Thomas Brabletz

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. pmc A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    Ulrike Burk
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    EMBO Rep 9:582-9. 2008
  2. doi request reprint EMT and MET in metastasis: where are the cancer stem cells?
    Thomas Brabletz
    Department of General and Visceral Surgery, Comprehensive Cancer Center and BIOSS Centre for Biological Signalling Studies, University of Freiburg Medical Center, Hugstetter Str 55, 79106 Freiburg, Germany
    Cancer Cell 22:699-701. 2012
  3. doi request reprint To differentiate or not--routes towards metastasis
    Thomas Brabletz
    Department of General and Visceral Surgery and Comprehensive Cancer Center, University of Freiburg Medical Center, Hugstetter Str 55, 79106 Freiburg, Germany
    Nat Rev Cancer 12:425-36. 2012
  4. pmc The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?
    Simone Brabletz
    Department of Visceral Surgery, University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany
    EMBO Rep 11:670-7. 2010
  5. doi request reprint Gastrointestinal stem cells in development and cancer
    S Brabletz
    Department of Visceral Surgery and Comprehensive Cancer Centre, University Medical Centre Freiburg, Germany
    J Pathol 217:307-17. 2009
  6. pmc MicroRNAs coordinately regulate protein complexes
    Steffen Sass
    MIPS, Institute for Bioinformatics and System Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstraße 1, D 85764 Neuherberg, Germany
    BMC Syst Biol 5:136. 2011
  7. doi request reprint The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    Ulrich Wellner
    Department of Visceral Surgery, University of Freiburg, 79106 Freiburg, Germany
    Nat Cell Biol 11:1487-95. 2009
  8. doi request reprint E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    Otto Schmalhofer
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany
    Cancer Metastasis Rev 28:151-66. 2009
  9. pmc The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells
    Simone Brabletz
    Department of Visceral Surgery, University of Freiburg, Freiburg, Germany
    EMBO J 30:770-82. 2011
  10. doi request reprint The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer
    Simone Spaderna
    Department of Visceral Surgery, University of Freiburg, Freiburg, Germany
    Cancer Res 68:537-44. 2008

Collaborators

Detail Information

Publications13

  1. pmc A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    Ulrike Burk
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    EMBO Rep 9:582-9. 2008
    ..Alternatively, depending on the environmental trigger, this loop might switch and induce epithelial differentiation, and thus explain the strong intratumorous heterogeneity observed in many human cancers...
  2. doi request reprint EMT and MET in metastasis: where are the cancer stem cells?
    Thomas Brabletz
    Department of General and Visceral Surgery, Comprehensive Cancer Center and BIOSS Centre for Biological Signalling Studies, University of Freiburg Medical Center, Hugstetter Str 55, 79106 Freiburg, Germany
    Cancer Cell 22:699-701. 2012
    ..Moreover, although EMT has been associated with stemness properties, one study indicates that they are not necessarily linked...
  3. doi request reprint To differentiate or not--routes towards metastasis
    Thomas Brabletz
    Department of General and Visceral Surgery and Comprehensive Cancer Center, University of Freiburg Medical Center, Hugstetter Str 55, 79106 Freiburg, Germany
    Nat Rev Cancer 12:425-36. 2012
    ..This simplified classification integrates clinically relevant aspects of dormancy, metastatic tropism and therapy resistance, and implies perspectives on treatment strategies against metastasis...
  4. pmc The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?
    Simone Brabletz
    Department of Visceral Surgery, University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany
    EMBO Rep 11:670-7. 2010
    ....
  5. doi request reprint Gastrointestinal stem cells in development and cancer
    S Brabletz
    Department of Visceral Surgery and Comprehensive Cancer Centre, University Medical Centre Freiburg, Germany
    J Pathol 217:307-17. 2009
    ....
  6. pmc MicroRNAs coordinately regulate protein complexes
    Steffen Sass
    MIPS, Institute for Bioinformatics and System Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstraße 1, D 85764 Neuherberg, Germany
    BMC Syst Biol 5:136. 2011
    ..Interactions between targets of co-expressed miRNAs (including miRNA clusters) have not yet been systematically investigated...
  7. doi request reprint The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    Ulrich Wellner
    Department of Visceral Surgery, University of Freiburg, 79106 Freiburg, Germany
    Nat Cell Biol 11:1487-95. 2009
    ..Thus, targeting the ZEB1-miR-200 feedback loop might form the basis of a promising treatment for fatal tumours, such as pancreatic cancer...
  8. doi request reprint E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    Otto Schmalhofer
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany
    Cancer Metastasis Rev 28:151-66. 2009
    ....
  9. pmc The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells
    Simone Brabletz
    Department of Visceral Surgery, University of Freiburg, Freiburg, Germany
    EMBO J 30:770-82. 2011
    ..These findings explain increased Notch signalling in some types of cancers, where mutations in Notch pathway genes are rare. Moreover, they indicate an additional way how ZEB1 exerts its tumour progressing functions...
  10. doi request reprint The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer
    Simone Spaderna
    Department of Visceral Surgery, University of Freiburg, Freiburg, Germany
    Cancer Res 68:537-44. 2008
    ..Thus, by linking EMT, loss of polarity, and metastasis, ZEB1 is a crucial promoter of malignant tumor progression...
  11. doi request reprint Roadblocks to translational advances on metastasis research
    Thomas Brabletz
    1 Department of General and Visceral Surgery, Comprehensive Cancer Center and BIOSS Centre for Biological Signalling Studies, University of Freiburg Medical Center, Freiburg, Germany 2
    Nat Med 19:1104-9. 2013
    ....
  12. doi request reprint Native promoter reporters validate transcriptional targets
    Otto Schmalhofer
    Department of Surgery, University of Freiburg, Germany
    Methods Mol Biol 468:111-28. 2008
    ..In this chapter, we describe how to generate such reporter plasmids using the MMP7 promoter as an example...
  13. doi request reprint Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition
    Ulf D Kahlert
    Division of Stereotactic Neurosurgery, Department of General Neurosurgery, University Medical Center Freiburg, Freiburg, Germany
    Cancer Lett 325:42-53. 2012
    ..These findings suggest that canonical WNT/β-catenin pathway is a critical regulator of GBM invasion and may represent a potential therapeutic target...