T Brabletz

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression
    Thomas Brabletz
    Department of Pathology, University of Erlangen, Krankenhausstr 8 10, 91054 Erlangen, Germany
    Nat Rev Cancer 5:744-9. 2005
  2. ncbi Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin
    Thomas Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Cells Tissues Organs 179:56-65. 2005
  3. ncbi Frontiers in Cancer Prevention Research - Fifth Annual AACR Conference
    Thomas Brabletz
    University of Erlangen, Department of Pathology, Krankenhaus Strasse 8-10, 91054 Erlangen, Germany
    IDrugs 10:20-2. 2007
  4. ncbi Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression
    Thomas Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Cancer Res 64:6973-7. 2004
  5. ncbi Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Proc Natl Acad Sci U S A 98:10356-61. 2001
  6. ncbi Mismatch repair deficiency in sporadic synchronous colorectal cancer
    W M Brueckl
    Department of Internal Medicine I, University of Erlangen Nuremberg, Krankenhausstr, 12, 91054 Erlangen, Germany
    Anticancer Res 20:4727-32. 2000
  7. ncbi Expression of the invasion factor laminin gamma2 in colorectal carcinomas is regulated by beta-catenin
    F Hlubek
    Department of Pathology, , Krankenhausstrasse 8-10, 91054 Erlangen, Germany
    Cancer Res 61:8089-93. 2001
  8. ncbi Tip60 is a cell-type-specific transcriptional regulator
    F Hlubek
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, 91054 Erlangen, Germany
    J Biochem 129:635-41. 2001
  9. ncbi beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 155:1033-8. 1999
  10. ncbi Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Germany
    Pathol Res Pract 194:701-4. 1998

Collaborators

Detail Information

Publications54

  1. ncbi Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression
    Thomas Brabletz
    Department of Pathology, University of Erlangen, Krankenhausstr 8 10, 91054 Erlangen, Germany
    Nat Rev Cancer 5:744-9. 2005
    ..We suggest an extended, integrated model that is consistent with all aspects of human tumour progression - the 'migrating cancer stem (MCS)-cell' concept...
  2. ncbi Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin
    Thomas Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Cells Tissues Organs 179:56-65. 2005
    ..Accumulating data demonstrate that aberrant nuclear expression of beta-catenin can also confer these two abilities to tumor cells, thereby driving malignant tumor progression...
  3. ncbi Frontiers in Cancer Prevention Research - Fifth Annual AACR Conference
    Thomas Brabletz
    University of Erlangen, Department of Pathology, Krankenhaus Strasse 8-10, 91054 Erlangen, Germany
    IDrugs 10:20-2. 2007
  4. ncbi Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression
    Thomas Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Cancer Res 64:6973-7. 2004
    ..These data indicate an active role for the tumor environment in malignant tumor progression...
  5. ncbi Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Proc Natl Acad Sci U S A 98:10356-61. 2001
    ....
  6. ncbi Mismatch repair deficiency in sporadic synchronous colorectal cancer
    W M Brueckl
    Department of Internal Medicine I, University of Erlangen Nuremberg, Krankenhausstr, 12, 91054 Erlangen, Germany
    Anticancer Res 20:4727-32. 2000
    ..In the present study MSI and mismatch repair (MMR) proteins were evaluated according to standardised criteria (exclusion of a family history, MSI analysed according to NCI recommendations)..
  7. ncbi Expression of the invasion factor laminin gamma2 in colorectal carcinomas is regulated by beta-catenin
    F Hlubek
    Department of Pathology, , Krankenhausstrasse 8-10, 91054 Erlangen, Germany
    Cancer Res 61:8089-93. 2001
    ....
  8. ncbi Tip60 is a cell-type-specific transcriptional regulator
    F Hlubek
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, 91054 Erlangen, Germany
    J Biochem 129:635-41. 2001
    ..This indicates that Tip60 may function by recruiting additional cell-type-specific cofactors...
  9. ncbi beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 155:1033-8. 1999
    ..Our results explain the high percentage of MMP-7 overexpression in colon tumors. Moreover they indicate that defects in the APC tumor suppressor gene may also have an influence on later steps of colon tumor progression...
  10. ncbi Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Germany
    Pathol Res Pract 194:701-4. 1998
    ..Possibly, surrounding tissue at the invasion front can give signals to the tumor cells, leading to a nuclear translocation of beta-Catenin, where it may play a direct role in tumor invasion processes...
  11. ncbi The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D1, and p16INK4A and is a region of low proliferation
    A Jung
    Department of Molekulare Pathologie, Pathologisches Institut, Universitat Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 159:1613-7. 2001
    ..In particular, the function of cyclin D1 should be reconsidered in view of these observations...
  12. ncbi Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 156:865-70. 2000
    ....
  13. ncbi Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation
    T Kirchner
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 157:1113-21. 2000
    ..The results indicate microenvironmental regulations of nuclear beta-catenin expression and a return of neoplastic cells to embryonic transcriptional susceptibilities during colonic carcinogenesis...
  14. ncbi Securin (hPTTG1) expression is regulated by beta-catenin/TCF in human colorectal carcinoma
    F Hlubek
    Department of Pathology, Ludwig Maximilians University of Munich, Thalkirchner Str 36, 80337 Munich, Germany
    Br J Cancer 94:1672-7. 2006
    ..This implies that deregulation of the beta-catenin/T-cell factor-signalling pathway leads to overexpression of securin in human colorectal cancer, which subsequently may contribute to tumour progression...
  15. ncbi Hodgkin's disease and peripheral T-cell lymphoma: composite lymphoma with evidence of Epstein-Barr virus infection
    G Niedobitek
    Institute for Pathology, Friedrich Alexander University, 91054 Erlangen, Germany
    J Pathol 191:394-9. 2000
    ..The detection of EBV-carrying cell populations admixed with the neoplastic T-cells at primary presentation and at relapse raises the possibility that the growth of the T-cell lymphoma was dependent on the presence of such cells...
  16. ncbi Negative regulation of CD4 expression in T cells by the transcriptional repressor ZEB
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Int Immunol 11:1701-8. 1999
    ..The conversion of the CD4 proximal enhancer into a potential silencer element by the transcriptional repressor ZEB offers an additional concept of CD4 gene regulation in T cells...
  17. ncbi Metaplasia, intraepithelial neoplasia and early cancer of the stomach are related to dedifferentiated epithelial cells defined by cytokeratin-7 expression in gastritis
    T Kirchner
    Department of Pathology, University of Erlangen Nuremberg, Erlangen, Germany
    Virchows Arch 439:512-22. 2001
    ..Thus, the "stem cell" and "dedifferentiation" hypotheses for cancer origin could complement one another, and dedifferentiation-redifferentiation processes might be decisive for carcinogenesis in the stomach...
  18. ncbi Relationship between microsatellite instability, response and survival in palliative patients with colorectal cancer undergoing first-line chemotherapy
    W M Brueckl
    Department of Internal Medicine I, Friedrich Alexander University Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    Anticancer Res 23:1773-7. 2003
    ..of high-dose 5-fluorouracil (5-FU) and folinic acid (FA)...
  19. ncbi Microsatellite instability in colorectal adenomas: relevance and clinical importance
    W M Brueckl
    Department of Internal Medicine I, Friedrich Alexander University, Erlangen Nuremberg, Germany
    Int J Colorectal Dis 15:189-96. 2000
    ..Finally, we consider the clinical importance of microsatellite status for the diagnosis of hereditary nonpolyposis colorectal cancer and the possibility of preventing adenomas and carcinomas by nonsteroidal anti-inflammatory drugs...
  20. ncbi Ki-67 expression and residual tumour (R) classification are associated with disease-free survival in desmoid tumour patients
    W M Brueckl
    Department of Internal Medicine I, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
    Anticancer Res 21:3615-20. 2001
    ..In patients presenting with Ki-67 positive desmoids, which are unlikely to be resected in a curative manner, alternative treatment (e.g. sulindac) may be preferable...
  21. ncbi 7-Deaza-2'-deoxyguanosine allows PCR and sequencing reactions from CpG islands
    A Jung
    Pathologisches Institut, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
    Mol Pathol 55:55-7. 2002
    ..Our results show that the addition of 7-deaza-2'-deoxyguanosine significantly improves results, particularly when small amounts of poor quality DNA are available as starting material...
  22. ncbi ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells
    Thomas Waerner
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Cancer Cell 10:227-39. 2006
    ..ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer...
  23. ncbi Wnt/FZD signaling and colorectal cancer morphogenesis
    Falk Hlubek
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, 91054 Erlangen, Germany
    Front Biosci 12:458-70. 2007
    ..Accumulating data demonstrate that aberrant nuclear expression of beta-catenin can also confer these two abilities to tumor cells, indicating the crucial role of aberrant Wnt-signaling for malignant tumor progression...
  24. ncbi Mycosis fungoides palmaris et plantaris--an unusual variant of cutaneous T-cell lymphoma
    Susanne Topf
    Department of Dermatology, University Hospital Erlangen, Hartmannstr 14, D 91052 Erlangen, Germany
    Eur J Dermatol 16:84-6. 2006
    ..We report on an 18-year old male patient, who had been previously diagnosed with palmoplantar eczema. Clinical, histopathological, immunohistochemical and molecular findings revealed an atypical case of MF...
  25. ncbi The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells
    Fairouz Benahmed
    INSERM U682, 3 avenue Moliere, 67200 Strasbourg, France
    Am J Pathol 170:733-44. 2007
    ..We exclude a role of the Notch pathway in this regulation. The regulation of CDX2 by the microenvironment might be relevant during the process of metastatic dissemination when the gene is transiently turned down in invasive cells...
  26. ncbi A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer
    Simone Spaderna
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Gastroenterology 131:830-40. 2006
    ..The aim of this study was to investigate the role, mechanisms, and clinical relevance of BM turnover in malignant colorectal cancer (CRC) progression...
  27. ncbi Wnt/beta-catenin signaling in cancer stemness and malignant behavior
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Opin Cell Biol 19:150-8. 2007
    ..Several intrinsic (cell-autonomous and/or autocrine) and extrinsic (paracrine, derived from the tumor microenvironment) factors may explain this heterogeneity of Wnt/beta-catenin signaling activity within the tumor mass...
  28. ncbi The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression
    Kirsten Aigner
    Max F Perutz Laboratories, Department of Medical Biochemistry, Medical University Vienna, Dr Bohrgasse 9, A 1030 Vienna, Austria
    FEBS Lett 581:1617-24. 2007
    ..Hence, the transcriptional repression of PKP3 by ZEB1 contributes to ZEB1-mediated disintegration of intercellular adhesion and epithelial to mesenchymal transition...
  29. ncbi Precancerous lesions upon sporadic activation of beta-catenin in mice
    Isabelle Coste
    Schering Plough Laboratory for Immunological Research, Dardilly, France
    Gastroenterology 132:1299-308. 2007
    ..However, these models do not reproduce the sporadic nature of the majority of human cancers, beginning with the activation of an oncogene at random in a single cell...
  30. ncbi Frizzled7 dictates embryonic morphogenesis: implications for colorectal cancer progression
    Elizabeth Vincan
    Department of Anatomy and Cell Biology, The University of Melbourne, Parkville, Victoria, Australia
    Front Biosci 12:4558-67. 2007
    ..Interestingly, expression of the Wnt receptor FZD7 in gut tissue is also conserved through evolution, suggesting that this receptor may be integral to the important role assigned to Wnt signalling in gut tissues...
  31. ncbi A human three-dimensional cell line model allows the study of dynamic and reversible epithelial-mesenchymal and mesenchymal-epithelial transition that underpins colorectal carcinogenesis
    Elizabeth Vincan
    Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia
    Cells Tissues Organs 185:20-8. 2007
    ..Importantly, we have demonstrated a pivotal role for FZD7 in these phenotype transitions, implicating Wnt signalling in orchestrating CRC morphogenesis...
  32. ncbi Heterogeneous expression of Wnt/beta-catenin target genes within colorectal cancer
    Falk Hlubek
    Department of Pathology, Ludwig Maximilians University of Munchen, Munchen, Germany
    Int J Cancer 121:1941-8. 2007
    ....
  33. ncbi Molecular signature for lymphatic metastasis in colorectal carcinomas
    Roland S Croner
    Department of Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Surg 247:803-10. 2008
    ..Microarray techniques provide a promising tool to identify stage-specific molecular signatures on primary tumor biopsies...
  34. ncbi A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    Ulrike Burk
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    EMBO Rep 9:582-9. 2008
    ..Alternatively, depending on the environmental trigger, this loop might switch and induce epithelial differentiation, and thus explain the strong intratumorous heterogeneity observed in many human cancers...
  35. ncbi The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer
    Simone Spaderna
    Department of Visceral Surgery, University of Freiburg, Freiburg, Germany
    Cancer Res 68:537-44. 2008
    ..Thus, by linking EMT, loss of polarity, and metastasis, ZEB1 is a crucial promoter of malignant tumor progression...
  36. ncbi beta-Catenin regulates the expression of tenascin-C in human colorectal tumors
    Katharina Beiter
    Pathologisch Anatomisches Institut, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
    Oncogene 24:8200-4. 2005
    ..Thus, by far the most common mutations in colorectal tumors, found in the Wnt-signaling pathway and leading to the stabilizing of beta-catenin, might influence invasion by altering adhesive properties and EMT of tumor cells...
  37. ncbi Beta-catenin and the morphogenesis of colorectal cancer
    Thomas Brabletz
    Institute of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Virchows Arch 441:1-11. 2002
    ..The possibility is discussed that, on the basis of this genetic alteration, the tumor microenvironment is an additional driving force of tumor progression...
  38. ncbi Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription
    Rina Rosin-Arbesfeld
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO J 22:1101-13. 2003
    ..Our evidence indicates that the rate of nuclear export of APC, rather than its nuclear import or steady-state levels, determines the transcriptional activity of beta-catenin...
  39. ncbi Gastric PDX-1 expression in pancreatic metaplasia and endocrine cell hyperplasia in atrophic corpus gastritis
    Maike Buettner
    Institute of Pathology, University of Erlangen Nuremberg, Erlangen, Germany
    Mod Pathol 17:56-61. 2004
    ....
  40. ncbi Beta-catenin activates a coordinated expression of the proinvasive factors laminin-5 gamma2 chain and MT1-MMP in colorectal carcinomas
    Falk Hlubek
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Int J Cancer 108:321-6. 2004
    ..This further supports an important role of beta-catenin for invasion and metastasis of colorectal carcinomas...
  41. ncbi Transcription of sonic hedgehog, a potential factor for gastric morphogenesis and gastric mucosa maintenance, is up-regulated in acidic conditions
    Arno Dimmler
    Institute of Pathology, University of Erlangen Nuremberg, Erlangen, Germany
    Lab Invest 83:1829-37. 2003
    ..The increase of gastric pH might play a role in the development of gastric mucosa atrophy via reduction of Shh transcription...
  42. ncbi Prognostic significance of microsatellite instability in curatively resected adenocarcinoma of the small intestine
    Wolfgang M Brueckl
    Department of Internal Medicine I, Friedrich Alexander University, Ulmenweg 18, Erlangen Nuremberg, D 91054 Erlangen, Germany
    Cancer Lett 203:181-90. 2004
    ..005 and P<0.001) for an increased survival in multivariate analysis. Therefore, it is suggested that analysis of the MSI status might prove useful in discerning prognosis within cancers of the same stage...
  43. ncbi Beta-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors
    Elke Hiendlmeyer
    , Krankenhausstrasse 8-10, 91054 Erlangen, Germany
    Cancer Res 64:1209-14. 2004
    ..Here we show that beta-catenin contributes to the transactivation of uPA. Therefore, beta-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer...
  44. ncbi Evidence for acid-induced loss of Cdx2 expression in duodenal gastric metaplasia
    Gerhard Faller
    Institute of Pathology, University of Erlangen Nuremberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    J Pathol 203:904-8. 2004
    ..Thus, it is suggested that increased acid exposure leads to GMD by impairing the transcription of Cdx2 and subsequently that of its intestine-specific target genes...
  45. ncbi DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells
    Guido T Bommer
    Department of Medicine II, University of Munich, 81377 Munich, Germany
    J Biol Chem 280:7962-75. 2005
    ..Our findings suggest that inhibition of DRO1 expression may be an important event in the development of colorectal and pancreatic cancers...
  46. ncbi Aberrant expression of TTF-1 and forkhead factor HFH-4 in atrophic gastritis and ciliated metaplasia suggests gastric broncho-pulmonary transdetermination
    Tilman Rau
    Institute of Pathology, University of Erlangen-Nuremberg, Erlangen, Germany
    J Pathol 206:383-7. 2005
    ..Evidence for this particular transdetermination is frequently found in atrophic gastritis even without fully developed ciliated cells...
  47. ncbi T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis
    Stefan Ruckert
    Pathologisches Institut, , Krankenhausstrasse 8-10, D-91054 Erlangen, Germany
    Cancer Res 62:3009-13. 2002
    ..It was found that mutations in the TCF-4 A(9) repeat do not contribute to tumorigenesis and seem to be passenger mutations...
  48. ncbi L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel
    J Cell Biol 168:633-42. 2005
    ..The transmembrane localization and shedding of L1 by metalloproteases could be useful for detection and as target for colon cancer therapy...
  49. ncbi Microarray versus conventional prediction of lymph node metastasis in colorectal carcinoma
    Roland S Croner
    Department of Surgery, University of Erlangen, Erlangen, Germany
    Cancer 104:395-404. 2005
    ..Currently, postoperative histology results are needed to determine lymph node status. Reliable preoperative information would be useful to advance treatment strategies...
  50. ncbi Forced expression of deltaN-TCF-1B in colon cancer derived cell lines is accompanied by the induction of CEACAM5/6 and mesothelin
    Beate Liebig
    Department of Internal Medicine 1, Section Molecular GI Oncology, University of Halle-Wittenberg, Halle, Germany
    Cancer Lett 223:159-67. 2005
    ..We conclude that forced expression of deltaN-TCF-1B in HT29 and SW480 is associated with up-regulation of GPI-anchored adhesion molecules, which were assigned to the tumour-host front in CRC patients...
  51. ncbi Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer
    Konstanze Lenhard
    Department of Medicine II, University of Munich, Germany
    Clin Gastroenterol Hepatol 3:142-9. 2005
    ..We postulate that a panel of merely a few genetic and epigenetic markers will be required for the highly sensitive and specific detection of CRCs and adenomas in fecal samples from affected patients...
  52. ncbi Predictive molecular markers for colorectal cancer patients with resected liver metastasis and adjuvant chemotherapy
    Silke Lassmann
    Institute of Pathology, University Hospital, Albert Ludwigs University Freiburg, Freiburg, Germany
    Gastroenterology 133:1831-9. 2007
    ....
  53. ncbi Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice
    Maksim V Yezhelyev
    Department of Surgery, University of Munich-Grosshadern, Munich, Marchioninstrasse 15, 81377 Munich, Germany
    Clin Cancer Res 10:8028-36. 2004
    ..The combination of AZM475271 with gemcitabine sensitized tumor cells to the cytotoxic effect of gemcitabine...
  54. ncbi Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability
    Clément Subtil
    INSERM U682, University Louis Pasteur, 67200 Strasbourg, France
    Cancer Lett 247:197-203. 2007
    ..However, they were not predictive of the Cdx2 protein pattern. These data suggest that mechanisms other than structural alterations at the CDX2 locus account for the change of expression in colorectal cancers...