack...
  23. ncbi request reprint Activation of fungal silent gene clusters: a new avenue to drug discovery
    Axel A Brakhage
    Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Friedrich Schiller University, Jena, Germany
    Prog Drug Res 66:1, 3-12. 2008
    ..The activation of these gene clusters by genetic engineering will lead to the discovery of many so far unknown products and therefore represents a novel avenue to drug discovery...
  24. pmc Protein kinase A regulates growth, sporulation, and pigment formation in Aspergillus fumigatus
    Christina Grosse
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Friedrich Schiller University Jena, 07745 Jena, Germany
    Appl Environ Microbiol 74:4923-33. 2008
    ..In contrast, proteins which were involved in nucleotide and amino acid biosynthesis were downregulated, as were enzymes involved in catabolism of carbon sources other than glucose...
  25. pmc Aspergillus fumigatus does not require fatty acid metabolism via isocitrate lyase for development of invasive aspergillosis
    Felicitas Schöbel
    Leibniz Institute for Natural Products Research and Infection Biology, Beutenbergstr 11a, 07745 Jena, Germany
    Infect Immun 75:1237-44. 2007
    ..Therefore, an antifungal drug inhibiting fungal isocitrate lyases, postulated to act against Candida infections, is assumed to be ineffective against A. fumigatus...
  26. ncbi request reprint Functional characterization of the Aspergillus fumigatus calcineurin
    Márcia Eliana da Silva Ferreira
    Faculdade de Ciências Farmacêuticas de Ribeirão, Universidade de Sao Paulo, Brazil
    Fungal Genet Biol 44:219-30. 2007
    ..These results suggest that calcineurin is involved in the regulation of the PHO pathway in A. fumigatus. Our work on calcineurin opens new venues for the research on sensing and nutrient acquisition in A. fumigatus...
  27. ncbi request reprint PKSP-dependent reduction of phagolysosome fusion and intracellular kill of Aspergillus fumigatus conidia by human monocyte-derived macrophages
    Bernhard Jahn
    Institut fur Medizinische Mikrobiologie und Hygiene, Johannes Gutenberg Universitat Mainz, Hochhaus am Augustusplatz, D 55101 Mainz, Germany
    Cell Microbiol 4:793-803. 2002
    ..This finding might help explain the attenuated virulence of pksP mutant strains in a murine animal model and provides a conceptual frame to understand the virulence of A. fumigatus...
  28. ncbi request reprint Impact of the cross-pathway control on the regulation of lysine and penicillin biosynthesis in Aspergillus nidulans
    Silke Busch
    Institut fur Mikrobiologie und Genetik, Georg August Universitat, Grisebachstrasse 8, 37077 Gottingen, Germany
    Curr Genet 42:209-19. 2003
    ..This work suggests that, upon amino acid starvation, the cross-pathway control overrules secondary metabolite biosynthesis and favours the metabolic flux towards amino acids instead of penicillin in A. nidulans...
  29. ncbi request reprint Analysis of mating-dependent transcription of Blakeslea trispora carotenoid biosynthesis genes carB and carRA by quantitative real-time PCR
    André D Schmidt
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knoell Institute, Jena, Germany
    Appl Microbiol Biotechnol 67:549-55. 2005
    ..Transcription levels of both carB and carRA were strongly induced only under mating conditions. These data suggest that beta-carotene production in B. trispora is due to increased transcription of the biosynthesis genes carB and carRA...
  30. ncbi request reprint Evolution of beta-lactam biosynthesis genes and recruitment of trans-acting factors
    Axel A Brakhage
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knoell Institute, Beutenbergstrasse 11a, D 07745 Jena, Germany
    Phytochemistry 66:1200-10. 2005
    ..Alternatively, it is conceivable that only a part of the beta-lactam biosynthesis gene cluster was transferred to some fungi, e.g., the acvA and ipnA gene without a regulatory gene...
  31. ncbi request reprint Nuclear translocation of the heterotrimeric CCAAT binding factor of Aspergillus oryzae is dependent on two redundant localising signals in a single subunit
    Hideya Goda
    Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, 464 8601 Japan
    Arch Microbiol 184:93-100. 2005
    ..nidulans. The nuclear translocation of the A. oryzae complex was found to be dependent on two redundant localising signals in HapB...
  32. ncbi request reprint Optimisation of a 2-D gel electrophoresis protocol for the human-pathogenic fungus Aspergillus fumigatus
    Olaf Kniemeyer
    Department of Microbiology and Molecular Biology, Friedrich Schiller University, Jena, Germany
    Curr Genet 49:178-89. 2006
    ..In A. fumigatus, differential patterns of enzymes of the gluconeogenesis, glyoxylate cycle and ethanol degradation pathway during growth on glucose and ethanol were observed...
  33. pmc The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus
    Márcia Eliana da Silva Ferreira
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Departamento de Ciencias Farmaceuticas, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
    Eukaryot Cell 5:207-11. 2006
    ..fumigatus strain. Deletion of akuB(KU80) had no influence on pathogenicity in a low-dose murine infection model...
  34. ncbi request reprint Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development
    Frank Ebel
    Max von Pettenkofer Institute, Munich, Germany
    Fungal Genet Biol 43:476-89. 2006
    ..Lipids, as potential substrates, were detected in conidia and macrophages. Additionally, germinating conidia within macrophages contain ICL, suggesting that the glyoxylate shunt might be a relevant target for development of antifungals...
  35. ncbi request reprint Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole
    Márcia Eliana da Silva Ferreira
    Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    Curr Genet 50:32-44. 2006
    ....
  36. ncbi request reprint Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2
    Kathrin Luther
    Max von Pettenkofer Institute, Ludwig Maximilians University, Munich, Germany
    Cell Microbiol 9:368-81. 2007
    ..Additionally we found that TLR2 and the adaptor protein MyD88 are required for efficient conidial phagocytosis, suggesting a link between the TLR2-mediated recognition of A. fumigatus and the phagocytic response...
  37. ncbi request reprint Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model
    Claudio Kupfahl
    Institute for Medical Microbiology and Hygiene, Faculty for Clinical Medicine Mannheim of the University Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Mol Microbiol 62:292-302. 2006
    ..fumigatus. Gliotoxin is not required for pathogenicity of the fungus in immunocompromised mice, despite the fact that a reduced cytotoxicity of the culture supernatant of gliP deletion strains was demonstrated...
  38. ncbi request reprint Characterisation of the laccase-encoding gene abr2 of the dihydroxynaphthalene-like melanin gene cluster of Aspergillus fumigatus
    Venelina Sugareva
    Department of Microbiology and Molecular Biology, Friedrich Schiller University, Jena, Germany
    Arch Microbiol 186:345-55. 2006
    ..An abr2p-lacZ gene fusion was expressed during sporulation, but not during vegetative growth confirming the pattern of laccase activity due to Abr2...
  39. pmc SreA-mediated iron regulation in Aspergillus fumigatus
    Markus Schrettl
    Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 70:27-43. 2008
    ..As all detrimental effects of sreA disruption are restricted to iron-replete conditions these data underscore that A. fumigatus faces iron-depleted conditions during infection...