Heiko Braak

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. doi request reprint The pathological process underlying Alzheimer's disease in individuals under thirty
    Heiko Braak
    Department of Neurology, Center for Clinical Research, University of Ulm, Germany
    Acta Neuropathol 121:171-81. 2011
  2. doi request reprint Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years
    Heiko Braak
    Clinical Neuroanatomy, Department of Neurology, and Laboratory for Neuropathology Institute of Pathology, Center for Clinical Research, University of Ulm, Germany
    J Neuropathol Exp Neurol 70:960-9. 2011
  3. ncbi request reprint Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid
    Heiko Braak
    Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstrasse 8 1, 89081, Ulm, Germany
    Acta Neuropathol 126:631-41. 2013
  4. doi request reprint [Pathogenesis and prevention of Alzheimer's disease: when and in what way does the pathological process begin?]
    H Braak
    Zentrum für Biomedizinische Forschung, Universitat Ulm, Helmholtzstr 8 1, 89081 Ulm, Deutschland
    Nervenarzt 84:477-82. 2013
  5. doi request reprint Evolutional aspects of Alzheimer's disease pathogenesis
    Heiko Braak
    Clinical Neuroanatomy, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany
    J Alzheimers Dis 33:S155-61. 2013
  6. doi request reprint Where, when, and in what form does sporadic Alzheimer's disease begin?
    Heiko Braak
    Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany
    Curr Opin Neurol 25:708-14. 2012
  7. doi request reprint Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons
    Heiko Braak
    Clinical Neuroanatomy, Center for Biomedical Research, Department of Neurology, University of Ulm, Ulm, Germany
    Neurobiol Aging 34:286-97. 2013
  8. doi request reprint Alzheimer's disease: pathogenesis and prevention
    Heiko Braak
    Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, Ulm University, Germany
    Alzheimers Dement 8:227-33. 2012
  9. doi request reprint Alzheimer's pathogenesis: is there neuron-to-neuron propagation?
    Heiko Braak
    Clinical Neuroanatomy Department of Neurology, Center for Clinical Research, University of Ulm, Ulm, Germany
    Acta Neuropathol 121:589-95. 2011
  10. doi request reprint Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases
    Heiko Braak
    Clinical Neuroanatomy, Department of Neurology, Center for Clinical Research, University of Ulm, Ulm, Germany
    J Neural Transm 118:809-19. 2011

Detail Information

Publications22

  1. doi request reprint The pathological process underlying Alzheimer's disease in individuals under thirty
    Heiko Braak
    Department of Neurology, Center for Clinical Research, University of Ulm, Germany
    Acta Neuropathol 121:171-81. 2011
    ..e., before puberty or in early young adulthood...
  2. doi request reprint Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years
    Heiko Braak
    Clinical Neuroanatomy, Department of Neurology, and Laboratory for Neuropathology Institute of Pathology, Center for Clinical Research, University of Ulm, Germany
    J Neuropathol Exp Neurol 70:960-9. 2011
    ..0001). These data suggest that tauopathy associated with sporadic Alzheimer disease may begin earlier than previously thought and possibly in the lower brainstem rather than in the transentorhinal region...
  3. ncbi request reprint Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid
    Heiko Braak
    Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstrasse 8 1, 89081, Ulm, Germany
    Acta Neuropathol 126:631-41. 2013
    ..This viewpoint attempts to address questions arising in connection with this apparent sequential discrepancy-questions and issues for which there are currently no clear-cut answers. ..
  4. doi request reprint [Pathogenesis and prevention of Alzheimer's disease: when and in what way does the pathological process begin?]
    H Braak
    Zentrum für Biomedizinische Forschung, Universitat Ulm, Helmholtzstr 8 1, 89081 Ulm, Deutschland
    Nervenarzt 84:477-82. 2013
    ..Evolutionally speaking, the propensity to develop tau lesions may be related to late developing and maturing nerve cell types in the human brain...
  5. doi request reprint Evolutional aspects of Alzheimer's disease pathogenesis
    Heiko Braak
    Clinical Neuroanatomy, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany
    J Alzheimers Dis 33:S155-61. 2013
    ..The propensity to develop tau lesions may be related to the exceptionally protracted myelination of late developing portions in the human brain...
  6. doi request reprint Where, when, and in what form does sporadic Alzheimer's disease begin?
    Heiko Braak
    Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany
    Curr Opin Neurol 25:708-14. 2012
    ..Intraneuronal lesions consisting of abnormal tau protein are seen to develop from the beginning until the end-phase of the pathological process underlying Alzheimer's disease. This review highlights the earliest phase of this process...
  7. doi request reprint Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons
    Heiko Braak
    Clinical Neuroanatomy, Center for Biomedical Research, Department of Neurology, University of Ulm, Ulm, Germany
    Neurobiol Aging 34:286-97. 2013
    ....
  8. doi request reprint Alzheimer's disease: pathogenesis and prevention
    Heiko Braak
    Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, Ulm University, Germany
    Alzheimers Dement 8:227-33. 2012
    ..Conclusions drawn from these considerations should encourage development of new preventative and disease-modifying strategies...
  9. doi request reprint Alzheimer's pathogenesis: is there neuron-to-neuron propagation?
    Heiko Braak
    Clinical Neuroanatomy Department of Neurology, Center for Clinical Research, University of Ulm, Ulm, Germany
    Acta Neuropathol 121:589-95. 2011
    ....
  10. doi request reprint Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases
    Heiko Braak
    Clinical Neuroanatomy, Department of Neurology, Center for Clinical Research, University of Ulm, Ulm, Germany
    J Neural Transm 118:809-19. 2011
    ..Its p62-immunoreactive profile may indicate that the hypothalamic paraventricular nucleus is somehow capable of effectively metabolizing misfolded proteins and/or preventing their aggregation...
  11. doi request reprint Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord
    Heiko Braak
    Department of Neurology, Center for Clinical Research, University of Ulm, Germany
    Acta Neuropathol 120:67-74. 2010
    ..Because these aggregates were not stained with antibodies against p62 and non-phosphorylated TDP-43, it is possible that phosphorylation of TDP-43 is required for its aggregation in sporadic ALS...
  12. doi request reprint [Pathophysiology of sporadic Parkinson's disease]
    H Braak
    Klinische Neuroanatomie, Zentrum für Klinische Forschung, Neurologische Universitätsklinik Ulm
    Fortschr Neurol Psychiatr 78:S2-4. 2010
    ..During this phase, the illness probably becomes clinically manifest. In the final stages 5 - 6, the lesions appear in the neocortex...
  13. doi request reprint Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia
    Kelly Del Tredici
    Clinical Neuroanatomy Section, Center for Biomedical Research, Department of Neurology, University of Ulm, Helmholtzstrasse 8 1, Ulm 89081, Germany
    J Neurol Neurosurg Psychiatry 84:774-83. 2013
    ..Noradrenergic therapeutic interventions might not only alleviate depressive symptoms and anxiety but also delay the onset of cognitive decline...
  14. doi request reprint Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease
    Kelly Del Tredici
    Clinical Neuroanatomy, Center for Clinical Research, Department of Neurology, University of Ulm, Helmholtzstrasse 8 1, 89081 Ulm, Germany
    Acta Neuropathol 119:703-13. 2010
    ..Potential disease-related changes in salivary volume, contents, and viscosity might make it possible, in combination with other tests, to employ human saliva as a biomarker...
  15. pmc Stages of pTDP-43 pathology in amyotrophic lateral sclerosis
    Johannes Brettschneider
    Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany
    Ann Neurol 74:20-38. 2013
    ..To see whether the distribution patterns of phosphorylated 43kDa TAR DNA-binding protein (pTDP-43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) permit recognition of neuropathological stages...
  16. doi request reprint Spinal cord lesions in sporadic Parkinson's disease
    Kelly Del Tredici
    Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Germany
    Acta Neuropathol 124:643-64. 2012
    ..The spinal cord lesions may contribute to clinical symptoms (e.g., pain, constipation, poor balance, lower urinary tract complaints, and sexual dysfunction) that occur during the premotor and motor phases of sporadic Parkinson's disease...
  17. doi request reprint Lewy pathology and neurodegeneration in premotor Parkinson's disease
    Kelly Del Tredici
    Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany
    Mov Disord 27:597-607. 2012
    ..This article reviews the neuropathology and anatomy of Lewy pathology-related neurodegeneration in relation to selected nonmotro and prodromal dysfunctions...
  18. doi request reprint Stages of granulovacuolar degeneration: their relation to Alzheimer's disease and chronic stress response
    Dietmar Rudolf Thal
    Laboratory of Neuropathology, Institute of Pathology, Center for Clinical Research, University of Ulm, Germany
    Acta Neuropathol 122:577-89. 2011
    ..Moreover, the association of the GVD stages with those of AD-related pathology but not with other neurodegenerative disorders points to a possible role of GVD and the response to chronic stress in the pathogenesis of AD...
  19. doi request reprint Paraffin sections of 70-100 μm: a novel technique and its benefits for studying the nervous system
    Simone Feldengut
    Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstrasse 8 1, 89081 Ulm, Germany
    J Neurosci Methods 215:241-4. 2013
    ..g., those associated with synucleinopathies, tauopathies, and TDP-43 proteinopathies...
  20. ncbi request reprint Diffusion tensor imaging analysis of sequential spreading of disease in amyotrophic lateral sclerosis confirms patterns of TDP-43 pathology
    Jan Kassubek
    1 Department of Neurology, University of Ulm, Ulm, Germany
    Brain 137:1733-40. 2014
    ....
  21. ncbi request reprint Amyotrophic lateral sclerosis--a model of corticofugal axonal spread
    Heiko Braak
    Clinical Neuroanatomy Section, Department of Neurology, Centre for Biomedical Research, University of Ulm, Helmholtzstrasse 8 1, 89081 Ulm, Germany
    Nat Rev Neurol 9:708-14. 2013
    ....
  22. doi request reprint Parenchymal and vascular Abeta-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease
    Dietmar Rudolf Thal
    Institute of Pathology Laboratory of Neuropathology University of Ulm, Ulm, Germany
    J Cell Mol Med 12:1848-62. 2008
    ..Therefore, it seems to be necessary to protect the brain from Abeta-toxicity already in stages of the disease with minor neuron loss before the onset of cognitive symptoms...