Anja Katrin Bosserhoff

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. pmc Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice
    Markus Moser
    Institute of Pathology, University Hospital RWTH, D 52074 Aachen, Germany
    Mol Cell Biol 22:1438-45. 2002
  2. pmc YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis
    Rainer Schmid
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    PLoS ONE 8:e82166. 2013
  3. pmc Targeting melanoma metastasis and immunosuppression with a new mode of melanoma inhibitory activity (MIA) protein inhibition
    Jennifer Schmidt
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    PLoS ONE 7:e37941. 2012
  4. pmc CTGF is overexpressed in malignant melanoma and promotes cell invasion and migration
    S Braig
    University of Regensburg Medical School, Institute of Pathology, Franz Josef Strauss Allee 11, Regensburg D 93053, Germany
    Br J Cancer 105:231-8. 2011
  5. pmc Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma
    Ramin Massoumi
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Exp Med 206:221-32. 2009
  6. pmc Enhanced cartilage regeneration in MIA/CD-RAP deficient mice
    R Schmid
    Institute of Pathology, University of Regensburg, Germany
    Cell Death Dis 1:e97. 2010
  7. pmc Role of miRNAs in the progression of malignant melanoma
    D W Mueller
    Institute of Pathology, Molecular Pathology, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg D 93053, Germany
    Br J Cancer 101:551-6. 2009
  8. doi request reprint N-cadherin promoter polymorphisms and risk of osteoarthritis
    Anke Ruedel
    2Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    FASEB J 28:683-91. 2014
  9. pmc Melanoma Inhibitory Activity (MIA) increases the invasiveness of pancreatic cancer cells
    Jamael El Fitori
    Department of General Surgery, University of Heidelberg, Germany
    Cancer Cell Int 5:3. 2005
  10. pmc Loss of full length CtBP1 expression enhances the invasive potential of human melanoma
    Andreas Winklmeier
    Institute of Pathology, University Regensburg, 93053 Regensburg, Germany
    BMC Cancer 9:52. 2009

Detail Information

Publications115 found, 100 shown here

  1. pmc Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice
    Markus Moser
    Institute of Pathology, University Hospital RWTH, D 52074 Aachen, Germany
    Mol Cell Biol 22:1438-45. 2002
    ..Taken together, our data indicate that MIA/CD-RAP is essentially required for formation of the highly ordered ultrastructural fiber architecture in cartilage and may have a role in regulating chondrocyte matrix interactions...
  2. pmc YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis
    Rainer Schmid
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    PLoS ONE 8:e82166. 2013
    ..Uncovering new downstream effectors that function via the activation of YBX1 supports the important role of MIA/CD-RAP in these processes. ..
  3. pmc Targeting melanoma metastasis and immunosuppression with a new mode of melanoma inhibitory activity (MIA) protein inhibition
    Jennifer Schmidt
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    PLoS ONE 7:e37941. 2012
    ..We believe AR71 is a lead structure for MIA inhibitors. More generally, inhibiting MIA dimerization is a novel therapeutic concept in melanoma therapy...
  4. pmc CTGF is overexpressed in malignant melanoma and promotes cell invasion and migration
    S Braig
    University of Regensburg Medical School, Institute of Pathology, Franz Josef Strauss Allee 11, Regensburg D 93053, Germany
    Br J Cancer 105:231-8. 2011
    ....
  5. pmc Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma
    Ramin Massoumi
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Exp Med 206:221-32. 2009
    ..Importantly, tumor thickness and progression-free and overall survival inversely correlated with CYLD expression. Our data suggest that Snail1-mediated suppression of CYLD plays a key role in melanoma malignancy...
  6. pmc Enhanced cartilage regeneration in MIA/CD-RAP deficient mice
    R Schmid
    Institute of Pathology, University of Regensburg, Germany
    Cell Death Dis 1:e97. 2010
    ..Taken together, our data indicate that MIA/CD-RAP is required for differentiation in cartilage potentially by regulating signaling processes during differentiation...
  7. pmc Role of miRNAs in the progression of malignant melanoma
    D W Mueller
    Institute of Pathology, Molecular Pathology, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg D 93053, Germany
    Br J Cancer 101:551-6. 2009
    ..In this review, recent progress to reveal the role of miRNAs in the tumourigenesis of malignant melanoma, as well as future prospects of melanoma-related miRNA research, will be addressed...
  8. doi request reprint N-cadherin promoter polymorphisms and risk of osteoarthritis
    Anke Ruedel
    2Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    FASEB J 28:683-91. 2014
    ..In summary, a CDH2 promoter polymorphism influences the risk of OA, and hnRNP K was found to be involved in the regulation of elevated N-cadherin expression in patients with OA carrying the minor allele of rs11564299...
  9. pmc Melanoma Inhibitory Activity (MIA) increases the invasiveness of pancreatic cancer cells
    Jamael El Fitori
    Department of General Surgery, University of Heidelberg, Germany
    Cancer Cell Int 5:3. 2005
    ..CONCLUSION: MIA is over-expressed in pancreatic cancer and has the potential of promoting the invasiveness of pancreatic cancer cells...
  10. pmc Loss of full length CtBP1 expression enhances the invasive potential of human melanoma
    Andreas Winklmeier
    Institute of Pathology, University Regensburg, 93053 Regensburg, Germany
    BMC Cancer 9:52. 2009
    ..The present study was performed to evaluate a more general role of CtBP1 in human melanoma and identify further CtBP1-regulated target genes...
  11. pmc Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis
    Alexandra E Denk
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Arthritis Res Ther 12:R45. 2010
    ..However, until today no data are available on whether these repellent factors are involved in the regulation of synovial fibroblast (SF) activity in rheumatoid arthritis (RA)...
  12. ncbi request reprint Specific expression and regulation of the new melanoma inhibitory activity-related gene MIA2 in hepatocytes
    Anja K Bosserhoff
    Institute of Pathology and Department of Internal Medicine I, University of Regensburg, 93053 Regensburg, Germany
    J Biol Chem 278:15225-31. 2003
    ..The increased transcription in more severe chronic liver disease suggests that MIA2 may serve as a marker of hepatic disease activity and severity...
  13. ncbi request reprint Multiple colon carcinomas in a patient with Cowden syndrome
    Anja Katrin Bosserhoff
    Institute of Pathology, University of Regensburg, 93053 Regensburg, Germany
    Int J Mol Med 18:643-7. 2006
    ..This case demonstrates that gastrointestinal hamartomas in Cowden syndrome patients can progress to invasive adenocarcinomas and should therefore be carefully monitored...
  14. ncbi request reprint Characterization and expression pattern of the novel MIA homolog TANGO
    A K Bosserhoff
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    Gene Expr Patterns 4:473-9. 2004
    ..The only cells lacking TANGO expression are cells belonging to the hematopoetic system. High levels of TANGO expression were observed both during embryogenesis and in adult tissues...
  15. ncbi request reprint Melanoma inhibitory activity (MIA): an important molecule in melanoma development and progression
    Anja Katrin Bosserhoff
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Pigment Cell Res 18:411-6. 2005
    ..Furthermore, newly discovered MIA-homologous genes are discussed...
  16. ncbi request reprint Active detachment involves inhibition of cell-matrix contacts of malignant melanoma cells by secretion of melanoma inhibitory activity
    Anja Katrin Bosserhoff
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Lab Invest 83:1583-94. 2003
    ..Further, our results suggest that inhibiting MIA functions in vivo may provide a novel therapeutic strategy for metastatic melanoma disease...
  17. ncbi request reprint Novel biomarkers in malignant melanoma
    Anja K Bosserhoff
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    Clin Chim Acta 367:28-35. 2006
    ..Here, recently published data related to new genes involved in melanoma pathogenesis, which may represent important biomarkers for the identification of genetic profiles or indication of progression of melanoma, are reviewed...
  18. ncbi request reprint Establishing the protein MIA (melanoma inhibitory activity) as a marker for chondrocyte differentiation
    Anja K Bosserhoff
    Institutes of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, Germany
    Biomaterials 24:3229-34. 2003
    ..Our data provide evidence that measuring MIA in tissue culture supernatant by a quantitative ELISA can be used as a marker for differentiated chondrocytes...
  19. ncbi request reprint Strong expression of methylthioadenosine phosphorylase (MTAP) in human colon carcinoma cells is regulated by TCF1/[beta]-catenin
    Frauke Bataille
    Institute of Pathology, University of Regensburg Medical School, Regensburg, Germany
    Lab Invest 85:124-36. 2005
    ..This finding may be of clinical significance concerning the homeostasis of normal colon epithelium and potential treatment of colon carcinoma...
  20. ncbi request reprint Expression levels of melanoma inhibitory activity correlate with time to progression in patients with high-grade glioma
    Peter Hau
    Klinik und Poliklinik fuer Neurologie der Universitaet Regensburg am Bezirksklinikum, 93053 Regensburg, Germany
    Oncol Rep 12:1355-64. 2004
    ..While a mechanistic relation has not yet been verified, factors such as a high fiber content of the extracellular matrix may explain this observation...
  21. ncbi request reprint Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues
    Stephanie Arndt
    University of Regensburg Medical School, Regensburg, Germany
    Lab Invest 85:1330-41. 2005
    ..Fussel-18 is the first example of a Smad-binding protein with a highly restricted expression pattern within the nervous system...
  22. ncbi request reprint In situ expression patterns of melanoma inhibitory activity 2 in healthy and diseased livers
    Claus Hellerbrand
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Liver Int 25:357-66. 2005
    ..Here, we analyzed the in situ expression of MIA2 protein and mRNA in healthy and diseased livers to get first insights into the function of MIA2...
  23. ncbi request reprint Influence of melanoma inhibitory activity on transforming growth factor-beta signaling in malignant melanoma
    Tanja Rothhammer
    Institute of Pathology, University of Regensburg Medical School, Regensburg, Germany
    Melanoma Res 16:309-16. 2006
    ..Treatment of HMB2 cells with a MEK inhibitor revealed a reduction of Ski and Sno expression, which leads to the conclusion that, in our melanoma cell model, Ski and Sno expression is regulated via MAPK/ERK signaling...
  24. ncbi request reprint Regulation of integrin activity by MIA
    Richard Bauer
    University of Regensburg Medical School, Institute of Pathology, D 93053 Regensburg, Germany
    J Biol Chem 281:11669-77. 2006
    ..Inhibiting MIA functions in vivo may therefore provide a novel therapeutic strategy for metastatic melanoma disease...
  25. doi request reprint p54nrb is a new regulator of progression of malignant melanoma
    Susanne Schiffner
    Institute of Pathology, Molecular Pathology, University of Regensburg Medical School, Regensburg, Germany
    Carcinogenesis 32:1176-82. 2011
    ..Our results demonstrate that p54(nrb) is highly expressed in malignant melanoma and, as a MIA target molecule, it seems to be involved in the development and progression of malignant melanoma...
  26. pmc Reduced expression of fibroblast growth factor receptor 2IIIb in hepatocellular carcinoma induces a more aggressive growth
    Thomas Amann
    University of Regensburg, Department of Internal Medicine I, D 93042 Regensburg, Germany
    Am J Pathol 176:1433-42. 2010
    ..Identification of the molecular mechanisms promoting regeneration in normal tissue while suppressing malignancy may lead to novel therapeutic targets of this highly aggressive tumor...
  27. ncbi request reprint Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma
    Claus Hellerbrand
    Department of Internal Medicine I and Institute of Pathology, University of Regensburg, D 93042 Regensburg, Germany
    Carcinogenesis 27:64-72. 2006
    ..Furthermore, in the light of a recent report revealing an association between MTAP activity and IFN sensitivity, our findings may have clinical significance for therapeutic strategies...
  28. ncbi request reprint Cloning and characterization of the expression pattern of a novel splice product MIA (splice) of malignant melanoma-derived growth-inhibiting activity (MIA/CD-RAP) [corrected]
    Peter Hau
    Department of Neurology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 119:562-9. 2002
    ..Whereas the biologic function of melanoma-inhibiting activity (splice) is not clear yet, it might provide a relevant diagnostic and therapeutic tool for malignant melanomas...
  29. doi request reprint MicroRNA miR-196a controls melanoma-associated genes by regulating HOX-C8 expression
    Daniel W Mueller
    Institute of Pathology, University of Regensburg Medical School, Regensburg, Germany
    Int J Cancer 129:1064-74. 2011
    ..This fact is underlined by a strongly reduced invasive behavior of melanoma cells re-expressing miR-196a in vitro...
  30. doi request reprint Cadherin-7 interacts with melanoma inhibitory activity protein and negatively modulates melanoma cell migration
    Andreas Winklmeier
    Institute of Pathology, University of Regensburg Medical School, Franz Josef Strauss Allee 11, Regensburg, Germany
    Cancer Sci 100:261-8. 2009
    ..In conclusion, these findings suggest that cadherin-7 regulates the expression and activity of MIA and the migration of melanoma cells playing a role in tumor development of malignant melanoma...
  31. doi request reprint Heterogeneous transition metal-based fluorescence polarization (HTFP) assay for probing protein interactions
    Alexander Riechers
    Institute for Organic Chemistry, University of Regensburg, Regensburg, Germany
    Biotechniques 47:837-44. 2009
    ....
  32. pmc Backbone dynamics of the human MIA protein studied by (15)N NMR relaxation: implications for extended interactions of SH3 domains
    Raphael Stoll
    Max Planck Institute of Biochemistry, D 82152 München, Germany
    Protein Sci 12:510-9. 2003
    ....
  33. ncbi request reprint Melanoma inhibitory activity promotes melanoma development through activation of YBX1
    Rainer Schmid
    Institute of Pathology, University of Regensburg Medical School, Regensburg, Germany
    Pigment Cell Melanoma Res 26:685-96. 2013
    ..In summary, we present for the first time effects of MIA on transcriptional regulation. Uncovering new potential downstream effectors working via activation of YBX1 supports the important role of MIA in melanoma. ..
  34. doi request reprint BMP activated Smad signaling strongly promotes migration and invasion of hepatocellular carcinoma cells
    Ulrike Maegdefrau
    Institute of Pathology, University of Regensburg, Germany
    Exp Mol Pathol 92:74-81. 2012
    ..In summary, our findings demonstrate enhanced expression levels of several BMPs in HCC supporting enhanced migratory and invasive phenotype of HCC cells mainly via activation of Smad signaling...
  35. pmc Fussel-15, a new player in wound healing, is deregulated in keloid and localized scleroderma
    Stephanie Arndt
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Am J Pathol 178:2622-31. 2011
    ..Permanent expression of Fussel-15 in keloid and skin sclerosis fibroblasts could be involved in the pathogenesis of these conditions, but the molecular mechanism underlying this up-regulation remains to be determined...
  36. doi request reprint Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma
    Thomas Amann
    Department of Internal Medicine I, University of Regensburg, D 93053, Regensburg, Germany
    Cancer Sci 100:646-53. 2009
    ..In summary, our data indicate that stromal HSC promotes HCC progression and suggest the HSC-HCC interaction as an interesting tumor differentiation-independent target for therapy of this highly aggressive cancer...
  37. ncbi request reprint Role of deleted in colon carcinoma in osteoarthritis and in chondrocyte migration
    Thomas Schubert
    University of Regensburg, Institute of Pathology, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Rheumatology (Oxford) 48:1435-41. 2009
    ..We analysed the potential role of the receptor deleted in colon carcinoma (DCC) in chondrocytes, as this may exert attractive activities...
  38. doi request reprint Melanoblasts in culture as an in vitro system to determine molecular changes in melanoma
    Anja Katrin Bosserhoff
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Exp Dermatol 20:435-40. 2011
    ..In summary, we feel that the analysis of MBrc generated in a reproducible system will give new insight into the role and importance of melanoma-associated genes...
  39. ncbi request reprint Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling
    Stephanie Arndt
    University of Regensburg Medical School, D 93053 Regensburg, Germany
    Mol Cell Neurosci 34:603-11. 2007
    ..This new protein expands the family of Ski/Sno proto-oncoproteins and represents a novel molecular regulator of BMP signaling...
  40. ncbi request reprint Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extracellular signal-regulated kinase signaling in melanoma cell lines
    Marion M Schuierer
    Institute of Pathology, Medical School of the University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    Cancer Res 64:5186-92. 2004
    ..Taken together, our results suggest that loss of RKIP in malignant melanoma contributes to enhanced invasiveness of transformed cells and therefore to progression of the disease...
  41. ncbi request reprint FHL2 suppresses growth and differentiation of the colon cancer cell line HT-29
    Thomas Amann
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Oncol Rep 23:1669-74. 2010
    ....
  42. ncbi request reprint Processing of MIA protein during melanoma cell migration
    Jennifer Schmidt
    Institute of Pathology, Molecular Pathology, University of Regensburg, Regensburg, Germany
    Int J Cancer 125:1587-94. 2009
    ....
  43. ncbi request reprint Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration
    Tanja Rothhammer
    University of Regensburg Medical School, Regensburg, Germany
    Cancer Res 65:448-56. 2005
    ....
  44. doi request reprint Constitutive HIF-1 activity in malignant melanoma
    Silke Kuphal
    University Medical Center Regensburg, D 93053 Regensburg, Germany
    Eur J Cancer 46:1159-69. 2010
    ..In summary, we identified an increased HIF-1alpha protein expression and activity in melanoma under normoxia mediated by ROS and the NFkappaB pathway...
  45. doi request reprint MicroRNA miR-196a is a central regulator of HOX-B7 and BMP4 expression in malignant melanoma
    Simone Braig
    Institute of Pathology, University of Regensburg Medical School, Franz Josef Strauss Allee 11, Regensburg, Germany
    Cell Mol Life Sci 67:3535-48. 2010
    ..In summary, our study provides insights into the early steps of melanoma progression and might thereby harbor therapeutic relevance...
  46. ncbi request reprint Tenascin-C protein is induced by transforming growth factor-beta1 but does not correlate with time to tumor progression in high-grade gliomas
    Peter Hau
    Department of Neurology, University of Regensburg, Universitatsstrasse 84, 93053, Regensburg, Germany
    J Neurooncol 77:1-7. 2006
    ..This study was designed to evaluate if TGF-beta1 induces the expression and deposition of Tenascin-C in the extracellular matrix of high-grade gliomas which may be pivotal for the invasion of these tumors into healthy parenchyma...
  47. doi request reprint Bone morphogenetic protein 4 is induced in hepatocellular carcinoma by hypoxia and promotes tumour progression
    Ulrike Maegdefrau
    Institute of Pathology, University of Regensburg, Germany
    J Pathol 218:520-9. 2009
    ..Therefore, BMP4 expression may have clinical relevance, and interfering with BMP4 signalling appears as an attractive therapeutic target for this highly aggressive tumour...
  48. doi request reprint Iron-induced expression of bone morphogenic protein 6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo
    Stephanie Arndt
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Gastroenterology 138:372-82. 2010
    ..Recent studies identified bone morphogenic protein 6 (BMP6) as a key regulator of hepatic hepcidin expression and iron metabolism, but the cellular source of BMP6 and the reason for its specific effect on hepatocytes are unknown...
  49. ncbi request reprint Integrin signaling in malignant melanoma
    Silke Kuphal
    Institute of Pathology, University of Regensburg, Germany
    Cancer Metastasis Rev 24:195-222. 2005
    ..Antagonists of several integrins are now under evaluation in clinical trials to determine their potential as therapeutics for malignant melanoma and other kinds of cancer...
  50. ncbi request reprint Characterization of Sno expression in malignant melanoma
    Ina Poser
    University of Regensburg Medical School, D 93053 Regensburg, Germany
    Int J Oncol 26:1411-7. 2005
    ..In summary, constitutive Sno expression was identified as an important mechanism to shut off antiproliferative TGF-beta signaling in malignant melanoma...
  51. ncbi request reprint Regulation and function of the atypical cadherin FAT1 in hepatocellular carcinoma
    Daniela Valletta
    Department of Internal Medicine I, University Hospital Regensburg, 93053 Regensburg, Germany, Institute of Pharmacy, University of Regensburg, 93053 Regensburg, Germany, Institute of Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland, Institute of Pathology, University Hospital Erlangen, 91054 Erlangen, Germany, Department of Pediatrics and Juvenile Medicine, University Hospital Regensburg, 93053 Regensburg, Germany and Institute of Functional Genomics and Institute of Pathology, University of Regensburg, 93053 Regensburg, Germany
    Carcinogenesis 35:1407-15. 2014
    ..FAT1 appears as relevant mediator of hypoxia and growth receptor signaling to critical tumorigenic pathways in HCC. This knowledge may facilitate the rational design of novel therapeutics against this highly aggressive malignancy...
  52. doi request reprint Bone morphogenetic proteins induce expression of metalloproteinases in melanoma cells and fibroblasts
    Tanja Rothhammer
    Institute of Pathology, University of Regensburg Medical School, Regensburg, Germany
    Eur J Cancer 44:2526-34. 2008
    ....
  53. doi request reprint Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma
    Ulrike Maegdefrau
    Institute of Pathology, University of Regensburg, Germany
    Lab Invest 91:1615-23. 2011
    ....
  54. pmc Cold atmospheric plasma (CAP) changes gene expression of key molecules of the wound healing machinery and improves wound healing in vitro and in vivo
    Stephanie Arndt
    Institute of Pathology, University Regensburg, Regensburg, Germany
    PLoS ONE 8:e79325. 2013
    ....
  55. doi request reprint Deregulation of protein methylation in melanoma
    Katharina Limm
    Institute of Pathology, University of Regensburg, Germany
    Eur J Cancer 49:1305-13. 2013
    ..The effects of endogeneous MTA on PRMTs as presented in this study can strongly support the migratory and invasive phenotype of melanoma cells...
  56. ncbi request reprint p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes
    Jurgen Radons
    Abteilung Hämatologie und internistische Onkologie, Universitatsklinikum Regensburg, D 93053 Regensburg, Germany
    Int J Mol Med 17:661-8. 2006
    ..The identification and characterization of these signaling pathways will enable us to develop new modulation strategies for therapeutic use in inflammatory joint diseases...
  57. ncbi request reprint Functional implication of truncated P-cadherin expression in malignant melanoma
    Richard Bauer
    Institute of Pathology, Molecular Pathology, University of Regensburg, D 93053 Regensburg, Germany
    Exp Mol Pathol 81:224-30. 2006
    ....
  58. pmc Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2
    Fusun Baumann
    Department of Neurology, University of Regensburg, Universitatsstrasse 84, 93053 Regensburg, Germany
    Neuro Oncol 11:368-80. 2009
    ..This novel interaction between lactate metabolism and TGF-beta2 might constitute a crucial mechanism for glioma migration...
  59. pmc Expression and function of methylthioadenosine phosphorylase in chronic liver disease
    Barbara Czech
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    PLoS ONE 8:e80703. 2013
    ..To study expression and function of methylthioadenosine phosphorylase (MTAP), the rate-limiting enzyme in the methionine and adenine salvage pathway, in chronic liver disease...
  60. ncbi request reprint MIA--a new target protein for malignant melanoma therapy
    Jennifer Schmidt
    Institute of Pathology, University of Regensburg, Germany
    Histol Histopathol 28:421-6. 2013
    ..The molecular understanding of the contribution of MIA protein to formation of metastases provides an excellent starting point for the development of a new strategy in malignant melanoma therapy...
  61. pmc fussel (fuss)--A negative regulator of BMP signaling in Drosophila melanogaster
    Susanne Fischer
    Institute of Zoology, University of Regensburg, Regensburg, Germany
    PLoS ONE 7:e42349. 2012
    ..Taken together we could show that fuss exerts a pivotal role as an antagonist of BMP signaling in Drosophila melanogaster...
  62. doi request reprint E-cadherin cell-cell communication in melanogenesis and during development of malignant melanoma
    Silke Kuphal
    Institute of Pathology, University of Regensburg, D 93053 Regensburg, Germany
    Arch Biochem Biophys 524:43-7. 2012
    ..The regulation and role of E-cadherin during melanoma development will be the focus of this review...
  63. ncbi request reprint TANGO is a tumor suppressor of malignant melanoma
    Stephanie Arndt
    Institute of Pathology, Molecular Pathology, University of Regensburg, Germany
    Int J Cancer 119:2812-20. 2006
    ..Our studies, therefore, indicate that reduction of TANGO expression contributes to tumor progression. These results taken together provide the first indications for a tumor suppressor role of TANGO gene in human malignant melanoma...
  64. ncbi request reprint Reduced expression of TANGO in colon and hepatocellular carcinomas
    Stephanie Arndt
    Institute of Pathology, University of Regensburg, D 93053 Regensburg, Germany
    Oncol Rep 18:885-91. 2007
    ..Thus, functional relevant loss of TANGO expression may contribute to general tumor development and progression, and may provide a new target for therapeutic strategies...
  65. doi request reprint Inducing anti-tumor cytokines and an immune response in melanoma by inhibition of MIA using the peptide AR71
    Alexander Riechers
    Institute of Pathology, University of Regensburg Franz Josef Strauss Allee 11 D 93053 Regensburg, Germany
    Eur J Dermatol 23:820-5. 2013
    ..Malignant melanoma is known for its aggressive metastatic spread and suppression of the host immune system. Immunosuppression in melanoma is mediated in part by the protein melanoma inhibitory activity (MIA)...
  66. doi request reprint Cold atmospheric plasma, a new strategy to induce senescence in melanoma cells
    Stephanie Arndt
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Exp Dermatol 22:284-9. 2013
    ..The mechanism of senescence with regard to plasma therapy was so far not described previously and is of great importance for therapeutic application of CAP...
  67. pmc Pitfalls in immunohistochemistry--a recent example
    Alexander Riechers
    Institute of Pathology, University of Regensburg, Germany
    Int J Clin Exp Pathol 5:137-9. 2012
    ....
  68. ncbi request reprint Loss of p14ARF expression in melanoma
    Rafael Dobrowolski
    Institute of Pathology, University of RWTH Aachen, Germany
    Arch Dermatol Res 293:545-51. 2002
    ..These results suggest that p14ARF inactivation is important in the development of melanomas...
  69. doi request reprint Migration-associated secretion of melanoma inhibitory activity at the cell rear is supported by KCa3.1 potassium channels
    Jennifer Schmidt
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    Cell Res 20:1224-38. 2010
    ..In summary, we have elucidated the migration-associated transport of MIA protein to the cell rear and also disclosed a new mechanism by which KCa3.1 potassium channels promote cell migration...
  70. doi request reprint DNA staining in agarose gels with Zn²+-cyclen-pyrene
    Florian Schmidt
    Institute of Organic Chemistry, University of Regensburg, Regensburg, Germany
    Nucleosides Nucleotides Nucleic Acids 29:748-59. 2010
    ..Cytotoxicity tests on HeLa and V-79 cells reveal that the zinc-cyclen pyrene probe is significant less toxic compared to ethidium bromide...
  71. pmc GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis
    Thomas Amann
    University of Regensburg, Department of Internal Medicine I, D 93042 Regensburg, Germany
    Am J Pathol 174:1544-52. 2009
    ..In summary, our findings suggest that increased GLUT1 expression levels in HCC cells functionally affect tumorigenicity, and thus, we propose GLUT1 as an innovative therapeutic target for this highly aggressive tumor...
  72. ncbi request reprint Expression of integrin alpha10 is induced in malignant melanoma
    Ann Kathrin Wenke
    Institute of Pathology, University Regensburg, 93053 Regensburg, Germany
    Cell Oncol 29:373-86. 2007
    ..In summary, these data indicate that AP-2 and Ets-1 regulated expression of integrin alpha10 plays a role in migration of malignant melanoma cells...
  73. ncbi request reprint Interactions of TANGO and leukocyte integrin CD11c/CD18 regulate the migration of human monocytes
    Stephanie Arndt
    Institute of Pathology, University of Regensburg Medical School, Regensburg, Germany
    J Leukoc Biol 82:1466-72. 2007
    ..Taken together, the results from this study present TANGO as a novel ligand for CD11c, regulating migratory processes of hematopoietic cells...
  74. ncbi request reprint Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines
    Marion M Schuierer
    University of Regensburg, Institute of Pathology, Franz Josef Straus Allee 11, 93053 Regensburg, Germany
    World J Gastroenterol 12:1529-35. 2006
    ..To analyse the Chibby expression and its function in colon carcinoma cell lines and colorectal carcinoma (CRC)...
  75. ncbi request reprint Down-regulation of COOH-terminal binding protein expression in malignant melanomas leads to induction of MIA expression
    Ina Poser
    Institute of Pathology, RWTH Aachen, Germany
    Cancer Res 62:5962-6. 2002
    ..Therefore, we speculate that CtBP1 has an important negative role in MIA regulation, and loss of CtBP1 is implicated in melanoma progression...
  76. ncbi request reprint Functional role of MIA in melanocytes and early development of melanoma
    Ina Poser
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    Oncogene 23:6115-24. 2004
    ..These results suggest that expression of MIA promotes melanoma progression by inducing further melanoma-associated genes...
  77. doi request reprint Quantification of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry in cultured tumor cells and liver biopsies
    Axel P Stevens
    Institute of Functional Genomics, University of Regensburg, Josef Engert Str 9, 93053 Regensburg, Germany
    J Chromatogr A 1217:3282-8. 2010
    ....
  78. doi request reprint Functional implication of Netrin expression in malignant melanoma
    Simone Kaufmann
    Institute of Pathology, University Hospital, University of Regensburg, Regensburg, Germany
    Cell Oncol 31:415-22. 2009
    ..Malignant melanoma cells are known to have altered expression of genes supporting proliferation and invasion, however, the expression of molecules of the Netrin family of repellent factors has not been analyzed in melanomas until now...
  79. ncbi request reprint RNA expression profiling of normal and tumor cells following photodynamic therapy with 5-aminolevulinic acid-induced protoporphyrin IX in vitro
    Peter J Wild
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Mol Cancer Ther 4:516-28. 2005
    ..RNA expression profiling of normal and tumor cell lines following photodynamic therapy with 5-aminolevulinic acid gave insight into the major molecular mechanisms induced by photodynamic therapy...
  80. doi request reprint H-cadherin expression reduces invasion of malignant melanoma
    Silke Kuphal
    Melanoma Genomics Group, The Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Pigment Cell Melanoma Res 22:296-306. 2009
    ..Our study presents for the first time the down-regulation of H-cadherin in malignant melanomas and its possible functional relevance in maintenance healthy skin architecture...
  81. ncbi request reprint Reduced expression of CYLD in human colon and hepatocellular carcinomas
    Claus Hellerbrand
    Department of Internal Medicine I, University Regensburg, 93053 Regensburg, Germany
    Carcinogenesis 28:21-7. 2007
    ..Thus, functional relevant loss of CYLD expression may contribute to tumor development and progression, and may provide a new target for therapeutic strategies...
  82. doi request reprint Loss of nephronectin promotes tumor progression in malignant melanoma
    Silke Kuphal
    Institute of Pathology, University Regensburg, D 93053 Regensburg, Germany
    Cancer Sci 99:229-33. 2008
    ..Interestingly, integrin alpha-8 expression, which was described as a receptor for POEM, is enhanced in malignant melanoma. Our studies thus indicate that loss of POEM expression may contribute to melanoma progression...
  83. ncbi request reprint Loss of maspin expression contributes to a more invasive potential in malignant melanoma
    Alexandra E Denk
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Pigment Cell Res 20:112-9. 2007
    ..In summary, we believe that maspin is a tumour suppressor in malignant melanoma...
  84. pmc Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro
    Corinna Seliger
    Department of Neurology and Wilhelm Sander NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany
    PLoS ONE 8:e78935. 2013
    ..In this study we tested the hypothesis, that lactate regulates TGF-beta2 expression and glioma cell migration via induction of Thrombospondin-1 (THBS-1), a TGF-beta activating protein...
  85. ncbi request reprint Epigenetic events in malignant melanoma
    Tanja Rothhammer
    Institute of Pathology, University of Regensburg Medical School, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    Pigment Cell Res 20:92-111. 2007
    ..This review gives an overview of the many different types of epigenetic modifications and their involvement in cancer and especially in melanoma development and progression...
  86. doi request reprint ETS-1/RhoC signaling regulates the transcription factor c-Jun in melanoma
    Barbara Spangler
    Institute of Pathology, University of Regensburg, 93053 Regensburg, Germany
    Int J Cancer 130:2801-11. 2012
    ..We conclude that the loss of E-cadherin mediated cell-adhesion induces c-Jun protein expression in a multistep process, offering several possibilities for therapeutic intervention...
  87. doi request reprint Phosphorylation of β-catenin results in lack of β-catenin signaling in melanoma
    Silke Kuphal
    University of Regensburg, Institute of Pathology, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Int J Oncol 39:235-43. 2011
    ..In summary, this study suggests a cell type-specific regulation of β-catenin function. This alternative β-catenin signaling pathway should be considered when thinking about targeting β-catenin in melanoma treatment...
  88. doi request reprint miRNA expression profiling in melanocytes and melanoma cell lines reveals miRNAs associated with formation and progression of malignant melanoma
    Daniel W Mueller
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 129:1740-51. 2009
    ....
  89. doi request reprint Quantitative analysis of 5'-deoxy-5'-methylthioadenosine in melanoma cells by liquid chromatography-stable isotope ratio tandem mass spectrometry
    Axel P Stevens
    Institute of Functional Genomics, University of Regensburg, Josef Engert Strasse 9, Regensburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 876:123-8. 2008
    ..However, there was a fourfold increase in intracellular MTA concentration in melanoma cells lacking MTAP, thus confirming the hypothesized accumulation of MTA in human cancer cells harboring a chromosome 9p21 deletion...
  90. doi request reprint The cartilage-specific transcription factor Sox9 regulates AP-2epsilon expression in chondrocytes
    Ann Kathrin Wenke
    Institute of Pathology, University Regensburg, Germany
    FEBS J 276:2494-504. 2009
    ..This is the first study to prove the direct regulation of AP-2epsilon by the transcription factor Sox9, and to indicate that AP-2epsilon potentially has an important role as a modulator of hypertrophic cartilage...
  91. ncbi request reprint Snail-regulated genes in malignant melanoma
    Silke Kuphal
    Institute of Pathology, University of Regensburg, D 93053 Regensburg, Germany
    Melanoma Res 15:305-13. 2005
    ..In summary, all examined genes which are influenced through Snail have a regulatory function in EMT processes as does Snail itself. The Snail target gene E-cadherin has no regulatory function with respect to the selected genes...
  92. ncbi request reprint Efficient transfection method for primary cells
    Astrid Hamm
    Institute of Pathology, RWTH, Aachen, Germany
    Tissue Eng 8:235-45. 2002
    ..In summary, this method presents an effective and fast mean for transfection of primary and stem cells demonstrated by four cell types which are only transfected with low efficiency by other methods...
  93. pmc Upregulation of HMG1 leads to melanoma inhibitory activity expression in malignant melanoma cells and contributes to their malignancy phenotype
    Ina Poser
    Institute of Pathology, University of Regensburg, 93053 Regensburg, Germany
    Mol Cell Biol 23:2991-8. 2003
    ..In summary, our study proves HMG1 and p65 to be important factors in MIA regulation and melanoma progression...
  94. ncbi request reprint Decrease of vascular smooth muscle cell locomotion by abciximab, but not tirofiban: a possible role of different affinity to alpha v beta 3 integrins
    Rüdiger Blindt
    University Hospital, Aachen, Medical Clinic I, Regensburg, Germany
    Coron Artery Dis 13:357-64. 2002
    ..Therefore, the objective of this study was to compare the effectiveness of abciximab and tirofiban to affect VSMC migration and invasion...
  95. ncbi request reprint Multiparameter immunofluorescence on paraffin-embedded tissue sections
    Frauke Bataille
    Institute of Pathology, University of Regensburg, Germany
    Appl Immunohistochem Mol Morphol 14:225-8. 2006
    ..In addition, procedures to reduce background staining and to avoid nonspecific double staining are described...
  96. doi request reprint Expression and function of the atypical cadherin FAT1 in chronic liver disease
    Daniela Valletta
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Biochem Biophys Res Commun 426:404-8. 2012
    ..Our findings suggest FAT1 as new therapeutic target for the prevention and treatment of hepatic fibrosis in chronic liver disease...
  97. ncbi request reprint Raf kinase inhibitor protein is downregulated in hepatocellular carcinoma
    Marion M Schuierer
    Institute of Pathology, University of Regensburg, 93053 Regensburg, Germany
    Oncol Rep 16:451-6. 2006
    ..In addition, our study demonstrates functional relevance of downregulation of RKIP in HCC that may play an important role in HCC development and progression...
  98. ncbi request reprint Inhibition of melanoma inhibitory activity (MIA) expression in melanoma cells leads to molecular and phenotypic changes
    Jutta Tatzel
    Institute of Pathology, University of Regensburg, D 93053 Regensburg, Germany
    Pigment Cell Res 18:92-101. 2005
    ..To our knowledge this is the first report demonstrating a correlation between MIA expression and pigmentation and morphology of melanocytic cells...
  99. doi request reprint Highly pigmented Tg(Grm1) mouse melanoma develops non-pigmented melanoma cells in distant metastases
    Susanne Schiffner
    Institute of Pathology, Molecular Pathology, University of Regensburg Medical School, Regensburg, Germany
    Exp Dermatol 21:786-8. 2012
    ..As such changes during metastasis are common in human melanoma, our findings demonstrate that this mouse model represents an even more useful tool to study unknown mechanisms of metastasis in human melanoma than previously assumed...
  100. doi request reprint Direct and tumor microenvironment mediated influences of 5'-deoxy-5'-(methylthio)adenosine on tumor progression of malignant melanoma
    Axel P Stevens
    Institute of Functional Genomics, University of Regensburg Medical School, Josef Engert Str 9, D 93053 Regensburg, Germany
    J Cell Biochem 106:210-9. 2009
    ..In summary, we demonstrated a tumor-supporting role of MTA...
  101. ncbi request reprint Mapping ATP-binding cassette transporter gene expression profiles in melanocytes and melanoma cells
    Susanne Heimerl
    Institute of Clinical Chemistry, University of Regensburg, Regensburg, Germany
    Melanoma Res 17:265-73. 2007
    ....