T Brabletz

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Germany
    Pathol Res Pract 194:701-4. 1998
  2. ncbi request reprint Beta-catenin and the morphogenesis of colorectal cancer
    Thomas Brabletz
    Institute of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Virchows Arch 441:1-11. 2002
  3. pmc Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 156:865-70. 2000
  4. pmc beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 155:1033-8. 1999
  5. ncbi request reprint Mismatch repair deficiency in sporadic synchronous colorectal cancer
    W M Brueckl
    Department of Internal Medicine I, University of Erlangen Nuremberg, Krankenhausstr, 12, 91054 Erlangen, Germany
    Anticancer Res 20:4727-32. 2000
  6. ncbi request reprint Tip60 is a cell-type-specific transcriptional regulator
    F Hlubek
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, 91054 Erlangen, Germany
    J Biochem 129:635-41. 2001
  7. ncbi request reprint Expression of the invasion factor laminin gamma2 in colorectal carcinomas is regulated by beta-catenin
    F Hlubek
    Department of Pathology, , Krankenhausstrasse 8-10, 91054 Erlangen, Germany
    Cancer Res 61:8089-93. 2001
  8. pmc Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Proc Natl Acad Sci U S A 98:10356-61. 2001
  9. pmc The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D1, and p16INK4A and is a region of low proliferation
    A Jung
    Department of Molekulare Pathologie, Pathologisches Institut, Universitat Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 159:1613-7. 2001
  10. pmc Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation
    T Kirchner
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 157:1113-21. 2000

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Germany
    Pathol Res Pract 194:701-4. 1998
    ..Possibly, surrounding tissue at the invasion front can give signals to the tumor cells, leading to a nuclear translocation of beta-Catenin, where it may play a direct role in tumor invasion processes...
  2. ncbi request reprint Beta-catenin and the morphogenesis of colorectal cancer
    Thomas Brabletz
    Institute of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Virchows Arch 441:1-11. 2002
    ..The possibility is discussed that, on the basis of this genetic alteration, the tumor microenvironment is an additional driving force of tumor progression...
  3. pmc Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 156:865-70. 2000
    ....
  4. pmc beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 155:1033-8. 1999
    ..Our results explain the high percentage of MMP-7 overexpression in colon tumors. Moreover they indicate that defects in the APC tumor suppressor gene may also have an influence on later steps of colon tumor progression...
  5. ncbi request reprint Mismatch repair deficiency in sporadic synchronous colorectal cancer
    W M Brueckl
    Department of Internal Medicine I, University of Erlangen Nuremberg, Krankenhausstr, 12, 91054 Erlangen, Germany
    Anticancer Res 20:4727-32. 2000
    ..In the present study MSI and mismatch repair (MMR) proteins were evaluated according to standardised criteria (exclusion of a family history, MSI analysed according to NCI recommendations)..
  6. ncbi request reprint Tip60 is a cell-type-specific transcriptional regulator
    F Hlubek
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, 91054 Erlangen, Germany
    J Biochem 129:635-41. 2001
    ..This indicates that Tip60 may function by recruiting additional cell-type-specific cofactors...
  7. ncbi request reprint Expression of the invasion factor laminin gamma2 in colorectal carcinomas is regulated by beta-catenin
    F Hlubek
    Department of Pathology, , Krankenhausstrasse 8-10, 91054 Erlangen, Germany
    Cancer Res 61:8089-93. 2001
    ....
  8. pmc Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Proc Natl Acad Sci U S A 98:10356-61. 2001
    ....
  9. pmc The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D1, and p16INK4A and is a region of low proliferation
    A Jung
    Department of Molekulare Pathologie, Pathologisches Institut, Universitat Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 159:1613-7. 2001
    ..In particular, the function of cyclin D1 should be reconsidered in view of these observations...
  10. pmc Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation
    T Kirchner
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 157:1113-21. 2000
    ..The results indicate microenvironmental regulations of nuclear beta-catenin expression and a return of neoplastic cells to embryonic transcriptional susceptibilities during colonic carcinogenesis...
  11. pmc Securin (hPTTG1) expression is regulated by beta-catenin/TCF in human colorectal carcinoma
    F Hlubek
    Department of Pathology, Ludwig Maximilians University of Munich, Thalkirchner Str 36, 80337 Munich, Germany
    Br J Cancer 94:1672-7. 2006
    ..This implies that deregulation of the beta-catenin/T-cell factor-signalling pathway leads to overexpression of securin in human colorectal cancer, which subsequently may contribute to tumour progression...
  12. ncbi request reprint Relationship between microsatellite instability, response and survival in palliative patients with colorectal cancer undergoing first-line chemotherapy
    W M Brueckl
    Department of Internal Medicine I, Friedrich Alexander University Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    Anticancer Res 23:1773-7. 2003
    ..of high-dose 5-fluorouracil (5-FU) and folinic acid (FA)...
  13. ncbi request reprint Negative regulation of CD4 expression in T cells by the transcriptional repressor ZEB
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Int Immunol 11:1701-8. 1999
    ..The conversion of the CD4 proximal enhancer into a potential silencer element by the transcriptional repressor ZEB offers an additional concept of CD4 gene regulation in T cells...
  14. ncbi request reprint Hodgkin's disease and peripheral T-cell lymphoma: composite lymphoma with evidence of Epstein-Barr virus infection
    G Niedobitek
    Institute for Pathology, Friedrich Alexander University, 91054 Erlangen, Germany
    J Pathol 191:394-9. 2000
    ..The detection of EBV-carrying cell populations admixed with the neoplastic T-cells at primary presentation and at relapse raises the possibility that the growth of the T-cell lymphoma was dependent on the presence of such cells...
  15. ncbi request reprint Microsatellite instability in colorectal adenomas: relevance and clinical importance
    W M Brueckl
    Department of Internal Medicine I, Friedrich Alexander University, Erlangen Nuremberg, Germany
    Int J Colorectal Dis 15:189-96. 2000
    ..Finally, we consider the clinical importance of microsatellite status for the diagnosis of hereditary nonpolyposis colorectal cancer and the possibility of preventing adenomas and carcinomas by nonsteroidal anti-inflammatory drugs...
  16. pmc 7-Deaza-2'-deoxyguanosine allows PCR and sequencing reactions from CpG islands
    A Jung
    Pathologisches Institut, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
    Mol Pathol 55:55-7. 2002
    ..Our results show that the addition of 7-deaza-2'-deoxyguanosine significantly improves results, particularly when small amounts of poor quality DNA are available as starting material...
  17. ncbi request reprint Ki-67 expression and residual tumour (R) classification are associated with disease-free survival in desmoid tumour patients
    W M Brueckl
    Department of Internal Medicine I, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
    Anticancer Res 21:3615-20. 2001
    ..In patients presenting with Ki-67 positive desmoids, which are unlikely to be resected in a curative manner, alternative treatment (e.g. sulindac) may be preferable...
  18. ncbi request reprint Metaplasia, intraepithelial neoplasia and early cancer of the stomach are related to dedifferentiated epithelial cells defined by cytokeratin-7 expression in gastritis
    T Kirchner
    Department of Pathology, University of Erlangen Nuremberg, Erlangen, Germany
    Virchows Arch 439:512-22. 2001
    ..Thus, the "stem cell" and "dedifferentiation" hypotheses for cancer origin could complement one another, and dedifferentiation-redifferentiation processes might be decisive for carcinogenesis in the stomach...
  19. ncbi request reprint Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes
    S Chuvpilo
    Department of Molecular Pathology, Institute of Pathology, University of Wurzburg, Germany
    J Immunol 162:7294-301. 1999
    ..These properties of NF-ATc/B and -C might be of importance for gene regulation in naive T lymphocytes in which NF-ATc/B and -C are predominantly synthesized...
  20. ncbi request reprint [The Rudolf Virchow Prize 2001. The role of the oncoprotein beta-catenin ni the progression of colorectal cancers]
    T Brabletz
    , Germany
    Verh Dtsch Ges Pathol 85:243-9. 2001
    ....
  21. ncbi request reprint [Morphogenetic aspects of colorectal cancer]
    T Brabletz
    Pathologisches Institut, Universitat Erlangen Nurnberg
    Pathologe 24:44-8. 2003
    ..These findings establish patterning as a relevant concept for tumor formation and link the neoplastic morphogenesis with embryogenesis...
  22. pmc Increased expression of high mobility group box 1 (HMGB1) is associated with an elevated level of the antiapoptotic c-IAP2 protein in human colon carcinomas
    K Volp
    Georg Speyer Haus, Paul Ehrich Strasse, 42 44, Frankfurt D 60596, Germany
    Gut 55:234-42. 2006
    ..In this study, we analysed human colon carcinoma for HMGB1 as well as for c-IAP2 expression levels. c-IAP2 is an antiapoptotic protein which may be upregulated as a consequence of nuclear factor kappaB (NFkappaB) activation via HMGB1...
  23. ncbi request reprint Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids
    E Vincan
    Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Oncogene 26:2340-52. 2007
    ..During development, FZD7 orchestrates either migratory or epithelialization events depending on the context. Our findings strongly implicate similar functional diversity for FZD7 during CRC morphogenesis...
  24. pmc The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
    K Aigner
    Max F Perutz Laboratories, Department of Medical Biochemistry, Medical University Vienna, Vienna, Austria
    Oncogene 26:6979-88. 2007
    ..In invasive ductal and lobular breast cancer, upregulation of ZEB1 was stringently coupled to cancer cell dedifferentiation. Our data show that ZEB1 represents a key player in pathologic EMTs associated with tumour progression...
  25. ncbi request reprint The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells
    I Gross
    INSERM, U682, Strasbourg, France
    Oncogene 27:107-15. 2008
    ..These data provide evidence that Cdx2 antagonizes the process of tumor cell dissemination, and they suggest that this homeobox gene might represent a new therapeutic target against metastatic spreading of colon cancer...